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Chang, Michelle

TitleBiological Faculty Engineer
InstitutionLawrence Berkeley National Lab
DepartmentMolecular Biophys & Integ Bio
Address1 Cyclotron Road
Berkeley CA 94720
Phone510/642-8545
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    Collapse Research 
    Collapse Research Activities and Funding
    Synthetic biology approaches to new fluorinated pharmaceuticals
    NIH/NIGMS R01GM123181Apr 1, 2017 - Feb 28, 2021
    Role: Principal Investigator
    Discovery and mechanistic study of fluorine biochemistry
    NIH DP2OD008696Sep 30, 2011 - Jun 30, 2016
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Weeks AM, Wang N, Pelton JG, Chang M. Entropy drives selective fluorine recognition in the fluoroacetyl-CoA thioesterase from Streptomyces cattleya. Proc Natl Acad Sci U S A. 2018 Mar 06; 115(10):E2193-E2201. PMID: 29453276.
      View in: PubMed
    2. McMurry JL, Chang M. Fluorothreonyl-tRNA deacylase prevents mistranslation in the organofluorine producer Streptomyces cattleya. Proc Natl Acad Sci U S A. 2017 Nov 07; 114(45):11920-11925. PMID: 29078362.
      View in: PubMed
    3. Thuronyi BW, Privalsky TM, Chang M. Engineered Fluorine Metabolism and Fluoropolymer Production in Living Cells. Angew Chem Int Ed Engl. 2017 Oct 23; 56(44):13637-13640. PMID: 28861937.
      View in: PubMed
    4. Ad O, Thuronyi BW, Chang M. Elucidating the mechanism of fluorinated extender unit loading for improved production of fluorine-containing polyketides. Proc Natl Acad Sci U S A. 2017 01 31; 114(5):E660-E668. PMID: 28096394.
      View in: PubMed
    5. Chang M. Reducing microplastics from facial exfoliating cleansers in wastewater through treatment versus consumer product decisions. Mar Pollut Bull. 2015 Dec 15; 101(1):330-333. PMID: 26563542.
      View in: PubMed
    6. Chang M, Zhao H. Editorial overview: Opportunities and challenges in synthetic biology. Curr Opin Chem Biol. 2015 Oct; 28:v-vi. PMID: 26456417.
      View in: PubMed
    7. Nichols EM, Gallagher JJ, Liu C, Su Y, Resasco J, Yu Y, Sun Y, Yang P, Chang M, Chang CJ. Hybrid bioinorganic approach to solar-to-chemical conversion. Proc Natl Acad Sci U S A. 2015 Sep 15; 112(37):11461-6. PMID: 26305947; PMCID: PMC4577177.
    8. Liu C, Gallagher JJ, Sakimoto KK, Nichols EM, Chang CJ, Chang M, Yang P. Nanowire-bacteria hybrids for unassisted solar carbon dioxide fixation to value-added chemicals. Nano Lett. 2015 May 13; 15(5):3634-9. PMID: 25848808.
      View in: PubMed
    9. Jones SR, Wilson TD, Brown ME, Rahn-Lee L, Yu Y, Fredriksen LL, Ozyamak E, Komeili A, Chang M. Genetic and biochemical investigations of the role of MamP in redox control of iron biomineralization in Magnetospirillum magneticum. Proc Natl Acad Sci U S A. 2015 Mar 31; 112(13):3904-9. PMID: 25775527; PMCID: PMC4386411.
    10. Walker MC, Chang M. Natural and engineered biosynthesis of fluorinated natural products. Chem Soc Rev. 2014 Sep 21; 43(18):6527-36. PMID: 24776946.
      View in: PubMed
    11. Brown ME, Chang M. Exploring bacterial lignin degradation. Curr Opin Chem Biol. 2014 Apr; 19:1-7. PMID: 24780273.
      View in: PubMed
    12. Siponen MI, Legrand P, Widdrat M, Jones SR, Zhang WJ, Chang M, Faivre D, Arnoux P, Pignol D. Structural insight into magnetochrome-mediated magnetite biomineralization. Nature. 2013 Oct 31; 502(7473):681-4. PMID: 24097349.
      View in: PubMed
    13. Walker MC, Thuronyi BW, Charkoudian LK, Lowry B, Khosla C, Chang M. Expanding the fluorine chemistry of living systems using engineered polyketide synthase pathways. Science. 2013 Sep 06; 341(6150):1089-94. PMID: 24009388; PMCID: PMC4057101.
    14. Wen M, Bond-Watts BB, Chang M. Production of advanced biofuels in engineered E. coli. Curr Opin Chem Biol. 2013 Jun; 17(3):472-9. PMID: 23659832.
      View in: PubMed
    15. Weeks AM, Chang M. Catalytic control of enzymatic fluorine specificity. Proc Natl Acad Sci U S A. 2012 Nov 27; 109(48):19667-72. PMID: 23150553; PMCID: PMC3511759.
    16. Brown ME, Barros T, Chang M. Identification and characterization of a multifunctional dye peroxidase from a lignin-reactive bacterium. ACS Chem Biol. 2012 Dec 21; 7(12):2074-81. PMID: 23054399.
      View in: PubMed
    17. Bond-Watts BB, Weeks AM, Chang M. Biochemical and structural characterization of the trans-enoyl-CoA reductase from Treponema denticola. Biochemistry. 2012 Aug 28; 51(34):6827-37. PMID: 22906002.
      View in: PubMed
    18. Walker MC, Wen M, Weeks AM, Chang M. Temporal and fluoride control of secondary metabolism regulates cellular organofluorine biosynthesis. ACS Chem Biol. 2012 Sep 21; 7(9):1576-85. PMID: 22769062.
      View in: PubMed
    19. Townes D, Existe A, Boncy J, Magloire R, Vely JF, Amsalu R, De Tavernier M, Muigai J, Hoibak S, Albert M, McMorrow M, Slutsker L, Kachur SP, Chang M. Malaria survey in post-earthquake Haiti--2010. Am J Trop Med Hyg. 2012 Jan; 86(1):29-31. PMID: 22232446; PMCID: PMC3247104.
    20. Weeks AM, Coyle SM, Jinek M, Doudna JA, Chang M. Structural and biochemical studies of a fluoroacetyl-CoA-specific thioesterase reveal a molecular basis for fluorine selectivity. Biochemistry. 2010 Nov 02; 49(43):9269-79. PMID: 20836570; PMCID: PMC3461317.
    21. Jo WJ, Loguinov A, Wintz H, Chang M, Smith AH, Kalman D, Zhang L, Smith MT, Vulpe CD. Comparative functional genomic analysis identifies distinct and overlapping sets of genes required for resistance to monomethylarsonous acid (MMAIII) and arsenite (AsIII) in yeast. Toxicol Sci. 2009 Oct; 111(2):424-36. PMID: 19635755; PMCID: PMC2742584.
    22. Dietrich JA, Yoshikuni Y, Fisher KJ, Woolard FX, Ockey D, McPhee DJ, Renninger NS, Chang M, Baker D, Keasling JD. A novel semi-biosynthetic route for artemisinin production using engineered substrate-promiscuous P450(BM3). ACS Chem Biol. 2009 Apr 17; 4(4):261-7. PMID: 19271725.
      View in: PubMed
    23. Chang M. Harnessing energy from plant biomass. Curr Opin Chem Biol. 2007 Dec; 11(6):677-84. PMID: 17942363.
      View in: PubMed
    24. Jo WJ, Loguinov A, Chang M, Wintz H, Nislow C, Arkin AP, Giaever G, Vulpe CD. Identification of genes involved in the toxic response of Saccharomyces cerevisiae against iron and copper overload by parallel analysis of deletion mutants. Toxicol Sci. 2008 Jan; 101(1):140-51. PMID: 17785683.
      View in: PubMed
    25. Chang M, Eachus RA, Trieu W, Ro DK, Keasling JD. Engineering Escherichia coli for production of functionalized terpenoids using plant P450s. Nat Chem Biol. 2007 May; 3(5):274-7. PMID: 17438551.
      View in: PubMed
    26. Chang M, Keasling JD. Production of isoprenoid pharmaceuticals by engineered microbes. Nat Chem Biol. 2006 Dec; 2(12):674-81. PMID: 17108985.
      View in: PubMed
    27. Newman JD, Marshall J, Chang M, Nowroozi F, Paradise E, Pitera D, Newman KL, Keasling JD. High-level production of amorpha-4,11-diene in a two-phase partitioning bioreactor of metabolically engineered Escherichia coli. Biotechnol Bioeng. 2006 Nov 05; 95(4):684-91. PMID: 16878333.
      View in: PubMed
    28. Ro DK, Paradise EM, Ouellet M, Fisher KJ, Newman KL, Ndungu JM, Ho KA, Eachus RA, Ham TS, Kirby J, Chang M, Withers ST, Shiba Y, Sarpong R, Keasling JD. Production of the antimalarial drug precursor artemisinic acid in engineered yeast. Nature. 2006 Apr 13; 440(7086):940-3. PMID: 16612385.
      View in: PubMed
    29. Chang M, Pralle A, Isacoff EY, Chang CJ. A selective, cell-permeable optical probe for hydrogen peroxide in living cells. J Am Chem Soc. 2004 Dec 01; 126(47):15392-3. PMID: 15563161; PMCID: PMC1434465.
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