Abergel, Rebecca

TitleChemist Staff Sci/Engr
InstitutionLawrence Berkeley National Lab
DepartmentChemical Sciences
Address1 Cyclotron Road
Berkeley CA 94720
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    Exploring the use of a hydroxypyridinone decorporation agent for the removal of toxic residual gadolinium from MRI contrast agent administration
    NIH/NIBIB R21EB023601Aug 1, 2017 - May 31, 2019
    Role: Principal Investigator
    Biomimetic Actinide Decorporation: Characterization and Preclinical Development
    NIH/NIAID RC2AI087604Sep 28, 2009 - Aug 31, 2012
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Junker AKR, Deblonde GJ, Abergel R, Sørensen TJ. Investigating subtle 4f vs. 5f coordination differences using kinetically inert Eu(iii), Tb(iii), and Cm(iii) complexes of a coumarin-appended 1,4,7,10-tetraazacyclododecane-1,4,7-triacetate (DO3A) ligand. Dalton Trans. 2018 May 18. PMID: 29774904.
      View in: PubMed
    2. Kelley MP, Deblonde GJ, Su J, Booth CH, Abergel R, Batista ER, Yang P. Bond Covalency and Oxidation State of Actinide Ions Complexed with Therapeutic Chelating Agent 3,4,3-LI(1,2-HOPO). Inorg Chem. 2018 May 07; 57(9):5352-5363. PMID: 29624372.
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    3. Deblonde GJ, Kelley MP, Su J, Batista ER, Yang P, Booth CH, Abergel R. Spectroscopic and Computational Characterization of Diethylenetriaminepentaacetic Acid/Transplutonium Chelates: Evidencing Heterogeneity in the Heavy Actinide(III) Series. Angew Chem Int Ed Engl. 2018 Apr 16; 57(17):4521-4526. PMID: 29473263.
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    4. Rees JA, Deblonde GJ, An DD, Ansoborlo C, Gauny SS, Abergel R. Evaluating the potential of chelation therapy to prevent and treat gadolinium deposition from MRI contrast agents. Sci Rep. 2018 Mar 13; 8(1):4419. PMID: 29535330.
      View in: PubMed
    5. Abergel R, de Jong WA, Deblonde GJ, Dau PD, Captain I, Eaton TM, Jian J, van Stipdonk MJ, Martens J, Berden G, Oomens J, Gibson JK. Cleaving Off Uranyl Oxygens through Chelation: A Mechanistic Study in the Gas Phase. Inorg Chem. 2017 Nov 06; 56(21):12930-12937. PMID: 29019408.
      View in: PubMed
    6. Deblonde GJ, Sturzbecher-Hoehne M, Rupert PB, An DD, Illy MC, Ralston CY, Brabec J, de Jong WA, Strong RK, Abergel R. Chelation and stabilization of berkelium in oxidation state +IV. Nat Chem. 2017 Sep; 9(9):843-849. PMID: 28837177.
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    7. Captain I, Deblonde GJ, Rupert PB, An DD, Illy MC, Rostan E, Ralston CY, Strong RK, Abergel R. Engineered Recognition of Tetravalent Zirconium and Thorium by Chelator-Protein Systems: Toward Flexible Radiotherapy and Imaging Platforms. Inorg Chem. 2016 Nov 21; 55(22):11930-11936. PMID: 27802058.
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    8. Barasch J, Hollmen M, Deng R, Hod EA, Rupert PB, Abergel R, Allred BE, Xu K, Darrah SF, Tekabe Y, Perlstein A, Wax R, Bruck E, Stauber J, Corbin KA, Buchen C, Slavkovich V, Graziano J, Spitalnik SL, Bao G, Strong RK, Qiu A. Disposal of iron by a mutant form of lipocalin 2. Nat Commun. 2016 Oct 31; 7:12973. PMID: 27796299.
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    9. Deblonde GJ, Abergel R. Active actinium. Nat Chem. 2016 Oct 21; 8(11):1084. PMID: 27768109.
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    10. Dau PD, Shuh DK, Sturzbecher-Hoehne M, Abergel R, Gibson JK. Divalent and trivalent gas-phase coordination complexes of californium: evaluating the stability of Cf(ii). Dalton Trans. 2016 Aug 02; 45(31):12338-45. PMID: 27424652.
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    11. Agbo P, Abergel R. Ligand-Sensitized Lanthanide Nanocrystals: Merging Solid-State Photophysics and Molecular Solution Chemistry. Inorg Chem. 2016 Oct 17; 55(20):9973-9980. PMID: 27362470.
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    12. Sturzbecher-Hoehne M, Yang P, D'Aléo A, Abergel R. Intramolecular sensitization of americium luminescence in solution: shining light on short-lived forbidden 5f transitions. Dalton Trans. 2016 Jun 14; 45(24):9912-9. PMID: 26961598.
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    13. Abergel R, Ansoborlo E. Curious curium. Nat Chem. 2016 Apr 22; 8(5):516. PMID: 27102687.
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    14. An DD, Kullgren B, Jarvis EE, Abergel R. From early prophylaxis to delayed treatment: Establishing the plutonium decorporation activity window of hydroxypyridinonate chelating agents. Chem Biol Interact. 2017 Apr 01; 267:80-88. PMID: 27038878.
      View in: PubMed
    15. Kamada K, Namikawa T, Senatore S, Matthews C, Lenne PF, Maury O, Andraud C, Ponce-Vargas M, Le Guennic B, Jacquemin D, Agbo P, An DD, Gauny SS, Liu X, Abergel R, Fages F, D'Aléo A. Boron Difluoride Curcuminoid Fluorophores with Enhanced Two-Photon Excited Fluorescence Emission and Versatile Living-Cell Imaging Properties. Chemistry. 2016 Apr 04; 22(15):5219-32. PMID: 26919627.
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    16. Allred BE, Rupert PB, Gauny SS, An DD, Ralston CY, Sturzbecher-Hoehne M, Strong RK, Abergel R. Siderocalin-mediated recognition, sensitization, and cellular uptake of actinides. Proc Natl Acad Sci U S A. 2015 Aug 18; 112(33):10342-7. PMID: 26240330; PMCID: PMC4547258.
    17. Choi TA, Endsley AN, Bunin DI, Colas C, An DD, Morales-Rivera JA, Villalobos JA, Shinn WM, Dabbs JE, Chang PY, Abergel R. Biodistribution of the multidentate hydroxypyridinonate ligand [(14) C]-3,4,3-LI(1,2-HOPO), a potent actinide decorporation agent. Drug Dev Res. 2015 May; 76(3):107-22. PMID: 25857483.
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    18. Sturzbecher-Hoehne M, Choi TA, Abergel R. Hydroxypyridinonate complex stability of group (IV) metals and tetravalent f-block elements: the key to the next generation of chelating agents for radiopharmaceuticals. Inorg Chem. 2015 Apr 06; 54(7):3462-8. PMID: 25799124.
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    19. Choi TA, Furimsky AM, Swezey R, Bunin DI, Byrge P, Iyer LV, Chang PY, Abergel R. In vitro metabolism and stability of the actinide chelating agent 3,4,3-LI(1,2-HOPO). J Pharm Sci. 2015 May; 104(5):1832-8. PMID: 25727482; PMCID: PMC4390475.
    20. Ansoborlo E, Ménager MT, Abergel R. 11th International Conference on Health Effects of Incorporated Radionuclides. Int J Radiat Biol. 2014 Nov; 90(11):945-7. PMID: 25363314.
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    21. Liu M, Wang J, Wu X, Wang E, Abergel R, Shuh DK, Raymond KN, Liu P. Characterization, HPLC method development and impurity identification for 3,4,3-LI(1,2-HOPO), a potent actinide chelator for radionuclide decorporation. J Pharm Biomed Anal. 2015 Jan; 102:443-9. PMID: 25459944; PMCID: PMC4314361.
    22. An DD, Villalobos JA, Morales-Rivera JA, Rosen CJ, Bjornstad KA, Gauny SS, Choi TA, Sturzbecher-Hoehne M, Abergel R. (238)Pu elimination profiles after delayed treatment with 3,4,3LI(1,2HOPO) in female and male Swiss-Webster mice. Int J Radiat Biol. 2014 Nov; 90(11):1055-61. PMID: 24937372.
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    23. Panyala NR, Sturzbecher-Hoehne M, Abergel R. Identification of process related trace level impurities in the actinide decorporation agent 3,4,3-LI(1,2-HOPO): Nozzle-skimmer fragmentation via ESI LC-QTOFMS. J Pharm Biomed Anal. 2014 Nov; 100:157-166. PMID: 25165012; PMCID: PMC4179986.
    24. Sturzbecher-Hoehne M, Kullgren B, Jarvis EE, An DD, Abergel R. Highly luminescent and stable hydroxypyridinonate complexes: a step towards new curium decontamination strategies. Chemistry. 2014 Aug 04; 20(32):9962-8. PMID: 25043376.
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    25. Deblonde GJ, Sturzbecher-Hoehne M, Abergel R. Solution thermodynamic stability of complexes formed with the octadentate hydroxypyridinonate ligand 3,4,3-LI(1,2-HOPO): a critical feature for efficient chelation of lanthanide(IV) and actinide(IV) ions. Inorg Chem. 2013 Aug 05; 52(15):8805-11. PMID: 23855806; PMCID: PMC3771511.
    26. Deblonde GJ, Sturzbecher-Hoehne M, Mason AB, Abergel R. Receptor recognition of transferrin bound to lanthanides and actinides: a discriminating step in cellular acquisition of f-block metals. Metallomics. 2013 Jun; 5(6):619-26. PMID: 23446908; PMCID: PMC3672314.
    27. Sturzbecher-Hoehne M, Goujon C, Deblonde GJ, Mason AB, Abergel R. Sensitizing curium luminescence through an antenna protein to investigate biological actinide transport mechanisms. J Am Chem Soc. 2013 Feb 20; 135(7):2676-83. PMID: 23363005; PMCID: PMC3603364.
    28. Bunin DI, Chang PY, Doppalapudi RS, Riccio ES, An D, Jarvis EE, Kullgren B, Abergel R. Dose-dependent efficacy and safety toxicology of hydroxypyridinonate actinide decorporation agents in rodents: towards a safe and effective human dosing regimen. Radiat Res. 2013 Feb; 179(2):171-82. PMID: 23289385; PMCID: PMC3633606.
    29. Kullgren B, Jarvis EE, An DD, Abergel R. Actinide chelation: biodistribution and in vivo complex stability of the targeted metal ions. Toxicol Mech Methods. 2013 Jan; 23(1):18-26. PMID: 22957518.
      View in: PubMed
    30. Correnti C, Clifton MC, Abergel R, Allred B, Hoette TM, Ruiz M, Cancedda R, Raymond KN, Descalzi F, Strong RK. Galline Ex-FABP is an antibacterial siderocalin and a lysophosphatidic acid sensor functioning through dual ligand specificities. Structure. 2011 Dec 07; 19(12):1796-806. PMID: 22153502; PMCID: PMC3240821.
    31. Sturzbecher-Hoehne M, Leung CN, D'Aléo A, Kullgren B, Prigent AL, Shuh DK, Raymond KN, Abergel R. 3,4,3-LI(1,2-HOPO): in vitro formation of highly stable lanthanide complexes translates into efficacious in vivo europium decorporation. Dalton Trans. 2011 Sep 07; 40(33):8340-6. PMID: 21766096.
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    32. Abergel R, Raymond KN. Multidentate terephthalamidate and hydroxypyridonate ligands: towards new orally active chelators. Hemoglobin. 2011; 35(3):276-90. PMID: 21599440.
      View in: PubMed
    33. Abergel R, Durbin PW, Kullgren B, Ebbe SN, Xu J, Chang PY, Bunin DI, Blakely EA, Bjornstad KA, Rosen CJ, Shuh DK, Raymond KN. Biomimetic actinide chelators: an update on the preclinical development of the orally active hydroxypyridonate decorporation agents 3,4,3-LI(1,2-HOPO) and 5-LIO(Me-3,2-HOPO). Health Phys. 2010 Sep; 99(3):401-7. PMID: 20699704; PMCID: PMC2921233.
    34. Abergel R, D'Aléo A, Leung CN, Shuh DK, Raymond KN. Using the antenna effect as a spectroscopic tool: photophysics and solution thermodynamics of the model luminescent hydroxypyridonate complex [Eu(III)(3,4,3-LI(1,2-HOPO))]-. Inorg Chem. 2009 Dec 07; 48(23):10868-70. PMID: 19902920; PMCID: PMC2873866.
    35. Wilson MK, Abergel R, Arceneaux JE, Raymond KN, Byers BR. Temporal production of the two Bacillus anthracis siderophores, petrobactin and bacillibactin. Biometals. 2010 Feb; 23(1):129-34. PMID: 19816776; PMCID: PMC3057204.
    36. Abergel R, Zawadzka AM, Hoette TM, Raymond KN. Enzymatic hydrolysis of trilactone siderophores: where chiral recognition occurs in enterobactin and bacillibactin iron transport. J Am Chem Soc. 2009 Sep 09; 131(35):12682-92. PMID: 19673474; PMCID: PMC2782669.
    37. Zawadzka AM, Abergel R, Nichiporuk R, Andersen UN, Raymond KN. Siderophore-mediated iron acquisition systems in Bacillus cereus: Identification of receptors for anthrax virulence-associated petrobactin . Biochemistry. 2009 Apr 28; 48(16):3645-57. PMID: 19254027; PMCID: PMC2782674.
    38. Hoette TM, Abergel R, Xu J, Strong RK, Raymond KN. The role of electrostatics in siderophore recognition by the immunoprotein Siderocalin. J Am Chem Soc. 2008 Dec 24; 130(51):17584-92. PMID: 19053425; PMCID: PMC2778733.
    39. Abergel R, Clifton MC, Pizarro JC, Warner JA, Shuh DK, Strong RK, Raymond KN. The siderocalin/enterobactin interaction: a link between mammalian immunity and bacterial iron transport. J Am Chem Soc. 2008 Aug 27; 130(34):11524-34. PMID: 18680288; PMCID: PMC3188318.
    40. Abergel R, Zawadzka AM, Raymond KN. Petrobactin-mediated iron transport in pathogenic bacteria: coordination chemistry of an unusual 3,4-catecholate/citrate siderophore. J Am Chem Soc. 2008 Feb 20; 130(7):2124-5. PMID: 18220393.
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    41. Abergel R, Raymond KN. Terephthalamide-containing ligands: fast removal of iron from transferrin. J Biol Inorg Chem. 2008 Feb; 13(2):229-40. PMID: 17990009.
      View in: PubMed
    42. Abergel R, Wilson MK, Arceneaux JE, Hoette TM, Strong RK, Byers BR, Raymond KN. Anthrax pathogen evades the mammalian immune system through stealth siderophore production. Proc Natl Acad Sci U S A. 2006 Dec 05; 103(49):18499-503. PMID: 17132740; PMCID: PMC1693691.
    43. Fischbach MA, Lin H, Zhou L, Yu Y, Abergel R, Liu DR, Raymond KN, Wanner BL, Strong RK, Walsh CT, Aderem A, Smith KD. The pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2. Proc Natl Acad Sci U S A. 2006 Oct 31; 103(44):16502-7. PMID: 17060628; PMCID: PMC1637611.
    44. Abergel R, Moore EG, Strong RK, Raymond KN. Microbial evasion of the immune system: structural modifications of enterobactin impair siderocalin recognition. J Am Chem Soc. 2006 Aug 30; 128(34):10998-9. PMID: 16925397; PMCID: PMC3188317.
    45. Wilson MK, Abergel R, Raymond KN, Arceneaux JE, Byers BR. Siderophores of Bacillus anthracis, Bacillus cereus, and Bacillus thuringiensis. Biochem Biophys Res Commun. 2006 Sep 15; 348(1):320-5. PMID: 16875672.
      View in: PubMed
    46. Abergel R, Warner JA, Shuh DK, Raymond KN. Enterobactin protonation and iron release: structural characterization of the salicylate coordination shift in ferric enterobactin. J Am Chem Soc. 2006 Jul 12; 128(27):8920-31. PMID: 16819888; PMCID: PMC3188320.
    47. Abergel R, Raymond KN. Synthesis and thermodynamic evaluation of mixed hexadentate linear iron chelators containing hydroxypyridinone and terephthalamide units. Inorg Chem. 2006 May 01; 45(9):3622-31. PMID: 16634594; PMCID: PMC3685440.
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