Cate, Jamie

TitleBiologist Faculty
InstitutionLawrence Berkeley National Lab
DepartmentMolecular Biophys & Integ Bio
Address1 Cyclotron Road
Berkeley CA 94720
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    Collapse Research 
    Collapse Research Activities and Funding
    Multiexon skipping to restore dystrophin protein expression using tethered RNPs
    NIH/NIAMS R21AR072370Sep 1, 2017 - Aug 31, 2019
    Role: Principal Investigator
    Center for RNA Systems Biology
    NIH/NIGMS P50GM102706Sep 1, 2012 - Aug 31, 2017
    Role: Principal Investigator
    Program in Virus Translational Control
    NIH/NIGMS P01GM073732Jun 1, 2006 - May 31, 2012
    Role: Co-Principal Investigator
    Atomic-Resolution Analysis of Translation Control
    NIH/NIGMS R01GM065050Aug 1, 2001 - Jan 31, 2018
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Lintner NG, McClure KF, Petersen D, Londregan AT, Piotrowski DW, Wei L, Xiao J, Bolt M, Loria PM, Maguire B, Geoghegan KF, Huang A, Rolph T, Liras S, Doudna JA, Dullea RG, Cate J. Correction: Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain. PLoS Biol. 2018 Apr; 16(4):e1002628. PMID: 29664898.
      View in: PubMed
    2. Lapinaite A, Doudna JA, Cate J. Programmable RNA recognition using a CRISPR-associated Argonaute. Proc Natl Acad Sci U S A. 2018 Mar 27; 115(13):3368-3373. PMID: 29531059.
      View in: PubMed
    3. Acosta-Sampson L, Döring K, Lin Y, Yu VY, Bukau B, Kramer G, Cate J. Role for ribosome-associated complex and stress-seventy subfamily B (RAC-Ssb) in integral membrane protein translation. J Biol Chem. 2017 12 01; 292(48):19610-19627. PMID: 28972146.
      View in: PubMed
    4. Chomvong K, Benjamin DI, Nomura DK, Cate J. Cellobiose Consumption Uncouples Extracellular Glucose Sensing and Glucose Metabolism in Saccharomyces cerevisiae. MBio. 2017 08 08; 8(4). PMID: 28790206.
      View in: PubMed
    5. Lintner NG, McClure KF, Petersen D, Londregan AT, Piotrowski DW, Wei L, Xiao J, Bolt M, Loria PM, Maguire B, Geoghegan KF, Huang A, Rolph T, Liras S, Doudna JA, Dullea RG, Cate J. Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain. PLoS Biol. 2017 Mar; 15(3):e2001882. PMID: 28323820.
      View in: PubMed
    6. Cate J. Human eIF3: from 'blobology' to biological insight. Philos Trans R Soc Lond B Biol Sci. 2017 Mar 19; 372(1716). PMID: 28138064.
      View in: PubMed
    7. Han BG, Watson Z, Cate J, Glaeser RM. Monolayer-crystal streptavidin support films provide an internal standard of cryo-EM image quality. J Struct Biol. 2017 Dec; 200(3):307-313. PMID: 28259651.
      View in: PubMed
    8. Sen A, Acosta-Sampson L, Alvaro CG, Ahn JS, Cate J, Thorner J. Internalization of Heterologous Sugar Transporters by Endogenous a-Arrestins in the Yeast Saccharomyces cerevisiae. Appl Environ Microbiol. 2016 12 15; 82(24):7074-7085. PMID: 27694235.
      View in: PubMed
    9. Samelson AJ, Jensen MK, Soto RA, Cate J, Marqusee S. Quantitative determination of ribosome nascent chain stability. Proc Natl Acad Sci U S A. 2016 11 22; 113(47):13402-13407. PMID: 27821780.
      View in: PubMed
    10. Chomvong K, Lin E, Blaisse M, Gillespie AE, Cate J. Relief of Xylose Binding to Cellobiose Phosphorylase by a Single Distal Mutation. ACS Synth Biol. 2017 Feb 17; 6(2):206-210. PMID: 27676450.
      View in: PubMed
    11. East-Seletsky A, O'Connell MR, Knight SC, Burstein D, Cate J, Tjian R, Doudna JA. Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection. Nature. 2016 Oct 13; 538(7624):270-273. PMID: 27669025.
      View in: PubMed
    12. Lee AS, Kranzusch PJ, Doudna JA, Cate J. eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation. Nature. 2016 08 04; 536(7614):96-9. PMID: 27462815; PMCID: PMC5003174 [Available on 02/04/17].
    13. Cocozaki AI, Altman RB, Huang J, Buurman ET, Kazmirski SL, Doig P, Prince DB, Blanchard SC, Cate J, Ferguson AD. Resistance mutations generate divergent antibiotic susceptibility profiles against translation inhibitors. Proc Natl Acad Sci U S A. 2016 07 19; 113(29):8188-93. PMID: 27382179.
      View in: PubMed
    14. Chomvong K, Bauer S, Benjamin DI, Li X, Nomura DK, Cate J. Bypassing the Pentose Phosphate Pathway: Towards Modular Utilization of Xylose. PLoS One. 2016; 11(6):e0158111. PMID: 27336308; PMCID: PMC4918971.
    15. Han BG, Watson Z, Kang H, Pulk A, Downing KH, Cate J, Glaeser RM. Long shelf-life streptavidin support-films suitable for electron microscopy of biological macromolecules. J Struct Biol. 2016 08; 195(2):238-244. PMID: 27320699.
      View in: PubMed
    16. Ryan OW, Poddar S, Cate J. CRISPR-Cas9 Genome Engineering in Saccharomyces cerevisiae Cells. Cold Spring Harb Protoc. 2016 06 01; 2016(6). PMID: 27250940.
      View in: PubMed
    17. Smith MD, Arake-Tacca L, Nitido A, Montabana E, Park A, Cate J. Assembly of eIF3 Mediated by Mutually Dependent Subunit Insertion. Structure. 2016 06 07; 24(6):886-96. PMID: 27210288; PMCID: PMC4938246 [Available on 06/07/17].
    18. Cate J. STRUCTURE. A Big Bang in spliceosome structural biology. Science. 2016 Mar 25; 351(6280):1390-2. PMID: 27013712.
      View in: PubMed
    19. Cate J, Ball AS. Editorial overview: Energy biotechnology. Curr Opin Biotechnol. 2016 Apr; 38:v-vii. PMID: 26965392.
      View in: PubMed
    20. Thakor N, Smith MD, Roberts L, Faye MD, Patel H, Wieden HJ, Cate J, Holcik M. Cellular mRNA recruits the ribosome via eIF3-PABP bridge to initiate internal translation. RNA Biol. 2017 05 04; 14(5):553-567. PMID: 26828225.
      View in: PubMed
    21. Li X, Park A, Estrela R, Kim SR, Jin YS, Cate J. Comparison of xylose fermentation by two high-performance engineered strains of Saccharomyces cerevisiae. Biotechnol Rep (Amst). 2016 Mar; 9:53-56. PMID: 28352592.
      View in: PubMed
    22. Glaeser RM, Han BG, Csencsits R, Killilea A, Pulk A, Cate J. Factors that Influence the Formation and Stability of Thin, Cryo-EM Specimens. Biophys J. 2016 Feb 23; 110(4):749-55. PMID: 26386606; PMCID: PMC4775786 [Available on 02/23/17].
    23. Li X, Chomvong K, Yu VY, Liang JM, Lin Y, Cate J. Cellobionic acid utilization: from Neurospora crassa to Saccharomyces cerevisiae. Biotechnol Biofuels. 2015; 8:120. PMID: 26279678; PMCID: PMC4537572.
    24. Wasserman MR, Pulk A, Zhou Z, Altman RB, Zinder JC, Green KD, Garneau-Tsodikova S, Cate J, Blanchard SC. Chemically related 4,5-linked aminoglycoside antibiotics drive subunit rotation in opposite directions. Nat Commun. 2015 Jul 30; 6:7896. PMID: 26224058.
      View in: PubMed
    25. Lee AS, Kranzusch PJ, Cate J. eIF3 targets cell-proliferation messenger RNAs for translational activation or repression. Nature. 2015 Jun 04; 522(7554):111-4. PMID: 25849773; PMCID: PMC4603833.
    26. Noeske J, Wasserman MR, Terry DS, Altman RB, Blanchard SC, Cate J. High-resolution structure of the Escherichia coli ribosome. Nat Struct Mol Biol. 2015 Apr; 22(4):336-41. PMID: 25775265; PMCID: PMC4429131.
    27. Li X, Yu VY, Lin Y, Chomvong K, Estrela R, Park A, Liang JM, Znameroski EA, Feehan J, Kim SR, Jin YS, Glass NL, Cate J. Expanding xylose metabolism in yeast for plant cell wall conversion to biofuels. Elife. 2015 Feb 03; 4. PMID: 25647728; PMCID: PMC4338637.
    28. Rui Z, Li X, Zhu X, Liu J, Domigan B, Barr I, Cate J, Zhang W. Microbial biosynthesis of medium-chain 1-alkenes by a nonheme iron oxidase. Proc Natl Acad Sci U S A. 2014 Dec 23; 111(51):18237-42. PMID: 25489112; PMCID: PMC4280606.
    29. Olivier NB, Altman RB, Noeske J, Basarab GS, Code E, Ferguson AD, Gao N, Huang J, Juette MF, Livchak S, Miller MD, Prince DB, Cate J, Buurman ET, Blanchard SC. Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome. Proc Natl Acad Sci U S A. 2014 Nov 18; 111(46):16274-9. PMID: 25368144; PMCID: PMC4246262.
    30. Ryan OW, Skerker JM, Maurer MJ, Li X, Tsai JC, Poddar S, Lee ME, DeLoache W, Dueber JE, Arkin AP, Cate J. Selection of chromosomal DNA libraries using a multiplex CRISPR system. Elife. 2014 Aug 19; 3. PMID: 25139909; PMCID: PMC4161972.
    31. Noeske J, Huang J, Olivier NB, Giacobbe RA, Zambrowski M, Cate J. Synergy of streptogramin antibiotics occurs independently of their effects on translation. Antimicrob Agents Chemother. 2014 Sep; 58(9):5269-79. PMID: 24957822; PMCID: PMC4135883.
    32. Chomvong K, Kordic V, Li X, Bauer S, Gillespie AE, Ha SJ, Oh EJ, Galazka JM, Jin YS, Cate J. Overcoming inefficient cellobiose fermentation by cellobiose phosphorylase in the presence of xylose. Biotechnol Biofuels. 2014; 7:85. PMID: 24944578; PMCID: PMC4061319.
    33. Xiong Y, Coradetti ST, Li X, Gritsenko MA, Clauss T, Petyuk V, Camp D, Smith R, Cate J, Yang F, Glass NL. The proteome and phosphoproteome of Neurospora crassa in response to cellulose, sucrose and carbon starvation. Fungal Genet Biol. 2014 Nov; 72:21-33. PMID: 24881580; PMCID: PMC4247816.
    34. Lintner NG, Cate J. Regulating the ribosome: a spotlight on RNA dark matter. Mol Cell. 2014 Apr 10; 54(1):1-2. PMID: 24725592; PMCID: PMC4260648.
    35. Ryan OW, Cate J. Multiplex engineering of industrial yeast genomes using CRISPRm. Methods Enzymol. 2014; 546:473-89. PMID: 25398354.
      View in: PubMed
    36. Vu VV, Beeson WT, Phillips CM, Cate J, Marletta MA. Determinants of regioselective hydroxylation in the fungal polysaccharide monooxygenases. J Am Chem Soc. 2014 Jan 15; 136(2):562-5. PMID: 24350607.
      View in: PubMed
    37. Znameroski EA, Li X, Tsai JC, Galazka JM, Glass NL, Cate J. Evidence for transceptor function of cellodextrin transporters in Neurospora crassa. J Biol Chem. 2014 Jan 31; 289(5):2610-9. PMID: 24344125; PMCID: PMC3908395.
    38. Smith MD, Gu Y, Querol-Audí J, Vogan JM, Nitido A, Cate J. Human-like eukaryotic translation initiation factor 3 from Neurospora crassa. PLoS One. 2013; 8(11):e78715. PMID: 24250809; PMCID: PMC3826745.
    39. Kim H, Lee WH, Galazka JM, Cate J, Jin YS. Analysis of cellodextrin transporters from Neurospora crassa in Saccharomyces cerevisiae for cellobiose fermentation. Appl Microbiol Biotechnol. 2014 Feb; 98(3):1087-94. PMID: 24190499.
      View in: PubMed
    40. Zepeda V, Dassa B, Borovok I, Lamed R, Bayer EA, Cate J. Draft Genome Sequence of the Cellulolytic Bacterium Clostridium papyrosolvens C7 (ATCC 700395). Genome Announc. 2013 Sep 12; 1(5). PMID: 24029755; PMCID: PMC3772139.
    41. Li S, Ha SJ, Kim HJ, Galazka JM, Cate J, Jin YS, Zhao H. Investigation of the functional role of aldose 1-epimerase in engineered cellobiose utilization. J Biotechnol. 2013 Oct 10; 168(1):1-6. PMID: 23954547.
      View in: PubMed
    42. Pulk A, Cate J. Control of ribosomal subunit rotation by elongation factor G. Science. 2013 Jun 28; 340(6140):1235970. PMID: 23812721; PMCID: PMC4274944.
    43. Sun C, Querol-Audí J, Mortimer SA, Arias-Palomo E, Doudna JA, Nogales E, Cate J. Two RNA-binding motifs in eIF3 direct HCV IRES-dependent translation. Nucleic Acids Res. 2013 Aug; 41(15):7512-21. PMID: 23766293; PMCID: PMC3753635.
    44. Querol-Audi J, Sun C, Vogan JM, Smith MD, Gu Y, Cate J, Nogales E. Architecture of human translation initiation factor 3. Structure. 2013 Jun 04; 21(6):920-8. PMID: 23623729; PMCID: PMC3739965.
    45. Wang L, Pulk A, Wasserman MR, Feldman MB, Altman RB, Cate J, Blanchard SC. Allosteric control of the ribosome by small-molecule antibiotics. Nat Struct Mol Biol. 2012 Sep; 19(9):957-63. PMID: 22902368; PMCID: PMC3645490.
    46. Noeske J, Cate J. Structural basis for protein synthesis: snapshots of the ribosome in motion. Curr Opin Struct Biol. 2012 Dec; 22(6):743-9. PMID: 22871550; PMCID: PMC3513557.
    47. Li X, Beeson WT, Phillips CM, Marletta MA, Cate J. Structural basis for substrate targeting and catalysis by fungal polysaccharide monooxygenases. Structure. 2012 Jun 06; 20(6):1051-61. PMID: 22578542; PMCID: PMC3753108.
    48. Znameroski EA, Coradetti ST, Roche CM, Tsai JC, Iavarone AT, Cate J, Glass NL. Induction of lignocellulose-degrading enzymes in Neurospora crassa by cellodextrins. Proc Natl Acad Sci U S A. 2012 Apr 17; 109(16):6012-7. PMID: 22474347; PMCID: PMC3341005.
    49. Beeson WT, Phillips CM, Cate J, Marletta MA. Oxidative cleavage of cellulose by fungal copper-dependent polysaccharide monooxygenases. J Am Chem Soc. 2012 Jan 18; 134(2):890-2. PMID: 22188218.
      View in: PubMed
    50. Sun C, Todorovic A, Querol-Audí J, Bai Y, Villa N, Snyder M, Ashchyan J, Lewis CS, Hartland A, Gradia S, Fraser CS, Doudna JA, Nogales E, Cate J. Functional reconstitution of human eukaryotic translation initiation factor 3 (eIF3). Proc Natl Acad Sci U S A. 2011 Dec 20; 108(51):20473-8. PMID: 22135459; PMCID: PMC3251073.
    51. Phillips CM, Beeson WT, Cate J, Marletta MA. Cellobiose dehydrogenase and a copper-dependent polysaccharide monooxygenase potentiate cellulose degradation by Neurospora crassa. ACS Chem Biol. 2011 Dec 16; 6(12):1399-406. PMID: 22004347.
      View in: PubMed
    52. Galazka JM, Cate J. A new diet for yeast to improve biofuel production. Bioeng Bugs. 2011 Jul-Aug; 2(4):199-202. PMID: 21637011; PMCID: PMC3225656.
    53. Dunkle JA, Wang L, Feldman MB, Pulk A, Chen VB, Kapral GJ, Noeske J, Richardson JS, Blanchard SC, Cate J. Structures of the bacterial ribosome in classical and hybrid states of tRNA binding. Science. 2011 May 20; 332(6032):981-4. PMID: 21596992; PMCID: PMC3176341.
    54. Beeson WT, Iavarone AT, Hausmann CD, Cate J, Marletta MA. Extracellular aldonolactonase from Myceliophthora thermophila. Appl Environ Microbiol. 2011 Jan; 77(2):650-6. PMID: 21075873; PMCID: PMC3020561.
    55. Dunkle JA, Xiong L, Mankin AS, Cate J. Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action. Proc Natl Acad Sci U S A. 2010 Oct 05; 107(40):17152-7. PMID: 20876128; PMCID: PMC2951456.
    56. Llano-Sotelo B, Dunkle J, Klepacki D, Zhang W, Fernandes P, Cate J, Mankin AS. Binding and action of CEM-101, a new fluoroketolide antibiotic that inhibits protein synthesis. Antimicrob Agents Chemother. 2010 Dec; 54(12):4961-70. PMID: 20855725; PMCID: PMC2981243.
    57. Sun C, Pager CT, Luo G, Sarnow P, Cate J. Hepatitis C virus core-derived peptides inhibit genotype 1b viral genome replication via interaction with DDX3X. PLoS One. 2010 Sep 17; 5(9). PMID: 20862261; PMCID: PMC2941470.
    58. Cai Q, Todorovic A, Andaya A, Gao J, Leary JA, Cate J. Distinct regions of human eIF3 are sufficient for binding to the HCV IRES and the 40S ribosomal subunit. J Mol Biol. 2010 Oct 22; 403(2):185-96. PMID: 20816988; PMCID: PMC2975054.
    59. Galazka JM, Tian C, Beeson WT, Martinez B, Glass NL, Cate J. Cellodextrin transport in yeast for improved biofuel production. Science. 2010 Oct 01; 330(6000):84-6. PMID: 20829451.
      View in: PubMed
    60. Dunkle JA, Cate J. Ribosome structure and dynamics during translocation and termination. Annu Rev Biophys. 2010; 39:227-44. PMID: 20192776.
      View in: PubMed
    61. Munro JB, Altman RB, Tung CS, Cate J, Sanbonmatsu KY, Blanchard SC. Spontaneous formation of the unlocked state of the ribosome is a multistep process. Proc Natl Acad Sci U S A. 2010 Jan 12; 107(2):709-14. PMID: 20018653; PMCID: PMC2818936.
    62. Cate J. Some reassembly required. Mol Microbiol. 2010 Feb; 75(4):793-4. PMID: 20025660; PMCID: PMC3496774.
    63. Tian C, Beeson WT, Iavarone AT, Sun J, Marletta MA, Cate J, Glass NL. Systems analysis of plant cell wall degradation by the model filamentous fungus Neurospora crassa. Proc Natl Acad Sci U S A. 2009 Dec 29; 106(52):22157-62. PMID: 20018766.
      View in: PubMed
    64. Zhang W, Dunkle JA, Cate J. Structures of the ribosome in intermediate states of ratcheting. Science. 2009 Aug 21; 325(5943):1014-7. PMID: 19696352; PMCID: PMC2919209.
    65. Borovinskaya MA, Shoji S, Fredrick K, Cate J. Structural basis for hygromycin B inhibition of protein biosynthesis. RNA. 2008 Aug; 14(8):1590-9. PMID: 18567815; PMCID: PMC2491480.
    66. Pai RD, Zhang W, Schuwirth BS, Hirokawa G, Kaji H, Kaji A, Cate J. Structural Insights into ribosome recycling factor interactions with the 70S ribosome. J Mol Biol. 2008 Mar 07; 376(5):1334-47. PMID: 18234219; PMCID: PMC2712656.
    67. Borovinskaya MA, Shoji S, Holton JM, Fredrick K, Cate J. A steric block in translation caused by the antibiotic spectinomycin. ACS Chem Biol. 2007 Aug 17; 2(8):545-552. PMID: 17696316; PMCID: PMC4624401.
    68. Borovinskaya MA, Pai RD, Zhang W, Schuwirth BS, Holton JM, Hirokawa G, Kaji H, Kaji A, Cate J. Structural basis for aminoglycoside inhibition of bacterial ribosome recycling. Nat Struct Mol Biol. 2007 Aug; 14(8):727-32. PMID: 17660832.
      View in: PubMed
    69. Berk V, Cate J. Insights into protein biosynthesis from structures of bacterial ribosomes. Curr Opin Struct Biol. 2007 Jun; 17(3):302-9. PMID: 17574829.
      View in: PubMed
    70. Berk V, Zhang W, Pai RD, Cate JH, Cate JH. Structural basis for mRNA and tRNA positioning on the ribosome. Proc Natl Acad Sci U S A. 2006 Oct 24; 103(43):15830-4. PMID: 17038497; PMCID: PMC1635088.
    71. Schuwirth BS, Day JM, Hau CW, Janssen GR, Dahlberg AE, Cate J, Vila-Sanjurjo A. Structural analysis of kasugamycin inhibition of translation. Nat Struct Mol Biol. 2006 Oct; 13(10):879-86. PMID: 16998486; PMCID: PMC2636691.
    72. Shenvi CL, Dong KC, Friedman EM, Hanson JA, Cate J. Accessibility of 18S rRNA in human 40S subunits and 80S ribosomes at physiological magnesium ion concentrations--implications for the study of ribosome dynamics. RNA. 2005 Dec; 11(12):1898-908. PMID: 16314459; PMCID: PMC1370877.
    73. Liau A, Karnik R, Majumdar A, Cate J. Mixing crowded biological solutions in milliseconds. Anal Chem. 2005 Dec 01; 77(23):7618-25. PMID: 16316169.
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    74. Schuwirth BS, Borovinskaya MA, Hau CW, Zhang W, Vila-Sanjurjo A, Holton JM, Cate J. Structures of the bacterial ribosome at 3.5 A resolution. Science. 2005 Nov 04; 310(5749):827-34. PMID: 16272117.
      View in: PubMed
    75. Cate J. The ins and outs of protein synthesis. Structure. 2005 Nov; 13(11):1584-5. PMID: 16271881.
      View in: PubMed
    76. Vila-Sanjurjo A, Schuwirth BS, Hau CW, Cate J. Structural basis for the control of translation initiation during stress. Nat Struct Mol Biol. 2004 Nov; 11(11):1054-9. PMID: 15502846.
      View in: PubMed
    77. Ke A, Zhou K, Ding F, Cate J, Doudna JA. A conformational switch controls hepatitis delta virus ribozyme catalysis. Nature. 2004 May 13; 429(6988):201-5. PMID: 15141216.
      View in: PubMed
    78. Vila-Sanjurjo A, Ridgeway WK, Seymaner V, Zhang W, Santoso S, Yu K, Cate J. X-ray crystal structures of the WT and a hyper-accurate ribosome from Escherichia coli. Proc Natl Acad Sci U S A. 2003 Jul 22; 100(15):8682-7. PMID: 12853578; PMCID: PMC166372.
    79. Cate J. Construction of low-resolution x-ray crystallographic electron density maps of the ribosome. Methods. 2001 Nov; 25(3):303-8. PMID: 11860284.
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