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Doudna, Jennifer

TitleBiologist Faculty
InstitutionLawrence Berkeley National Lab
DepartmentMolecular Biophys & Integ Bio
Address1 Cyclotron Road
Berkeley CA 94720
Phone510/643-0225
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Rouet R, Thuma BA, Roy MD, Lintner NG, Rubitski DM, Finley JE, Wisniewska HM, Mendonsa R, Hirsh A, de Oñate L, Compte J, Mclellan TJ, Bellenger J, Feng X, Varghese A, Chrunyk BA, Borzilleri KA, Hesp KD, Zhou K, Ma N, Tu M, Dullea R, Mcclure KF, Wilson RC, Liras S, Mascitti V, Doudna J. Receptor-Mediated Delivery of CRISPR-Cas9 Endonuclease for Cell Type Specific Gene Editing. J Am Chem Soc. 2018 Apr 18. PMID: 29668265.
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    2. Lintner NG, McClure KF, Petersen D, Londregan AT, Piotrowski DW, Wei L, Xiao J, Bolt M, Loria PM, Maguire B, Geoghegan KF, Huang A, Rolph T, Liras S, Doudna J, Dullea RG, Cate JHD. Correction: Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain. PLoS Biol. 2018 Apr; 16(4):e1002628. PMID: 29664898.
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    3. Lapinaite A, Doudna J, Cate JHD. Programmable RNA recognition using a CRISPR-associated Argonaute. Proc Natl Acad Sci U S A. 2018 Mar 27; 115(13):3368-3373. PMID: 29531059.
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    4. Knight SC, Tjian R, Doudna J. Genomes in Focus: Development and Applications of CRISPR-Cas9 Imaging Technologies. Angew Chem Int Ed Engl. 2018 Apr 09; 57(16):4329-4337. PMID: 29080263.
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    5. Kiessling LL, Doudna J. Spotlight: A Conversation with Laura Kiessling and Jennifer Doudna. ACS Chem Biol. 2018 Feb 16; 13(2):290-295. PMID: 29448761.
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    6. Chen JS, Ma E, Harrington LB, Da Costa M, Tian X, Palefsky JM, Doudna J. CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity. Science. 2018 Feb 15. PMID: 29449511.
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    7. Strutt SC, Torrez RM, Kaya E, Negrete OA, Doudna J. RNA-dependent RNA targeting by CRISPR-Cas9. Elife. 2018 Jan 05; 7. PMID: 29303478.
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    8. Moreno-Mateos MA, Fernandez JP, Rouet R, Vejnar CE, Lane MA, Mis E, Khokha MK, Doudna J, Giraldez AJ. CRISPR-Cpf1 mediates efficient homology-directed repair and temperature-controlled genome editing. Nat Commun. 2017 Dec 08; 8(1):2024. PMID: 29222508.
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    9. Blair JD, Hockemeyer D, Doudna J, Bateup HS, Floor SN. Widespread Translational Remodeling during Human Neuronal Differentiation. Cell Rep. 2017 Nov 14; 21(7):2005-2016. PMID: 29141229.
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    10. Harrington LB, Paez-Espino D, Staahl BT, Chen JS, Ma E, Kyrpides NC, Doudna J. A thermostable Cas9 with increased lifetime in human plasma. Nat Commun. 2017 Nov 10; 8(1):1424. PMID: 29127284.
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    11. Chen JS, Dagdas YS, Kleinstiver BP, Welch MM, Sousa AA, Harrington LB, Sternberg SH, Joung JK, Yildiz A, Doudna J. Enhanced proofreading governs CRISPR-Cas9 targeting accuracy. Nature. 2017 10 19; 550(7676):407-410. PMID: 28931002.
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    12. Knott GJ, East-Seletsky A, Cofsky JC, Holton JM, Charles E, O'Connell MR, Doudna J. Guide-bound structures of an RNA-targeting A-cleaving CRISPR-Cas13a enzyme. Nat Struct Mol Biol. 2017 Oct; 24(10):825-833. PMID: 28892041.
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    13. Harrington LB, Doxzen KW, Ma E, Liu JJ, Knott GJ, Edraki A, Garcia B, Amrani N, Chen JS, Cofsky JC, Kranzusch PJ, Sontheimer EJ, Davidson AR, Maxwell KL, Doudna J. A Broad-Spectrum Inhibitor of CRISPR-Cas9. Cell. 2017 Sep 07; 170(6):1224-1233.e15. PMID: 28844692.
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    14. Dagdas YS, Chen JS, Sternberg SH, Doudna J, Yildiz A. A conformational checkpoint between DNA binding and cleavage by CRISPR-Cas9. Sci Adv. 2017 Aug; 3(8):eaao0027. PMID: 28808686.
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    15. Wright AV, Liu JJ, Knott GJ, Doxzen KW, Nogales E, Doudna J. Structures of the CRISPR genome integration complex. Science. 2017 09 15; 357(6356):1113-1118. PMID: 28729350.
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    16. Shin J, Jiang F, Liu JJ, Bray NL, Rauch BJ, Baik SH, Nogales E, Bondy-Denomy J, Corn JE, Doudna J. Disabling Cas9 by an anti-CRISPR DNA mimic. Sci Adv. 2017 Jul; 3(7):e1701620. PMID: 28706995.
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    17. Gaj T, Staahl BT, Rodrigues GMC, Limsirichai P, Ekman FK, Doudna J, Schaffer DV. Targeted gene knock-in by homology-directed genome editing using Cas9 ribonucleoprotein and AAV donor delivery. Nucleic Acids Res. 2017 Jun 20; 45(11):e98. PMID: 28334779.
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    18. Doxzen KW, Doudna J. DNA recognition by an RNA-guided bacterial Argonaute. PLoS One. 2017; 12(5):e0177097. PMID: 28520746.
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    19. Boyle EA, Andreasson JOL, Chircus LM, Sternberg SH, Wu MJ, Guegler CK, Doudna J, Greenleaf WJ. High-throughput biochemical profiling reveals sequence determinants of dCas9 off-target binding and unbinding. Proc Natl Acad Sci U S A. 2017 05 23; 114(21):5461-5466. PMID: 28495970.
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    20. East-Seletsky A, O'Connell MR, Burstein D, Knott GJ, Doudna J. RNA Targeting by Functionally Orthogonal Type VI-A CRISPR-Cas Enzymes. Mol Cell. 2017 May 04; 66(3):373-383.e3. PMID: 28475872.
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    21. Liu TY, Iavarone AT, Doudna J. Correction: RNA and DNA Targeting by a Reconstituted Thermus thermophilus Type III-A CRISPR-Cas System. PLoS One. 2017; 12(4):e0175612. PMID: 28384323.
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    22. Jiang F, Doudna J. CRISPR-Cas9 Structures and Mechanisms. Annu Rev Biophys. 2017 May 22; 46:505-529. PMID: 28375731.
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    23. Lintner NG, McClure KF, Petersen D, Londregan AT, Piotrowski DW, Wei L, Xiao J, Bolt M, Loria PM, Maguire B, Geoghegan KF, Huang A, Rolph T, Liras S, Doudna J, Dullea RG, Cate JH. Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain. PLoS Biol. 2017 Mar; 15(3):e2001882. PMID: 28323820.
      View in: PubMed
    24. Gorski SA, Vogel J, Doudna J. RNA-based recognition and targeting: sowing the seeds of specificity. Nat Rev Mol Cell Biol. 2017 04; 18(4):215-228. PMID: 28196981.
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    25. Staahl BT, Benekareddy M, Coulon-Bainier C, Banfal AA, Floor SN, Sabo JK, Urnes C, Munares GA, Ghosh A, Doudna J. Efficient genome editing in the mouse brain by local delivery of engineered Cas9 ribonucleoprotein complexes. Nat Biotechnol. 2017 05; 35(5):431-434. PMID: 28191903.
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    26. Liu TY, Iavarone AT, Doudna J. RNA and DNA Targeting by a Reconstituted Thermus thermophilus Type III-A CRISPR-Cas System. PLoS One. 2017; 12(1):e0170552. PMID: 28114398.
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    27. Koh HR, Kidwell MA, Doudna J, Myong S. RNA Scanning of a Molecular Machine with a Built-in Ruler. J Am Chem Soc. 2017 01 11; 139(1):262-268. PMID: 27958730.
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    28. Fellmann C, Gowen BG, Lin PC, Doudna J, Corn JE. Cornerstones of CRISPR-Cas in drug discovery and therapy. Nat Rev Drug Discov. 2017 02; 16(2):89-100. PMID: 28008168.
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    29. Burstein D, Harrington LB, Strutt SC, Probst AJ, Anantharaman K, Thomas BC, Doudna J, Banfield JF. New CRISPR-Cas systems from uncultivated microbes. Nature. 2017 02 09; 542(7640):237-241. PMID: 28005056.
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    30. Heler R, Wright AV, Vucelja M, Bikard D, Doudna J, Marraffini LA. Mutations in Cas9 Enhance the Rate of Acquisition of Viral Spacer Sequences during the CRISPR-Cas Immune Response. Mol Cell. 2017 Jan 05; 65(1):168-175. PMID: 28017588.
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    31. Hultquist JF, Schumann K, Woo JM, Manganaro L, McGregor MJ, Doudna J, Simon V, Krogan NJ, Marson A. A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human T Cells. Cell Rep. 2016 10 25; 17(5):1438-1452. PMID: 27783955.
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    32. Chen X, Shen Y, Draper W, Buenrostro JD, Litzenburger U, Cho SW, Satpathy AT, Carter AC, Ghosh RP, East-Seletsky A, Doudna J, Greenleaf WJ, Liphardt JT, Chang HY. ATAC-see reveals the accessible genome by transposase-mediated imaging and sequencing. Nat Methods. 2016 Dec; 13(12):1013-1020. PMID: 27749837.
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    33. Schulze-Gahmen U, Echeverria I, Stjepanovic G, Bai Y, Lu H, Schneidman-Duhovny D, Doudna J, Zhou Q, Sali A, Hurley JH. Insights into HIV-1 proviral transcription from integrative structure and dynamics of the Tat:AFF4:P-TEFb:TAR complex. Elife. 2016 10 12; 5. PMID: 27731797.
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    34. East-Seletsky A, O'Connell MR, Knight SC, Burstein D, Cate JH, Tjian R, Doudna J. Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection. Nature. 2016 Oct 13; 538(7624):270-273. PMID: 27669025.
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    35. Singh D, Sternberg SH, Fei J, Doudna J, Ha T. Real-time observation of DNA recognition and rejection by the RNA-guided endonuclease Cas9. Nat Commun. 2016 Sep 14; 7:12778. PMID: 27624851; PMCID: PMC5027287.
    36. Barrangou R, Doudna J. Applications of CRISPR technologies in research and beyond. Nat Biotechnol. 2016 Sep 08; 34(9):933-941. PMID: 27606440.
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    37. Wright AV, Doudna J. Protecting genome integrity during CRISPR immune adaptation. Nat Struct Mol Biol. 2016 Oct; 23(10):876-883. PMID: 27595346.
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    38. Hochstrasser ML, Taylor DW, Kornfeld JE, Nogales E, Doudna J. DNA Targeting by a Minimal CRISPR RNA-Guided Cascade. Mol Cell. 2016 09 01; 63(5):840-51. PMID: 27588603.
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    39. Lee AS, Kranzusch PJ, Doudna J, Cate JH. eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation. Nature. 2016 08 04; 536(7614):96-9. PMID: 27462815; PMCID: PMC5003174 [Available on 02/04/17].
    40. Carlson LA, Bai Y, Keane SC, Doudna J, Hurley JH. Reconstitution of selective HIV-1 RNA packaging in vitro by membrane-bound Gag assemblies. Elife. 2016 06 25; 5. PMID: 27343348; PMCID: PMC4946900.
    41. Nuñez JK, Bai L, Harrington LB, Hinder TL, Doudna J. CRISPR Immunological Memory Requires a Host Factor for Specificity. Mol Cell. 2016 06 16; 62(6):824-833. PMID: 27211867.
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    42. Oh S, Flynn RA, Floor SN, Purzner J, Martin L, Do BT, Schubert S, Vaka D, Morrissy S, Li Y, Kool M, Hovestadt V, Jones DT, Northcott PA, Risch T, Warnatz HJ, Yaspo ML, Adams CM, Leib RD, Breese M, Marra MA, Malkin D, Lichter P, Doudna J, Pfister SM, Taylor MD, Chang HY, Cho YJ. Medulloblastoma-associated DDX3 variant selectively alters the translational response to stress. Oncotarget. 2016 May 10; 7(19):28169-82. PMID: 27058758.
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    43. Isaac RS, Jiang F, Doudna J, Lim WA, Narlikar GJ, Almeida R. Nucleosome breathing and remodeling constrain CRISPR-Cas9 function. Elife. 2016 04 28; 5. PMID: 27130520; PMCID: PMC4880442.
    44. Kaya E, Doxzen KW, Knoll KR, Wilson RC, Strutt SC, Kranzusch PJ, Doudna J. A bacterial Argonaute with noncanonical guide RNA specificity. Proc Natl Acad Sci U S A. 2016 Apr 12; 113(15):4057-62. PMID: 27035975; PMCID: PMC4839417.
    45. Nelles DA, Fang MY, O'Connell MR, Xu JL, Markmiller SJ, Doudna J, Yeo GW. Programmable RNA Tracking in Live Cells with CRISPR/Cas9. Cell. 2016 Apr 07; 165(2):488-96. PMID: 26997482; PMCID: PMC4826288 [Available on 04/07/17].
    46. Amit I, Baker D, Barker R, Berger B, Bertozzi C, Bhatia S, Biffi A, Demichelis F, Doudna J, Dowdy SF, Endy D, Helmstaedter M, Junca H, June C, Kamb S, Khvorova A, Kim DH, Kim JS, Krishnan Y, Lakadamyali M, Lappalainen T, Lewin S, Liao J, Loman N, Lundberg E, Lynd L, Martin C, Mellman I, Miyawaki A, Mummery C, Nelson K, Paz J, Peralta-Yahya P, Picotti P, Polyak K, Prather K, Qin J, Quake S, Regev A, Rogers JA, Shetty R, Sommer M, Stevens M, Stolovitzky G, Takahashi M, Tang F, Teichmann S, Torres-Padilla ME, Tripathi L, Vemula P, Verdine G, Vollmer F, Wang J, Ying JY, Zhang F, Zhang T. Voices of biotech. Nat Biotechnol. 2016 Mar; 34(3):270-5. PMID: 26963549.
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    47. Nuñez JK, Harrington LB, Doudna J. Chemical and Biophysical Modulation of Cas9 for Tunable Genome Engineering. ACS Chem Biol. 2016 Mar 18; 11(3):681-8. PMID: 26857072.
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    48. Jiang F, Taylor DW, Chen JS, Kornfeld JE, Zhou K, Thompson AJ, Nogales E, Doudna J. Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage. Science. 2016 Feb 19; 351(6275):867-71. PMID: 26841432.
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    49. Wright AV, Nuñez JK, Doudna J. Biology and Applications of CRISPR Systems: Harnessing Nature's Toolbox for Genome Engineering. Cell. 2016 Jan 14; 164(1-2):29-44. PMID: 26771484.
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    50. Floor SN, Doudna J. Tunable protein synthesis by transcript isoforms in human cells. Elife. 2016 Jan 06; 5. PMID: 26735365; PMCID: PMC4764583.
    51. Floor SN, Barkovich KJ, Condon KJ, Shokat KM, Doudna J. Analog sensitive chemical inhibition of the DEAD-box protein DDX3. Protein Sci. 2016 Mar; 25(3):638-49. PMID: 26650549; PMCID: PMC4815421 [Available on 03/01/17].
    52. Doudna J. Genome-editing revolution: My whirlwind year with CRISPR. Nature. 2015 Dec 24; 528(7583):469-71. PMID: 26701037.
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    53. Doudna J, Gersbach CA. Genome editing: the end of the beginning. Genome Biol. 2015 Dec 23; 16:292. PMID: 26700220; PMCID: PMC4699356.
    54. Doudna J. Perspective: Embryo editing needs scrutiny. Nature. 2015 Dec 03; 528(7580):S6. PMID: 26630598.
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    55. Floor SN, Doudna J. Get in LINE: Competition for Newly Minted Retrotransposon Proteins at the Ribosome. Mol Cell. 2015 Dec 03; 60(5):712-714. PMID: 26638173.
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    56. Floor SN, Condon KJ, Sharma D, Jankowsky E, Doudna J. Autoinhibitory Interdomain Interactions and Subfamily-specific Extensions Redefine the Catalytic Core of the Human DEAD-box Protein DDX3. J Biol Chem. 2016 Jan 29; 291(5):2412-21. PMID: 26598523; PMCID: PMC4732223 [Available on 01/29/17].
    57. Knight SC, Xie L, Deng W, Guglielmi B, Witkowsky LB, Bosanac L, Zhang ET, El Beheiry M, Masson JB, Dahan M, Liu Z, Doudna J, Tjian R. Dynamics of CRISPR-Cas9 genome interrogation in living cells. Science. 2015 Nov 13; 350(6262):823-6. PMID: 26564855.
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    58. Redding S, Sternberg SH, Marshall M, Gibb B, Bhat P, Guegler CK, Wiedenheft B, Doudna J, Greene EC. Surveillance and Processing of Foreign DNA by the Escherichia coli CRISPR-Cas System. Cell. 2015 Nov 05; 163(4):854-65. PMID: 26522594; PMCID: PMC4636941 [Available on 11/05/16].
    59. Ma E, Harrington LB, O'Connell MR, Zhou K, Doudna J. Single-Stranded DNA Cleavage by Divergent CRISPR-Cas9 Enzymes. Mol Cell. 2015 Nov 05; 60(3):398-407. PMID: 26545076; PMCID: PMC4636735 [Available on 11/05/16].
    60. Sternberg SH, LaFrance B, Kaplan M, Doudna J. Conformational control of DNA target cleavage by CRISPR-Cas9. Nature. 2015 Nov 05; 527(7576):110-3. PMID: 26524520; PMCID: PMC4859810.
    61. Nuñez JK, Harrington LB, Kranzusch PJ, Engelman AN, Doudna J. Foreign DNA capture during CRISPR-Cas adaptive immunity. Nature. 2015 Nov 26; 527(7579):535-8. PMID: 26503043; PMCID: PMC4662619.
    62. Kranzusch PJ, Wilson SC, Lee AS, Berger JM, Doudna J, Vance RE. Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling. Mol Cell. 2015 Sep 17; 59(6):891-903. PMID: 26300263; PMCID: PMC4575873.
    63. Schumann K, Lin S, Boyer E, Simeonov DR, Subramaniam M, Gate RE, Haliburton GE, Ye CJ, Bluestone JA, Doudna J, Marson A. Generation of knock-in primary human T cells using Cas9 ribonucleoproteins. Proc Natl Acad Sci U S A. 2015 Aug 18; 112(33):10437-42. PMID: 26216948; PMCID: PMC4547290.
    64. Jiang F, Zhou K, Ma L, Gressel S, Doudna J. STRUCTURAL BIOLOGY. A Cas9-guide RNA complex preorganized for target DNA recognition. Science. 2015 Jun 26; 348(6242):1477-81. PMID: 26113724.
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    65. Sternberg SH, Doudna J. Expanding the Biologist's Toolkit with CRISPR-Cas9. Mol Cell. 2015 May 21; 58(4):568-74. PMID: 26000842.
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    66. Bosley KS, Botchan M, Bredenoord AL, Carroll D, Charo RA, Charpentier E, Cohen R, Corn J, Doudna J, Feng G, Greely HT, Isasi R, Ji W, Kim JS, Knoppers B, Lanphier E, Li J, Lovell-Badge R, Martin GS, Moreno J, Naldini L, Pera M, Perry AC, Venter JC, Zhang F, Zhou Q. CRISPR germline engineering--the community speaks. Nat Biotechnol. 2015 May; 33(5):478-86. PMID: 25965754.
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    67. Taylor DW, Zhu Y, Staals RH, Kornfeld JE, Shinkai A, van der Oost J, Nogales E, Doudna J. Structural biology. Structures of the CRISPR-Cmr complex reveal mode of RNA target positioning. Science. 2015 May 01; 348(6234):581-5. PMID: 25837515; PMCID: PMC4582657.
    68. Baltimore D, Berg P, Botchan M, Carroll D, Charo RA, Church G, Corn JE, Daley GQ, Doudna J, Fenner M, Greely HT, Jinek M, Martin GS, Penhoet E, Puck J, Sternberg SH, Weissman JS, Yamamoto KR. Biotechnology. A prudent path forward for genomic engineering and germline gene modification. Science. 2015 Apr 03; 348(6230):36-8. PMID: 25791083; PMCID: PMC4394183.
    69. Jiang F, Doudna J. The structural biology of CRISPR-Cas systems. Curr Opin Struct Biol. 2015 Feb; 30:100-111. PMID: 25723899.
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    70. Doudna J. Genomic engineering and the future of medicine. JAMA. 2015 Feb 24; 313(8):791-2. PMID: 25710652.
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    71. Wright AV, Sternberg SH, Taylor DW, Staahl BT, Bardales JA, Kornfeld JE, Doudna J. Rational design of a split-Cas9 enzyme complex. Proc Natl Acad Sci U S A. 2015 Mar 10; 112(10):2984-9. PMID: 25713377; PMCID: PMC4364227.
    72. Nuñez JK, Lee AS, Engelman A, Doudna J. Integrase-mediated spacer acquisition during CRISPR-Cas adaptive immunity. Nature. 2015 Mar 12; 519(7542):193-8. PMID: 25707795; PMCID: PMC4359072.
    73. Wilson RC, Tambe A, Kidwell MA, Noland CL, Schneider CP, Doudna J. Dicer-TRBP complex formation ensures accurate mammalian microRNA biogenesis. Mol Cell. 2015 Feb 05; 57(3):397-407. PMID: 25557550; PMCID: PMC4320653.
    74. Lin S, Staahl BT, Alla RK, Doudna J. Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery. Elife. 2014 Dec 15; 3:e04766. PMID: 25497837; PMCID: PMC4383097.
    75. Doudna J, Charpentier E. Genome editing. The new frontier of genome engineering with CRISPR-Cas9. Science. 2014 Nov 28; 346(6213):1258096. PMID: 25430774.
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    76. Hochstrasser ML, Doudna J. Cutting it close: CRISPR-associated endoribonuclease structure and function. Trends Biochem Sci. 2015 Jan; 40(1):58-66. PMID: 25468820.
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    77. Staals RH, Zhu Y, Taylor DW, Kornfeld JE, Sharma K, Barendregt A, Koehorst JJ, Vlot M, Neupane N, Varossieau K, Sakamoto K, Suzuki T, Dohmae N, Yokoyama S, Schaap PJ, Urlaub H, Heck AJ, Nogales E, Doudna J, Shinkai A, van der Oost J. RNA targeting by the type III-A CRISPR-Cas Csm complex of Thermus thermophilus. Mol Cell. 2014 Nov 20; 56(4):518-30. PMID: 25457165; PMCID: PMC4342149.
    78. Kapral GJ, Jain S, Noeske J, Doudna J, Richardson DC, Richardson JS. New tools provide a second look at HDV ribozyme structure, dynamics and cleavage. Nucleic Acids Res. 2014 Nov 10; 42(20):12833-46. PMID: 25326328; PMCID: PMC4227795.
    79. O'Connell MR, Oakes BL, Sternberg SH, East-Seletsky A, Kaplan M, Doudna J. Programmable RNA recognition and cleavage by CRISPR/Cas9. Nature. 2014 Dec 11; 516(7530):263-6. PMID: 25274302; PMCID: PMC4268322.
    80. Bai Y, Tambe A, Zhou K, Doudna J. RNA-guided assembly of Rev-RRE nuclear export complexes. Elife. 2014 Aug 27; 3:e03656. PMID: 25163983; PMCID: PMC4142337.
    81. Kidwell MA, Chan JM, Doudna J. Evolutionarily conserved roles of the dicer helicase domain in regulating RNA interference processing. J Biol Chem. 2014 Oct 10; 289(41):28352-62. PMID: 25135636; PMCID: PMC4192488.
    82. Kranzusch PJ, Lee ASY, Wilson SC, Solovykh MS, Vance RE, Berger JM, Doudna J. Structure-guided reprogramming of human cGAS dinucleotide linkage specificity. Cell. 2014 Aug 28; 158(5):1011-1021. PMID: 25131990; PMCID: PMC4157622.
    83. Mortimer SA, Kidwell MA, Doudna J. Insights into RNA structure and function from genome-wide studies. Nat Rev Genet. 2014 Jul; 15(7):469-79. PMID: 24821474.
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    84. Nuñez JK, Kranzusch PJ, Noeske J, Wright AV, Davies CW, Doudna J. Cas1-Cas2 complex formation mediates spacer acquisition during CRISPR-Cas adaptive immunity. Nat Struct Mol Biol. 2014 Jun; 21(6):528-34. PMID: 24793649; PMCID: PMC4075942.
    85. Hochstrasser ML, Taylor DW, Bhat P, Guegler CK, Sternberg SH, Nogales E, Doudna J. CasA mediates Cas3-catalyzed target degradation during CRISPR RNA-guided interference. Proc Natl Acad Sci U S A. 2014 May 06; 111(18):6618-23. PMID: 24748111; PMCID: PMC4020112.
    86. Jinek M, Jiang F, Taylor DW, Sternberg SH, Kaya E, Ma E, Anders C, Hauer M, Zhou K, Lin S, Kaplan M, Iavarone AT, Charpentier E, Nogales E, Doudna J. Structures of Cas9 endonucleases reveal RNA-mediated conformational activation. Science. 2014 Mar 14; 343(6176):1247997. PMID: 24505130; PMCID: PMC4184034.
    87. Sternberg SH, Redding S, Jinek M, Greene EC, Doudna J. DNA interrogation by the CRISPR RNA-guided endonuclease Cas9. Nature. 2014 Mar 06; 507(7490):62-7. PMID: 24476820; PMCID: PMC4106473.
    88. Doudna J, Sontheimer EJ. Methods in Enzymology. The use of CRISPR/Cas9, ZFNs, and TALENs in generating site-specific genome alterations. Preface. Methods Enzymol. 2014; 546:xix-xx. PMID: 25398356.
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    89. Niewoehner O, Jinek M, Doudna J. Evolution of CRISPR RNA recognition and processing by Cas6 endonucleases. Nucleic Acids Res. 2014 Jan; 42(2):1341-53. PMID: 24150936; PMCID: PMC3902920.
    90. Staals RHJ, Agari Y, Maki-Yonekura S, Zhu Y, Taylor DW, van Duijn E, Barendregt A, Vlot M, Koehorst JJ, Sakamoto K, Masuda A, Dohmae N, Schaap PJ, Doudna J, Heck AJR, Yonekura K, van der Oost J, Shinkai A. Structure and activity of the RNA-targeting Type III-B CRISPR-Cas complex of Thermus thermophilus. Mol Cell. 2013 Oct 10; 52(1):135-145. PMID: 24119403; PMCID: PMC4006948.
    91. Cox EM, Sagan SM, Mortimer SA, Doudna J, Sarnow P. Enhancement of hepatitis C viral RNA abundance by precursor miR-122 molecules. RNA. 2013 Dec; 19(12):1825-32. PMID: 24106328; PMCID: PMC3884667.
    92. Pattanayak V, Lin S, Guilinger JP, Ma E, Doudna J, Liu DR. High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity. Nat Biotechnol. 2013 Sep; 31(9):839-43. PMID: 23934178; PMCID: PMC3782611.
    93. Lo TW, Pickle CS, Lin S, Ralston EJ, Gurling M, Schartner CM, Bian Q, Doudna J, Meyer BJ. Precise and heritable genome editing in evolutionarily diverse nematodes using TALENs and CRISPR/Cas9 to engineer insertions and deletions. Genetics. 2013 Oct; 195(2):331-48. PMID: 23934893.
      View in: PubMed
    94. Gilbert LA, Larson MH, Morsut L, Liu Z, Brar GA, Torres SE, Stern-Ginossar N, Brandman O, Whitehead EH, Doudna J, Lim WA, Weissman JS, Qi LS. CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes. Cell. 2013 Jul 18; 154(2):442-51. PMID: 23849981; PMCID: PMC3770145.
    95. Kidwell MA, Doudna J. Activating silent argonautes. Nat Struct Mol Biol. 2013 Jul; 20(7):769-71. PMID: 23984440.
      View in: PubMed
    96. Bai Y, Zhou K, Doudna J. Hepatitis C virus 3'UTR regulates viral translation through direct interactions with the host translation machinery. Nucleic Acids Res. 2013 Sep; 41(16):7861-74. PMID: 23783572; PMCID: PMC3763534.
    97. Sun C, Querol-Audí J, Mortimer SA, Arias-Palomo E, Doudna J, Nogales E, Cate JH. Two RNA-binding motifs in eIF3 direct HCV IRES-dependent translation. Nucleic Acids Res. 2013 Aug; 41(15):7512-21. PMID: 23766293; PMCID: PMC3753635.
    98. Kranzusch PJ, Lee AS, Berger JM, Doudna J. Structure of human cGAS reveals a conserved family of second-messenger enzymes in innate immunity. Cell Rep. 2013 May 30; 3(5):1362-8. PMID: 23707061; PMCID: PMC3800681.
    99. Lee HY, Zhou K, Smith AM, Noland CL, Doudna J. Differential roles of human Dicer-binding proteins TRBP and PACT in small RNA processing. Nucleic Acids Res. 2013 Jul; 41(13):6568-76. PMID: 23661684; PMCID: PMC3711433.
    100. Taylor DW, Ma E, Shigematsu H, Cianfrocco MA, Noland CL, Nagayama K, Nogales E, Doudna J, Wang HW. Substrate-specific structural rearrangements of human Dicer. Nat Struct Mol Biol. 2013 Jun; 20(6):662-70. PMID: 23624860; PMCID: PMC3676429.
    101. Noland CL, Doudna J. Multiple sensors ensure guide strand selection in human RNAi pathways. RNA. 2013 May; 19(5):639-48. PMID: 23531496; PMCID: PMC3677279.
    102. Lee HY, Haurwitz RE, Apffel A, Zhou K, Smart B, Wenger CD, Laderman S, Bruhn L, Doudna J. RNA-protein analysis using a conditional CRISPR nuclease. Proc Natl Acad Sci U S A. 2013 Apr 02; 110(14):5416-21. PMID: 23493562; PMCID: PMC3619310.
    103. Charpentier E, Doudna J. Biotechnology: Rewriting a genome. Nature. 2013 Mar 07; 495(7439):50-1. PMID: 23467164.
      View in: PubMed
    104. Qi LS, Larson MH, Gilbert LA, Doudna J, Weissman JS, Arkin AP, Lim WA. Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. Cell. 2013 Feb 28; 152(5):1173-83. PMID: 23452860; PMCID: PMC3664290.
    105. Mortimer SA, Doudna J. Unconventional miR-122 binding stabilizes the HCV genome by forming a trimolecular RNA structure. Nucleic Acids Res. 2013 Apr; 41(7):4230-40. PMID: 23416544; PMCID: PMC3627571.
    106. Jinek M, East A, Cheng A, Lin S, Ma E, Doudna J. RNA-programmed genome editing in human cells. Elife. 2013 Jan 29; 2:e00471. PMID: 23386978; PMCID: PMC3557905.
    107. Wilson RC, Doudna J. Molecular mechanisms of RNA interference. Annu Rev Biophys. 2013; 42:217-39. PMID: 23654304.
      View in: PubMed
    108. Koh HR, Kidwell MA, Ragunathan K, Doudna J, Myong S. ATP-independent diffusion of double-stranded RNA binding proteins. Proc Natl Acad Sci U S A. 2013 Jan 02; 110(1):151-6. PMID: 23251028; PMCID: PMC3538233.
    109. Lee HY, Doudna J. TRBP alters human precursor microRNA processing in vitro. RNA. 2012 Nov; 18(11):2012-9. PMID: 23006623; PMCID: PMC3479391.
    110. Qi L, Haurwitz RE, Shao W, Doudna J, Arkin AP. RNA processing enables predictable programming of gene expression. Nat Biotechnol. 2012 Oct; 30(10):1002-6. PMID: 22983090.
      View in: PubMed
    111. van Duijn E, Barbu IM, Barendregt A, Jore MM, Wiedenheft B, Lundgren M, Westra ER, Brouns SJ, Doudna J, van der Oost J, Heck AJ. Native tandem and ion mobility mass spectrometry highlight structural and modular similarities in clustered-regularly-interspaced shot-palindromic-repeats (CRISPR)-associated protein complexes from Escherichia coli and Pseudomonas aeruginosa. Mol Cell Proteomics. 2012 Nov; 11(11):1430-41. PMID: 22918228; PMCID: PMC3494201.
    112. Jinek M, Chylinski K, Fonfara I, Hauer M, Doudna J, Charpentier E. A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science. 2012 Aug 17; 337(6096):816-21. PMID: 22745249.
      View in: PubMed
    113. Ma E, Zhou K, Kidwell MA, Doudna J. Coordinated activities of human dicer domains in regulatory RNA processing. J Mol Biol. 2012 Sep 28; 422(4):466-76. PMID: 22727743; PMCID: PMC3461841.
    114. Kaya E, Doudna J. Biochemistry. Guided tour to the heart of RISC. Science. 2012 May 25; 336(6084):985-6. PMID: 22628640.
      View in: PubMed
    115. Haurwitz RE, Sternberg SH, Doudna J. Csy4 relies on an unusual catalytic dyad to position and cleave CRISPR RNA. EMBO J. 2012 Jun 13; 31(12):2824-32. PMID: 22522703; PMCID: PMC3380207.
    116. Sashital DG, Wiedenheft B, Doudna J. Mechanism of foreign DNA selection in a bacterial adaptive immune system. Mol Cell. 2012 Jun 08; 46(5):606-15. PMID: 22521690; PMCID: PMC3397241.
    117. Sternberg SH, Haurwitz RE, Doudna J. Mechanism of substrate selection by a highly specific CRISPR endoribonuclease. RNA. 2012 Apr; 18(4):661-72. PMID: 22345129; PMCID: PMC3312554.
    118. Wiedenheft B, Sternberg SH, Doudna J. RNA-guided genetic silencing systems in bacteria and archaea. Nature. 2012 Feb 15; 482(7385):331-8. PMID: 22337052.
      View in: PubMed
    119. Arribere JA, Doudna J, Gilbert WV. Reconsidering movement of eukaryotic mRNAs between polysomes and P bodies. Mol Cell. 2011 Dec 09; 44(5):745-58. PMID: 22152478; PMCID: PMC3240842.
    120. Sun C, Todorovic A, Querol-Audí J, Bai Y, Villa N, Snyder M, Ashchyan J, Lewis CS, Hartland A, Gradia S, Fraser CS, Doudna J, Nogales E, Cate JH. Functional reconstitution of human eukaryotic translation initiation factor 3 (eIF3). Proc Natl Acad Sci U S A. 2011 Dec 20; 108(51):20473-8. PMID: 22135459; PMCID: PMC3251073.
    121. Mehle A, Dugan VG, Taubenberger JK, Doudna J. Reassortment and mutation of the avian influenza virus polymerase PA subunit overcome species barriers. J Virol. 2012 Feb; 86(3):1750-7. PMID: 22090127; PMCID: PMC3264373.
    122. Berry KE, Waghray S, Mortimer SA, Bai Y, Doudna J. Crystal structure of the HCV IRES central domain reveals strategy for start-codon positioning. Structure. 2011 Oct 12; 19(10):1456-66. PMID: 22000514; PMCID: PMC3209822.
    123. Wiedenheft B, Lander GC, Zhou K, Jore MM, Brouns SJJ, van der Oost J, Doudna J, Nogales E. Structures of the RNA-guided surveillance complex from a bacterial immune system. Nature. 2011 Sep 21; 477(7365):486-489. PMID: 21938068; PMCID: PMC4165517.
    124. Noland CL, Ma E, Doudna J. siRNA repositioning for guide strand selection by human Dicer complexes. Mol Cell. 2011 Jul 08; 43(1):110-21. PMID: 21726814; PMCID: PMC3143821.
    125. Lucks JB, Mortimer SA, Trapnell C, Luo S, Aviran S, Schroth GP, Pachter L, Doudna J, Arkin AP. Multiplexed RNA structure characterization with selective 2'-hydroxyl acylation analyzed by primer extension sequencing (SHAPE-Seq). Proc Natl Acad Sci U S A. 2011 Jul 05; 108(27):11063-8. PMID: 21642531; PMCID: PMC3131332.
    126. Aviran S, Trapnell C, Lucks JB, Mortimer SA, Luo S, Schroth GP, Doudna J, Arkin AP, Pachter L. Modeling and automation of sequencing-based characterization of RNA structure. Proc Natl Acad Sci U S A. 2011 Jul 05; 108(27):11069-74. PMID: 21642536; PMCID: PMC3131376.
    127. Sashital DG, Jinek M, Doudna J. An RNA-induced conformational change required for CRISPR RNA cleavage by the endoribonuclease Cse3. Nat Struct Mol Biol. 2011 Jun; 18(6):680-7. PMID: 21572442.
      View in: PubMed
    128. Wiedenheft B, van Duijn E, Bultema JB, Bultema J, Waghmare SP, Waghmare S, Zhou K, Barendregt A, Westphal W, Heck AJ, Heck A, Boekema EJ, Boekema E, Dickman MJ, Dickman M, Doudna J. RNA-guided complex from a bacterial immune system enhances target recognition through seed sequence interactions. Proc Natl Acad Sci U S A. 2011 Jun 21; 108(25):10092-7. PMID: 21536913; PMCID: PMC3121849.
    129. Jore MM, Lundgren M, van Duijn E, Bultema JB, Westra ER, Waghmare SP, Wiedenheft B, Pul U, Wurm R, Wagner R, Beijer MR, Barendregt A, Zhou K, Snijders AP, Dickman MJ, Doudna J, Boekema EJ, Heck AJ, van der Oost J, Brouns SJ. Structural basis for CRISPR RNA-guided DNA recognition by Cascade. Nat Struct Mol Biol. 2011 May; 18(5):529-36. PMID: 21460843.
      View in: PubMed
    130. Jinek M, Coyle SM, Doudna J. Coupled 5' nucleotide recognition and processivity in Xrn1-mediated mRNA decay. Mol Cell. 2011 Mar 04; 41(5):600-8. PMID: 21362555; PMCID: PMC3090138.
    131. Ataide SF, Schmitz N, Shen K, Ke A, Shan SO, Doudna J, Ban N. The crystal structure of the signal recognition particle in complex with its receptor. Science. 2011 Feb 18; 331(6019):881-6. PMID: 21330537; PMCID: PMC3758919.
    132. Berry KE, Peng B, Koditek D, Beeman D, Pagratis N, Perry JK, Parrish J, Zhong W, Doudna J, Shih IH. Optimized high-throughput screen for hepatitis C virus translation inhibitors. J Biomol Screen. 2011 Feb; 16(2):211-20. PMID: 21297107; PMCID: PMC3260011.
    133. Weeks AM, Coyle SM, Jinek M, Doudna J, Chang MC. Structural and biochemical studies of a fluoroacetyl-CoA-specific thioesterase reveal a molecular basis for fluorine selectivity. Biochemistry. 2010 Nov 02; 49(43):9269-79. PMID: 20836570; PMCID: PMC3461317.
    134. Chakravarthy S, Sternberg SH, Kellenberger CA, Doudna J. Substrate-specific kinetics of Dicer-catalyzed RNA processing. J Mol Biol. 2010 Dec 03; 404(3):392-402. PMID: 20932845; PMCID: PMC3005596.
    135. Haurwitz RE, Jinek M, Wiedenheft B, Zhou K, Doudna J. Sequence- and structure-specific RNA processing by a CRISPR endonuclease. Science. 2010 Sep 10; 329(5997):1355-8. PMID: 20829488; PMCID: PMC3133607.
    136. Berry KE, Waghray S, Doudna J. The HCV IRES pseudoknot positions the initiation codon on the 40S ribosomal subunit. RNA. 2010 Aug; 16(8):1559-69. PMID: 20584896; PMCID: PMC2905755.
    137. Clarkson BK, Gilbert WV, Doudna J. Functional overlap between eIF4G isoforms in Saccharomyces cerevisiae. PLoS One. 2010 Feb 09; 5(2):e9114. PMID: 20161741; PMCID: PMC2817733.
    138. Mehle A, Doudna J. A host of factors regulating influenza virus replication. Viruses. 2010 Feb; 2(2):566-73. PMID: 21994648; PMCID: PMC3185602.
    139. Jinek M, Fabian MR, Coyle SM, Sonenberg N, Doudna J. Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylation. Nat Struct Mol Biol. 2010 Feb; 17(2):238-40. PMID: 20098421; PMCID: PMC2920127.
    140. Sashital DG, Doudna J. Structural insights into RNA interference. Curr Opin Struct Biol. 2010 Feb; 20(1):90-7. PMID: 20053548; PMCID: PMC2855239.
    141. Mehle A, Doudna J. Adaptive strategies of the influenza virus polymerase for replication in humans. Proc Natl Acad Sci U S A. 2009 Dec 15; 106(50):21312-6. PMID: 19995968; PMCID: PMC2789757.
    142. Wang HW, Noland C, Siridechadilok B, Taylor DW, Ma E, Felderer K, Doudna J, Nogales E. Structural insights into RNA processing by the human RISC-loading complex. Nat Struct Mol Biol. 2009 Nov; 16(11):1148-53. PMID: 19820710; PMCID: PMC2845538.
    143. Fabian MR, Mathonnet G, Sundermeier T, Mathys H, Zipprich JT, Svitkin YV, Rivas F, Jinek M, Wohlschlegel J, Doudna J, Chen CY, Shyu AB, Yates JR, Hannon GJ, Filipowicz W, Duchaine TF, Sonenberg N. Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation. Mol Cell. 2009 Sep 24; 35(6):868-80. PMID: 19716330; PMCID: PMC2803087.
    144. Wiedenheft B, Zhou K, Jinek M, Coyle SM, Ma W, Doudna J. Structural basis for DNase activity of a conserved protein implicated in CRISPR-mediated genome defense. Structure. 2009 Jun 10; 17(6):904-12. PMID: 19523907.
      View in: PubMed
    145. Fraser CS, Hershey JW, Doudna J. The pathway of hepatitis C virus mRNA recruitment to the human ribosome. Nat Struct Mol Biol. 2009 Apr; 16(4):397-404. PMID: 19287397; PMCID: PMC2689074.
    146. Fukunaga R, Doudna J. dsRNA with 5' overhangs contributes to endogenous and antiviral RNA silencing pathways in plants. EMBO J. 2009 Mar 04; 28(5):545-55. PMID: 19165150; PMCID: PMC2657584.
    147. Jinek M, Doudna J. A three-dimensional view of the molecular machinery of RNA interference. Nature. 2009 Jan 22; 457(7228):405-12. PMID: 19158786.
      View in: PubMed
    148. Coyle SM, Gilbert WV, Doudna J. Direct link between RACK1 function and localization at the ribosome in vivo. Mol Cell Biol. 2009 Mar; 29(6):1626-34. PMID: 19114558; PMCID: PMC2648249.
    149. Mehle A, Doudna J. An inhibitory activity in human cells restricts the function of an avian-like influenza virus polymerase. Cell Host Microbe. 2008 Aug 14; 4(2):111-22. PMID: 18692771; PMCID: PMC2597520.
    150. Zhou M, Sandercock AM, Fraser CS, Ridlova G, Stephens E, Schenauer MR, Yokoi-Fong T, Barsky D, Leary JA, Hershey JW, Doudna J, Robinson CV. Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3. Proc Natl Acad Sci U S A. 2008 Nov 25; 105(47):18139-44. PMID: 18599441; PMCID: PMC2587604.
    151. Puglisi JD, Doudna J. Nucleic acids and their protein partners. Curr Opin Struct Biol. 2008 Jun; 18(3):279-81. PMID: 18547801.
      View in: PubMed
    152. Ma E, MacRae IJ, Kirsch JF, Doudna J. Autoinhibition of human dicer by its internal helicase domain. J Mol Biol. 2008 Jun 27; 380(1):237-43. PMID: 18508075; PMCID: PMC2927216.
    153. MacRae IJ, Ma E, Zhou M, Robinson CV, Doudna J. In vitro reconstitution of the human RISC-loading complex. Proc Natl Acad Sci U S A. 2008 Jan 15; 105(2):512-7. PMID: 18178619; PMCID: PMC2206567.
    154. MacRae IJ, Zhou K, Doudna J. Structural determinants of RNA recognition and cleavage by Dicer. Nat Struct Mol Biol. 2007 Oct; 14(10):934-40. PMID: 17873886.
      View in: PubMed
    155. Gilbert WV, Zhou K, Butler TK, Doudna J. Cap-independent translation is required for starvation-induced differentiation in yeast. Science. 2007 Aug 31; 317(5842):1224-7. PMID: 17761883.
      View in: PubMed
    156. MacRae IJ, Doudna J. An unusual case of pseudo-merohedral twinning in orthorhombic crystals of Dicer. Acta Crystallogr D Biol Crystallogr. 2007 Sep; 63(Pt 9):993-9. PMID: 17704568.
      View in: PubMed
    157. Fraser CS, Berry KE, Hershey JW, Doudna J. eIF3j is located in the decoding center of the human 40S ribosomal subunit. Mol Cell. 2007 Jun 22; 26(6):811-9. PMID: 17588516.
      View in: PubMed
    158. Fraser CS, Doudna J. Quantitative studies of ribosome conformational dynamics. Q Rev Biophys. 2007 May; 40(2):163-89. PMID: 18072984.
      View in: PubMed
    159. Kiessling LL, Doudna J, Johnsson K, Mapp AK, Marletta MA, Seeberger PH, Williamson JR, Wedde SG. A higher degree of difficulty. ACS Chem Biol. 2007 Apr 24; 2(4):197-9. PMID: 17455890.
      View in: PubMed
    160. Ke A, Ding F, Batchelor JD, Doudna J. Structural roles of monovalent cations in the HDV ribozyme. Structure. 2007 Mar; 15(3):281-7. PMID: 17355864.
      View in: PubMed
    161. Damoc E, Fraser CS, Zhou M, Videler H, Mayeur GL, Hershey JW, Doudna J, Robinson CV, Leary JA. Structural characterization of the human eukaryotic initiation factor 3 protein complex by mass spectrometry. Mol Cell Proteomics. 2007 Jul; 6(7):1135-46. PMID: 17322308.
      View in: PubMed
    162. MacRae IJ, Doudna J. Ribonuclease revisited: structural insights into ribonuclease III family enzymes. Curr Opin Struct Biol. 2007 Feb; 17(1):138-45. PMID: 17194582.
      View in: PubMed
    163. Siu FY, Spanggord RJ, Doudna J. SRP RNA provides the physiologically essential GTPase activation function in cotranslational protein targeting. RNA. 2007 Feb; 13(2):240-50. PMID: 17164479; PMCID: PMC1781372.
    164. Fraser CS, Doudna J. Structural and mechanistic insights into hepatitis C viral translation initiation. Nat Rev Microbiol. 2007 Jan; 5(1):29-38. PMID: 17128284.
      View in: PubMed
    165. Wu S, Ke A, Doudna J. A fast and efficient procedure to produce scFvs specific for large macromolecular complexes. J Immunol Methods. 2007 Jan 10; 318(1-2):95-101. PMID: 17126854; PMCID: PMC2920608.
    166. Green R, Doudna J. RNAs regulate biology. ACS Chem Biol. 2006 Jul 21; 1(6):335-8. PMID: 17163766.
      View in: PubMed
    167. Chmiel NH, Rio DC, Doudna J. Distinct contributions of KH domains to substrate binding affinity of Drosophila P-element somatic inhibitor protein. RNA. 2006 Feb; 12(2):283-91. PMID: 16428607; PMCID: PMC1370908.
    168. Macrae IJ, Zhou K, Li F, Repic A, Brooks AN, Cande WZ, Adams PD, Doudna J. Structural basis for double-stranded RNA processing by Dicer. Science. 2006 Jan 13; 311(5758):195-8. PMID: 16410517.
      View in: PubMed
    169. Macrae IJ, Li F, Zhou K, Cande WZ, Doudna J. Structure of Dicer and mechanistic implications for RNAi. Cold Spring Harb Symp Quant Biol. 2006; 71:73-80. PMID: 17381283.
      View in: PubMed
    170. Karbstein K, Doudna J. GTP-dependent formation of a ribonucleoprotein subcomplex required for ribosome biogenesis. J Mol Biol. 2006 Feb 17; 356(2):432-43. PMID: 16376378.
      View in: PubMed
    171. Siridechadilok B, Fraser CS, Hall RJ, Doudna J, Nogales E. Structural roles for human translation factor eIF3 in initiation of protein synthesis. Science. 2005 Dec 02; 310(5753):1513-5. PMID: 16322461.
      View in: PubMed
    172. Karbstein K, Jonas S, Doudna J. An essential GTPase promotes assembly of preribosomal RNA processing complexes. Mol Cell. 2005 Nov 23; 20(4):633-43. PMID: 16307926.
      View in: PubMed
    173. Spanggord RJ, Siu F, Ke A, Doudna J. RNA-mediated interaction between the peptide-binding and GTPase domains of the signal recognition particle. Nat Struct Mol Biol. 2005 Dec; 12(12):1116-22. PMID: 16299512.
      View in: PubMed
    174. Doudna J. Chemical biology at the crossroads of molecular structure and mechanism. Nat Chem Biol. 2005 Nov; 1(6):300-3. PMID: 16408062.
      View in: PubMed
    175. Chen L, Lullo DJ, Ma E, Celniker SE, Rio DC, Doudna J. Identification and analysis of U5 snRNA variants in Drosophila. RNA. 2005 Oct; 11(10):1473-7. PMID: 16199758; PMCID: PMC1370830.
    176. MacRae IJ, Doudna J. Ro's role in RNA reconnaissance. Cell. 2005 May 20; 121(4):495-496. PMID: 15907458.
      View in: PubMed
    177. Yu Y, Ji H, Doudna J, Leary JA. Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes. Protein Sci. 2005 Jun; 14(6):1438-46. PMID: 15883184; PMCID: PMC2253395.
    178. Doudna J, Lorsch JR. Ribozyme catalysis: not different, just worse. Nat Struct Mol Biol. 2005 May; 12(5):395-402. PMID: 15870731.
      View in: PubMed
    179. Ji H, Fraser CS, Yu Y, Leary J, Doudna J. Coordinated assembly of human translation initiation complexes by the hepatitis C virus internal ribosome entry site RNA. Proc Natl Acad Sci U S A. 2004 Dec 07; 101(49):16990-5. PMID: 15563596; PMCID: PMC534415.
    180. Ke A, Doudna J. Crystallization of RNA and RNA-protein complexes. Methods. 2004 Nov; 34(3):408-14. PMID: 15325657.
      View in: PubMed
    181. Rambo RP, Doudna J. Assembly of an active group II intron-maturase complex by protein dimerization. Biochemistry. 2004 Jun 01; 43(21):6486-97. PMID: 15157082.
      View in: PubMed
    182. Ke A, Zhou K, Ding F, Cate JH, Doudna J. A conformational switch controls hepatitis delta virus ribozyme catalysis. Nature. 2004 May 13; 429(6988):201-5. PMID: 15141216.
      View in: PubMed
    183. Sagar MB, Lucast L, Doudna J. Conserved but nonessential interaction of SRP RNA with translation factor EF-G. RNA. 2004 May; 10(5):772-8. PMID: 15100432; PMCID: PMC1370567.
    184. Lupták A, Doudna J. Distinct sites of phosphorothioate substitution interfere with folding and splicing of the Anabaena group I intron. Nucleic Acids Res. 2004; 32(7):2272-80. PMID: 15107495; PMCID: PMC407829.
    185. Karbstein K, Doudna J. RNA: primed for packing? Chem Biol. 2004 Feb; 11(2):149-51. PMID: 15123272.
      View in: PubMed
    186. Doudna J, Batey RT. Structural insights into the signal recognition particle. Annu Rev Biochem. 2004; 73:539-57. PMID: 15189152.
      View in: PubMed
    187. Fraser CS, Lee JY, Mayeur GL, Bushell M, Doudna J, Hershey JW. The j-subunit of human translation initiation factor eIF3 is required for the stable binding of eIF3 and its subcomplexes to 40 S ribosomal subunits in vitro. J Biol Chem. 2004 Mar 05; 279(10):8946-56. PMID: 14688252.
      View in: PubMed
    188. Batey RT, Doudna J. Structural and energetic analysis of metal ions essential to SRP signal recognition domain assembly. Biochemistry. 2002 Oct 01; 41(39):11703-10. PMID: 12269812.
      View in: PubMed
    189. Battle DJ, Doudna J. Specificity of RNA-RNA helix recognition. Proc Natl Acad Sci U S A. 2002 Sep 03; 99(18):11676-81. PMID: 12189204; PMCID: PMC129328.
    190. Doudna J, Cech TR. The chemical repertoire of natural ribozymes. Nature. 2002 Jul 11; 418(6894):222-8. PMID: 12110898.
      View in: PubMed
    191. Kieft JS, Zhou K, Grech A, Jubin R, Doudna J. Crystal structure of an RNA tertiary domain essential to HCV IRES-mediated translation initiation. Nat Struct Biol. 2002 May; 9(5):370-4. PMID: 11927953.
      View in: PubMed
    192. Doudna J, Rath VL. Structure and function of the eukaryotic ribosome: the next frontier. Cell. 2002 Apr 19; 109(2):153-6. PMID: 12007402.
      View in: PubMed
    193. Zhang L, Doudna J. Structural insights into group II intron catalysis and branch-site selection. Science. 2002 Mar 15; 295(5562):2084-8. PMID: 11859154.
      View in: PubMed
    194. Murray JM, Doudna J. Creative catalysis: pieces of the RNA world jigsaw. Trends Biochem Sci. 2001 Dec; 26(12):699-701. PMID: 11738588.
      View in: PubMed
    195. Lupták A, Ferré-D'Amaré AR, Zhou K, Zilm KW, Doudna J. Direct pK(a) measurement of the active-site cytosine in a genomic hepatitis delta virus ribozyme. J Am Chem Soc. 2001 Sep 05; 123(35):8447-52. PMID: 11525650.
      View in: PubMed
    196. Doherty EA, Batey RT, Masquida B, Doudna J. A universal mode of helix packing in RNA. Nat Struct Biol. 2001 Apr; 8(4):339-43. PMID: 11276255.
      View in: PubMed
    197. Batey RT, Sagar MB, Doudna J. Structural and energetic analysis of RNA recognition by a universally conserved protein from the signal recognition particle. J Mol Biol. 2001 Mar 16; 307(1):229-46. PMID: 11243816.
      View in: PubMed
    198. Spahn CM, Kieft JS, Grassucci RA, Penczek PA, Zhou K, Doudna J, Frank J. Hepatitis C virus IRES RNA-induced changes in the conformation of the 40s ribosomal subunit. Science. 2001 Mar 09; 291(5510):1959-62. PMID: 11239155.
      View in: PubMed
    199. Lucast LJ, Batey RT, Doudna J. Large-scale purification of a stable form of recombinant tobacco etch virus protease. Biotechniques. 2001 Mar; 30(3):544-6, 548, 550 passim. PMID: 11252791.
      View in: PubMed
    200. Kieft JS, Zhou K, Jubin R, Doudna J. Mechanism of ribosome recruitment by hepatitis C IRES RNA. RNA. 2001 Feb; 7(2):194-206. PMID: 11233977; PMCID: PMC1370078.
    201. Doherty EA, Doudna J. Ribozyme structures and mechanisms. Annu Rev Biophys Biomol Struct. 2001; 30:457-75. PMID: 11441810.
      View in: PubMed
    202. Battle DJ, Doudna J. The stem-loop binding protein forms a highly stable and specific complex with the 3' stem-loop of histone mRNAs. RNA. 2001 Jan; 7(1):123-32. PMID: 11214174; PMCID: PMC1370062.
    203. Kieft JS, Grech A, Adams P, Doudna J. Mechanisms of internal ribosome entry in translation initiation. Cold Spring Harb Symp Quant Biol. 2001; 66:277-83. PMID: 12762029.
      View in: PubMed
    204. Hanna RL, Gryaznov SM, Doudna J. A phosphoramidate substrate analog is a competitive inhibitor of the Tetrahymena group I ribozyme. Chem Biol. 2000 Nov; 7(11):845-54. PMID: 11094338.
      View in: PubMed
    205. Doudna J. Structural genomics of RNA. Nat Struct Biol. 2000 Nov; 7 Suppl:954-6. PMID: 11103998.
      View in: PubMed
    206. Jubin R, Vantuno NE, Kieft JS, Murray MG, Doudna J, Lau JY, Baroudy BM. Hepatitis C virus internal ribosome entry site (IRES) stem loop IIId contains a phylogenetically conserved GGG triplet essential for translation and IRES folding. J Virol. 2000 Nov; 74(22):10430-7. PMID: 11044087; PMCID: PMC110917.
    207. Hanna R, Doudna J. Metal ions in ribozyme folding and catalysis. Curr Opin Chem Biol. 2000 Apr; 4(2):166-70. PMID: 10742186.
      View in: PubMed
    208. Engelhardt MA, Doherty EA, Knitt DS, Doudna J, Herschlag D. The P5abc peripheral element facilitates preorganization of the tetrahymena group I ribozyme for catalysis. Biochemistry. 2000 Mar 14; 39(10):2639-51. PMID: 10704214.
      View in: PubMed
    209. Batey RT, Rambo RP, Lucast L, Rha B, Doudna J. Crystal structure of the ribonucleoprotein core of the signal recognition particle. Science. 2000 Feb 18; 287(5456):1232-9. PMID: 10678824.
      View in: PubMed
    210. Ferré-D'Amaré AR, Doudna J. Crystallization and structure determination of a hepatitis delta virus ribozyme: use of the RNA-binding protein U1A as a crystallization module. J Mol Biol. 2000 Jan 21; 295(3):541-56. PMID: 10623545.
      View in: PubMed
    211. Cate JH, Doudna J. Solving large RNA structures by X-ray crystallography. Methods Enzymol. 2000; 317:169-80. PMID: 10829280.
      View in: PubMed
    212. Doherty EA, Doudna J. Ribozyme structures and mechanisms. Annu Rev Biochem. 2000; 69:597-615. PMID: 10966470.
      View in: PubMed
    213. Doudna J. Cashing in on crystals. Curr Biol. 1999 Oct 07; 9(19):R731-4. PMID: 10530999.
      View in: PubMed
    214. Kieft JS, Zhou K, Jubin R, Murray MG, Lau JY, Doudna J. The hepatitis C virus internal ribosome entry site adopts an ion-dependent tertiary fold. J Mol Biol. 1999 Sep 24; 292(3):513-29. PMID: 10497018.
      View in: PubMed
    215. Wadkins TS, Perrotta AT, Ferré-D'Amaré AR, Doudna J, Been MD. A nested double pseudoknot is required for self-cleavage activity of both the genomic and antigenomic hepatitis delta virus ribozymes. RNA. 1999 Jun; 5(6):720-7. PMID: 10376872; PMCID: PMC1369799.
    216. Doherty EA, Herschlag D, Doudna J. Assembly of an exceptionally stable RNA tertiary interface in a group I ribozyme. Biochemistry. 1999 Mar 09; 38(10):2982-90. PMID: 10074350.
      View in: PubMed
    217. Ferré-D'Amaré AR, Doudna J. RNA folds: insights from recent crystal structures. Annu Rev Biophys Biomol Struct. 1999; 28:57-73. PMID: 10410795.
      View in: PubMed
    218. Basu S, Rambo RP, Strauss-Soukup J, Cate JH, Ferré-D'Amaré AR, Strobel SA, Doudna J. A specific monovalent metal ion integral to the AA platform of the RNA tetraloop receptor. Nat Struct Biol. 1998 Nov; 5(11):986-92. PMID: 9808044.
      View in: PubMed
    219. Ferré-D'Amaré AR, Zhou K, Doudna J. Crystal structure of a hepatitis delta virus ribozyme. Nature. 1998 Oct 08; 395(6702):567-74. PMID: 9783582.
      View in: PubMed
    220. Doudna J. Ribozymes: the hammerhead swings into action. Curr Biol. 1998 Jul 02; 8(14):R495-7. PMID: 9663384.
      View in: PubMed
    221. Ferré-D'Amaré AR, Zhou K, Doudna J. A general module for RNA crystallization. J Mol Biol. 1998 Jun 12; 279(3):621-31. PMID: 9641982.
      View in: PubMed
    222. Batey RT, Doudna J. The parallel universe of RNA folding. Nat Struct Biol. 1998 May; 5(5):337-40. PMID: 9586989.
      View in: PubMed
    223. Strobel SA, Doudna J. RNA seeing double: close-packing of helices in RNA tertiary structure. Trends Biochem Sci. 1997 Jul; 22(7):262-6. PMID: 9255068.
      View in: PubMed
    224. Cate JH, Hanna RL, Doudna J. A magnesium ion core at the heart of a ribozyme domain. Nat Struct Biol. 1997 Jul; 4(7):553-8. PMID: 9228948.
      View in: PubMed
    225. Doudna J, Cate JH. RNA structure: crystal clear? Curr Opin Struct Biol. 1997 Jun; 7(3):310-6. PMID: 9204271.
      View in: PubMed
    226. Doherty EA, Doudna J. The P4-P6 domain directs higher order folding of the Tetrahymena ribozyme core. Biochemistry. 1997 Mar 18; 36(11):3159-69. PMID: 9115992.
      View in: PubMed
    227. Cate JH, Doudna J. A sparse matrix approach to crystallizing ribozymes and RNA motifs. Methods Mol Biol. 1997; 74:379-86. PMID: 9204453.
      View in: PubMed
    228. Doudna J, Doherty EA. Emerging themes in RNA folding. Fold Des. 1997; 2(5):R65-70. PMID: 9377708.
      View in: PubMed
    229. Ferré-d'Amaré AR, Doudna J. Establishing suitability of RNA preparations for crystallization. Determination of polydispersity. Methods Mol Biol. 1997; 74:371-7. PMID: 9204452.
      View in: PubMed
    230. Doudna J. Preparation of homogeneous ribozyme RNA for crystallization. Methods Mol Biol. 1997; 74:365-70. PMID: 9204451.
      View in: PubMed
    231. Cate JH, Doudna J. Metal-binding sites in the major groove of a large ribozyme domain. Structure. 1996 Oct 15; 4(10):1221-9. PMID: 8939748.
      View in: PubMed
    232. Cate JH, Gooding AR, Podell E, Zhou K, Golden BL, Kundrot CE, Cech TR, Doudna J. Crystal structure of a group I ribozyme domain: principles of RNA packing. Science. 1996 Sep 20; 273(5282):1678-85. PMID: 8781224.
      View in: PubMed
    233. Cate JH, Gooding AR, Podell E, Zhou K, Golden BL, Szewczak AA, Kundrot CE, Cech TR, Doudna J. RNA tertiary structure mediation by adenosine platforms. Science. 1996 Sep 20; 273(5282):1696-9. PMID: 8781229.
      View in: PubMed
    234. Ferré-D'Amaré AR, Doudna J. Use of cis- and trans-ribozymes to remove 5' and 3' heterogeneities from milligrams of in vitro transcribed RNA. Nucleic Acids Res. 1996 Mar 01; 24(5):977-8. PMID: 8600468; PMCID: PMC145725.
    235. Doudna J. Hammerhead ribozyme structure: U-turn for RNA structural biology. Structure. 1995 Aug 15; 3(8):747-50. PMID: 7582890.
      View in: PubMed
    236. Doudna J, Cech TR, Sullenger BA. Selection of an RNA molecule that mimics a major autoantigenic epitope of human insulin receptor. Proc Natl Acad Sci U S A. 1995 Mar 14; 92(6):2355-9. PMID: 7534420; PMCID: PMC42482.
    237. Doudna J, Cech TR. Self-assembly of a group I intron active site from its component tertiary structural domains. RNA. 1995 Mar; 1(1):36-45. PMID: 7489486; PMCID: PMC1369057.
    238. Doudna J. Hammering out the shape of a ribozyme. Structure. 1994 Dec 15; 2(12):1271-2. PMID: 7704535.
      View in: PubMed
    239. Doudna J, Grosshans C, Gooding A, Kundrot CE. Crystallization of ribozymes and small RNA motifs by a sparse matrix approach. Proc Natl Acad Sci U S A. 1993 Aug 15; 90(16):7829-33. PMID: 8356090; PMCID: PMC47236.
    240. Doudna J, Usman N, Szostak JW. Ribozyme-catalyzed primer extension by trinucleotides: a model for the RNA-catalyzed replication of RNA. Biochemistry. 1993 Mar 02; 32(8):2111-5. PMID: 7680575.
      View in: PubMed
    241. Bartel DP, Doudna J, Usman N, Szostak JW. Template-directed primer extension catalyzed by the Tetrahymena ribozyme. Mol Cell Biol. 1991 Jun; 11(6):3390-4. PMID: 2038341; PMCID: PMC360195.
    242. Doudna J, Couture S, Szostak JW. A multisubunit ribozyme that is a catalyst of and template for complementary strand RNA synthesis. Science. 1991 Mar 29; 251(5001):1605-8. PMID: 1707185.
      View in: PubMed
    243. Doudna J, Szostak JW, Rich A, Usman N. Chemical synthesis of oligoribonucleotides containing 2-aminopurine: substrates for the investigation of ribozyme function. J Org Chem. 1990 Oct 12; 55(21):5547-9. PMID: 11540922.
      View in: PubMed
    244. Couture S, Ellington AD, Gerber AS, Cherry JM, Doudna J, Green R, Hanna M, Pace U, Rajagopal J, Szostak JW. Mutational analysis of conserved nucleotides in a self-splicing group I intron. J Mol Biol. 1990 Oct 05; 215(3):345-58. PMID: 1700131.
      View in: PubMed
    245. Doudna J, Szostak JW. Miniribozymes, small derivatives of the sunY intron, are catalytically active. Mol Cell Biol. 1989 Dec; 9(12):5480-3. PMID: 2685567; PMCID: PMC363717.
    246. Doudna J, Cormack BP, Szostak JW. RNA structure, not sequence, determines the 5' splice-site specificity of a group I intron. Proc Natl Acad Sci U S A. 1989 Oct; 86(19):7402-6. PMID: 2678103; PMCID: PMC298070.
    247. Doudna J, Szostak JW. RNA-catalysed synthesis of complementary-strand RNA. Nature. 1989 Jun 15; 339(6225):519-22. PMID: 2660003.
      View in: PubMed
    248. Rajagopal J, Doudna J, Szostak JW. Stereochemical course of catalysis by the Tetrahymena ribozyme. Science. 1989 May 12; 244(4905):692-4. PMID: 2470151.
      View in: PubMed
    249. Doudna J, Gerber AS, Cherry JM, Szostak JW. Genetic dissection of an RNA enzyme. Cold Spring Harb Symp Quant Biol. 1987; 52:173-80. PMID: 2456876.
      View in: PubMed

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