Bissell, Mina

TitleBiochemist Dist Sci/Engr
InstitutionLawrence Berkeley National Lab
DepartmentBiological Systems & Eng
Address1 Cyclotron Road
Berkeley CA 94720
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    Collapse Research 
    Collapse Research Activities and Funding
    Characterization and Functional Analysis of Breast Cancer Secreted Exosomes in Ma
    NIH/NCI U01CA169538Sep 18, 2012 - Aug 31, 2017
    Role: Co-Principal Investigator
    Myoepithelial cell differentiation defects in ductal carcinoma in situ (DCIS)
    NIH/NCI U01CA143233Sep 30, 2009 - Aug 31, 2014
    Role: Co-Principal Investigator
    Bioengineering 3-D Models for Breast Cancer Therapy
    NIH/NCI U54CA126552Sep 21, 2006 - Aug 31, 2012
    Role: Principal Investigator
    Conference on Tumor Induction and Progression
    NIH/NCI R13CA113258Feb 1, 2005 - Jan 31, 2006
    Role: Principal Investigator
    12th International ISD Conference: Cancer &Development
    NIH/NCI R13CA098946Sep 1, 2002 - Aug 31, 2003
    Role: Principal Investigator
    NIH/NCI R13CA069896Mar 20, 1996 - Mar 14, 1997
    Role: Principal Investigator
    Definition of the Microenvironment in Breast Cancer
    NIH/NCI R01CA064786Jun 1, 1995 - Jul 31, 2021
    Role: Principal Investigator
    Definition of Microenvironment in Breast Cancer
    NIH/NCI R37CA064786Jun 1, 1995 - May 31, 2014
    Role: Principal Investigator
    Role of Metalloproteinases in Mammary Gland Remodeling
    NIH/NCI R01CA057621Apr 15, 1993 - Aug 31, 2018
    Role: Co-Principal Investigator
    NIH/NHLBI S15HL047751Sep 1, 1991 - Aug 31, 1992
    Role: Principal Investigator
    NIH/NHLBI S15HL045870Aug 1, 1990 - Jul 31, 1991
    Role: Principal Investigator
    NIH/NCRR S07RR005918Apr 1, 1984 - Sep 29, 1992
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Ricca BL, Venugopalan G, Furuta S, Tanner K, Orellana WA, Reber CD, Brownfield DG, Bissell M, Fletcher DA. Transient external force induces phenotypic reversion of malignant epithelial structures via nitric oxide signaling. Elife. 2018 Mar 21; 7. PMID: 29560858.
      View in: PubMed
    2. Furuta S, Ren G, Mao JH, Bissell M. Laminin signals initiate the reciprocal loop that informs breast-specific gene expression and homeostasis by activating NO, p53 and microRNAs. Elife. 2018 Mar 21; 7. PMID: 29560860.
      View in: PubMed
    3. Fiore APZP, Spencer VA, Mori H, Carvalho HF, Bissell M, Bruni-Cardoso A. Laminin-111 and the Level of Nuclear Actin Regulate Epithelial Quiescence via Exportin-6. Cell Rep. 2017 06 06; 19(10):2102-2115. PMID: 28591581.
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    4. Furuta S, Bissell M. Pathways Involved in Formation of Mammary Organoid Architecture Have Keys to Understanding Drug Resistance and to Discovery of Druggable Targets. Cold Spring Harb Symp Quant Biol. 2016; 81:207-217. PMID: 28416576.
      View in: PubMed
    5. Peinado H, Zhang H, Matei IR, Costa-Silva B, Hoshino A, Rodrigues G, Psaila B, Kaplan RN, Bromberg JF, Kang Y, Bissell M, Cox TR, Giaccia AJ, Erler JT, Hiratsuka S, Ghajar CM, Lyden D. Pre-metastatic niches: organ-specific homes for metastases. Nat Rev Cancer. 2017 05; 17(5):302-317. PMID: 28303905.
      View in: PubMed
    6. Snijders AM, Lee SY, Hang B, Hao W, Bissell M, Mao JH. FAM83 family oncogenes are broadly involved in human cancers: an integrative multi-omics approach. Mol Oncol. 2017 Feb; 11(2):167-179. PMID: 28078827.
      View in: PubMed
    7. Bissell M. Goodbye flat biology - time for the 3rd and the 4th dimensions. J Cell Sci. 2017 01 01; 130(1):3-5. PMID: 28043963.
      View in: PubMed
    8. Simian M, Bissell M. Organoids: A historical perspective of thinking in three dimensions. J Cell Biol. 2017 Jan 02; 216(1):31-40. PMID: 28031422.
      View in: PubMed
    9. Ghajar CM, Bissell M. Metastasis: Pathways of parallel progression. Nature. 2016 Dec 14. PMID: 27974802.
      View in: PubMed
    10. Bissell M. Thinking in three dimensions: discovering reciprocal signaling between the extracellular matrix and nucleus and the wisdom of microenvironment and tissue architecture. Mol Biol Cell. 2016 Nov 01; 27(21):3205-3209. PMID: 27799496.
      View in: PubMed
    11. Melchionna R, Iapicca P, Di Modugno F, Trono P, Sperduti I, Fassan M, Cataldo I, Rusev BC, Lawlor RT, Diodoro MG, Milella M, Grazi GL, Bissell M, Scarpa A, Nisticò P. The pattern of hMENA isoforms is regulated by TGF-ß1 in pancreatic cancer and may predict patient outcome. Oncoimmunology. 2016; 5(12):e1221556. PMID: 28123868.
      View in: PubMed
    12. Jorgens DM, Inman JL, Wojcik M, Robertson C, Palsdottir H, Tsai WT, Huang H, Bruni-Cardoso A, López CS, Bissell M, Xu K, Auer M. Deep nuclear invaginations are linked to cytoskeletal filaments - integrated bioimaging of epithelial cells in 3D culture. J Cell Sci. 2017 01 01; 130(1):177-189. PMID: 27505896.
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    13. Mori H, Bhat R, Bruni-Cardoso A, Chen EI, Jorgens DM, Coutinho K, Louie K, Bowen BB, Inman JL, Tecca V, Lee SJ, Becker-Weimann S, Northen T, Seiki M, Borowsky AD, Auer M, Bissell M. New insight into the role of MMP14 in metabolic balance. PeerJ. 2016; 4:e2142. PMID: 27478693; PMCID: PMC4950575.
    14. Matsubara M, Bissell M. Inhibitors of Rho kinase (ROCK) signaling revert the malignant phenotype of breast cancer cells in 3D context. Oncotarget. 2016 May 31; 7(22):31602-22. PMID: 27203208.
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    15. Agre P, Bertozzi C, Bissell M, Campbell KP, Cummings RD, Desai UR, Estes M, Flotte T, Fogleman G, Gage F, Ginsburg D, Gordon JI, Hart G, Hascall V, Kiessling L, Kornfeld S, Lowe J, Magnani J, Mahal LK, Medzhitov R, Roberts RJ, Sackstein R, Sarkar R, Schnaar R, Schwartz N, Varki A, Walt D, Weissman I. Training the next generation of biomedical investigators in glycosciences. J Clin Invest. 2016 Feb; 126(2):405-8. PMID: 26829621; PMCID: PMC4731185 [Available on 02/01/17].
    16. Hines WC, Kuhn I, Thi K, Chu B, Stanford-Moore G, Sampayo R, Garbe JC, Stampfer M, Borowsky AD, Bissell M. 184AA3: a xenograft model of ER+ breast adenocarcinoma. Breast Cancer Res Treat. 2016 Jan; 155(1):37-52. PMID: 26661596; PMCID: PMC4706787 [Available on 01/01/17].
    17. Hoshino A, Costa-Silva B, Shen TL, Rodrigues G, Hashimoto A, Tesic Mark M, Molina H, Kohsaka S, Di Giannatale A, Ceder S, Singh S, Williams C, Soplop N, Uryu K, Pharmer L, King T, Bojmar L, Davies AE, Ararso Y, Zhang T, Zhang H, Hernandez J, Weiss JM, Dumont-Cole VD, Kramer K, Wexler LH, Narendran A, Schwartz GK, Healey JH, Sandstrom P, Labori KJ, Kure EH, Grandgenett PM, Hollingsworth MA, de Sousa M, Kaur S, Jain M, Mallya K, Batra SK, Jarnagin WR, Brady MS, Fodstad O, Muller V, Pantel K, Minn AJ, Bissell M, Garcia BA, Kang Y, Rajasekhar VK, Ghajar CM, Matei I, Peinado H, Bromberg J, Lyden D. Tumour exosome integrins determine organotropic metastasis. Nature. 2015 Nov 19; 527(7578):329-35. PMID: 26524530; PMCID: PMC4788391.
    18. Veiseh M, Leith SJ, Tolg C, Elhayek SS, Bahrami SB, Collis L, Hamilton S, McCarthy JB, Bissell M, Turley E. Uncovering the dual role of RHAMM as an HA receptor and a regulator of CD44 expression in RHAMM-expressing mesenchymal progenitor cells. Front Cell Dev Biol. 2015; 3:63. PMID: 26528478; PMCID: PMC4606125.
    19. Gomes AM, Bhat R, Correia AL, Mott JD, Ilan N, Vlodavsky I, Pavão MS, Bissell M. Mammary Branching Morphogenesis Requires Reciprocal Signaling by Heparanase and MMP-14. J Cell Biochem. 2015 Aug; 116(8):1668-79. PMID: 25735873.
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    20. Lee SE, Chen Q, Bhat R, Petkiewicz S, Smith JM, Ferry VE, Correia AL, Alivisatos AP, Bissell M. Reversible Aptamer-Au Plasmon Rulers for Secreted Single Molecules. Nano Lett. 2015 Jul 08; 15(7):4564-70. PMID: 26039492; PMCID: PMC4545488.
    21. Hines WC, Yaswen P, Bissell M. Modelling breast cancer requires identification and correction of a critical cell lineage-dependent transduction bias. Nat Commun. 2015 Apr 21; 6:6927. PMID: 25896888; PMCID: PMC4411288.
    22. Inman JL, Robertson C, Mott JD, Bissell M. Mammary gland development: cell fate specification, stem cells and the microenvironment. Development. 2015 Mar 15; 142(6):1028-42. PMID: 25758218.
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    23. Zhang P, Lo A, Huang Y, Huang G, Liang G, Mott J, Karpen GH, Blakely EA, Bissell M, Barcellos-Hoff MH, Snijders AM, Mao JH. Identification of genetic loci that control mammary tumor susceptibility through the host microenvironment. Sci Rep. 2015 Mar 09; 5:8919. PMID: 25747469; PMCID: PMC4352890.
    24. Diamond MI, Cai S, Boudreau A, Carey CJ, Lyle N, Pappu RV, Swamidass SJ, Bissell M, Piwnica-Worms H, Shao J. Subcellular localization and Ser-137 phosphorylation regulate tumor-suppressive activity of profilin-1. J Biol Chem. 2015 Apr 03; 290(14):9075-86. PMID: 25681442; PMCID: PMC4423694.
    25. Mroue R, Inman J, Mott J, Budunova I, Bissell M. Asymmetric expression of connexins between luminal epithelial- and myoepithelial- cells is essential for contractile function of the mammary gland. Dev Biol. 2015 Mar 01; 399(1):15-26. PMID: 25500615.
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    26. Chuong CM, Bhat R, Widelitz RB, Bissell M. SnapShot: Branching Morphogenesis. Cell. 2014 Aug 28; 158(5):1212-1212.e1. PMID: 25171418; PMCID: PMC4381872.
    27. Parikh AP, Curtis RE, Kuhn I, Becker-Weimann S, Bissell M, Xing EP, Wu W. Network analysis of breast cancer progression and reversal using a tree-evolving network algorithm. PLoS Comput Biol. 2014 Jul; 10(7):e1003713. PMID: 25057922; PMCID: PMC4109850.
    28. Snijders AM, Langley S, Mao JH, Bhatnagar S, Bjornstad KA, Rosen CJ, Lo A, Huang Y, Blakely EA, Karpen GH, Bissell M, Wyrobek AJ. An interferon signature identified by RNA-sequencing of mammary tissues varies across the estrous cycle and is predictive of metastasis-free survival. Oncotarget. 2014 Jun 30; 5(12):4011-25. PMID: 24994117; PMCID: PMC4147302.
    29. Esserman LJ, Thompson IM, Reid B, Nelson P, Ransohoff DF, Welch HG, Hwang S, Berry DA, Kinzler KW, Black WC, Bissell M, Parnes H, Srivastava S. Addressing overdiagnosis and overtreatment in cancer: a prescription for change. Lancet Oncol. 2014 May; 15(6):e234-42. PMID: 24807866; PMCID: PMC4322920.
    30. Veiseh M, Kwon DH, Borowsky AD, Tolg C, Leong HS, Lewis JD, Turley EA, Bissell M. Cellular heterogeneity profiling by hyaluronan probes reveals an invasive but slow-growing breast tumor subset. Proc Natl Acad Sci U S A. 2014 Apr 29; 111(17):E1731-9. PMID: 24733940; PMCID: PMC4035999.
    31. Hines WC, Su Y, Kuhn I, Polyak K, Bissell M. Sorting out the FACS: a devil in the details. Cell Rep. 2014 Mar 13; 6(5):779-81. PMID: 24630040.
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    32. Weigelt B, Ghajar CM, Bissell M. The need for complex 3D culture models to unravel novel pathways and identify accurate biomarkers in breast cancer. Adv Drug Deliv Rev. 2014 Apr; 69-70:42-51. PMID: 24412474; PMCID: PMC4186247.
    33. Nisticò P, Di Modugno F, Spada S, Bissell M. ß1 and ß4 integrins: from breast development to clinical practice. Breast Cancer Res. 2014; 16(5):459. PMID: 25606594; PMCID: PMC4384274.
    34. Bhat R, Bissell M. Of plasticity and specificity: dialectics of the micro- and macro-environment and the organ phenotype. Wiley Interdiscip Rev Membr Transp Signal. 2014; 3(2):147-163. PMID: 24678448.
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    35. Onodera Y, Nam JM, Bissell M. Increased sugar uptake promotes oncogenesis via EPAC/RAP1 and O-GlcNAc pathways. J Clin Invest. 2014 Jan; 124(1):367-84. PMID: 24316969; PMCID: PMC3871217.
    36. Strachan DC, Ruffell B, Oei Y, Bissell M, Coussens LM, Pryer N, Daniel D. CSF1R inhibition delays cervical and mammary tumor growth in murine models by attenuating the turnover of tumor-associated macrophages and enhancing infiltration by CD8+ T cells. Oncoimmunology. 2013 Dec 01; 2(12):e26968. PMID: 24498562.
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    37. Bissell M. Reproducibility: The risks of the replication drive. Nature. 2013 Nov 21; 503(7476):333-4. PMID: 24273798.
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    38. Bhat R, Bissell M. Of plasticity and specificity: dialectics of the microenvironment and macroenvironment and the organ phenotype. Wiley Interdiscip Rev Dev Biol. 2014 Mar-Apr; 3(2):147-63. PMID: 24719287.
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    39. Becker-Weimann S, Xiong G, Furuta S, Han J, Kuhn I, Akavia UD, Pe'er D, Bissell M, Xu R. NFkB disrupts tissue polarity in 3D by preventing integration of microenvironmental signals. Oncotarget. 2013 Nov; 4(11):2010-20. PMID: 24243820; PMCID: PMC3875766.
    40. Boudreau A, Tanner K, Wang D, Geyer FC, Reis-Filho JS, Bissell M. 14-3-3s stabilizes a complex of soluble actin and intermediate filament to enable breast tumor invasion. Proc Natl Acad Sci U S A. 2013 Oct 08; 110(41):E3937-44. PMID: 24067649; PMCID: PMC3799319.
    41. Bascom JL, Radisky DC, Koh E, Fata JE, Lo A, Mori H, Roosta N, Hirai Y, Bissell M. Epimorphin is a novel regulator of the progesterone receptor isoform-a. Cancer Res. 2013 Sep 15; 73(18):5719-29. PMID: 23867473; PMCID: PMC3783262.
    42. Ghajar CM, Peinado H, Mori H, Matei IR, Evason KJ, Brazier H, Almeida D, Koller A, Hajjar KA, Stainier DY, Chen EI, Lyden D, Bissell M. The perivascular niche regulates breast tumour dormancy. Nat Cell Biol. 2013 Jul; 15(7):807-17. PMID: 23728425; PMCID: PMC3826912.
    43. Brownfield DG, Venugopalan G, Lo A, Mori H, Tanner K, Fletcher DA, Bissell M. Patterned collagen fibers orient branching mammary epithelium through distinct signaling modules. Curr Biol. 2013 Apr 22; 23(8):703-9. PMID: 23562267; PMCID: PMC3705902.
    44. Correia AL, Mori H, Chen EI, Schmitt FC, Bissell M. The hemopexin domain of MMP3 is responsible for mammary epithelial invasion and morphogenesis through extracellular interaction with HSP90ß. Genes Dev. 2013 Apr 01; 27(7):805-17. PMID: 23592797; PMCID: PMC3639420.
    45. Mori H, Lo AT, Inman JL, Alcaraz J, Ghajar CM, Mott JD, Nelson CM, Chen CS, Zhang H, Bascom JL, Seiki M, Bissell M. Transmembrane/cytoplasmic, rather than catalytic, domains of Mmp14 signal to MAPK activation and mammary branching morphogenesis via binding to integrin ß1. Development. 2013 Jan 15; 140(2):343-52. PMID: 23250208; PMCID: PMC3597211.
    46. Mroue R, Bissell M. Three-dimensional cultures of mouse mammary epithelial cells. Methods Mol Biol. 2013; 945:221-50. PMID: 23097110; PMCID: PMC3666564.
    47. Vidi PA, Bissell M, Lelièvre SA. Three-dimensional culture of human breast epithelial cells: the how and the why. Methods Mol Biol. 2013; 945:193-219. PMID: 23097109; PMCID: PMC3666567.
    48. Lee SE, Alivisatos AP, Bissell M. Toward plasmonics-enabled spatiotemporal activity patterns in three-dimensional culture models. Syst Biomed (Austin). 2013 Jan; 1(1). PMID: 24224142.
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    49. Ordinario E, Han HJ, Furuta S, Heiser LM, Jakkula LR, Rodier F, Spellman PT, Campisi J, Gray JW, Bissell M, Kohwi Y, Kohwi-Shigematsu T. ATM suppresses SATB1-induced malignant progression in breast epithelial cells. PLoS One. 2012; 7(12):e51786. PMID: 23251624; PMCID: PMC3519734.
    50. Di Modugno F, Iapicca P, Boudreau A, Mottolese M, Terrenato I, Perracchio L, Carstens RP, Santoni A, Bissell M, Nisticò P. Splicing program of human MENA produces a previously undescribed isoform associated with invasive, mesenchymal-like breast tumors. Proc Natl Acad Sci U S A. 2012 Nov 20; 109(47):19280-5. PMID: 23129656; PMCID: PMC3511125.
    51. Ashton RS, Conway A, Pangarkar C, Bergen J, Lim KI, Shah P, Bissell M, Schaffer DV. Astrocytes regulate adult hippocampal neurogenesis through ephrin-B signaling. Nat Neurosci. 2012 Oct; 15(10):1399-406. PMID: 22983209; PMCID: PMC3458152.
    52. Lee SY, Meier R, Furuta S, Lenburg ME, Kenny PA, Xu R, Bissell M. FAM83A confers EGFR-TKI resistance in breast cancer cells and in mice. J Clin Invest. 2012 Sep; 122(9):3211-20. PMID: 22886303; PMCID: PMC3428077.
    53. Lee SE, Sasaki DY, Park Y, Xu R, Brennan JS, Bissell M, Lee LP. Photonic gene circuits by optically addressable siRNA-Au nanoantennas. ACS Nano. 2012 Sep 25; 6(9):7770-80. PMID: 22827439; PMCID: PMC3458151.
    54. Jahchan NS, Wang D, Bissell M, Luo K. SnoN regulates mammary gland alveologenesis and onset of lactation by promoting prolactin/Stat5 signaling. Development. 2012 Sep; 139(17):3147-56. PMID: 22833129; PMCID: PMC3413161.
    55. Liu H, Radisky DC, Yang D, Xu R, Radisky ES, Bissell M, Bishop JM. MYC suppresses cancer metastasis by direct transcriptional silencing of av and ß3 integrin subunits. Nat Cell Biol. 2012 May 13; 14(6):567-74. PMID: 22581054; PMCID: PMC3366024.
    56. Lo AT, Mori H, Mott J, Bissell M. Constructing three-dimensional models to study mammary gland branching morphogenesis and functional differentiation. J Mammary Gland Biol Neoplasia. 2012 Jun; 17(2):103-10. PMID: 22573197.
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    57. Boudreau A, van't Veer LJ, Bissell M. An "elite hacker": breast tumors exploit the normal microenvironment program to instruct their progression and biological diversity. Cell Adh Migr. 2012 May-Jun; 6(3):236-48. PMID: 22863741; PMCID: PMC3427238.
    58. Mori H, Borowsky AD, Bhat R, Ghajar CM, Seiki M, Bissell M. Laser scanning-based tissue autofluorescence/fluorescence imaging (LS-TAFI), a new technique for analysis of microanatomy in whole-mount tissues. Am J Pathol. 2012 Jun; 180(6):2249-56. PMID: 22542846; PMCID: PMC3378916.
    59. Dusek RL, Bascom JL, Vogel H, Baron S, Borowsky AD, Bissell M, Attardi LD. Deficiency of the p53/p63 target Perp alters mammary gland homeostasis and promotes cancer. Breast Cancer Res. 2012 Apr 20; 14(2):R65. PMID: 22515648; PMCID: PMC3446400.
    60. Nakasone ES, Askautrud HA, Kees T, Park JH, Plaks V, Ewald AJ, Fein M, Rasch MG, Tan YX, Qiu J, Park J, Sinha P, Bissell M, Frengen E, Werb Z, Egeblad M. Imaging tumor-stroma interactions during chemotherapy reveals contributions of the microenvironment to resistance. Cancer Cell. 2012 Apr 17; 21(4):488-503. PMID: 22516258; PMCID: PMC3332002.
    61. Kim J, Villadsen R, Sørlie T, Fogh L, Grønlund SZ, Fridriksdottir AJ, Kuhn I, Rank F, Wielenga VT, Solvang H, Edwards PA, Børresen-Dale AL, Rønnov-Jessen L, Bissell M, Petersen OW. Tumor initiating but differentiated luminal-like breast cancer cells are highly invasive in the absence of basal-like activity. Proc Natl Acad Sci U S A. 2012 Apr 17; 109(16):6124-9. PMID: 22454501; PMCID: PMC3341000.
    62. Bissell M, Ghajar CM, Lee LP. From single cells to biology. Integr Biol (Camb). 2012 Apr; 4(4):357-9. PMID: 22436976.
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    63. Correia AL, Bissell M. The tumor microenvironment is a dominant force in multidrug resistance. Drug Resist Updat. 2012 Feb-Apr; 15(1-2):39-49. PMID: 22335920; PMCID: PMC3658318.
    64. Nisticò P, Bissell M, Radisky DC. Epithelial-mesenchymal transition: general principles and pathological relevance with special emphasis on the role of matrix metalloproteinases. Cold Spring Harb Perspect Biol. 2012 Feb 01; 4(2). PMID: 22300978; PMCID: PMC3281569.
    65. Tanner K, Mori H, Mroue R, Bruni-Cardoso A, Bissell M. Coherent angular motion in the establishment of multicellular architecture of glandular tissues. Proc Natl Acad Sci U S A. 2012 Feb 07; 109(6):1973-8. PMID: 22308439; PMCID: PMC3277511.
    66. Freed-Pastor WA, Mizuno H, Zhao X, Langerød A, Moon SH, Rodriguez-Barrueco R, Barsotti A, Chicas A, Li W, Polotskaia A, Bissell M, Osborne TF, Tian B, Lowe SW, Silva JM, Børresen-Dale AL, Levine AJ, Bargonetti J, Prives C. Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway. Cell. 2012 Jan 20; 148(1-2):244-58. PMID: 22265415; PMCID: PMC3511889.
    67. Vidi PA, Chandramouly G, Gray M, Wang L, Liu E, Kim JJ, Roukos V, Bissell M, Moghe PV, Lelièvre SA. Interconnected contribution of tissue morphogenesis and the nuclear protein NuMA to the DNA damage response. J Cell Sci. 2012 Jan 15; 125(Pt 2):350-61. PMID: 22331358; PMCID: PMC3283872.
    68. Neumaier T, Swenson J, Pham C, Polyzos A, Lo AT, Yang P, Dyball J, Asaithamby A, Chen DJ, Bissell M, Thalhammer S, Costes SV. Evidence for formation of DNA repair centers and dose-response nonlinearity in human cells. Proc Natl Acad Sci U S A. 2012 Jan 10; 109(2):443-8. PMID: 22184222; PMCID: PMC3258602.
    69. Veiseh M, Breadner D, Ma J, Akentieva N, Savani RC, Harrison R, Mikilus D, Collis L, Gustafson S, Lee TY, Koropatnick J, Luyt LG, Bissell M, Turley EA. Imaging of homeostatic, neoplastic, and injured tissues by HA-based probes. Biomacromolecules. 2012 Jan 09; 13(1):12-22. PMID: 22066590; PMCID: PMC3658319.
    70. Bissell M. Heeding a mentor's advice: a lesson in persistence. Nat Cell Biol. 2011 Dec 01; 13(12):1386. PMID: 22134757.
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    71. Furuta S, Ghajar CM, Bissell M. Caveolin-1: would-be Achilles' heel of tumor microenvironment? Cell Cycle. 2011 Oct 15; 10(20):3431. PMID: 22030625.
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    72. Alcaraz J, Mori H, Ghajar CM, Brownfield D, Galgoczy R, Bissell M. Collective epithelial cell invasion overcomes mechanical barriers of collagenous extracellular matrix by a narrow tube-like geometry and MMP14-dependent local softening. Integr Biol (Camb). 2011 Dec; 3(12):1153-66. PMID: 21993836; PMCID: PMC3719864.
    73. Pontiggia O, Sampayo R, Raffo D, Motter A, Xu R, Bissell M, Joffé EB, Simian M. The tumor microenvironment modulates tamoxifen resistance in breast cancer: a role for soluble stromal factors and fibronectin through ß1 integrin. Breast Cancer Res Treat. 2012 Jun; 133(2):459-71. PMID: 21935603; PMCID: PMC3719875.
    74. Huang C, Park CC, Hilsenbeck SG, Ward R, Rimawi MF, Wang YC, Shou J, Bissell M, Osborne CK, Schiff R. ß1 integrin mediates an alternative survival pathway in breast cancer cells resistant to lapatinib. Breast Cancer Res. 2011 Aug 31; 13(4):R84. PMID: 21884573; PMCID: PMC3236347.
    75. Furuta S, Jeng YM, Zhou L, Huang L, Kuhn I, Bissell M, Lee WH. IL-25 causes apoptosis of IL-25R-expressing breast cancer cells without toxicity to nonmalignant cells. Sci Transl Med. 2011 Apr 13; 3(78):78ra31. PMID: 21490275; PMCID: PMC3199022.
    76. Bissell M, Hines WC. Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression. Nat Med. 2011 Mar; 17(3):320-9. PMID: 21383745; PMCID: PMC3569482.
    77. Chanson L, Brownfield D, Garbe JC, Kuhn I, Stampfer MR, Bissell M, LaBarge MA. Self-organization is a dynamic and lineage-intrinsic property of mammary epithelial cells. Proc Natl Acad Sci U S A. 2011 Feb 22; 108(8):3264-9. PMID: 21300877; PMCID: PMC3044373.
    78. Spencer VA, Costes S, Inman JL, Xu R, Chen J, Hendzel MJ, Bissell M. Depletion of nuclear actin is a key mediator of quiescence in epithelial cells. J Cell Sci. 2011 Jan 01; 124(Pt 1):123-32. PMID: 21172822; PMCID: PMC3001411.
    79. Andersen K, Mori H, Fata J, Bascom J, Oyjord T, Mælandsmo GM, Bissell M. The metastasis-promoting protein S100A4 regulates mammary branching morphogenesis. Dev Biol. 2011 Apr 15; 352(2):181-90. PMID: 21195708; PMCID: PMC3643517.
    80. Beliveau A, Mott JD, Lo A, Chen EI, Koller AA, Yaswen P, Muschler J, Bissell M. Raf-induced MMP9 disrupts tissue architecture of human breast cells in three-dimensional culture and is necessary for tumor growth in vivo. Genes Dev. 2010 Dec 15; 24(24):2800-11. PMID: 21159820; PMCID: PMC3003198.
    81. Bissell M. Cell biology: a love affair. Mol Biol Cell. 2010 Nov 15; 21(22):3790. PMID: 21079012; PMCID: PMC2982110.
    82. Tanner K, Boudreau A, Bissell M, Kumar S. Dissecting regional variations in stress fiber mechanics in living cells with laser nanosurgery. Biophys J. 2010 Nov 03; 99(9):2775-83. PMID: 21044574; PMCID: PMC2965957.
    83. Xu R, Spencer VA, Groesser DL, Bissell M. Laminin regulates PI3K basal localization and activation to sustain STAT5 activation. Cell Cycle. 2010 Nov 01; 9(21):4315-22. PMID: 20980837; PMCID: PMC3055185.
    84. Ghajar CM, Bissell M. Tumor engineering: the other face of tissue engineering. Tissue Eng Part A. 2010 Jul; 16(7):2153-6. PMID: 20214448; PMCID: PMC2947934.
    85. Nam JM, Onodera Y, Bissell M, Park CC. Breast cancer cells in three-dimensional culture display an enhanced radioresponse after coordinate targeting of integrin alpha5beta1 and fibronectin. Cancer Res. 2010 Jul 01; 70(13):5238-48. PMID: 20516121; PMCID: PMC2933183.
    86. Han J, Chang H, Giricz O, Lee GY, Baehner FL, Gray JW, Bissell M, Kenny PA, Parvin B. Molecular predictors of 3D morphogenesis by breast cancer cell lines in 3D culture. PLoS Comput Biol. 2010 Feb 26; 6(2):e1000684. PMID: 20195492; PMCID: PMC2829039.
    87. Spencer VA, Xu R, Bissell M. Gene expression in the third dimension: the ECM-nucleus connection. J Mammary Gland Biol Neoplasia. 2010 Mar; 15(1):65-71. PMID: 20107877; PMCID: PMC2912292.
    88. Inman JL, Bissell M. Apical polarity in three-dimensional culture systems: where to now? J Biol. 2010; 9(1):2. PMID: 20092610; PMCID: PMC2871524.
    89. Bissell M. Integrative biology editorial 2010. One year and beyond: the excitement continues. Integr Biol (Camb). 2010 Jan; 2(1):9. PMID: 20473406.
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    90. Weigelt B, Lo AT, Park CC, Gray JW, Bissell M. HER2 signaling pathway activation and response of breast cancer cells to HER2-targeting agents is dependent strongly on the 3D microenvironment. Breast Cancer Res Treat. 2010 Jul; 122(1):35-43. PMID: 19701706; PMCID: PMC2935800.
    91. Mori H, Gjorevski N, Inman JL, Bissell M, Nelson CM. Self-organization of engineered epithelial tubules by differential cellular motility. Proc Natl Acad Sci U S A. 2009 Sep 01; 106(35):14890-5. PMID: 19706461; PMCID: PMC2736456.
    92. Chen A, Cuevas I, Kenny PA, Miyake H, Mace K, Ghajar C, Boudreau A, Bissell MJ, Bissell M, Boudreau N. Endothelial cell migration and vascular endothelial growth factor expression are the result of loss of breast tissue polarity. Cancer Res. 2009 Aug 15; 69(16):6721-9. PMID: 19654314; PMCID: PMC2760003.
    93. Ghajar CM, Meier R, Bissell M. Quis custodiet ipsos custodies: who watches the watchmen? Am J Pathol. 2009 Jun; 174(6):1996-9. PMID: 19465642; PMCID: PMC2684164.
    94. Xu R, Boudreau A, Bissell M. Tissue architecture and function: dynamic reciprocity via extra- and intra-cellular matrices. Cancer Metastasis Rev. 2009 Jun; 28(1-2):167-76. PMID: 19160017; PMCID: PMC2720096.
    95. Fournier MV, Fata JE, Martin KJ, Yaswen P, Bissell M. Interaction of E-cadherin and PTEN regulates morphogenesis and growth arrest in human mammary epithelial cells. Cancer Res. 2009 May 15; 69(10):4545-52. PMID: 19417140; PMCID: PMC2746025.
    96. Bissell M. Mina Bissell: Context is everything. [An interview by Ben Short]. J Cell Biol. 2009 May 04; 185(3):374-5. PMID: 19414604; PMCID: PMC2700401.
    97. Zhang X, Fournier MV, Ware JL, Bissell M, Yacoub A, Zehner ZE. Inhibition of vimentin or beta1 integrin reverts morphology of prostate tumor cells grown in laminin-rich extracellular matrix gels and reduces tumor growth in vivo. Mol Cancer Ther. 2009 Mar; 8(3):499-508. PMID: 19276168; PMCID: PMC2703491.
    98. Radisky DC, Stallings-Mann M, Hirai Y, Bissell M. Single proteins might have dual but related functions in intracellular and extracellular microenvironments. Nat Rev Mol Cell Biol. 2009 Mar; 10(3):228-34. PMID: 19190671; PMCID: PMC2746016.
    99. Mirzoeva OK, Das D, Heiser LM, Bhattacharya S, Siwak D, Gendelman R, Bayani N, Wang NJ, Neve RM, Guan Y, Hu Z, Knight Z, Feiler HS, Gascard P, Parvin B, Spellman PT, Shokat KM, Wyrobek AJ, Bissell M, McCormick F, Kuo WL, Mills GB, Gray JW, Korn WM. Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition. Cancer Res. 2009 Jan 15; 69(2):565-72. PMID: 19147570; PMCID: PMC2737189.
    100. Xu R, Nelson CM, Muschler JL, Veiseh M, Vonderhaar BK, Bissell M. Sustained activation of STAT5 is essential for chromatin remodeling and maintenance of mammary-specific function. J Cell Biol. 2009 Jan 12; 184(1):57-66. PMID: 19139262; PMCID: PMC2615090.
    101. Chen CS, Nelson CM, Khauv D, Bennett S, Radisky ES, Hirai Y, Bissell M, Radisky DC. Homology with vesicle fusion mediator syntaxin-1a predicts determinants of epimorphin/syntaxin-2 function in mammary epithelial morphogenesis. J Biol Chem. 2009 Mar 13; 284(11):6877-84. PMID: 19129200; PMCID: PMC2652326.
    102. Simian M, Bissell M, Barcellos-Hoff MH, Shyamala G. Estrogen and progesterone receptors have distinct roles in the establishment of the hyperplastic phenotype in PR-A transgenic mice. Breast Cancer Res. 2009; 11(5):R72. PMID: 19788752; PMCID: PMC2790852.
    103. Rønnov-Jessen L, Bissell M. Breast cancer by proxy: can the microenvironment be both the cause and consequence? Trends Mol Med. 2009 Jan; 15(1):5-13. PMID: 19091631; PMCID: PMC2746030.
    104. Ghajar CM, Bissell M. Extracellular matrix control of mammary gland morphogenesis and tumorigenesis: insights from imaging. Histochem Cell Biol. 2008 Dec; 130(6):1105-18. PMID: 19009245; PMCID: PMC2949356.
    105. LaBarge MA, Nelson CM, Villadsen R, Fridriksdottir A, Ruth JR, Stampfer MR, Petersen OW, Bissell M. Human mammary progenitor cell fate decisions are products of interactions with combinatorial microenvironments. Integr Biol (Camb). 2009 Jan; 1(1):70-9. PMID: 20023793; PMCID: PMC2933184.
    106. Alcaraz J, Xu R, Mori H, Nelson CM, Mroue R, Spencer VA, Brownfield D, Radisky DC, Bustamante C, Bissell M. Laminin and biomimetic extracellular elasticity enhance functional differentiation in mammary epithelia. EMBO J. 2008 Nov 05; 27(21):2829-38. PMID: 18843297.
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    108. Nelson CM, Khauv D, Bissell M, Radisky DC. Change in cell shape is required for matrix metalloproteinase-induced epithelial-mesenchymal transition of mammary epithelial cells. J Cell Biochem. 2008 Sep 01; 105(1):25-33. PMID: 18506791; PMCID: PMC2838485.
    109. Martin KJ, Patrick DR, Bissell M, Fournier MV. Prognostic breast cancer signature identified from 3D culture model accurately predicts clinical outcome across independent datasets. PLoS One. 2008 Aug 20; 3(8):e2994. PMID: 18714348; PMCID: PMC2500166.
    110. LaBarge MA, Bissell M. Is CD133 a marker of metastatic colon cancer stem cells? J Clin Invest. 2008 Jun; 118(6):2021-4. PMID: 18497883; PMCID: PMC2391070.
    111. Park CC, Zhang HJ, Yao ES, Park CJ, Bissell M. Beta1 integrin inhibition dramatically enhances radiotherapy efficacy in human breast cancer xenografts. Cancer Res. 2008 Jun 01; 68(11):4398-405. PMID: 18519702; PMCID: PMC3719863.
    112. Hu M, Yao J, Carroll DK, Weremowicz S, Chen H, Carrasco D, Richardson A, Violette S, Nikolskaya T, Nikolsky Y, Bauerlein EL, Hahn WC, Gelman RS, Allred C, Bissell M, Schnitt S, Polyak K. Regulation of in situ to invasive breast carcinoma transition. Cancer Cell. 2008 May; 13(5):394-406. PMID: 18455123; PMCID: PMC3705908.
    113. Weigelt B, Bissell M. Unraveling the microenvironmental influences on the normal mammary gland and breast cancer. Semin Cancer Biol. 2008 Oct; 18(5):311-21. PMID: 18455428; PMCID: PMC2548304.
    114. Turley EA, Veiseh M, Radisky DC, Bissell M. Mechanisms of disease: epithelial-mesenchymal transition--does cellular plasticity fuel neoplastic progression? Nat Clin Pract Oncol. 2008 May; 5(5):280-90. PMID: 18349857; PMCID: PMC2846172.
    115. Faddy HM, Smart CE, Xu R, Lee GY, Kenny PA, Feng M, Rao R, Brown MA, Bissell M, Roberts-Thomson SJ, Monteith GR. Localization of plasma membrane and secretory calcium pumps in the mammary gland. Biochem Biophys Res Commun. 2008 May 09; 369(3):977-81. PMID: 18334228; PMCID: PMC3234104.
    116. Rizki A, Weaver VM, Lee SY, Rozenberg GI, Chin K, Myers CA, Bascom JL, Mott JD, Semeiks JR, Grate LR, Mian IS, Borowsky AD, Jensen RA, Idowu MO, Chen F, Chen DJ, Petersen OW, Gray JW, Bissell M. A human breast cell model of preinvasive to invasive transition. Cancer Res. 2008 Mar 01; 68(5):1378-87. PMID: 18316601; PMCID: PMC2662716.
    117. Nelson CM, Inman JL, Bissell M. Three-dimensional lithographically defined organotypic tissue arrays for quantitative analysis of morphogenesis and neoplastic progression. Nat Protoc. 2008; 3(4):674-8. PMID: 18388950; PMCID: PMC2920258.
    118. Rizki A, Mott JD, Bissell M. Polo-like kinase 1 is involved in invasion through extracellular matrix. Cancer Res. 2007 Dec 01; 67(23):11106-10. PMID: 18056432; PMCID: PMC3730820.
    119. Hirai Y, Bissell M, Radisky DC. Extracellular localization of epimorphin/syntaxin-2. Blood. 2007 Oct 15; 110(8):3082; author reply 3082-3. PMID: 17916751; PMCID: PMC2018679.
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    121. Andarawewa KL, Erickson AC, Chou WS, Costes SV, Gascard P, Mott JD, Bissell M, Barcellos-Hoff MH. Ionizing radiation predisposes nonmalignant human mammary epithelial cells to undergo transforming growth factor beta induced epithelial to mesenchymal transition. Cancer Res. 2007 Sep 15; 67(18):8662-70. PMID: 17875706.
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    122. Radisky DC, Kenny PA, Bissell M. Fibrosis and cancer: do myofibroblasts come also from epithelial cells via EMT? J Cell Biochem. 2007 Jul 01; 101(4):830-9. PMID: 17211838; PMCID: PMC2838476.
    123. LaBarge MA, Petersen OW, Bissell M. Of microenvironments and mammary stem cells. Stem Cell Rev. 2007 Jun; 3(2):137-46. PMID: 17873346; PMCID: PMC3004778.
    124. Kenny PA, Lee GY, Myers CA, Neve RM, Semeiks JR, Spellman PT, Lorenz K, Lee EH, Barcellos-Hoff MH, Petersen OW, Gray JW, Bissell M. The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression. Mol Oncol. 2007 Jun; 1(1):84-96. PMID: 18516279.
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    125. Itoh M, Nelson CM, Myers CA, Bissell M. Rap1 integrates tissue polarity, lumen formation, and tumorigenic potential in human breast epithelial cells. Cancer Res. 2007 May 15; 67(10):4759-66. PMID: 17510404; PMCID: PMC2841018.
    126. Kenny PA, Lee GY, Bissell M. Targeting the tumor microenvironment. Front Biosci. 2007 May 01; 12:3468-74. PMID: 17485314; PMCID: PMC2841020.
    127. Sandal T, Valyi-Nagy K, Spencer VA, Folberg R, Bissell M, Maniotis AJ. Epigenetic reversion of breast carcinoma phenotype is accompanied by changes in DNA sequestration as measured by AluI restriction enzyme. Am J Pathol. 2007 May; 170(5):1739-49. PMID: 17456778; PMCID: PMC1854967.
    128. Le Beyec J, Xu R, Lee SY, Nelson CM, Rizki A, Alcaraz J, Bissell M. Cell shape regulates global histone acetylation in human mammary epithelial cells. Exp Cell Res. 2007 Aug 15; 313(14):3066-75. PMID: 17524393; PMCID: PMC2040058.
    129. Villadsen R, Fridriksdottir AJ, Rønnov-Jessen L, Gudjonsson T, Rank F, LaBarge MA, Bissell M, Petersen OW. Evidence for a stem cell hierarchy in the adult human breast. J Cell Biol. 2007 Apr 09; 177(1):87-101. PMID: 17420292; PMCID: PMC2064114.
    130. Radisky DC, Bissell M. NF-kappaB links oestrogen receptor signalling and EMT. Nat Cell Biol. 2007 Apr; 9(4):361-3. PMID: 17401385.
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    131. Lee GY, Kenny PA, Lee EH, Bissell M. Three-dimensional culture models of normal and malignant breast epithelial cells. Nat Methods. 2007 Apr; 4(4):359-65. PMID: 17396127; PMCID: PMC2933182.
    132. Hamilton SR, Fard SF, Paiwand FF, Tolg C, Veiseh M, Wang C, McCarthy JB, Bissell M, Koropatnick J, Turley EA. The hyaluronan receptors CD44 and Rhamm (CD168) form complexes with ERK1,2 that sustain high basal motility in breast cancer cells. J Biol Chem. 2007 Jun 01; 282(22):16667-80. PMID: 17392272; PMCID: PMC2949353.
    133. Xu R, Spencer VA, Bissell M. Extracellular matrix-regulated gene expression requires cooperation of SWI/SNF and transcription factors. J Biol Chem. 2007 May 18; 282(20):14992-9. PMID: 17387179; PMCID: PMC2933196.
    134. Fata JE, Mori H, Ewald AJ, Zhang H, Yao E, Werb Z, Bissell M. The MAPK(ERK-1,2) pathway integrates distinct and antagonistic signals from TGFalpha and FGF7 in morphogenesis of mouse mammary epithelium. Dev Biol. 2007 Jun 01; 306(1):193-207. PMID: 17448457; PMCID: PMC2763137.
    135. Beliveau A, Bassett E, Lo AT, Garbe J, Rubio MA, Bissell M, Campisi J, Yaswen P. p53-dependent integration of telomere and growth factor deprivation signals. Proc Natl Acad Sci U S A. 2007 Mar 13; 104(11):4431-6. PMID: 17360541; PMCID: PMC1838618.
    136. Bissell M. Modelling molecular mechanisms of breast cancer and invasion: lessons from the normal gland. Biochem Soc Trans. 2007 Feb; 35(Pt 1):18-22. PMID: 17212581; PMCID: PMC2846175.
    137. Kenny PA, Bissell M. Targeting TACE-dependent EGFR ligand shedding in breast cancer. J Clin Invest. 2007 Feb; 117(2):337-45. PMID: 17218988; PMCID: PMC1764856.
    138. Spencer VA, Xu R, Bissell M. Extracellular matrix, nuclear and chromatin structure, and gene expression in normal tissues and malignant tumors: a work in progress. Adv Cancer Res. 2007; 97:275-94. PMID: 17419950; PMCID: PMC2912285.
    139. Tolg C, Hamilton SR, Nakrieko KA, Kooshesh F, Walton P, McCarthy JB, Bissell M, Turley EA. Rhamm-/- fibroblasts are defective in CD44-mediated ERK1,2 motogenic signaling, leading to defective skin wound repair. J Cell Biol. 2006 Dec 18; 175(6):1017-28. PMID: 17158951; PMCID: PMC2064710.
    140. Nelson CM, Vanduijn MM, Inman JL, Fletcher DA, Bissell M. Tissue geometry determines sites of mammary branching morphogenesis in organotypic cultures. Science. 2006 Oct 13; 314(5797):298-300. PMID: 17038622; PMCID: PMC2933179.
    141. Weir ML, Oppizzi ML, Henry MD, Onishi A, Campbell KP, Bissell M, Muschler JL. Dystroglycan loss disrupts polarity and beta-casein induction in mammary epithelial cells by perturbing laminin anchoring. J Cell Sci. 2006 Oct 01; 119(Pt 19):4047-58. PMID: 16968749; PMCID: PMC2996718.
    142. Fournier MV, Martin KJ, Kenny PA, Xhaja K, Bosch I, Yaswen P, Bissell M. Gene expression signature in organized and growth-arrested mammary acini predicts good outcome in breast cancer. Cancer Res. 2006 Jul 15; 66(14):7095-102. PMID: 16849555; PMCID: PMC2933218.
    143. Kenny PA, Nelson CM, Bissell M. The Ecology of Tumors: By perturbing the microenvironment, wounds and infection may be key to tumor development. Scientist. 2006 Apr 01; 20(4):30. PMID: 21132085.
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    145. Liu H, Radisky DC, Nelson CM, Zhang H, Fata JE, Roth RA, Bissell M. Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2. Proc Natl Acad Sci U S A. 2006 Mar 14; 103(11):4134-9. PMID: 16537497; PMCID: PMC1390746.
    146. Park CC, Zhang H, Pallavicini M, Gray JW, Baehner F, Park CJ, Bissell M. Beta1 integrin inhibitory antibody induces apoptosis of breast cancer cells, inhibits growth, and distinguishes malignant from normal phenotype in three dimensional cultures and in vivo. Cancer Res. 2006 Feb 01; 66(3):1526-35. PMID: 16452209; PMCID: PMC2933188.
    147. Nelson CM, Bissell M. Of extracellular matrix, scaffolds, and signaling: tissue architecture regulates development, homeostasis, and cancer. Annu Rev Cell Dev Biol. 2006; 22:287-309. PMID: 16824016; PMCID: PMC2933192.
    148. Radisky DC, Bissell M. Matrix metalloproteinase-induced genomic instability. Curr Opin Genet Dev. 2006 Feb; 16(1):45-50. PMID: 16377172; PMCID: PMC2933219.
    149. Nelson CM, Bissell M. Modeling dynamic reciprocity: engineering three-dimensional culture models of breast architecture, function, and neoplastic transformation. Semin Cancer Biol. 2005 Oct; 15(5):342-52. PMID: 15963732; PMCID: PMC2933210.
    150. Bascom JL, Fata JE, Hirai Y, Sternlicht MD, Bissell M. Epimorphin overexpression in the mouse mammary gland promotes alveolar hyperplasia and mammary adenocarcinoma. Cancer Res. 2005 Oct 01; 65(19):8617-21. PMID: 16204027.
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    151. Krakowski AR, Laboureau J, Mauviel A, Bissell M, Luo K. Cytoplasmic SnoN in normal tissues and nonmalignant cells antagonizes TGF-beta signaling by sequestration of the Smad proteins. Proc Natl Acad Sci U S A. 2005 Aug 30; 102(35):12437-42. PMID: 16109768; PMCID: PMC1194926.
    152. Wu W, Xing EP, Myers C, Mian IS, Bissell M. Evaluation of normalization methods for cDNA microarray data by k-NN classification. BMC Bioinformatics. 2005 Jul 26; 6:191. PMID: 16045803; PMCID: PMC1201132.
    153. Adriance MC, Inman JL, Petersen OW, Bissell M. Myoepithelial cells: good fences make good neighbors. Breast Cancer Res. 2005; 7(5):190-7. PMID: 16168137; PMCID: PMC1242144.
    154. Radisky DC, Levy DD, Littlepage LE, Liu H, Nelson CM, Fata JE, Leake D, Godden EL, Albertson DG, Nieto MA, Werb Z, Bissell M. Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature. 2005 Jul 07; 436(7047):123-7. PMID: 16001073; PMCID: PMC2784913.
    155. Gudjonsson T, Adriance MC, Sternlicht MD, Petersen OW, Bissell M. Myoepithelial cells: their origin and function in breast morphogenesis and neoplasia. J Mammary Gland Biol Neoplasia. 2005 Jul; 10(3):261-72. PMID: 16807805; PMCID: PMC2798159.
    156. Lakhani S, Bissell M. Introduction: the role of myoepithelial cells in integration of form and function in the mammary gland. J Mammary Gland Biol Neoplasia. 2005 Jul; 10(3):197-8. PMID: 16807799.
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    157. Liu H, Radisky DC, Bissell M. Proliferation and polarity in breast cancer: untying the Gordian knot. Cell Cycle. 2005 May; 4(5):646-9. PMID: 15846085.
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    158. Maniotis AJ, Valyi-Nagy K, Karavitis J, Moses J, Boddipali V, Wang Y, Nuñez R, Setty S, Arbieva Z, Bissell M, Folberg R. Chromatin organization measured by AluI restriction enzyme changes with malignancy and is regulated by the extracellular matrix and the cytoskeleton. Am J Pathol. 2005 Apr; 166(4):1187-203. PMID: 15793298; PMCID: PMC1602386.
    159. Kaminker P, Plachot C, Kim SH, Chung P, Crippen D, Petersen OW, Bissell M, Campisi J, Lelièvre SA. Higher-order nuclear organization in growth arrest of human mammary epithelial cells: a novel role for telomere-associated protein TIN2. J Cell Sci. 2005 Mar 15; 118(Pt 6):1321-30. PMID: 15741234; PMCID: PMC2933191.
    160. Bissell M, Labarge MA. Context, tissue plasticity, and cancer: are tumor stem cells also regulated by the microenvironment? Cancer Cell. 2005 Jan; 7(1):17-23. PMID: 15652746; PMCID: PMC2933216.
    161. Alcaraz J, Nelson CM, Bissell M. Biomechanical approaches for studying integration of tissue structure and function in mammary epithelia. J Mammary Gland Biol Neoplasia. 2004 Oct; 9(4):361-74. PMID: 15838605; PMCID: PMC2933199.
    162. Singh J, Itahana Y, Knight-Krajewski S, Kanagawa M, Campbell KP, Bissell M, Muschler J. Proteolytic enzymes and altered glycosylation modulate dystroglycan function in carcinoma cells. Cancer Res. 2004 Sep 01; 64(17):6152-9. PMID: 15342399.
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    163. Rizki A, Bissell M. Homeostasis in the breast: it takes a village. Cancer Cell. 2004 Jul; 6(1):1-2. PMID: 15261134.
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    164. Blaustein M, Pelisch F, Coso OA, Bissell M, Kornblihtt AR, Srebrow A. Mammary epithelial-mesenchymal interaction regulates fibronectin alternative splicing via phosphatidylinositol 3-kinase. J Biol Chem. 2004 May 14; 279(20):21029-37. PMID: 15028734.
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    165. Liu H, Radisky DC, Wang F, Bissell M. Polarity and proliferation are controlled by distinct signaling pathways downstream of PI3-kinase in breast epithelial tumor cells. J Cell Biol. 2004 Feb 16; 164(4):603-12. PMID: 14769856; PMCID: PMC2171976.
    166. Radisky DC, Bissell M. Cancer. Respect thy neighbor! Science. 2004 Feb 06; 303(5659):775-7. PMID: 14764858.
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    167. Come SE, Buzdar AU, Arteaga CL, Bissell M, Brown MA, Ellis MJ, Goss PE, Green JE, Ingle JN, Lee AV, Medina D, Nicholson RI, Santen RJ, Schiff R, Hart CS. Proceedings of the Third International Conference on Recent Advances and Future Directions in Endocrine Manipulation of Breast Cancer: conference summary statement. Clin Cancer Res. 2004 Jan 01; 10(1 Pt 2):327S-330S. PMID: 14734487.
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    168. Grant MR, Hunt CA, Xia L, Fata JE, Bissell M. Modeling mammary gland morphogenesis as a reaction-diffusion process. Conf Proc IEEE Eng Med Biol Soc. 2004; 1:679-82. PMID: 17271768.
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    169. Novaro V, Radisky DC, Ramos Castro NE, Weisz A, Bissell M. Malignant mammary cells acquire independence from extracellular context for regulation of estrogen receptor alpha. Clin Cancer Res. 2004 Jan 01; 10(1 Pt 2):402S-9S. PMID: 14734499.
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    170. Kenny PA, Bissell M. Tumor reversion: correction of malignant behavior by microenvironmental cues. Int J Cancer. 2003 Dec 10; 107(5):688-95. PMID: 14566816; PMCID: PMC2933180.
    171. Bissell M, Rizki A, Mian IS. Tissue architecture: the ultimate regulator of breast epithelial function. Curr Opin Cell Biol. 2003 Dec; 15(6):753-62. PMID: 14644202; PMCID: PMC2933200.
    172. Itoh M, Bissell M. The organization of tight junctions in epithelia: implications for mammary gland biology and breast tumorigenesis. J Mammary Gland Biol Neoplasia. 2003 Oct; 8(4):449-62. PMID: 14985640; PMCID: PMC2933220.
    173. Petersen OW, Gudjonsson T, Villadsen R, Bissell M, Rønnov-Jessen L. Epithelial progenitor cell lines as models of normal breast morphogenesis and neoplasia. Cell Prolif. 2003 Oct; 36 Suppl 1:33-44. PMID: 14521514; PMCID: PMC2933221.
    174. Wiseman BS, Sternlicht MD, Lund LR, Alexander CM, Mott J, Bissell M, Soloway P, Itohara S, Werb Z. Site-specific inductive and inhibitory activities of MMP-2 and MMP-3 orchestrate mammary gland branching morphogenesis. J Cell Biol. 2003 Sep 15; 162(6):1123-33. PMID: 12975354; PMCID: PMC2172848.
    175. Park CC, Henshall-Powell RL, Erickson AC, Talhouk R, Parvin B, Bissell M, Barcellos-Hoff MH. Ionizing radiation induces heritable disruption of epithelial cell interactions. Proc Natl Acad Sci U S A. 2003 Sep 16; 100(19):10728-33. PMID: 12960393; PMCID: PMC196872.
    176. Fata JE, Werb Z, Bissell M. Regulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymes. Breast Cancer Res. 2004; 6(1):1-11. PMID: 14680479; PMCID: PMC314442.
    177. Radisky DC, Hirai Y, Bissell M. Delivering the message: epimorphin and mammary epithelial morphogenesis. Trends Cell Biol. 2003 Aug; 13(8):426-34. PMID: 12888295; PMCID: PMC2933193.
    178. Novaro V, Roskelley CD, Bissell M. Collagen-IV and laminin-1 regulate estrogen receptor alpha expression and function in mouse mammary epithelial cells. J Cell Sci. 2003 Jul 15; 116(Pt 14):2975-86. PMID: 12808020; PMCID: PMC2933217.
    179. Gudjonsson T, Rønnov-Jessen L, Villadsen R, Bissell M, Petersen OW. To create the correct microenvironment: three-dimensional heterotypic collagen assays for human breast epithelial morphogenesis and neoplasia. Methods. 2003 Jul; 30(3):247-55. PMID: 12798139; PMCID: PMC2933212.
    180. Schmeichel KL, Bissell M. Modeling tissue-specific signaling and organ function in three dimensions. J Cell Sci. 2003 Jun 15; 116(Pt 12):2377-88. PMID: 12766184; PMCID: PMC2933213.
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