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Williams, Evan

TitleChemist Faculty
InstitutionLawrence Berkeley National Lab
DepartmentClimate & Ecosystems
Address1 Cyclotron Road
Berkeley CA 94720
Phone510/643-7161
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    Collapse Research 
    Collapse Research Activities and Funding
    High Definition Ion Mobility Spectrometer
    NIH S10OD020062May 1, 2015 - Apr 30, 2016
    Role: Principal Investigator
    Integrated Methods for Structural Elucidation of Proteins and Macromolecular Comp
    NIH/NIGMS R01GM097357Apr 1, 2012 - Mar 31, 2016
    Role: Principal Investigator
    Development of Single Particle Analyzer of Mass and Mobility (SPAMM)
    NIH/NIGMS R01GM096097Jul 1, 2011 - Jun 30, 2015
    Role: Principal Investigator
    Acquisition of a QTOF Mass Spectrometer
    NIH/NCRR S10RR022393Apr 15, 2006 - Apr 14, 2007
    Role: Principal Investigator
    Protein Conformation and Noncovalent Interactions
    NIH/NIGMS R01GM064712Feb 1, 2002 - Jan 31, 2011
    Role: Principal Investigator
    PROTEIN STRUCTURE BY FOURIER-TRANSFORM MASS SPECTROMETRY
    NIH/NIGMS R29GM050336Sep 7, 1995 - Aug 31, 2000
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Harper CC, Elliott AG, Lin HW, Williams E. Determining Energies and Cross Sections of Individual Ions Using Higher-Order Harmonics in Fourier Transform Charge Detection Mass Spectrometry (FT-CDMS). J Am Soc Mass Spectrom. 2018 Jun 02. PMID: 29860679.
      View in: PubMed
    2. Heiles S, Berden G, Oomens J, Williams E. Competition between salt bridge and non-zwitterionic structures in deprotonated amino acid dimers. Phys Chem Chem Phys. 2018 May 30. PMID: 29845141.
      View in: PubMed
    3. DiTucci MJ, Stachl CN, Williams E. Long distance ion-water interactions in aqueous sulfate nanodrops persist to ambient temperatures in the upper atmosphere. Chem Sci. 2018 Apr 28; 9(16):3970-3977. PMID: 29780530.
      View in: PubMed
    4. El-Baba TJ, Fuller DR, Woodall DW, Raab SA, Conant CR, Dilger JM, Toker Y, Williams E, Russell DH, Clemmer DE. Melting proteins confined in nanodroplets with 10.6 µm light provides clues about early steps of denaturation. Chem Commun (Camb). 2018 Mar 27; 54(26):3270-3273. PMID: 29536995.
      View in: PubMed
    5. Aebersold R, Agar JN, Amster IJ, Baker MS, Bertozzi CR, Boja ES, Costello CE, Cravatt BF, Fenselau C, Garcia BA, Ge Y, Gunawardena J, Hendrickson RC, Hergenrother PJ, Huber CG, Ivanov AR, Jensen ON, Jewett MC, Kelleher NL, Kiessling LL, Krogan NJ, Larsen MR, Loo JA, Ogorzalek Loo RR, Lundberg E, MacCoss MJ, Mallick P, Mootha VK, Mrksich M, Muir TW, Patrie SM, Pesavento JJ, Pitteri SJ, Rodriguez H, Saghatelian A, Sandoval W, Schlüter H, Sechi S, Slavoff SA, Smith LM, Snyder MP, Thomas PM, Uhlén M, Van Eyk JE, Vidal M, Walt DR, White FM, Williams E, Wohlschlager T, Wysocki VH, Yates NA, Young NL, Zhang B. How many human proteoforms are there? Nat Chem Biol. 2018 Feb 14; 14(3):206-214. PMID: 29443976.
      View in: PubMed
    6. Xia Z, Williams E. Protein-Glass Surface Interactions and Ion Desalting in Electrospray Ionization with Submicron Emitters. J Am Soc Mass Spectrom. 2017 Oct 12. PMID: 29027129.
      View in: PubMed
    7. Susa AC, Lippens JL, Xia Z, Loo JA, Campuzano IDG, Williams E. Submicrometer Emitter ESI Tips for Native Mass Spectrometry of Membrane Proteins in Ionic and Nonionic Detergents. J Am Soc Mass Spectrom. 2018 Jan; 29(1):203-206. PMID: 29027132.
      View in: PubMed
    8. Elliott AG, Harper CC, Lin HW, Williams E. Mass, mobility and MSn measurements of single ions using charge detection mass spectrometry. Analyst. 2017 Jul 24; 142(15):2760-2769. PMID: 28636005.
      View in: PubMed
    9. Elliott AG, Harper CC, Lin HW, Susa AC, Xia Z, Williams E. Simultaneous Measurements of Mass and Collisional Cross-Section of Single Ions with Charge Detection Mass Spectrometry. Anal Chem. 2017 Jul 18; 89(14):7701-7708. PMID: 28621517.
      View in: PubMed
    10. Susa AC, Xia Z, Williams E. Native Mass Spectrometry from Common Buffers with Salts That Mimic the Extracellular Environment. Angew Chem Int Ed Engl. 2017 Jun 26; 56(27):7912-7915. PMID: 28510995.
      View in: PubMed
    11. Cooper RJ, O'Brien JT, Chang TM, Williams E. Structural and electrostatic effects at the surfaces of size- and charge-selected aqueous nanodrops. Chem Sci. 2017 Jul 01; 8(7):5201-5213. PMID: 28970907.
      View in: PubMed
    12. Mortensen DN, Susa AC, Williams E. Collisional Cross-Sections with T-Wave Ion Mobility Spectrometry without Experimental Calibration. J Am Soc Mass Spectrom. 2017 Jul; 28(7):1282-1292. PMID: 28432656.
      View in: PubMed
    13. Clemmer DE, Russell DH, Williams E. Characterizing the Conformationome: Toward a Structural Understanding of the Proteome. Acc Chem Res. 2017 Mar 21; 50(3):556-560. PMID: 28945417.
      View in: PubMed
    14. DiTucci MJ, Böhm F, Schwaab G, Williams E, Havenith M. Effects of multivalent hexacyanoferrates and their ion pairs on water molecule dynamics measured with terahertz spectroscopy. Phys Chem Chem Phys. 2017 Mar 08; 19(10):7297-7306. PMID: 28239695.
      View in: PubMed
    15. Susa AC, Xia Z, Williams E. Small Emitter Tips for Native Mass Spectrometry of Proteins and Protein Complexes from Nonvolatile Buffers That Mimic the Intracellular Environment. Anal Chem. 2017 Mar 07; 89(5):3116-3122. PMID: 28192954.
      View in: PubMed
    16. Heiles S, Cooper RJ, DiTucci MJ, Williams E. Sequential water molecule binding enthalpies for aqueous nanodrops containing a mono-, di- or trivalent ion and between 20 and 500 water molecules. Chem Sci. 2017 Apr 01; 8(4):2973-2982. PMID: 28451364.
      View in: PubMed
    17. Regazzoni LG, Grigoryan H, Ji Z, Chen X, Daniels SI, Huang D, Sanchez S, Tang N, Sillé FC, Iavarone AT, Williams E, Zhang L, Rappaport SM. Using lysine adducts of human serum albumin to investigate the disposition of exogenous formaldehyde in human blood. Toxicol Lett. 2017 Feb 15; 268:26-35. PMID: 28104429.
      View in: PubMed
    18. Elliott AG, Merenbloom SI, Chakrabarty S, Williams E. Single Particle Analyzer of Mass: A Charge Detection Mass Spectrometer with a Multi-Detector Electrostatic Ion Trap. Int J Mass Spectrom. 2017 Mar; 414:45-55. PMID: 29129967.
      View in: PubMed
    19. DiTucci MJ, Williams E. Nanometer patterning of water by tetraanionic ferrocyanide stabilized in aqueous nanodrops. Chem Sci. 2017 Feb 01; 8(2):1391-1399. PMID: 28451280.
      View in: PubMed
    20. Susa AC, Xia Z, Tang HYH, Tainer JA, Williams E. Charging of Proteins in Native Mass Spectrometry. J Am Soc Mass Spectrom. 2017 Feb; 28(2):332-340. PMID: 27734326.
      View in: PubMed
    21. Grigoryan H, Edmands W, Lu SS, Yano Y, Regazzoni L, Iavarone AT, Williams E, Rappaport SM. Adductomics Pipeline for Untargeted Analysis of Modifications to Cys34 of Human Serum Albumin. Anal Chem. 2016 Nov 01; 88(21):10504-10512. PMID: 27684351.
      View in: PubMed
    22. Mortensen DN, Williams E. Microsecond and nanosecond polyproline II helix formation in aqueous nanodrops measured by mass spectrometry. Chem Commun (Camb). 2016 Oct 06; 52(82):12218-12221. PMID: 27711437.
      View in: PubMed
    23. Mortensen DN, Williams E. Surface-Induced Protein Unfolding in Submicron Electrospray Emitters. Anal Chem. 2016 Oct 04; 88(19):9662-9668. PMID: 27615434.
      View in: PubMed
    24. Chakrabarty S, Williams E. The effect of halide and iodate anions on the hydrogen-bonding network of water in aqueous nanodrops. Phys Chem Chem Phys. 2016 Sep 14; 18(36):25483-25490. PMID: 27711560.
      View in: PubMed
    25. Mortensen DN, Williams E. Electrothermal supercharging of proteins in native MS: effects of protein isoelectric point, buffer, and nanoESI-emitter tip size. Analyst. 2016 Oct 07; 141(19):5598-606. PMID: 27441318.
      View in: PubMed
    26. Cassidy-Amstutz C, Oltrogge L, Going CC, Lee A, Teng P, Quintanilla D, East-Seletsky A, Williams E, Savage DF. Identification of a Minimal Peptide Tag for in Vivo and in Vitro Loading of Encapsulin. Biochemistry. 2016 06 21; 55(24):3461-8. PMID: 27224728.
      View in: PubMed
    27. Bhattacharyya M, Stratton MM, Going CC, McSpadden ED, Huang Y, Susa AC, Elleman A, Cao YM, Pappireddi N, Burkhardt P, Gee CL, Barros T, Schulman H, Williams E, Kuriyan J. Molecular mechanism of activation-triggered subunit exchange in Ca(2+)/calmodulin-dependent protein kinase II. Elife. 2016 03 07; 5. PMID: 26949248; PMCID: PMC4859805.
    28. Mortensen DN, Williams E. Ultrafast (1 µs) Mixing and Fast Protein Folding in Nanodrops Monitored by Mass Spectrometry. J Am Chem Soc. 2016 Mar 16; 138(10):3453-60. PMID: 26902747.
      View in: PubMed
    29. Going CC, Xia Z, Williams E. Real-time HD Exchange Kinetics of Proteins from Buffered Aqueous Solution with Electrothermal Supercharging and Top-Down Tandem Mass Spectrometry. J Am Soc Mass Spectrom. 2016 Jun; 27(6):1019-27. PMID: 26919868; PMCID: PMC4865425 [Available on 06/01/17].
    30. Cooper RJ, DiTucci MJ, Chang TM, Williams E. Delayed Onset of Crystallinity in Ion-Containing Aqueous Nanodrops. J Am Chem Soc. 2016 Jan 13; 138(1):96-9. PMID: 26714195.
      View in: PubMed
    31. Heiles S, Cooper RJ, Berden G, Oomens J, Williams E. Hydrogen bond mediated stabilization of the salt bridge structure for the glycine dimer anion. Phys Chem Chem Phys. 2015 Nov 11; 17(45):30642-7. PMID: 26524433.
      View in: PubMed
    32. Going CC, Xia Z, Williams E. New supercharging reagents produce highly charged protein ions in native mass spectrometry. Analyst. 2015 Nov 07; 140(21):7184-94. PMID: 26421324; PMCID: PMC4617834.
    33. Masson A, Williams E, Rizzo TR. Molecular hydrogen messengers can lead to structural infidelity: A cautionary tale of protonated glycine. J Chem Phys. 2015 Sep 14; 143(10):104313. PMID: 26374041.
      View in: PubMed
    34. Cooper RJ, Heiles S, Williams E. Effects of electronic structure on the hydration of PbNO3(+) and SrNO3(+) ion pairs. Phys Chem Chem Phys. 2015 Jun 28; 17(24):15963-75. PMID: 26028325.
      View in: PubMed
    35. Heiles S, Cooper RJ, DiTucci MJ, Williams E. Hydration of guanidinium depends on its local environment. Chem Sci. 2015 Jun 01; 6(6):3420-3429. PMID: 28706704.
      View in: PubMed
    36. Going CC, Williams E. Supercharging with m-nitrobenzyl alcohol and propylene carbonate: forming highly charged ions with extended, near-linear conformations. Anal Chem. 2015 Apr 07; 87(7):3973-80. PMID: 25719488.
      View in: PubMed
    37. O'Brien JT, Williams E, Holman HY. Ambient infrared laser ablation mass spectrometry (AIRLAB-MS) of live plant tissue with plume capture by continuous flow solvent probe. Anal Chem. 2015 Mar 03; 87(5):2631-8. PMID: 25622206.
      View in: PubMed
    38. DiTucci MJ, Heiles S, Williams E. Role of water in stabilizing ferricyanide trianion and ion-induced effects to the hydrogen-bonding water network at long distance. J Am Chem Soc. 2015 Feb 04; 137(4):1650-7. PMID: 25569605.
      View in: PubMed
    39. Mortensen DN, Williams E. Investigating protein folding and unfolding in electrospray nanodrops upon rapid mixing using theta-glass emitters. Anal Chem. 2015 Jan 20; 87(2):1281-7. PMID: 25525976; PMCID: PMC4303338 [Available on 12/18/15].
    40. Cassou CA, Williams E. Desalting protein ions in native mass spectrometry using supercharging reagents. Analyst. 2014 Oct 07; 139(19):4810-9. PMID: 25133273; PMCID: PMC4245020.
    41. Mortensen DN, Williams E. Theta-glass capillaries in electrospray ionization: rapid mixing and short droplet lifetimes. Anal Chem. 2014 Sep 16; 86(18):9315-21. PMID: 25160559; PMCID: PMC4165459.
    42. Cooper RJ, Heiles S, DiTucci MJ, Williams E. Hydration of guanidinium: second shell formation at small cluster size. J Phys Chem A. 2014 Jul 31; 118(30):5657-66. PMID: 24999751.
      View in: PubMed
    43. Chang TM, Chakrabarty S, Williams E. Hydration of gaseous m-aminobenzoic acid: ionic vs neutral hydrogen bonding and water bridges. J Am Chem Soc. 2014 Jul 23; 136(29):10440-9. PMID: 24971758.
      View in: PubMed
    44. Susa AC, Mortensen DN, Williams E. Effects of cations on protein and peptide charging in electrospray ionization from aqueous solutions. J Am Soc Mass Spectrom. 2014 Jun; 25(6):918-27. PMID: 24729190; PMCID: PMC4051497.
    45. Cassou CA, Williams E. Anions in electrothermal supercharging of proteins with electrospray ionization follow a reverse Hofmeister series. Anal Chem. 2014 Feb 04; 86(3):1640-7. PMID: 24410546; PMCID: PMC3983018.
    46. Chang TM, Cooper RJ, Williams E. Locating protonated amines in clathrates. J Am Chem Soc. 2013 Oct 02; 135(39):14821-30. PMID: 24007314.
      View in: PubMed
    47. Cooper RJ, Chang TM, Williams E. Hydrated alkali metal ions: spectroscopic evidence for clathrates. J Phys Chem A. 2013 Aug 01; 117(30):6571-9. PMID: 23808387.
      View in: PubMed
    48. Flick TG, Merenbloom SI, Williams E. Effects of metal ion adduction on the gas-phase conformations of protein ions. J Am Soc Mass Spectrom. 2013 Nov; 24(11):1654-62. PMID: 23733259; PMCID: PMC3795793.
    49. Gillis EA, Demireva M, Sarwar MG, Chudzinski MG, Taylor MS, Williams E, Fridgen TD. Structure and energetics of gas phase halogen-bonding in mono-, bi-, and tri-dentate anion receptors as studied by BIRD. Phys Chem Chem Phys. 2013 May 28; 15(20):7638-47. PMID: 23591590.
      View in: PubMed
    50. Flick TG, Donald WA, Williams E. Electron capture dissociation of trivalent metal ion-peptide complexes. J Am Soc Mass Spectrom. 2013 Feb; 24(2):193-201. PMID: 23283726; PMCID: PMC3570592.
    51. Cassou CA, Sterling HJ, Susa AC, Williams E. Electrothermal supercharging in mass spectrometry and tandem mass spectrometry of native proteins. Anal Chem. 2013 Jan 02; 85(1):138-46. PMID: 23194134; PMCID: PMC3536820.
    52. Chang TM, Prell JS, Warrick ER, Williams E. Where's the charge? Protonation sites in gaseous ions change with hydration. J Am Chem Soc. 2012 Sep 26; 134(38):15805-13. PMID: 22954377.
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    53. Flick TG, Williams E. Supercharging with trivalent metal ions in native mass spectrometry. J Am Soc Mass Spectrom. 2012 Nov; 23(11):1885-95. PMID: 22948901; PMCID: PMC3474886.
    54. Flick TG, Cassou CA, Chang TM, Williams E. Solution additives that desalt protein ions in native mass spectrometry. Anal Chem. 2012 Sep 04; 84(17):7511-7. PMID: 22881839; PMCID: PMC3433631.
    55. Demireva M, O'Brien JT, Williams E. Water-induced folding of 1,7-diammoniumheptane. J Am Chem Soc. 2012 Jul 11; 134(27):11216-24. PMID: 22708846.
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    56. O'Brien JT, Williams E. Effects of ions on hydrogen-bonding water networks in large aqueous nanodrops. J Am Chem Soc. 2012 Jun 20; 134(24):10228-36. PMID: 22616651.
      View in: PubMed
    57. Grigoryan H, Li H, Iavarone AT, Williams E, Rappaport SM. Cys34 adducts of reactive oxygen species in human serum albumin. Chem Res Toxicol. 2012 Aug 20; 25(8):1633-42. PMID: 22591159; PMCID: PMC4763613.
    58. Sterling HJ, Cassou CA, Susa AC, Williams E. Electrothermal supercharging of proteins in native electrospray ionization. Anal Chem. 2012 Apr 17; 84(8):3795-801. PMID: 22409200; PMCID: PMC3328611.
    59. Merenbloom SI, Flick TG, Williams E. How hot are your ions in TWAVE ion mobility spectrometry? J Am Soc Mass Spectrom. 2012 Mar; 23(3):553-62. PMID: 22203576; PMCID: PMC3296450.
    60. Sterling HJ, Kintzer AF, Feld GK, Cassou CA, Krantz BA, Williams E. Supercharging protein complexes from aqueous solution disrupts their native conformations. J Am Soc Mass Spectrom. 2012 Feb; 23(2):191-200. PMID: 22161509; PMCID: PMC3265691.
    61. Gillis EA, Demireva M, Nanda K, Beran G, Williams E, Fridgen TD. Structures and energetics of electrosprayed uracil(n)Ca2+ clusters (n = 14-4) in the gas phase. Phys Chem Chem Phys. 2012 Mar 14; 14(10):3304-15. PMID: 22139344.
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    62. O'Brien JT, Williams E. Coordination numbers of hydrated divalent transition metal ions investigated with IRPD spectroscopy. J Phys Chem A. 2011 Dec 29; 115(51):14612-9. PMID: 22098330.
      View in: PubMed
    63. Donald WA, Leib RD, Demireva M, Williams E. Ions in size-selected aqueous nanodrops: sequential water molecule binding energies and effects of water on ion fluorescence. J Am Chem Soc. 2011 Nov 23; 133(46):18940-9. PMID: 21999364.
      View in: PubMed
    64. Merenbloom SI, Flick TG, Daly MP, Williams E. Effects of select anions from the Hofmeister series on the gas-phase conformations of protein ions measured with traveling-wave ion mobility spectrometry/mass spectrometry. J Am Soc Mass Spectrom. 2011 Nov; 22(11):1978-90. PMID: 21952780; PMCID: PMC3212098.
    65. Flick TG, Merenbloom SI, Williams E. Anion effects on sodium ion and acid molecule adduction to protein ions in electrospray ionization mass spectrometry. J Am Soc Mass Spectrom. 2011 Nov; 22(11):1968-77. PMID: 21952761; PMCID: PMC3319465.
    66. Sterling HJ, Prell JS, Cassou CA, Williams E. Protein conformation and supercharging with DMSO from aqueous solution. J Am Soc Mass Spectrom. 2011 Jul; 22(7):1178-86. PMID: 21953100; PMCID: PMC3107942.
    67. Rappaport SM, Li H, Grigoryan H, Funk WE, Williams E. Adductomics: characterizing exposures to reactive electrophiles. Toxicol Lett. 2012 Aug 13; 213(1):83-90. PMID: 21501670; PMCID: PMC4758449.
    68. Prell JS, Chang TM, Biles JA, Berden G, Oomens J, Williams E. Isomer population analysis of gaseous ions from infrared multiple photon dissociation kinetics. J Phys Chem A. 2011 Apr 07; 115(13):2745-51. PMID: 21410158.
      View in: PubMed
    69. Prell JS, O'Brien JT, Williams E. Structural and electric field effects of ions in aqueous nanodrops. J Am Chem Soc. 2011 Apr 06; 133(13):4810-8. PMID: 21405134.
      View in: PubMed
    70. Sterling HJ, Cassou CA, Trnka MJ, Burlingame AL, Krantz BA, Williams E. The role of conformational flexibility on protein supercharging in native electrospray ionization. Phys Chem Chem Phys. 2011 Nov 07; 13(41):18288-96. PMID: 21399817; PMCID: PMC3415327.
    71. Leib RD, Williams E. Simultaneous quantitation of amino acid mixtures using clustering agents. J Am Soc Mass Spectrom. 2011 Apr; 22(4):624-32. PMID: 21472601; PMCID: PMC3062766.
    72. Flick TG, Merenbloom SI, Williams E. A simple and robust method for determining the number of basic sites in peptides and proteins using electrospray ionization mass spectrometry. Anal Chem. 2011 Mar 15; 83(6):2210-4. PMID: 21338067; PMCID: PMC3089436.
    73. Li H, Grigoryan H, Funk WE, Lu SS, Rose S, Williams E, Rappaport SM. Profiling Cys34 adducts of human serum albumin by fixed-step selected reaction monitoring. Mol Cell Proteomics. 2011 Mar; 10(3):M110.004606. PMID: 21193536; PMCID: PMC3047157.
    74. Donald WA, Leib RD, Demireva M, Negru B, Neumark DM, Williams E. Average sequential water molecule binding enthalpies of M(H2O)(19-124)2+ (M = Co, Fe, Mn, and Cu) measured with ultraviolet photodissociation at 193 and 248 nm. J Phys Chem A. 2011 Jan 13; 115(1):2-12. PMID: 21142113.
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    75. Cooper TE, O'Brien JT, Williams E, Armentrout PB. Zn2+ has a primary hydration sphere of five: IR action spectroscopy and theoretical studies of hydrated Zn2+ complexes in the gas phase. J Phys Chem A. 2010 Dec 09; 114(48):12646-55. PMID: 21077603.
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    76. Kintzer AF, Sterling HJ, Tang II, Williams E, Krantz BA. Anthrax toxin receptor drives protective antigen oligomerization and stabilizes the heptameric and octameric oligomer by a similar mechanism. PLoS One. 2010 Nov 08; 5(11):e13888. PMID: 21079738.
      View in: PubMed
    77. Feld GK, Thoren KL, Kintzer AF, Sterling HJ, Tang II, Greenberg SG, Williams E, Krantz BA. Structural basis for the unfolding of anthrax lethal factor by protective antigen oligomers. Nat Struct Mol Biol. 2010 Nov; 17(11):1383-90. PMID: 21037566; PMCID: PMC3133606.
    78. Prell JS, Correra TC, Chang TM, Biles JA, Williams E. Entropy drives an attached water molecule from the C- to N-terminus on protonated proline. J Am Chem Soc. 2010 Oct 27; 132(42):14733-5. PMID: 20886878.
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    79. Donald WA, Williams E. An improved cluster pair correlation method for obtaining the absolute proton hydration energy and enthalpy evaluated with an expanded data set. J Phys Chem B. 2010 Oct 21; 114(41):13189-200. PMID: 20863092.
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    80. Sterling HJ, Williams E. Real-time hydrogen/deuterium exchange kinetics via supercharged electrospray ionization tandem mass spectrometry. Anal Chem. 2010 Nov 01; 82(21):9050-7. PMID: 20942406.
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    81. Sterling HJ, Daly MP, Feld GK, Thoren KL, Kintzer AF, Krantz BA, Williams E. Effects of supercharging reagents on noncovalent complex structure in electrospray ionization from aqueous solutions. J Am Soc Mass Spectrom. 2010 Oct; 21(10):1762-74. PMID: 20673639; PMCID: PMC3141049.
    82. O'Brien JT, Prell JS, Bush MF, Williams E. Sulfate ion patterns water at long distance. J Am Chem Soc. 2010 Jun 23; 132(24):8248-9. PMID: 20518523.
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    83. Prell JS, Chang TM, O'Brien JT, Williams E. Hydration isomers of protonated phenylalanine and derivatives: relative stabilities from infrared photodissociation. J Am Chem Soc. 2010 Jun 09; 132(22):7811-9. PMID: 20469865.
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    84. Donald WA, Leib RD, Demireva M, Negru B, Neumark DM, Williams E. "Weighing" photon energies with mass spectrometry: effects of water on ion fluorescence. J Am Chem Soc. 2010 May 26; 132(20):6904-5. PMID: 20438075.
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    85. Kintzer AF, Sterling HJ, Tang II, Abdul-Gader A, Miles AJ, Wallace BA, Williams E, Krantz BA. Role of the protective antigen octamer in the molecular mechanism of anthrax lethal toxin stabilization in plasma. J Mol Biol. 2010 Jun 25; 399(5):741-58. PMID: 20433851; PMCID: PMC2892534.
    86. Donald WA, Demireva M, Leib RD, Aiken MJ, Williams E. Electron hydration and ion-electron pairs in water clusters containing trivalent metal ions. J Am Chem Soc. 2010 Apr 07; 132(13):4633-40. PMID: 20218722.
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    87. Demireva M, Williams E. Measuring internal energy deposition in collisional activation using hydrated ion nanocalorimetry to obtain peptide dissociation energies and entropies. J Am Soc Mass Spectrom. 2010 Jul; 21(7):1133-43. PMID: 20363645.
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    88. Flick TG, Leib RD, Williams E. Direct standard-free quantitation of Tamiflu and other pharmaceutical tablets using clustering agents with electrospray ionization mass spectrometry. Anal Chem. 2010 Feb 15; 82(4):1179-82. PMID: 20092258; PMCID: PMC2821454.
    89. Sterling HJ, Batchelor JD, Wemmer DE, Williams E. Effects of buffer loading for electrospray ionization mass spectrometry of a noncovalent protein complex that requires high concentrations of essential salts. J Am Soc Mass Spectrom. 2010 Jun; 21(6):1045-9. PMID: 20226685; PMCID: PMC2893594.
    90. Prell JS, O'Brien JT, Williams E. IRPD spectroscopy and ensemble measurements: effects of different data acquisition and analysis methods. J Am Soc Mass Spectrom. 2010 May; 21(5):800-9. PMID: 20185332.
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    91. Prell JS, Flick TG, Oomens J, Berden G, Williams E. Coordination of trivalent metal cations to peptides: results from IRMPD spectroscopy and theory. J Phys Chem A. 2010 Jan 21; 114(2):854-60. PMID: 19950916.
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    92. Chung MK, Riby J, Li H, Iavarone AT, Williams E, Zheng Y, Rappaport SM. A sandwich enzyme-linked immunosorbent assay for adducts of polycyclic aromatic hydrocarbons with human serum albumin. Anal Biochem. 2010 May 01; 400(1):123-9. PMID: 20083082; PMCID: PMC2842209.
    93. Funk WE, Li H, Iavarone AT, Williams E, Riby J, Rappaport SM. Enrichment of cysteinyl adducts of human serum albumin. Anal Biochem. 2010 May 01; 400(1):61-8. PMID: 20074543; PMCID: PMC2835821.
    94. Donald WA, Williams E. Measuring the extent and width of internal energy deposition in ion activation using nanocalorimetry. J Am Soc Mass Spectrom. 2010 Apr; 21(4):615-25. PMID: 20106678.
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    95. Flick TG, Leib RD, Williams E. Standard-free quantitation of mixtures using clusters formed by electrospray mass spectrometry. Anal Chem. 2009 Oct 15; 81(20):8434-40. PMID: 19754104; PMCID: PMC2761983.
    96. Donald WA, Leib RD, Demireva M, O'Brien JT, Prell JS, Williams E. Directly relating reduction energies of gaseous Eu(H2O)n(3+), n = 55-140, to aqueous solution: the absolute SHE potential and real proton solvation energy. J Am Chem Soc. 2009 Sep 23; 131(37):13328-37. PMID: 19711981; PMCID: PMC2909332.
    97. Bush MF, O'Brien JT, Prell JS, Wu CC, Saykally RJ, Williams E. Hydration of alkaline earth metal dications: effects of metal ion size determined using infrared action spectroscopy. J Am Chem Soc. 2009 Sep 23; 131(37):13270-7. PMID: 19754186.
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    98. Batchelor JD, Sterling HJ, Hong E, Williams E, Wemmer DE. Receiver domains control the active-state stoichiometry of Aquifex aeolicus sigma54 activator NtrC4, as revealed by electrospray ionization mass spectrometry. J Mol Biol. 2009 Oct 30; 393(3):634-43. PMID: 19699748; PMCID: PMC2763505.
    99. Prell JS, O'Brien JT, Steill JD, Oomens J, Williams E. Structures of protonated dipeptides: the role of arginine in stabilizing salt bridges. J Am Chem Soc. 2009 Aug 19; 131(32):11442-9. PMID: 19624125.
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    100. Kintzer AF, Thoren KL, Sterling HJ, Dong KC, Feld GK, Tang II, Zhang TT, Williams E, Berger JM, Krantz BA. The protective antigen component of anthrax toxin forms functional octameric complexes. J Mol Biol. 2009 Sep 25; 392(3):614-29. PMID: 19627991; PMCID: PMC2742380.
    101. Sterling HJ, Williams E. Origin of supercharging in electrospray ionization of noncovalent complexes from aqueous solution. J Am Soc Mass Spectrom. 2009 Oct; 20(10):1933-43. PMID: 19682923; PMCID: PMC2789484.
    102. Donald WA, Leib RD, O'Brien JT, Williams E. Directly relating gas-phase cluster measurements to solution-phase hydrolysis, the absolute standard hydrogen electrode potential, and the absolute proton solvation energy. Chemistry. 2009 Jun 08; 15(24):5926-34. PMID: 19440999; PMCID: PMC2757329.
    103. Leib RD, Flick TG, Williams E. Direct quantitation of peptide mixtures without standards using clusters formed by electrospray ionization mass spectrometry. Anal Chem. 2009 May 15; 81(10):3965-72. PMID: 19354265; PMCID: PMC4251781.
    104. Prell JS, Williams E. Structures of thermal, mass-selected water clusters probed with hydrophobic ion tags and infrared photodissociation spectroscopy. J Am Chem Soc. 2009 Mar 25; 131(11):4110-9. PMID: 19292492.
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    105. O'Brien JT, Prell JS, Steill JD, Oomens J, Williams E. Changes in binding motif of protonated heterodimers containing valine and amines investigated using IRMPD spectroscopy between 800 and 3700 cm(-1) and theory. J Am Chem Soc. 2009 Mar 25; 131(11):3905-12. PMID: 19256491.
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    106. Prell JS, Demireva M, Oomens J, Williams E. Role of sequence in salt-bridge formation for alkali metal cationized GlyArg and ArgGly investigated with IRMPD spectroscopy and theory. J Am Chem Soc. 2009 Jan 28; 131(3):1232-42. PMID: 19117387.
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    107. Bush MF, Oomens J, Williams E. Proton affinity and zwitterion stability: new results from infrared spectroscopy and theory of cationized lysine and analogues in the gas phase. J Phys Chem A. 2009 Jan 15; 113(2):431-8. PMID: 19128186.
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    108. Bush MF, Saykally RJ, Williams E. Infrared action spectra of Ca2+(H2O)(11-69) exhibit spectral signatures for condensed-phase structures with increasing cluster size. J Am Chem Soc. 2008 Nov 19; 130(46):15482-9. PMID: 18939831.
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    109. Holm AI, Donald WA, Hvelplund P, Larsen MK, Nielsen SB, Williams E. Investigation of energy deposited by femtosecond electron transfer in collisions using hydrated ion nanocalorimetry. J Phys Chem A. 2008 Oct 30; 112(43):10721-7. PMID: 18834102; PMCID: PMC2646606.
    110. O'Brien JT, Prell JS, Steill JD, Oomens J, Williams E. Interactions of mono- and divalent metal ions with aspartic and glutamic acid investigated with IR photodissociation spectroscopy and theory. J Phys Chem A. 2008 Oct 30; 112(43):10823-30. PMID: 18828579.
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    111. Prell JS, O'Brien JT, Holm AI, Leib RD, Donald WA, Williams E. Electron capture by a hydrated gaseous peptide: effects of water on fragmentation and molecular survival. J Am Chem Soc. 2008 Sep 24; 130(38):12680-9. PMID: 18761457; PMCID: PMC2673717.
    112. Bush MF, Oomens J, Saykally RJ, Williams E. Alkali metal ion binding to glutamine and glutamine derivatives investigated by infrared action spectroscopy and theory. J Phys Chem A. 2008 Sep 18; 112(37):8578-84. PMID: 18714968.
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    113. Donald WA, Leib RD, O'Brien JT, Holm AI, Williams E. Nanocalorimetry in mass spectrometry: a route to understanding ion and electron solvation. Proc Natl Acad Sci U S A. 2008 Nov 25; 105(47):18102-7. PMID: 18687894; PMCID: PMC2587548.
    114. Bush MF, Saykally RJ, Williams E. Reactivity and infrared spectroscopy of gaseous hydrated trivalent metal ions. J Am Chem Soc. 2008 Jul 16; 130(28):9122-8. PMID: 18558673.
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    115. O'Brien JT, Williams E. Hydration of gaseous copper dications probed by IR action spectroscopy. J Phys Chem A. 2008 Jul 03; 112(26):5893-901. PMID: 18543884.
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    116. Bush MF, Oomens J, Saykally RJ, Williams E. Effects of alkaline earth metal ion complexation on amino acid zwitterion stability: results from infrared action spectroscopy. J Am Chem Soc. 2008 May 21; 130(20):6463-71. PMID: 18444620.
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    117. Donald WA, Williams E. Evaluation of different implementations of the Thomson liquid drop model: comparison to monovalent and divalent cluster ion experimental data. J Phys Chem A. 2008 Apr 24; 112(16):3515-22. PMID: 18358015; PMCID: PMC2562779.
    118. O'Brien JT, Prell JS, Holm AI, Williams E. Effects of electron kinetic energy and ion-electron inelastic collisions in electron capture dissociation measured using ion nanocalorimetry. J Am Soc Mass Spectrom. 2008 Jun; 19(6):772-9. PMID: 18372190; PMCID: PMC2435054.
    119. Donald WA, Leib RD, O'Brien JT, Bush MF, Williams E. Absolute standard hydrogen electrode potential measured by reduction of aqueous nanodrops in the gas phase. J Am Chem Soc. 2008 Mar 19; 130(11):3371-81. PMID: 18288835; PMCID: PMC2562797.
    120. Forbes MW, Bush MF, Polfer NC, Oomens J, Dunbar RC, Williams E, Jockusch RA. Infrared spectroscopy of arginine cation complexes: direct observation of gas-phase zwitterions. J Phys Chem A. 2007 Nov 22; 111(46):11759-70. PMID: 17973465.
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    121. Bush MF, Saykally RJ, Williams E. Hydration of the calcium dication: direct evidence for second shell formation from infrared spectroscopy. Chemphyschem. 2007 Oct 22; 8(15):2245-53. PMID: 17876863.
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    122. Bush MF, Prell JS, Saykally RJ, Williams E. One water molecule stabilizes the cationized arginine zwitterion. J Am Chem Soc. 2007 Nov 07; 129(44):13544-53. PMID: 17929811.
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    123. Holm AI, Hvelplund P, Kadhane U, Larsen MK, Liu B, Nielsen SB, Panja S, Pedersen JM, Skrydstrup T, Støchkel K, Williams E, Worm ES. On the mechanism of electron-capture-induced dissociation of peptide dications from 15n-labeling and crown-ether complexation. J Phys Chem A. 2007 Oct 04; 111(39):9641-3. PMID: 17850054.
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    124. Bush MF, Forbes MW, Jockusch RA, Oomens J, Polfer NC, Saykally RJ, Williams E. Infrared spectroscopy of cationized lysine and epsilon-N-methyllysine in the gas phase: effects of alkali-metal ion size and proton affinity on zwitterion stability. J Phys Chem A. 2007 Aug 16; 111(32):7753-60. PMID: 17636967.
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    125. Leib RD, Donald WA, O'Brien JT, Bush MF, Williams E. Reduction energy of 1 M aqueous ruthenium(III) hexaammine in the gas phase: a route toward establishing an absolute electrochemical scale. J Am Chem Soc. 2007 Jun 27; 129(25):7716-7. PMID: 17542579; PMCID: PMC2565573.
    126. Leib RD, Donald WA, Bush MF, O'Brien JT, Williams E. Nonergodicity in electron capture dissociation investigated using hydrated ion nanocalorimetry. J Am Soc Mass Spectrom. 2007 Jul; 18(7):1217-31. PMID: 17521917; PMCID: PMC2034202.
    127. Leib RD, Donald WA, Bush MF, O'brien JT, Williams E. Internal energy deposition in electron capture dissociation measured using hydrated divalent metal ions as nanocalorimeters. J Am Chem Soc. 2007 Apr 25; 129(16):4894-5. PMID: 17394314; PMCID: PMC2560990.
    128. Bush MF, Saykally RJ, Williams E. Evidence for water rings in the hexahydrated sulfate dianion from IR spectroscopy. J Am Chem Soc. 2007 Feb 28; 129(8):2220-1. PMID: 17266315.
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    129. Bush MF, O'Brien JT, Prell JS, Saykally RJ, Williams E. Infrared spectroscopy of cationized arginine in the gas phase: direct evidence for the transition from nonzwitterionic to zwitterionic structure. J Am Chem Soc. 2007 Feb 14; 129(6):1612-22. PMID: 17249666; PMCID: PMC2675882.
    130. Robinson EW, Sellon RE, Williams E. Peak deconvolution in high-field asymmetric waveform ion mobility spectrometry (FAIMS) to characterize macromolecular conformations. Int J Mass Spectrom. 2007 Jan 01; 259(1-3):87-95. PMID: 19079801.
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    131. Chakraborty T, Holm AI, Hvelplund P, Nielsen SB, Poully JC, Worm ES, Williams E. On the survival of peptide cations after electron capture: role of internal hydrogen bonding and microsolvation. J Am Soc Mass Spectrom. 2006 Dec; 17(12):1675-80. PMID: 16926097.
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    132. Robinson EW, Leib RD, Williams E. The role of conformation on electron capture dissociation of ubiquitin. J Am Soc Mass Spectrom. 2006 Oct; 17(10):1470-1479. PMID: 16890453.
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    133. Lemoff AS, Bush MF, O'Brien JT, Williams E. Structures of lithiated lysine and structural analogues in the gas phase: effects of water and proton affinity on zwitterionic stability. J Phys Chem A. 2006 Jul 13; 110(27):8433-42. PMID: 16821826.
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    134. Bush MF, Saykally RJ, Williams E. Formation of hydrated triply charged metal ions from aqueous solutions using nanodrop mass spectrometry. Int J Mass Spectrom. 2006 Jul 01; 253(3):256-262. PMID: 19081753.
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    135. Krishnaswamy SR, Williams E, Kirsch JF. Free energies of protein-protein association determined by electrospray ionization mass spectrometry correlate accurately with values obtained by solution methods. Protein Sci. 2006 Jun; 15(6):1465-75. PMID: 16731980; PMCID: PMC2242526.
    136. Robinson EW, Garcia DE, Leib RD, Williams E. Enhanced mixture analysis of poly(ethylene glycol) using high-field asymmetric waveform ion mobility spectrometry combined with fourier transform ion cyclotron resonance mass spectrometry. Anal Chem. 2006 Apr 01; 78(7):2190-8. PMID: 16579597; PMCID: PMC2562220.
    137. Lemoff AS, Wu CC, Bush MF, Williams E. Binding energies of water to doubly hydrated cationized glutamine and structural analogues in the gas phase. J Phys Chem A. 2006 Mar 16; 110(10):3662-9. PMID: 16526649.
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    138. Kamariotis A, Boyarkin OV, Mercier SR, Beck RD, Bush MF, Williams E, Rizzo TR. Infrared spectroscopy of hydrated amino acids in the gas phase: protonated and lithiated valine. J Am Chem Soc. 2006 Jan 25; 128(3):905-16. PMID: 16417381.
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    139. Robinson EW, Williams E. Multidimensional separations of ubiquitin conformers in the gas phase: relating ion cross sections to H/D exchange measurements. J Am Soc Mass Spectrom. 2005 Sep; 16(9):1427-1437. PMID: 16023362.
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    140. Lemoff AS, Bush MF, Wu CC, Williams E. Structures and hydration enthalpies of cationized glutamine and structural analogues in the gas phase. J Am Chem Soc. 2005 Jul 27; 127(29):10276-86. PMID: 16028939.
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    141. Wong RL, Williams E, Counterman AE, Clemmer DE. Evaluation of ion mobility spectroscopy for determining charge-solvated versus salt-bridge structures of protonated trimers. J Am Soc Mass Spectrom. 2005 Jul; 16(7):1009-19. PMID: 15914022.
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    142. Lemoff AS, Bush MF, Williams E. Structures of cationized proline analogues: evidence for the zwitterionic form. J Phys Chem A. 2005 Mar 10; 109(9):1903-10. PMID: 16833523.
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    143. Jurchen JC, Garcia DE, Williams E. Further studies on the origins of asymmetric charge partitioning in protein homodimers. J Am Soc Mass Spectrom. 2004 Oct; 15(10):1408-1415. PMID: 15465353.
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    144. Iavarone AT, Udekwu OA, Williams E. Buffer loading for counteracting metal salt-induced signal suppression in electrospray ionization. Anal Chem. 2004 Jul 15; 76(14):3944-50. PMID: 15253628; PMCID: PMC1343452.
    145. Lemoff AS, Williams E. Binding energies of water to lithiated valine: formation of solution-phase structure in vacuo. J Am Soc Mass Spectrom. 2004 Jul; 15(7):1014-24. PMID: 15234361.
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    146. Iavarone AT, Paech K, Williams E. Effects of charge state and cationizing agent on the electron capture dissociation of a peptide. Anal Chem. 2004 Apr 15; 76(8):2231-8. PMID: 15080732; PMCID: PMC1343469.
    147. Jurchen JC, Garcia DE, Williams E. Gas-phase dissociation pathways of multiply charged peptide clusters. J Am Soc Mass Spectrom. 2003 Dec; 14(12):1373-86. PMID: 14652186; PMCID: PMC1343450.
    148. Jurchen JC, Cooper RE, Williams E. The role of acidic residues and of sodium ion adduction on the gas-phase H/D exchange of peptides and peptide dimers. J Am Soc Mass Spectrom. 2003 Dec; 14(12):1477-87. PMID: 14652194; PMCID: PMC1343451.
    149. Lemoff AS, Bush MF, Williams E. Binding energies of water to sodiated valine and structural isomers in the gas phase: the effect of proton affinity on zwitterion stability. J Am Chem Soc. 2003 Nov 05; 125(44):13576-84. PMID: 14583055.
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    150. Iavarone AT, Williams E. Collisionally activated dissociation of supercharged proteins formed by electrospray ionization. Anal Chem. 2003 Sep 01; 75(17):4525-33. PMID: 14632060; PMCID: PMC1343449.
    151. Kelley WP, Wolters AM, Sack JT, Jockusch RA, Jurchen JC, Williams E, Sweedler JV, Gilly WF. Characterization of a novel gastropod toxin (6-bromo-2-mercaptotryptamine) that inhibits shaker K channel activity. J Biol Chem. 2003 Sep 12; 278(37):34934-42. PMID: 12815055.
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    152. Jurchen JC, Williams E. Origin of asymmetric charge partitioning in the dissociation of gas-phase protein homodimers. J Am Chem Soc. 2003 Mar 05; 125(9):2817-26. PMID: 12603172; PMCID: PMC1325210.
    153. Iavarone AT, Williams E. Mechanism of charging and supercharging molecules in electrospray ionization. J Am Chem Soc. 2003 Feb 26; 125(8):2319-27. PMID: 12590562; PMCID: PMC1343448.
    154. Gross DS, Williams E. On the dissociation and conformation of gas-phase methonium ions. Int J Mass Spectrom Ion Process. 1996 Dec 20; 157-158:305-318. PMID: 16479265.
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