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Campisi, Judith

TitleBiochemist Project Sci/Engr
InstitutionLawrence Berkeley National Lab
DepartmentBiological Systems & Eng
Address1 Cyclotron Road
Berkeley CA 94720
Phone415/209-2066
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Zhang X, Zhang S, Liu X, Wang Y, Chang J, Zhang X, Mackintosh SG, Tackett AJ, He Y, Lv D, Laberge RM, Campisi J, Wang J, Zheng G, Zhou D. Oxidation resistance 1 is a novel senolytic target. Aging Cell. 2018 May 15; e12780. PMID: 29766639.
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    2. Jeon OH, David N, Campisi J, Elisseeff JH. Senescent cells and osteoarthritis: a painful connection. J Clin Invest. 2018 Apr 02; 128(4):1229-1237. PMID: 29608139.
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    3. Wiley CD, Schaum N, Alimirah F, Lopez-Dominguez JA, Orjalo AV, Scott G, Desprez PY, Benz C, Davalos AR, Campisi J. Small-molecule MDM2 antagonists attenuate the senescence-associated secretory phenotype. Sci Rep. 2018 Feb 05; 8(1):2410. PMID: 29402901.
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    4. Chinta SJ, Woods G, Demaria M, Rane A, Zou Y, McQuade A, Rajagopalan S, Limbad C, Madden DT, Campisi J, Andersen JK. Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson's Disease. Cell Rep. 2018 Jan 23; 22(4):930-940. PMID: 29386135.
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    5. Kohli J, Campisi J, Demaria M. A novel suicide gene therapy for the treatment of p16Ink4a-overexpressing tumors. Oncotarget. 2018 Jan 26; 9(7):7274-7281. PMID: 29484109.
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    6. Hernandez-Segura A, de Jong TV, Melov S, Guryev V, Campisi J, Demaria M. Unmasking Transcriptional Heterogeneity in Senescent Cells. Curr Biol. 2017 Sep 11; 27(17):2652-2660.e4. PMID: 28844647.
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    7. Wiley CD, Flynn JM, Morrissey C, Lebofsky R, Shuga J, Dong X, Unger MA, Vijg J, Melov S, Campisi J. Analysis of individual cells identifies cell-to-cell variability following induction of cellular senescence. Aging Cell. 2017 Oct; 16(5):1043-1050. PMID: 28699239.
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    8. Jeon OH, Kim C, Laberge RM, Demaria M, Rathod S, Vasserot AP, Chung JW, Kim DH, Poon Y, David N, Baker DJ, van Deursen JM, Campisi J, Elisseeff JH. Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment. Nat Med. 2017 Jun; 23(6):775-781. PMID: 28436958.
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    9. Baker DJ, Alimirah F, van Deursen JM, Campisi J, Hildesheim J. Oncogenic senescence: a multi-functional perspective. Oncotarget. 2017 Apr 18; 8(16):27661-27672. PMID: 28416761.
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    10. Perrott KM, Wiley CD, Desprez PY, Campisi J. Apigenin suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells. Geroscience. 2017 Apr; 39(2):161-173. PMID: 28378188.
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    11. Baar MP, Brandt RMC, Putavet DA, Klein JDD, Derks KWJ, Bourgeois BRM, Stryeck S, Rijksen Y, van Willigenburg H, Feijtel DA, van der Pluijm I, Essers J, van Cappellen WA, van IJcken WF, Houtsmuller AB, Pothof J, de Bruin RWF, Madl T, Hoeijmakers JHJ, Campisi J, de Keizer PLJ. Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging. Cell. 2017 Mar 23; 169(1):132-147.e16. PMID: 28340339.
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    12. Demaria M, O'Leary MN, Chang J, Shao L, Liu S, Alimirah F, Koenig K, Le C, Mitin N, Deal AM, Alston S, Academia EC, Kilmarx S, Valdovinos A, Wang B, de Bruin A, Kennedy BK, Melov S, Zhou D, Sharpless NE, Muss H, Campisi J. Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse. Cancer Discov. 2017 Feb; 7(2):165-176. PMID: 27979832.
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    13. Hodes RJ, Sierra F, Austad SN, Epel E, Neigh GN, Erlandson KM, Schafer MJ, LeBrasseur NK, Wiley C, Campisi J, Sehl ME, Scalia R, Eguchi S, Kasinath BS, Halter JB, Cohen HJ, Demark-Wahnefried W, Ahles TA, Barzilai N, Hurria A, Hunt PW. Disease drivers of aging. Ann N Y Acad Sci. 2016 12; 1386(1):45-68. PMID: 27943360.
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    14. Campisi J. Cellular Senescence and Lung Function during Aging. Yin and Yang. Ann Am Thorac Soc. 2016 Dec; 13(Supplement_5):S402-S406. PMID: 28005423.
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    15. Childs BG, Baker DJ, Wijshake T, Conover CA, Campisi J, van Deursen JM. Senescent intimal foam cells are deleterious at all stages of atherosclerosis. Science. 2016 10 28; 354(6311):472-477. PMID: 27789842.
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    16. Andriani GA, Almeida VP, Faggioli F, Mauro M, Tsai WL, Santambrogio L, Maslov A, Gadina M, Campisi J, Vijg J, Montagna C. Whole Chromosome Instability induces senescence and promotes SASP. Sci Rep. 2016 10 12; 6:35218. PMID: 27731420.
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    17. Pinti M, Appay V, Campisi J, Frasca D, Fülöp T, Sauce D, Larbi A, Weinberger B, Cossarizza A. Aging of the immune system: Focus on inflammation and vaccination. Eur J Immunol. 2016 10; 46(10):2286-2301. PMID: 27595500.
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    18. Wiley CD, Campisi J. From Ancient Pathways to Aging Cells-Connecting Metabolism and Cellular Senescence. Cell Metab. 2016 Jun 14; 23(6):1013-1021. PMID: 27304503; PMCID: PMC4911819 [Available on 06/14/17].
    19. Lecot P, Alimirah F, Desprez PY, Campisi J, Wiley C. Context-dependent effects of cellular senescence in cancer development. Br J Cancer. 2016 May 24; 114(11):1180-4. PMID: 27140310; PMCID: PMC4891501.
    20. Menon R, Behnia F, Polettini J, Saade GR, Campisi J, Velarde M. Placental membrane aging and HMGB1 signaling associated with human parturition. Aging (Albany NY). 2016 Feb; 8(2):216-30. PMID: 26851389; PMCID: PMC4789578.
    21. Trego KS, Groesser T, Davalos AR, Parplys AC, Zhao W, Nelson MR, Hlaing A, Shih B, Rydberg B, Pluth JM, Tsai MS, Hoeijmakers JHJ, Sung P, Wiese C, Campisi J, Cooper PK. Non-catalytic Roles for XPG with BRCA1 and BRCA2 in Homologous Recombination and Genome Stability. Mol Cell. 2016 Feb 18; 61(4):535-546. PMID: 26833090; PMCID: PMC4761302 [Available on 02/18/17].
    22. Chang J, Wang Y, Shao L, Laberge RM, Demaria M, Campisi J, Janakiraman K, Sharpless NE, Ding S, Feng W, Luo Y, Wang X, Aykin-Burns N, Krager K, Ponnappan U, Hauer-Jensen M, Meng A, Zhou D. Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice. Nat Med. 2016 Jan; 22(1):78-83. PMID: 26657143; PMCID: PMC4762215 [Available on 01/01/17].
    23. Liu S, Uppal H, Demaria M, Desprez PY, Campisi J, Kapahi P. Simvastatin suppresses breast cancer cell proliferation induced by senescent cells. Sci Rep. 2015 Dec 14; 5:17895. PMID: 26658759.
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    24. Wiley CD, Velarde MC, Lecot P, Liu S, Sarnoski EA, Freund A, Shirakawa K, Lim HW, Davis SS, Ramanathan A, Gerencser AA, Verdin E, Campisi J. Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype. Cell Metab. 2016 Feb 09; 23(2):303-14. PMID: 26686024; PMCID: PMC4749409 [Available on 02/09/17].
    25. Menendez JA, Rubio MA, Campisi J, Lupu R. Heregulin, a new regulator of telomere length in human cells. Oncotarget. 2015 Nov 24; 6(37):39422-36. PMID: 26318724; PMCID: PMC4741836.
    26. Menendez JA, Benboudjema L, Vellon L, Rubio MA, Espinoza I, Campisi J, Lupu R. Heregulin, a new interactor of the telosome/shelterin complex in human telomeres. Oncotarget. 2015 Nov 24; 6(37):39408-21. PMID: 26327598; PMCID: PMC4741835.
    27. Kang C, Xu Q, Martin TD, Li MZ, Demaria M, Aron L, Lu T, Yankner BA, Campisi J, Elledge SJ. The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4. Science. 2015 Sep 25; 349(6255):aaa5612. PMID: 26404840; PMCID: PMC4942138.
    28. Velarde MC, Demaria M, Melov S, Campisi J. Pleiotropic age-dependent effects of mitochondrial dysfunction on epidermal stem cells. Proc Natl Acad Sci U S A. 2015 Aug 18; 112(33):10407-12. PMID: 26240345; PMCID: PMC4547253.
    29. Laberge RM, Sun Y, Orjalo AV, Patil CK, Freund A, Zhou L, Curran SC, Davalos AR, Wilson-Edell KA, Liu S, Limbad C, Demaria M, Li P, Hubbard GB, Ikeno Y, Javors M, Desprez PY, Benz CC, Kapahi P, Nelson PS, Campisi J. MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation. Nat Cell Biol. 2015 Aug; 17(8):1049-61. PMID: 26147250; PMCID: PMC4691706.
    30. Christy B, Demaria M, Campisi J, Huang J, Jones D, Dodds SG, Williams C, Hubbard G, Livi CB, Gao X, Weintraub S, Curiel T, Sharp ZD, Hasty P. p53 and rapamycin are additive. Oncotarget. 2015 Jun 30; 6(18):15802-13. PMID: 26158292; PMCID: PMC4599238.
    31. White RR, Milholland B, de Bruin A, Curran S, Laberge RM, van Steeg H, Campisi J, Maslov AY, Vijg J. Controlled induction of DNA double-strand breaks in the mouse liver induces features of tissue ageing. Nat Commun. 2015 Apr 10; 6:6790. PMID: 25858675; PMCID: PMC4394211.
    32. Demaria M, Desprez PY, Campisi J, Velarde MC. Cell Autonomous and Non-Autonomous Effects of Senescent Cells in the Skin. J Invest Dermatol. 2015 Jul; 135(7):1722-1726. PMID: 25855157; PMCID: PMC4466004.
    33. Gilchrest BA, Campisi J, Chang HY, Fisher GJ, Kulesz-Martin MF. Montagna Symposium 2014-skin aging: molecular mechanisms and tissue consequences. J Invest Dermatol. 2015 Apr; 135(4):950-3. PMID: 25785950; PMCID: PMC4367196.
    34. Neves J, Demaria M, Campisi J, Jasper H. Of flies, mice, and men: evolutionarily conserved tissue damage responses and aging. Dev Cell. 2015 Jan 12; 32(1):9-18. PMID: 25584795; PMCID: PMC4450349.
    35. Demaria M, Ohtani N, Youssef SA, Rodier F, Toussaint W, Mitchell JR, Laberge RM, Vijg J, Van Steeg H, Dollé ME, Hoeijmakers JH, de Bruin A, Hara E, Campisi J. An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA. Dev Cell. 2014 Dec 22; 31(6):722-33. PMID: 25499914; PMCID: PMC4349629.
    36. Kennedy BK, Berger SL, Brunet A, Campisi J, Cuervo AM, Epel ES, Franceschi C, Lithgow GJ, Morimoto RI, Pessin JE, Rando TA, Richardson A, Schadt EE, Wyss-Coray T, Sierra F. Geroscience: linking aging to chronic disease. Cell. 2014 Nov 06; 159(4):709-13. PMID: 25417146; PMCID: PMC4852871.
    37. Simm A, Campisi J. Stress and aging. Exp Gerontol. 2014 Nov; 59:1-2. PMID: 25439102.
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    38. Childs BG, Baker DJ, Kirkland JL, Campisi J, van Deursen JM. Senescence and apoptosis: dueling or complementary cell fates? EMBO Rep. 2014 Nov; 15(11):1139-53. PMID: 25312810; PMCID: PMC4253488.
    39. Chinta SJ, Woods G, Rane A, Demaria M, Campisi J, Andersen JK. Cellular senescence and the aging brain. Exp Gerontol. 2015 Aug; 68:3-7. PMID: 25281806; PMCID: PMC4382436.
    40. Tomé M, Sepúlveda JC, Delgado M, Andrades JA, Campisi J, González MA, Bernad A. miR-335 correlates with senescence/aging in human mesenchymal stem cells and inhibits their therapeutic actions through inhibition of AP-1 activity. Stem Cells. 2014 Aug; 32(8):2229-44. PMID: 24648336; PMCID: PMC4207125.
    41. Sepúlveda JC, Tomé M, Fernández ME, Delgado M, Campisi J, Bernad A, González MA. Cell senescence abrogates the therapeutic potential of human mesenchymal stem cells in the lethal endotoxemia model. Stem Cells. 2014 Jul; 32(7):1865-77. PMID: 24496748; PMCID: PMC4209016.
    42. Wiley C, Campisi J. NAD+ controls neural stem cell fate in the aging brain. EMBO J. 2014 Jun 17; 33(12):1289-91. PMID: 24894550; PMCID: PMC4194118.
    43. Franceschi C, Campisi J. Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Gerontol A Biol Sci Med Sci. 2014 Jun; 69 Suppl 1:S4-9. PMID: 24833586.
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    44. Campisi J, Robert L. Cell senescence: role in aging and age-related diseases. Interdiscip Top Gerontol. 2014; 39:45-61. PMID: 24862014; PMCID: PMC4211612.
    45. Campisi J. Cell biology: The beginning of the end. Nature. 2014 Jan 02; 505(7481):35-6. PMID: 24352243; PMCID: PMC4167797.
    46. Davalos AR, Kawahara M, Malhotra GK, Schaum N, Huang J, Ved U, Beausejour CM, Coppe JP, Rodier F, Campisi J. p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes. J Cell Biol. 2013 May 13; 201(4):613-29. PMID: 23649808; PMCID: PMC3653366.
    47. Tchkonia T, Zhu Y, van Deursen J, Campisi J, Kirkland JL. Cellular senescence and the senescent secretory phenotype: therapeutic opportunities. J Clin Invest. 2013 Mar; 123(3):966-72. PMID: 23454759; PMCID: PMC3582125.
    48. Velarde MC, Demaria M, Campisi J. Senescent cells and their secretory phenotype as targets for cancer therapy. Interdiscip Top Gerontol. 2013; 38:17-27. PMID: 23503512; PMCID: PMC4167737.
    49. Howcroft TK, Campisi J, Louis GB, Smith MT, Wise B, Wyss-Coray T, Augustine AD, McElhaney JE, Kohanski R, Sierra F. The role of inflammation in age-related disease. Aging (Albany NY). 2013 Jan; 5(1):84-93. PMID: 23474627; PMCID: PMC3616233.
    50. Hasty P, Sharp ZD, Curiel TJ, Campisi J. mTORC1 and p53: clash of the gods? Cell Cycle. 2013 Jan 01; 12(1):20-5. PMID: 23255104; PMCID: PMC3570511.
    51. Ordinario E, Han HJ, Furuta S, Heiser LM, Jakkula LR, Rodier F, Spellman PT, Campisi J, Gray JW, Bissell MJ, Kohwi Y, Kohwi-Shigematsu T. ATM suppresses SATB1-induced malignant progression in breast epithelial cells. PLoS One. 2012; 7(12):e51786. PMID: 23251624; PMCID: PMC3519734.
    52. Campisi J. Aging, cellular senescence, and cancer. Annu Rev Physiol. 2013; 75:685-705. PMID: 23140366; PMCID: PMC4166529.
    53. Sun Y, Campisi J, Higano C, Beer TM, Porter P, Coleman I, True L, Nelson PS. Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B. Nat Med. 2012 Sep; 18(9):1359-68. PMID: 22863786; PMCID: PMC3677971.
    54. Zou Y, Zhang N, Ellerby LM, Davalos AR, Zeng X, Campisi J, Desprez PY. Responses of human embryonic stem cells and their differentiated progeny to ionizing radiation. Biochem Biophys Res Commun. 2012 Sep 14; 426(1):100-5. PMID: 22917535; PMCID: PMC3498829.
    55. Demaria M, Campisi J. Matters of life and breath: A role for hypoxia in determining cell state. Aging (Albany NY). 2012 Aug; 4(8):523-4. PMID: 22915708; PMCID: PMC3461339.
    56. Gombar S, Jung HJ, Dong F, Calder B, Atzmon G, Barzilai N, Tian XL, Pothof J, Hoeijmakers JH, Campisi J, Vijg J, Suh Y. Comprehensive microRNA profiling in B-cells of human centenarians by massively parallel sequencing. BMC Genomics. 2012 Jul 31; 13:353. PMID: 22846614; PMCID: PMC3563618.
    57. Anisimov VN, Bartke A, Barzilai N, Batin MA, Blagosklonny MV, Brown-Borg H, Budovskaya Y, Campisi J, Friguet B, Fraifeld V, Franceschi C, Gems D, Gladyshev V, Gorbunova V, Gudkov AV, Kennedy B, Konovalenko M, Kraemer B, Moskalev A, Petropoulos I, Pasyukova E, Rattan S, Rogina B, Seluanov A, Shaposhnikov M, Shmookler Reis R, Tavernarakis N, Vijg J, Yashin A, Zimniak P. The second international conference "genetics of aging and longevity". Aging (Albany NY). 2012 May; 4(5):305-17. PMID: 22661237.
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    58. Laberge RM, Zhou L, Sarantos MR, Rodier F, Freund A, de Keizer PL, Liu S, Demaria M, Cong YS, Kapahi P, Desprez PY, Hughes RE, Campisi J. Glucocorticoids suppress selected components of the senescence-associated secretory phenotype. Aging Cell. 2012 Aug; 11(4):569-78. PMID: 22404905; PMCID: PMC3387333.
    59. Freund A, Laberge RM, Demaria M, Campisi J. Lamin B1 loss is a senescence-associated biomarker. Mol Biol Cell. 2012 Jun; 23(11):2066-75. PMID: 22496421; PMCID: PMC3364172.
    60. Haines B, Demaria M, Mao X, Xie L, Campisi J, Jin K, Greenberg DA. Hypoxia-inducible factor-1 and neuroglobin expression. Neurosci Lett. 2012 Apr 18; 514(2):137-40. PMID: 22342914; PMCID: PMC3526664.
    61. Velarde MC, Flynn JM, Day NU, Melov S, Campisi J. Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin. Aging (Albany NY). 2012 Jan; 4(1):3-12. PMID: 22278880; PMCID: PMC3292901.
    62. Campisi J, Andersen JK, Kapahi P, Melov S. Cellular senescence: a link between cancer and age-related degenerative disease? Semin Cancer Biol. 2011 Dec; 21(6):354-9. PMID: 21925603; PMCID: PMC3230665.
    63. Coppé JP, Rodier F, Patil CK, Freund A, Desprez PY, Campisi J. Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype. J Biol Chem. 2011 Oct 21; 286(42):36396-403. PMID: 21880712; PMCID: PMC3196093.
    64. Bird JL, Jennert-Burston KC, Bachler MA, Mason PA, Lowe JE, Heo SJ, Campisi J, Faragher RG, Cox LS. Recapitulation of Werner syndrome sensitivity to camptothecin by limited knockdown of the WRN helicase/exonuclease. Biogerontology. 2012 Feb; 13(1):49-62. PMID: 21786128.
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    65. Laberge RM, Awad P, Campisi J, Desprez PY. Epithelial-mesenchymal transition induced by senescent fibroblasts. Cancer Microenviron. 2012 Apr; 5(1):39-44. PMID: 21706180; PMCID: PMC3343197.
    66. Trego KS, Chernikova SB, Davalos AR, Perry JJ, Finger LD, Ng C, Tsai MS, Yannone SM, Tainer JA, Campisi J, Cooper PK. The DNA repair endonuclease XPG interacts directly and functionally with the WRN helicase defective in Werner syndrome. Cell Cycle. 2011 Jun 15; 10(12):1998-2007. PMID: 21558802; PMCID: PMC3154418.
    67. Campisi J. Parsing p53 Transactivation. Dev Cell. 2011 May 17; 20(5):573-4. PMID: 21571212.
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    68. Campisi J. Interview with Judith Campisi, Ph.D. Interview by Vicki Glaser. Rejuvenation Res. 2011 Apr; 14(2):233-6. PMID: 21595505.
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    69. Freund A, Patil CK, Campisi J. p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype. EMBO J. 2011 Apr 20; 30(8):1536-48. PMID: 21399611; PMCID: PMC3102277.
    70. Krtolica A, Larocque N, Genbacev O, Ilic D, Coppe JP, Patil CK, Zdravkovic T, McMaster M, Campisi J, Fisher SJ. GROa regulates human embryonic stem cell self-renewal or adoption of a neuronal fate. Differentiation. 2011 Apr; 81(4):222-32. PMID: 21396766.
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    71. Rodier F, Campisi J. Four faces of cellular senescence. J Cell Biol. 2011 Feb 21; 192(4):547-56. PMID: 21321098; PMCID: PMC3044123.
    72. Campisi J. Estela Medrano: a life of gentle passion. Aging Cell. 2011 Feb; 10(1):2-3. PMID: 21223464.
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    73. Rodier F, Muñoz DP, Teachenor R, Chu V, Le O, Bhaumik D, Coppé JP, Campeau E, Beauséjour CM, Kim SH, Davalos AR, Campisi J. DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion. J Cell Sci. 2011 Jan 01; 124(Pt 1):68-81. PMID: 21118958; PMCID: PMC3001408.
    74. Campisi J. Cellular senescence: putting the paradoxes in perspective. Curr Opin Genet Dev. 2011 Feb; 21(1):107-12. PMID: 21093253; PMCID: PMC3073609.
    75. Bazarov AV, Van Sluis M, Hines WC, Bassett E, Beliveau A, Campeau E, Mukhopadhyay R, Lee WJ, Melodyev S, Zaslavsky Y, Lee L, Rodier F, Chicas A, Lowe SW, Benhattar J, Ren B, Campisi J, Yaswen P. p16(INK4a) -mediated suppression of telomerase in normal and malignant human breast cells. Aging Cell. 2010 Oct; 9(5):736-46. PMID: 20569236; PMCID: PMC2941554.
    76. Rae MJ, Butler RN, Campisi J, de Grey AD, Finch CE, Gough M, Martin GM, Vijg J, Perrott KM, Logan BJ. The demographic and biomedical case for late-life interventions in aging. Sci Transl Med. 2010 Jul 14; 2(40):40cm21. PMID: 20630854; PMCID: PMC3677970.
    77. de Keizer PL, Laberge RM, Campisi J. p53: Pro-aging or pro-longevity? Aging (Albany NY). 2010 Jul; 2(7):377-9. PMID: 20657035; PMCID: PMC2933881.
    78. Davalos AR, Coppe JP, Campisi J, Desprez PY. Senescent cells as a source of inflammatory factors for tumor progression. Cancer Metastasis Rev. 2010 Jun; 29(2):273-83. PMID: 20390322; PMCID: PMC2865636.
    79. Freund A, Orjalo AV, Desprez PY, Campisi J. Inflammatory networks during cellular senescence: causes and consequences. Trends Mol Med. 2010 May; 16(5):238-46. PMID: 20444648; PMCID: PMC2879478.
    80. Arnoult N, Schluth-Bolard C, Letessier A, Drascovic I, Bouarich-Bourimi R, Campisi J, Kim SH, Boussouar A, Ottaviani A, Magdinier F, Gilson E, Londoño-Vallejo A. Replication timing of human telomeres is chromosome arm-specific, influenced by subtelomeric structures and connected to nuclear localization. PLoS Genet. 2010 Apr 22; 6(4):e1000920. PMID: 20421929; PMCID: PMC2858680.
    81. Held JM, Danielson SR, Behring JB, Atsriku C, Britton DJ, Puckett RL, Schilling B, Campisi J, Benz CC, Gibson BW. Targeted quantitation of site-specific cysteine oxidation in endogenous proteins using a differential alkylation and multiple reaction monitoring mass spectrometry approach. Mol Cell Proteomics. 2010 Jul; 9(7):1400-10. PMID: 20233844; PMCID: PMC2938085.
    82. Le ON, Rodier F, Fontaine F, Coppe JP, Campisi J, DeGregori J, Laverdière C, Kokta V, Haddad E, Beauséjour CM. Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status. Aging Cell. 2010 Jun; 9(3):398-409. PMID: 20331441; PMCID: PMC2894262.
    83. Coppé JP, Patil CK, Rodier F, Krtolica A, Beauséjour CM, Parrinello S, Hodgson JG, Chin K, Desprez PY, Campisi J. A human-like senescence-associated secretory phenotype is conserved in mouse cells dependent on physiological oxygen. PLoS One. 2010 Feb 12; 5(2):e9188. PMID: 20169192.
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    84. Coppé JP, Desprez PY, Krtolica A, Campisi J. The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu Rev Pathol. 2010; 5:99-118. PMID: 20078217; PMCID: PMC4166495.
    85. Rodier F, Campisi J. When DNA damage goes invisible. Cell Cycle. 2009 Nov 15; 8(22):3632-3. PMID: 19875922.
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    86. Orjalo AV, Bhaumik D, Gengler BK, Scott GK, Campisi J. Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network. Proc Natl Acad Sci U S A. 2009 Oct 06; 106(40):17031-6. PMID: 19805069; PMCID: PMC2761322.
    87. Campeau E, Ruhl VE, Rodier F, Smith CL, Rahmberg BL, Fuss JO, Campisi J, Yaswen P, Cooper PK, Kaufman PD. A versatile viral system for expression and depletion of proteins in mammalian cells. PLoS One. 2009 Aug 06; 4(8):e6529. PMID: 19657394; PMCID: PMC2717805.
    88. Rodier F, Coppé JP, Patil CK, Hoeijmakers WA, Muñoz DP, Raza SR, Freund A, Campeau E, Davalos AR, Campisi J. Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. Nat Cell Biol. 2009 Aug; 11(8):973-9. PMID: 19597488; PMCID: PMC2743561.
    89. Bhaumik D, Patil CK, Campisi J. MicroRNAs: an important player in maintaining a balance between inflammation and tumor suppression. Cell Cycle. 2009 Jun 15; 8(12):1822. PMID: 19471128.
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    90. Bhaumik D, Scott GK, Schokrpur S, Patil CK, Orjalo AV, Rodier F, Lithgow GJ, Campisi J. MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8. Aging (Albany NY). 2009 Apr; 1(4):402-11. PMID: 20148189; PMCID: PMC2818025.
    91. Campisi J, Yaswen P. Aging and cancer cell biology, 2009. Aging Cell. 2009 Jun; 8(3):221-5. PMID: 19627264.
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    92. Kaminker PG, Kim SH, Desprez PY, Campisi J. A novel form of the telomere-associated protein TIN2 localizes to the nuclear matrix. Cell Cycle. 2009 Mar 15; 8(6):931-9. PMID: 19229133; PMCID: PMC2751576.
    93. Campisi J, Sedivy J. How does proliferative homeostasis change with age? What causes it and how does it contribute to aging? J Gerontol A Biol Sci Med Sci. 2009 Feb; 64(2):164-6. PMID: 19228778; PMCID: PMC2655008.
    94. Campisi J, Vijg J. Does damage to DNA and other macromolecules play a role in aging? If so, how? J Gerontol A Biol Sci Med Sci. 2009 Feb; 64(2):175-8. PMID: 19228786; PMCID: PMC2655027.
    95. Blagosklonny MV, Campisi J, Sinclair DA. Aging: past, present and future. Aging (Albany NY). 2009 Jan 07; 1(1):1-5. PMID: 20157590; PMCID: PMC2815757.
    96. Debacq-Chainiaux F, Erusalimsky JD, Campisi J, Toussaint O. Protocols to detect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo. Nat Protoc. 2009; 4(12):1798-806. PMID: 20010931.
      View in: PubMed
    97. Coppé JP, Patil CK, Rodier F, Sun Y, Muñoz DP, Goldstein J, Nelson PS, Desprez PY, Campisi J. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol. 2008 Dec 02; 6(12):2853-68. PMID: 19053174.
      View in: PubMed
    98. Holcomb VB, Rodier F, Choi Y, Busuttil RA, Vogel H, Vijg J, Campisi J, Hasty P. Ku80 deletion suppresses spontaneous tumors and induces a p53-mediated DNA damage response. Cancer Res. 2008 Nov 15; 68(22):9497-502. PMID: 19010925; PMCID: PMC4034752.
    99. Busuttil RA, Muñoz DP, Garcia AM, Rodier F, Kim WH, Suh Y, Hasty P, Campisi J, Vijg J. Effect of Ku80 deficiency on mutation frequencies and spectra at a LacZ reporter locus in mouse tissues and cells. PLoS One. 2008; 3(10):e3458. PMID: 18941635; PMCID: PMC2565499.
    100. Blagosklonny MV, Campisi J. Cancer and aging: more puzzles, more promises? Cell Cycle. 2008 Sep 01; 7(17):2615-8. PMID: 18719390.
      View in: PubMed
    101. Vijg J, Campisi J. Puzzles, promises and a cure for ageing. Nature. 2008 Aug 28; 454(7208):1065-71. PMID: 18756247; PMCID: PMC2774752.
    102. Coppe JP, Boysen M, Sun CH, Wong BJ, Kang MK, Park NH, Desprez PY, Campisi J, Krtolica A. A role for fibroblasts in mediating the effects of tobacco-induced epithelial cell growth and invasion. Mol Cancer Res. 2008 Jul; 6(7):1085-98. PMID: 18644973; PMCID: PMC2768668.
    103. Kim SH, Davalos AR, Heo SJ, Rodier F, Zou Y, Beausejour C, Kaminker P, Yannone SM, Campisi J. Telomere dysfunction and cell survival: roles for distinct TIN2-containing complexes. J Cell Biol. 2008 May 05; 181(3):447-60. PMID: 18443218; PMCID: PMC2364703.
    104. Campisi J. Aging and cancer cell biology, 2008. Aging Cell. 2008 Jun; 7(3):281-4. PMID: 18331618.
      View in: PubMed
    105. Rodier F, Campisi J, Bhaumik D. Two faces of p53: aging and tumor suppression. Nucleic Acids Res. 2007; 35(22):7475-84. PMID: 17942417; PMCID: PMC2190721.
    106. Campisi J, d'Adda di Fagagna F. Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol. 2007 Sep; 8(9):729-40. PMID: 17667954.
      View in: PubMed
    107. Campisi J. Aging and cancer cell biology, 2007. Aging Cell. 2007 Jun; 6(3):261-3. PMID: 17517036.
      View in: PubMed
    108. Benz CC, Campisi J, Cohen HJ, Ershler WB, Irminger-Finger I. Meeting report: Translational Research at the Aging and Cancer Interface. Cancer Res. 2007 May 15; 67(10):4560-3. PMID: 17510382.
      View in: PubMed
    109. Beliveau A, Bassett E, Lo AT, Garbe J, Rubio MA, Bissell MJ, Campisi J, Yaswen P. p53-dependent integration of telomere and growth factor deprivation signals. Proc Natl Acad Sci U S A. 2007 Mar 13; 104(11):4431-6. PMID: 17360541; PMCID: PMC1838618.
    110. Yaswen P, Campisi J. Oncogene-induced senescence pathways weave an intricate tapestry. Cell. 2007 Jan 26; 128(2):233-4. PMID: 17254959.
      View in: PubMed
    111. Itahana K, Campisi J, Dimri GP. Methods to detect biomarkers of cellular senescence: the senescence-associated beta-galactosidase assay. Methods Mol Biol. 2007; 371:21-31. PMID: 17634571.
      View in: PubMed
    112. Beausejour CM, Campisi J. Ageing: balancing regeneration and cancer. Nature. 2006 Sep 28; 443(7110):404-5. PMID: 16957734.
      View in: PubMed
    113. Coppé JP, Kauser K, Campisi J, Beauséjour CM. Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence. J Biol Chem. 2006 Oct 06; 281(40):29568-74. PMID: 16880208.
      View in: PubMed
    114. Cheng WH, Kusumoto R, Opresko PL, Sui X, Huang S, Nicolette ML, Paull TT, Campisi J, Seidman M, Bohr VA. Collaboration of Werner syndrome protein and BRCA1 in cellular responses to DNA interstrand cross-links. Nucleic Acids Res. 2006; 34(9):2751-60. PMID: 16714450; PMCID: PMC1464112.
    115. Chiang YJ, Nguyen ML, Gurunathan S, Kaminker P, Tessarollo L, Campisi J, Hodes RJ. Generation and characterization of telomere length maintenance in tankyrase 2-deficient mice. Mol Cell Biol. 2006 Mar; 26(6):2037-43. PMID: 16507984; PMCID: PMC1430286.
    116. Huang S, Chen L, Libina N, Janes J, Martin GM, Campisi J, Oshima J. Correction of cellular phenotypes of Hutchinson-Gilford Progeria cells by RNA interference. Hum Genet. 2005 Dec; 118(3-4):444-50. PMID: 16208517.
      View in: PubMed
    117. Patil CK, Mian IS, Campisi J. The thorny path linking cellular senescence to organismal aging. Mech Ageing Dev. 2005 Oct; 126(10):1040-5. PMID: 16153470.
      View in: PubMed
    118. Busuttil RA, Rubio M, Dollé ME, Campisi J, Vijg J. Mutant frequencies and spectra depend on growth state and passage number in cells cultured from transgenic lacZ-plasmid reporter mice. DNA Repair (Amst). 2006 Jan 05; 5(1):52-60. PMID: 16126462.
      View in: PubMed
    119. Campisi J. Suppressing cancer: the importance of being senescent. Science. 2005 Aug 05; 309(5736):886-7. PMID: 16081723.
      View in: PubMed
    120. Goldstein JC, Rodier F, Garbe JC, Stampfer MR, Campisi J. Caspase-independent cytochrome c release is a sensitive measure of low-level apoptosis in cell culture models. Aging Cell. 2005 Aug; 4(4):217-22. PMID: 16026336.
      View in: PubMed
    121. Kaminker P, Plachot C, Kim SH, Chung P, Crippen D, Petersen OW, Bissell MJ, Campisi J, Lelièvre SA. Higher-order nuclear organization in growth arrest of human mammary epithelial cells: a novel role for telomere-associated protein TIN2. J Cell Sci. 2005 Mar 15; 118(Pt 6):1321-30. PMID: 15741234; PMCID: PMC2933191.
    122. Campisi J. Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell. 2005 Feb 25; 120(4):513-22. PMID: 15734683.
      View in: PubMed
    123. Parrinello S, Coppe JP, Krtolica A, Campisi J. Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation. J Cell Sci. 2005 Feb 01; 118(Pt 3):485-96. PMID: 15657080; PMCID: PMC4939801.
    124. Rodier F, Kim SH, Nijjar T, Yaswen P, Campisi J. Cancer and aging: the importance of telomeres in genome maintenance. Int J Biochem Cell Biol. 2005 May; 37(5):977-90. PMID: 15743672.
      View in: PubMed
    125. Campisi J. Aging, tumor suppression and cancer: high wire-act! Mech Ageing Dev. 2005 Jan; 126(1):51-8. PMID: 15610762.
      View in: PubMed
    126. Davalos AR, Kaminker P, Hansen RK, Campisi J. ATR and ATM-dependent movement of BLM helicase during replication stress ensures optimal ATM activation and 53BP1 focus formation. Cell Cycle. 2004 Dec; 3(12):1579-86. PMID: 15539948.
      View in: PubMed
    127. Kim SH, Beausejour C, Davalos AR, Kaminker P, Heo SJ, Campisi J. TIN2 mediates functions of TRF2 at human telomeres. J Biol Chem. 2004 Oct 15; 279(42):43799-804. PMID: 15292264.
      View in: PubMed
    128. Chiang YJ, Kim SH, Tessarollo L, Campisi J, Hodes RJ. Telomere-associated protein TIN2 is essential for early embryonic development through a telomerase-independent pathway. Mol Cell Biol. 2004 Aug; 24(15):6631-4. PMID: 15254230; PMCID: PMC444850.
    129. Rubio MA, Davalos AR, Campisi J. Telomere length mediates the effects of telomerase on the cellular response to genotoxic stress. Exp Cell Res. 2004 Aug 01; 298(1):17-27. PMID: 15242758.
      View in: PubMed
    130. Busuttil RA, Dollé M, Campisi J, Vijga J. Genomic instability, aging, and cellular senescence. Ann N Y Acad Sci. 2004 Jun; 1019:245-55. PMID: 15247023.
      View in: PubMed
    131. Butler RN, Warner HR, Williams TF, Austad SN, Brody JA, Campisi J, Cerami A, Cohen G, Cristofalo VJ, Drachman DA, Finch CE, Fridovich I, Harley CB, Havlik RJ, Martin GM, Miller RA, Olshansky SJ, Pereira-Smith OM, Smith JR, Sprott RL, West MD, Wilmoth JR, Wright WE. The aging factor in health and disease: the promise of basic research on aging. Aging Clin Exp Res. 2004 Apr; 16(2):104-11; discussion 111-2. PMID: 15195984.
      View in: PubMed
    132. Campisi J. Fragile fugue: p53 in aging, cancer and IGF signaling. Nat Med. 2004 Mar; 10(3):231-2. PMID: 14991040.
      View in: PubMed
    133. Itahana K, Campisi J, Dimri GP. Mechanisms of cellular senescence in human and mouse cells. Biogerontology. 2004; 5(1):1-10. PMID: 15138376.
      View in: PubMed
    134. Busuttil RA, Rubio M, Dollé ME, Campisi J, Vijg J. Oxygen accelerates the accumulation of mutations during the senescence and immortalization of murine cells in culture. Aging Cell. 2003 Dec; 2(6):287-94. PMID: 14677631.
      View in: PubMed
    135. Chen D, Xu W, Bales E, Colmenares C, Conacci-Sorrell M, Ishii S, Stavnezer E, Campisi J, Fisher DE, Ben-Ze'ev A, Medrano EE. SKI activates Wnt/beta-catenin signaling in human melanoma. Cancer Res. 2003 Oct 15; 63(20):6626-34. PMID: 14583455.
      View in: PubMed
    136. Davalos AR, Campisi J. Bloom syndrome cells undergo p53-dependent apoptosis and delayed assembly of BRCA1 and NBS1 repair complexes at stalled replication forks. J Cell Biol. 2003 Sep 29; 162(7):1197-209. PMID: 14517203; PMCID: PMC2173967.
    137. Tan S, Guschin D, Davalos A, Lee YL, Snowden AW, Jouvenot Y, Zhang HS, Howes K, McNamara AR, Lai A, Ullman C, Reynolds L, Moore M, Isalan M, Berg LP, Campos B, Qi H, Spratt SK, Case CC, Pabo CO, Campisi J, Gregory PD. Zinc-finger protein-targeted gene regulation: genomewide single-gene specificity. Proc Natl Acad Sci U S A. 2003 Oct 14; 100(21):11997-2002. PMID: 14514889; PMCID: PMC218702.
    138. Beauséjour CM, Krtolica A, Galimi F, Narita M, Lowe SW, Yaswen P, Campisi J. Reversal of human cellular senescence: roles of the p53 and p16 pathways. EMBO J. 2003 Aug 15; 22(16):4212-22. PMID: 12912919; PMCID: PMC175806.
    139. Chen L, Huang S, Lee L, Davalos A, Schiestl RH, Campisi J, Oshima J. WRN, the protein deficient in Werner syndrome, plays a critical structural role in optimizing DNA repair. Aging Cell. 2003 Aug; 2(4):191-9. PMID: 12934712.
      View in: PubMed
    140. Parrinello S, Samper E, Krtolica A, Goldstein J, Melov S, Campisi J. Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts. Nat Cell Biol. 2003 Aug; 5(8):741-7. PMID: 12855956; PMCID: PMC4940195.
    141. Kim SH, Han S, You YH, Chen DJ, Campisi J. The human telomere-associated protein TIN2 stimulates interactions between telomeric DNA tracts in vitro. EMBO Rep. 2003 Jul; 4(7):685-91. PMID: 12835755; PMCID: PMC1326318.
    142. Campisi J. Cancer and ageing: rival demons? Nat Rev Cancer. 2003 May; 3(5):339-49. PMID: 12724732.
      View in: PubMed
    143. Kim SH, Parrinello S, Kim J, Campisi J. Mus musculus and Mus spretus homologues of the human telomere-associated protein TIN2. Genomics. 2003 Apr; 81(4):422-32. PMID: 12676566.
      View in: PubMed
    144. Hasty P, Campisi J, Hoeijmakers J, van Steeg H, Vijg J. Aging and genome maintenance: lessons from the mouse? Science. 2003 Feb 28; 299(5611):1355-9. PMID: 12610296.
      View in: PubMed
    145. Itahana K, Zou Y, Itahana Y, Martinez JL, Beausejour C, Jacobs JJ, Van Lohuizen M, Band V, Campisi J, Dimri GP. Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1. Mol Cell Biol. 2003 Jan; 23(1):389-401. PMID: 12482990; PMCID: PMC140680.
    146. Campisi J. Cellular senescence and apoptosis: how cellular responses might influence aging phenotypes. Exp Gerontol. 2003 Jan-Feb; 38(1-2):5-11. PMID: 12543256.
      View in: PubMed
    147. Campisi J. Analysis of tumor suppressor gene-induced senescence. Methods Mol Biol. 2003; 223:155-72. PMID: 12777728.
      View in: PubMed
    148. Krtolica A, Campisi J. Cancer and aging: a model for the cancer promoting effects of the aging stroma. Int J Biochem Cell Biol. 2002 Nov; 34(11):1401-14. PMID: 12200035.
      View in: PubMed
    149. Krtolica A, Ortiz de Solorzano C, Lockett S, Campisi J. Quantification of epithelial cells in coculture with fibroblasts by fluorescence image analysis. Cytometry. 2002 Oct 01; 49(2):73-82. PMID: 12357463.
      View in: PubMed
    150. Dimri GP, Martinez JL, Jacobs JJ, Keblusek P, Itahana K, Van Lohuizen M, Campisi J, Wazer DE, Band V. The Bmi-1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells. Cancer Res. 2002 Aug 15; 62(16):4736-45. PMID: 12183433.
      View in: PubMed
    151. Rubio MA, Kim SH, Campisi J. Reversible manipulation of telomerase expression and telomere length. Implications for the ionizing radiation response and replicative senescence of human cells. J Biol Chem. 2002 Aug 09; 277(32):28609-17. PMID: 12034742.
      View in: PubMed
    152. de Grey AD, Ames BN, Andersen JK, Bartke A, Campisi J, Heward CB, McCarter RJ, Stock G. Time to talk SENS: critiquing the immutability of human aging. Ann N Y Acad Sci. 2002 Apr; 959:452-62; discussion 463-5. PMID: 11976218.
      View in: PubMed
    153. Campisi J. Between Scylla and Charybdis: p53 links tumor suppression and aging. Mech Ageing Dev. 2002 Mar 31; 123(6):567-73. PMID: 11850020.
      View in: PubMed
    154. Itahana K, Dimri GP, Hara E, Itahana Y, Zou Y, Desprez PY, Campisi J. A role for p53 in maintaining and establishing the quiescence growth arrest in human cells. J Biol Chem. 2002 May 17; 277(20):18206-14. PMID: 11880381.
      View in: PubMed
    155. Blagosklonny MV, Campisi J, Keyomarsi K, Medrano EE. No restriction points in life and science. Cell Cycle. 2002 Mar-Apr; 1(2):100-2. PMID: 12429915.
      View in: PubMed
    156. Kim Sh SH, Kaminker P, Campisi J. Telomeres, aging and cancer: in search of a happy ending. Oncogene. 2002 Jan 21; 21(4):503-11. PMID: 11850775.
      View in: PubMed
    157. Oshima J, Huang S, Pae C, Campisi J, Schiestl RH. Lack of WRN results in extensive deletion at nonhomologous joining ends. Cancer Res. 2002 Jan 15; 62(2):547-51. PMID: 11809708.
      View in: PubMed
    158. Campisi J. Cancer and aging: yin, yang, and p53. Sci Aging Knowledge Environ. 2002 Jan 09; 2002(1):pe1. PMID: 14602974.
      View in: PubMed
    159. Campisi J, Kim SH, Lim CS, Rubio M. Cellular senescence, cancer and aging: the telomere connection. Exp Gerontol. 2001 Nov; 36(10):1619-37. PMID: 11672984.
      View in: PubMed
    160. Campisi J. Cellular senescence as a tumor-suppressor mechanism. Trends Cell Biol. 2001 Nov; 11(11):S27-31. PMID: 11684439.
      View in: PubMed
    161. Campisi J. From cells to organisms: can we learn about aging from cells in culture? Exp Gerontol. 2001 Apr; 36(4-6):607-18. PMID: 11295503.
      View in: PubMed
    162. Campisi J. Aging, chromatin, and food restriction--connecting the dots. Science. 2000 Sep 22; 289(5487):2062-3. PMID: 11032557.
      View in: PubMed
    163. Campisi J. Cancer, aging and cellular senescence. In Vivo. 2000 Jan-Feb; 14(1):183-8. PMID: 10757076.
      View in: PubMed
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