Isacoff, Ehud

TitleBiologist Faculty
InstitutionLawrence Berkeley National Lab
DepartmentMolecular Biophys & Integ Bio
Address1 Cyclotron Road
Berkeley CA 94720
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Tochitsky I, Kienzler MA, Isacoff E, Kramer RH. Restoring Vision to the Blind with Chemical Photoswitches. Chem Rev. 2018 Jun 06. PMID: 29874052.
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    2. Xiao T, Ackerman CM, Carroll EC, Jia S, Hoagland A, Chan J, Thai B, Liu CS, Isacoff E, Chang CJ. Copper regulates rest-activity cycles through the locus coeruleus-norepinephrine system. Nat Chem Biol. 2018 Jun 04. PMID: 29867144.
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    3. Berry MH, Holt A, Levitz J, Broichhagen J, Gaub BM, Visel M, Stanley C, Aghi K, Kim YJ, Cao K, Kramer RH, Trauner D, Flannery J, Isacoff E. Author Correction: Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor. Nat Commun. 2018 Mar 13; 9(1):1112. PMID: 29535310.
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    4. Gaub BM, Berry MH, Visel M, Holt A, Isacoff E, Flannery JG. Optogenetic Retinal Gene Therapy with the Light Gated GPCR Vertebrate Rhodopsin. Methods Mol Biol. 2018; 1715:177-189. PMID: 29188513.
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    5. Donthamsetti PC, Winter N, Schönberger M, Levitz J, Stanley C, Javitch JA, Isacoff E, Trauner D. Optical Control of Dopamine Receptors Using a Photoswitchable Tethered Inverse Agonist. J Am Chem Soc. 2017 Dec 27; 139(51):18522-18535. PMID: 29166564.
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    6. Berry MH, Holt A, Levitz J, Broichhagen J, Gaub BM, Visel M, Stanley C, Aghi K, Kim YJ, Cao K, Kramer RH, Trauner D, Flannery J, Isacoff E. Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor. Nat Commun. 2017 Nov 30; 8(1):1862. PMID: 29192252.
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    7. Kienzler MA, Isacoff E. Precise modulation of neuronal activity with synthetic photoswitchable ligands. Curr Opin Neurobiol. 2017 08; 45:202-209. PMID: 28690101.
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    8. Palty R, Fu Z, Isacoff E. Sequential Steps of CRAC Channel Activation. Cell Rep. 2017 05 30; 19(9):1929-1939. PMID: 28564609.
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    9. Berlin S, Isacoff E. Synapses in the spotlight with synthetic optogenetics. EMBO Rep. 2017 05; 18(5):677-692. PMID: 28396573.
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    10. Levitz J, Broichhagen J, Leippe P, Konrad D, Trauner D, Isacoff E. Dual optical control and mechanistic insights into photoswitchable group II and III metabotropic glutamate receptors. Proc Natl Acad Sci U S A. 2017 04 25; 114(17):E3546-E3554. PMID: 28396447.
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    11. Pantoja C, Hoagland A, Carroll E, Schoppik D, Isacoff E. Measuring Behavioral Individuality in the Acoustic Startle Behavior in Zebrafish. Bio Protoc. 2017 Apr 05; 7(7). PMID: 28752108.
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    12. Tomczak AP, Fernández-Trillo J, Bharill S, Papp F, Panyi G, Stühmer W, Isacoff E, Pardo LA. A new mechanism of voltage-dependent gating exposed by KV10.1 channels interrupted between voltage sensor and pore. J Gen Physiol. 2017 May 01; 149(5):577-593. PMID: 28360219.
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    13. Newman ZL, Hoagland A, Aghi K, Worden K, Levy SL, Son JH, Lee LP, Isacoff E. Input-Specific Plasticity and Homeostasis at the Drosophila Larval Neuromuscular Junction. Neuron. 2017 Mar 22; 93(6):1388-1404.e10. PMID: 28285823.
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    14. Levitz J, Habrian C, Bharill S, Fu Z, Vafabakhsh R, Isacoff E. Mechanism of Assembly and Cooperativity of Homomeric and Heteromeric Metabotropic Glutamate Receptors. Neuron. 2016 Oct 05; 92(1):143-159. PMID: 27641494.
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    15. Pantoja C, Hoagland A, Carroll EC, Karalis V, Conner A, Isacoff E. Neuromodulatory Regulation of Behavioral Individuality in Zebrafish. Neuron. 2016 Aug 03; 91(3):587-601. PMID: 27397519; PMCID: PMC4976045 [Available on 08/03/17].
    16. Chen Y, Bharill S, O'Hagan R, Isacoff E, Chalfie M. MEC-10 and MEC-19 Reduce the Neurotoxicity of the MEC-4(d) DEG/ENaC Channel in Caenorhabditis elegans. G3 (Bethesda). 2016 04 07; 6(4):1121-30. PMID: 27172609.
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    17. Huang Y, Bharill S, Karandur D, Peterson SM, Marita M, Shi X, Kaliszewski MJ, Smith AW, Isacoff E, Kuriyan J. Molecular basis for multimerization in the activation of the epidermal growth factor receptor. Elife. 2016 03 28; 5. PMID: 27017828; PMCID: PMC4902571.
    18. Levitz J, Royal P, Comoglio Y, Wdziekonski B, Schaub S, Clemens DM, Isacoff E, Sandoz G. Heterodimerization within the TREK channel subfamily produces a diverse family of highly regulated potassium channels. Proc Natl Acad Sci U S A. 2016 Apr 12; 113(15):4194-9. PMID: 27035963; PMCID: PMC4839437 [Available on 10/12/16].
    19. Sprowl JA, Ong SS, Gibson AA, Hu S, Du G, Lin W, Li L, Bharill S, Ness RA, Stecula A, Offer SM, Diasio RB, Nies AT, Schwab M, Cavaletti G, Schlatter E, Ciarimboli G, Schellens JH, Isacoff E, Sali A, Chen T, Baker SD, Sparreboom A, Pabla N. A phosphotyrosine switch regulates organic cation transporters. Nat Commun. 2016 Mar 16; 7:10880. PMID: 26979622; PMCID: PMC4799362.
    20. Chen Y, Bharill S, Altun Z, O'Hagan R, Coblitz B, Isacoff E, Chalfie M. Caenorhabditis elegans paraoxonase-like proteins control the functional expression of DEG/ENaC mechanosensory proteins. Mol Biol Cell. 2016 Apr 15; 27(8):1272-85. PMID: 26941331.
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    21. Berlin S, Szobota S, Reiner A, Carroll EC, Kienzler MA, Guyon A, Xiao T, Trauner D, Isacoff E. A family of photoswitchable NMDA receptors. Elife. 2016 Mar 01; 5. PMID: 26929991; PMCID: PMC4786437.
    22. Grimm SS, Isacoff E. Allosteric substrate switching in a voltage-sensing lipid phosphatase. Nat Chem Biol. 2016 Apr; 12(4):261-7. PMID: 26878552; PMCID: PMC4798927.
    23. Levitz J, Popescu AT, Reiner A, Isacoff E. A Toolkit for Orthogonal and in vivo Optical Manipulation of Ionotropic Glutamate Receptors. Front Mol Neurosci. 2016; 9:2. PMID: 26869877; PMCID: PMC4735401.
    24. Barber DM, Schönberger M, Burgstaller J, Levitz J, Weaver CD, Isacoff E, Baier H, Trauner D. Optical control of neuronal activity using a light-operated GIRK channel opener (LOGO). Chem Sci. 2016; 7(3):2347-2352. PMID: 28090283.
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    25. Palty R, Isacoff E. Cooperative Binding of Stromal Interaction Molecule 1 (STIM1) to the N and C Termini of Calcium Release-activated Calcium Modulator 1 (Orai1). J Biol Chem. 2016 Jan 01; 291(1):334-41. PMID: 26546674; PMCID: PMC4697168 [Available on 01/01/17].
    26. Broichhagen J, Damijonaitis A, Levitz J, Sokol KR, Leippe P, Konrad D, Isacoff E, Trauner D. Orthogonal Optical Control of a G Protein-Coupled Receptor with a SNAP-Tethered Photochromic Ligand. ACS Cent Sci. 2015 Oct 28; 1(7):383-93. PMID: 27162996; PMCID: PMC4827557.
    27. Chen Y, Bharill S, Isacoff E, Chalfie M. Subunit composition of a DEG/ENaC mechanosensory channel of Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2015 Sep 15; 112(37):11690-5. PMID: 26324944; PMCID: PMC4577206.
    28. Vafabakhsh R, Levitz J, Isacoff E. Conformational dynamics of a class C G-protein-coupled receptor. Nature. 2015 Aug 27; 524(7566):497-501. PMID: 26258295; PMCID: PMC4597782.
    29. Berlin S, Carroll EC, Newman ZL, Okada HO, Quinn CM, Kallman B, Rockwell NC, Martin SS, Lagarias JC, Isacoff E. Photoactivatable genetically encoded calcium indicators for targeted neuronal imaging. Nat Methods. 2015 Sep; 12(9):852-8. PMID: 26167640; PMCID: PMC4597790.
    30. Gaub BM, Berry MH, Holt AE, Isacoff E, Flannery JG. Optogenetic Vision Restoration Using Rhodopsin for Enhanced Sensitivity. Mol Ther. 2015 Oct; 23(10):1562-71. PMID: 26137852; PMCID: PMC4817926.
    31. Palty R, Stanley C, Isacoff E. Critical role for Orai1 C-terminal domain and TM4 in CRAC channel gating. Cell Res. 2015 Aug; 25(8):963-80. PMID: 26138675; PMCID: PMC4528054.
    32. Mony L, Berger TK, Isacoff E. A specialized molecular motion opens the Hv1 voltage-gated proton channel. Nat Struct Mol Biol. 2015 Apr; 22(4):283-290. PMID: 25730777; PMCID: PMC4385474.
    33. Ball RW, Peled ES, Guerrero G, Isacoff E. BMP signaling and microtubule organization regulate synaptic strength. Neuroscience. 2015 Apr 16; 291:155-66. PMID: 25681521; PMCID: PMC4369397.
    34. Carroll EC, Berlin S, Levitz J, Kienzler MA, Yuan Z, Madsen D, Larsen DS, Isacoff E. Two-photon brightness of azobenzene photoswitches designed for glutamate receptor optogenetics. Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7):E776-85. PMID: 25653339; PMCID: PMC4343171.
    35. Reiner A, Levitz J, Isacoff E. Controlling ionotropic and metabotropic glutamate receptors with light: principles and potential. Curr Opin Pharmacol. 2015 Feb; 20:135-43. PMID: 25573450; PMCID: PMC4318769.
    36. Berger TK, Isacoff E. Fluorescent labeling for patch-clamp fluorometry (PCF) measurements of real-time protein motion in ion channels. Methods Mol Biol. 2015; 1266:93-106. PMID: 25560069.
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    37. Gaub BM, Berry MH, Holt AE, Reiner A, Kienzler MA, Dolgova N, Nikonov S, Aguirre GD, Beltran WA, Flannery JG, Isacoff E. Restoration of visual function by expression of a light-gated mammalian ion channel in retinal ganglion cells or ON-bipolar cells. Proc Natl Acad Sci U S A. 2014 Dec 23; 111(51):E5574-83. PMID: 25489083; PMCID: PMC4280620.
    38. Friedmann D, Hoagland A, Berlin S, Isacoff E. A spinal opsin controls early neural activity and drives a behavioral light response. Curr Biol. 2015 Jan 05; 25(1):69-74. PMID: 25484291; PMCID: PMC4286461.
    39. Rullo A, Reiner A, Reiter A, Trauner D, Isacoff E, Woolley GA. Long wavelength optical control of glutamate receptor ion channels using a tetra-ortho-substituted azobenzene derivative. Chem Commun (Camb). 2014 Dec 04; 50(93):14613-5. PMID: 25311049.
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    40. Comoglio Y, Levitz J, Kienzler MA, Lesage F, Isacoff E, Sandoz G. Phospholipase D2 specifically regulates TREK potassium channels via direct interaction and local production of phosphatidic acid. Proc Natl Acad Sci U S A. 2014 Sep 16; 111(37):13547-52. PMID: 25197053; PMCID: PMC4169921.
    41. Fogel H, Frere S, Segev O, Bharill S, Shapira I, Gazit N, O'Malley T, Slomowitz E, Berdichevsky Y, Walsh DM, Isacoff E, Hirsch JA, Slutsky I. APP homodimers transduce an amyloid-ß-mediated increase in release probability at excitatory synapses. Cell Rep. 2014 Jun 12; 7(5):1560-1576. PMID: 24835997.
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    42. Bharill S, Fu Z, Palty R, Isacoff E. Stoichiometry and specific assembly of Best ion channels. Proc Natl Acad Sci U S A. 2014 Apr 29; 111(17):6491-6. PMID: 24748110; PMCID: PMC4035945.
    43. Reiner A, Isacoff E. Tethered ligands reveal glutamate receptor desensitization depends on subunit occupancy. Nat Chem Biol. 2014 Apr; 10(4):273-80. PMID: 24561661; PMCID: PMC4041372.
    44. Peled ES, Newman ZL, Isacoff E. Evoked and spontaneous transmission favored by distinct sets of synapses. Curr Biol. 2014 Mar 03; 24(5):484-93. PMID: 24560571; PMCID: PMC4017949.
    45. Reiner A, Isacoff E. Photoswitching of cell surface receptors using tethered ligands. Methods Mol Biol. 2014; 1148:45-68. PMID: 24718794.
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    46. Kienzler MA, Reiner A, Trautman E, Yoo S, Trauner D, Isacoff E. A red-shifted, fast-relaxing azobenzene photoswitch for visible light control of an ionotropic glutamate receptor. J Am Chem Soc. 2013 Nov 27; 135(47):17683-6. PMID: 24171511; PMCID: PMC3990231.
    47. Isacoff E, Jan LY, Minor DL. Conduits of life's spark: a perspective on ion channel research since the birth of neuron. Neuron. 2013 Oct 30; 80(3):658-74. PMID: 24183018; PMCID: PMC3867263.
    48. Reiner A, Isacoff E. The Brain Prize 2013: the optogenetics revolution. Trends Neurosci. 2013 Oct; 36(10):557-60. PMID: 24054067.
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    49. Reiner A, Levitz J, Isacoff E. Bringing optogenetics to the synapse. Neuron. 2013 Jul 24; 79(2):209-10. PMID: 23889927.
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    50. Patti J, Isacoff E. Measuring membrane voltage with fluorescent proteins. Cold Spring Harb Protoc. 2013 Jul 01; 2013(7):606-13. PMID: 23818671.
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    51. Kauwe G, Isacoff E. Rapid feedback regulation of synaptic efficacy during high-frequency activity at the Drosophila larval neuromuscular junction. Proc Natl Acad Sci U S A. 2013 May 28; 110(22):9142-7. PMID: 23674684; PMCID: PMC3670382.
    52. Hastie P, Ulbrich MH, Wang HL, Arant RJ, Lau AG, Zhang Z, Isacoff E, Chen L. AMPA receptor/TARP stoichiometry visualized by single-molecule subunit counting. Proc Natl Acad Sci U S A. 2013 Mar 26; 110(13):5163-8. PMID: 23479622; PMCID: PMC3612642.
    53. Levitz J, Pantoja C, Gaub B, Janovjak H, Reiner A, Hoagland A, Schoppik D, Kane B, Stawski P, Schier AF, Trauner D, Isacoff E. Optical control of metabotropic glutamate receptors. Nat Neurosci. 2013 Apr; 16(4):507-16. PMID: 23455609; PMCID: PMC3681425.
    54. Sandoz G, Isacoff E. [Optical remote control of native ion channels]. Med Sci (Paris). 2012 Nov; 28(11):934-7. PMID: 23171896.
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    55. Sandoz G, Levitz J, Kramer RH, Isacoff E. Optical control of endogenous proteins with a photoswitchable conditional subunit reveals a role for TREK1 in GABA(B) signaling. Neuron. 2012 Jun 21; 74(6):1005-14. PMID: 22726831; PMCID: PMC3383668.
    56. Liu L, Kohout SC, Xu Q, Müller S, Kimberlin CR, Isacoff E, Minor DL. A glutamate switch controls voltage-sensitive phosphatase function. Nat Struct Mol Biol. 2012 May 06; 19(6):633-41. PMID: 22562138; PMCID: PMC3529583.
    57. Reiner A, Arant RJ, Isacoff E. Assembly stoichiometry of the GluK2/GluK5 kainate receptor complex. Cell Rep. 2012 Mar 29; 1(3):234-40. PMID: 22509486.
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    58. Ahrens KF, Heider B, Lee H, Isacoff E, Siegel RM. Two-photon scanning microscopy of in vivo sensory responses of cortical neurons genetically encoded with a fluorescent voltage sensor in rat. Front Neural Circuits. 2012; 6:15. PMID: 22461770; PMCID: PMC3310150.
    59. Jgamadze D, Bergen J, Stone D, Jang JH, Schaffer DV, Isacoff E, Pautot S. Colloids as mobile substrates for the implantation and integration of differentiated neurons into the mammalian brain. PLoS One. 2012; 7(1):e30293. PMID: 22295079; PMCID: PMC3266246.
    60. Li D, Hérault K, Isacoff E, Oheim M, Ropert N. Optogenetic activation of LiGluR-expressing astrocytes evokes anion channel-mediated glutamate release. J Physiol. 2012 Feb 15; 590(4):855-73. PMID: 22219341; PMCID: PMC3381315.
    61. Yu Y, Ulbrich MH, Li MH, Dobbins S, Zhang WK, Tong L, Isacoff E, Yang J. Molecular mechanism of the assembly of an acid-sensing receptor ion channel complex. Nat Commun. 2012; 3:1252. PMID: 23212381; PMCID: PMC3575195.
    62. Berger TK, Isacoff E. The pore of the voltage-gated proton channel. Neuron. 2011 Dec 22; 72(6):991-1000. PMID: 22196334; PMCID: PMC3244940.
    63. Warp E, Agarwal G, Wyart C, Friedmann D, Oldfield CS, Conner A, Del Bene F, Arrenberg AB, Baier H, Isacoff E. Emergence of patterned activity in the developing zebrafish spinal cord. Curr Biol. 2012 Jan 24; 22(2):93-102. PMID: 22197243; PMCID: PMC3267884.
    64. Findeisen F, Tolia A, Arant R, Kim EY, Isacoff E, Minor DL. Calmodulin overexpression does not alter Cav1.2 function or oligomerization state. Channels (Austin). 2011 Jul-Aug; 5(4):320-4. PMID: 21712653; PMCID: PMC3225732.
    65. Zhu J, Yu Y, Ulbrich MH, Li MH, Isacoff E, Honig B, Yang J. Structural model of the TRPP2/PKD1 C-terminal coiled-coil complex produced by a combined computational and experimental approach. Proc Natl Acad Sci U S A. 2011 Jun 21; 108(25):10133-8. PMID: 21642537; PMCID: PMC3121833.
    66. Caporale N, Kolstad KD, Lee T, Tochitsky I, Dalkara D, Trauner D, Kramer R, Dan Y, Isacoff E, Flannery JG. LiGluR restores visual responses in rodent models of inherited blindness. Mol Ther. 2011 Jul; 19(7):1212-9. PMID: 21610698; PMCID: PMC3129552.
    67. Peled ES, Isacoff E. Optical quantal analysis of synaptic transmission in wild-type and rab3-mutant Drosophila motor axons. Nat Neurosci. 2011 Apr; 14(4):519-26. PMID: 21378971.
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    68. Agarwal G, Isacoff E. Specializations of a pheromonal glomerulus in the Drosophila olfactory system. J Neurophysiol. 2011 Apr; 105(4):1711-21. PMID: 21289134; PMCID: PMC3075298.
    69. Sandoz G, Bell SC, Isacoff E. Optical probing of a dynamic membrane interaction that regulates the TREK1 channel. Proc Natl Acad Sci U S A. 2011 Feb 08; 108(6):2605-10. PMID: 21262820; PMCID: PMC3038738.
    70. Abuin L, Bargeton B, Ulbrich MH, Isacoff E, Kellenberger S, Benton R. Functional architecture of olfactory ionotropic glutamate receptors. Neuron. 2011 Jan 13; 69(1):44-60. PMID: 21220098; PMCID: PMC3050028.
    71. Janovjak H, Sandoz G, Isacoff E. A modern ionotropic glutamate receptor with a K(+) selectivity signature sequence. Nat Commun. 2011; 2:232. PMID: 21407198.
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    72. Heider B, Nathanson JL, Isacoff E, Callaway EM, Siegel RM. Two-photon imaging of calcium in virally transfected striate cortical neurons of behaving monkey. PLoS One. 2010 Nov 04; 5(11):e13829. PMID: 21079806; PMCID: PMC2973959.
    73. Del Bene F, Wyart C, Robles E, Tran A, Looger L, Scott EK, Isacoff E, Baier H. Filtering of visual information in the tectum by an identified neural circuit. Science. 2010 Oct 29; 330(6004):669-73. PMID: 21030657; PMCID: PMC3243732.
    74. Koprowski P, Grajkowski W, Isacoff E, Kubalski A. Genetic screen for potassium leaky small mechanosensitive channels (MscS) in Escherichia coli: recognition of cytoplasmic ß domain as a new gating element. J Biol Chem. 2011 Jan 07; 286(1):877-88. PMID: 20978126; PMCID: PMC3013047.
    75. Nakajo K, Ulbrich MH, Kubo Y, Isacoff E. Stoichiometry of the KCNQ1 - KCNE1 ion channel complex. Proc Natl Acad Sci U S A. 2010 Nov 02; 107(44):18862-7. PMID: 20962273; PMCID: PMC2973890.
    76. Kim EY, Rumpf CH, Van Petegem F, Arant RJ, Findeisen F, Cooley ES, Isacoff E, Minor DL. Multiple C-terminal tail Ca(2+)/CaMs regulate Ca(V)1.2 function but do not mediate channel dimerization. EMBO J. 2010 Dec 01; 29(23):3924-38. PMID: 20953164; PMCID: PMC3020648.
    77. Papagiakoumou E, Anselmi F, Bègue A, de Sars V, Glückstad J, Isacoff E, Emiliani V. Scanless two-photon excitation of channelrhodopsin-2. Nat Methods. 2010 Oct; 7(10):848-54. PMID: 20852649.
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    78. Lee H, Dean C, Isacoff E. Alternative splicing of neuroligin regulates the rate of presynaptic differentiation. J Neurosci. 2010 Aug 25; 30(34):11435-46. PMID: 20739565; PMCID: PMC3241922.
    79. Schwarzer C, Wong S, Shi J, Matthes E, Illek B, Ianowski JP, Arant RJ, Isacoff E, Vais H, Foskett JK, Maiellaro I, Hofer AM, Machen TE. Pseudomonas aeruginosa Homoserine lactone activates store-operated cAMP and cystic fibrosis transmembrane regulator-dependent Cl- secretion by human airway epithelia. J Biol Chem. 2010 Nov 05; 285(45):34850-63. PMID: 20739289; PMCID: PMC2966100.
    80. Janovjak H, Szobota S, Wyart C, Trauner D, Isacoff E. A light-gated, potassium-selective glutamate receptor for the optical inhibition of neuronal firing. Nat Neurosci. 2010 Aug; 13(8):1027-32. PMID: 20581843; PMCID: PMC2915903.
    81. Kohout SC, Bell SC, Liu L, Xu Q, Minor DL, Isacoff E. Electrochemical coupling in the voltage-dependent phosphatase Ci-VSP. Nat Chem Biol. 2010 May; 6(5):369-75. PMID: 20364128; PMCID: PMC2857593.
    82. Siegel MS, Isacoff E. Green fluorescent proteins (GFPs) for measuring voltage. Cold Spring Harb Protoc. 2010 Apr; 2010(4):pdb.top76. PMID: 20360380.
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    83. Szobota S, Isacoff E. Optical control of neuronal activity. Annu Rev Biophys. 2010; 39:329-48. PMID: 20192766.
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    84. Tombola F, Ulbrich MH, Kohout SC, Isacoff E. The opening of the two pores of the Hv1 voltage-gated proton channel is tuned by cooperativity. Nat Struct Mol Biol. 2010 Jan; 17(1):44-50. PMID: 20023640; PMCID: PMC2925041.
    85. Tombola F, Ulbrich MH, Isacoff E. Architecture and gating of Hv1 proton channels. J Physiol. 2009 Nov 15; 587(Pt 22):5325-9. PMID: 19915215; PMCID: PMC2793866.
    86. Kubo Y, Isacoff E. Dynamic aspects of functioning membrane proteins. J Physiol. 2009 Nov 15; 587(Pt 22):5315-6. PMID: 19915214; PMCID: PMC2793864.
    87. Isacoff E, Smith SJ. New technologies. Curr Opin Neurobiol. 2009 Oct; 19(5):511-2. PMID: 19896828.
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    88. Wyart C, Del Bene F, Warp E, Scott EK, Trauner D, Baier H, Isacoff E. Optogenetic dissection of a behavioural module in the vertebrate spinal cord. Nature. 2009 Sep 17; 461(7262):407-10. PMID: 19759620; PMCID: PMC2770190.
    89. Yu Y, Ulbrich MH, Li MH, Buraei Z, Chen XZ, Ong AC, Tong L, Isacoff E, Yang J. Structural and molecular basis of the assembly of the TRPP2/PKD1 complex. Proc Natl Acad Sci U S A. 2009 Jul 14; 106(28):11558-63. PMID: 19556541.
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    90. Martos V, Bell SC, Santos E, Isacoff E, Trauner D, de Mendoza J. Molecular recognition and self-assembly special feature: Calix[4]arene-based conical-shaped ligands for voltage-dependent potassium channels. Proc Natl Acad Sci U S A. 2009 Jun 30; 106(26):10482-6. PMID: 19435843; PMCID: PMC2705557.
    91. Numano R, Szobota S, Lau AY, Gorostiza P, Volgraf M, Roux B, Trauner D, Isacoff E. Nanosculpting reversed wavelength sensitivity into a photoswitchable iGluR. Proc Natl Acad Sci U S A. 2009 Apr 21; 106(16):6814-9. PMID: 19342491; PMCID: PMC2672514.
    92. Marriott G, Mao S, Sakata T, Ran J, Jackson DK, Petchprayoon C, Gomez TJ, Warp E, Tulyathan O, Aaron HL, Isacoff E, Yan Y. Optical lock-in detection imaging microscopy for contrast-enhanced imaging in living cells. Proc Natl Acad Sci U S A. 2008 Nov 18; 105(46):17789-94. PMID: 19004775; PMCID: PMC2584753.
    93. Kohout SC, Isacoff E. To dislodge an enzyme from an ion channel, try steroids. Nat Chem Biol. 2008 Nov; 4(11):650-1. PMID: 18936745.
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    94. Gorostiza P, Isacoff E. Optical switches for remote and noninvasive control of cell signaling. Science. 2008 Oct 17; 322(5900):395-9. PMID: 18927384.
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    95. Gorostiza P, Isacoff E. Nanoengineering ion channels for optical control. Physiology (Bethesda). 2008 Oct; 23:238-47. PMID: 18927200.
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    96. Ulbrich MH, Isacoff E. Rules of engagement for NMDA receptor subunits. Proc Natl Acad Sci U S A. 2008 Sep 16; 105(37):14163-8. PMID: 18779583; PMCID: PMC2544595.
    97. Baker BJ, Mutoh H, Dimitrov D, Akemann W, Perron A, Iwamoto Y, Jin L, Cohen LB, Isacoff E, Pieribone VA, Hughes T, Knöpfel T. Genetically encoded fluorescent sensors of membrane potential. Brain Cell Biol. 2008 Aug; 36(1-4):53-67. PMID: 18679801; PMCID: PMC2775812.
    98. Pautot S, Wyart C, Isacoff E. Colloid-guided assembly of oriented 3D neuronal networks. Nat Methods. 2008 Aug; 5(8):735-40. PMID: 18641658; PMCID: PMC2713726.
    99. Tombola F, Ulbrich MH, Isacoff E. The voltage-gated proton channel Hv1 has two pores, each controlled by one voltage sensor. Neuron. 2008 May 22; 58(4):546-56. PMID: 18498736; PMCID: PMC2430592.
    100. Kohout SC, Ulbrich MH, Bell SC, Isacoff E. Subunit organization and functional transitions in Ci-VSP. Nat Struct Mol Biol. 2008 Jan; 15(1):106-8. PMID: 18084307.
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    101. Wang S, Szobota S, Wang Y, Volgraf M, Liu Z, Sun C, Trauner D, Isacoff E, Zhang X. All optical interface for parallel, remote, and spatiotemporal control of neuronal activity. Nano Lett. 2007 Dec; 7(12):3859-63. PMID: 18034506.
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    102. Stowers RS, Isacoff E. Drosophila huntingtin-interacting protein 14 is a presynaptic protein required for photoreceptor synaptic transmission and expression of the palmitoylated proteins synaptosome-associated protein 25 and cysteine string protein. J Neurosci. 2007 Nov 21; 27(47):12874-83. PMID: 18032660.
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    103. Pathak MM, Yarov-Yarovoy V, Agarwal G, Roux B, Barth P, Kohout S, Tombola F, Isacoff E. Closing in on the resting state of the Shaker K(+) channel. Neuron. 2007 Oct 04; 56(1):124-40. PMID: 17920020.
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    104. Gorostiza P, Isacoff E. Optical switches and triggers for the manipulation of ion channels and pores. Mol Biosyst. 2007 Oct; 3(10):686-704. PMID: 17882331.
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    105. Gorostiza P, Volgraf M, Numano R, Szobota S, Trauner D, Isacoff E. Mechanisms of photoswitch conjugation and light activation of an ionotropic glutamate receptor. Proc Natl Acad Sci U S A. 2007 Jun 26; 104(26):10865-70. PMID: 17578923; PMCID: PMC1904147.
    106. Szobota S, Gorostiza P, Del Bene F, Wyart C, Fortin DL, Kolstad KD, Tulyathan O, Volgraf M, Numano R, Aaron HL, Scott EK, Kramer RH, Flannery J, Baier H, Trauner D, Isacoff E. Remote control of neuronal activity with a light-gated glutamate receptor. Neuron. 2007 May 24; 54(4):535-45. PMID: 17521567.
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    107. Miller EW, Tulyathan O, Tulyanthan O, Isacoff E, Chang CJ. Molecular imaging of hydrogen peroxide produced for cell signaling. Nat Chem Biol. 2007 May; 3(5):263-7. PMID: 17401379.
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    108. Ulbrich MH, Isacoff E. Subunit counting in membrane-bound proteins. Nat Methods. 2007 Apr; 4(4):319-21. PMID: 17369835; PMCID: PMC2744285.
    109. Volgraf M, Gorostiza P, Szobota S, Helix MR, Isacoff E, Trauner D. Reversibly caged glutamate: a photochromic agonist of ionotropic glutamate receptors. J Am Chem Soc. 2007 Jan 17; 129(2):260-1. PMID: 17212390.
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    110. Tombola F, Pathak MM, Gorostiza P, Isacoff E. The twisted ion-permeation pathway of a resting voltage-sensing domain. Nature. 2007 Feb 01; 445(7127):546-9. PMID: 17187057.
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    111. Baker BJ, Lee H, Pieribone VA, Cohen LB, Isacoff E, Knopfel T, Kosmidis EK. Three fluorescent protein voltage sensors exhibit low plasma membrane expression in mammalian cells. J Neurosci Methods. 2007 Mar 30; 161(1):32-8. PMID: 17126911.
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    112. Kaláb P, Pralle A, Isacoff E, Heald R, Weis K. Analysis of a RanGTP-regulated gradient in mitotic somatic cells. Nature. 2006 Mar 30; 440(7084):697-701. PMID: 16572176.
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    113. Zeng L, Miller EW, Pralle A, Isacoff E, Chang CJ. A selective turn-on fluorescent sensor for imaging copper in living cells. J Am Chem Soc. 2006 Jan 11; 128(1):10-1. PMID: 16390096; PMCID: PMC1414792.
    114. Tombola F, Pathak MM, Isacoff E. How does voltage open an ion channel? Annu Rev Cell Dev Biol. 2006; 22:23-52. PMID: 16704338.
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    115. Volgraf M, Gorostiza P, Numano R, Kramer RH, Isacoff E, Trauner D. Allosteric control of an ionotropic glutamate receptor with an optical switch. Nat Chem Biol. 2006 Jan; 2(1):47-52. PMID: 16408092; PMCID: PMC1447676.
    116. Tombola F, Pathak MM, Isacoff E. How far will you go to sense voltage? Neuron. 2005 Dec 08; 48(5):719-25. PMID: 16337910.
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    117. Gorostiza P, Tombola F, Verdaguer A, Smith SB, Bustamante C, Isacoff E. Molecular handles for the mechanical manipulation of single-membrane proteins in living cells. IEEE Trans Nanobioscience. 2005 Dec; 4(4):269-76. PMID: 16433292; PMCID: PMC1414782.
    118. Miller EW, Albers AE, Pralle A, Isacoff E, Chang CJ. Boronate-based fluorescent probes for imaging cellular hydrogen peroxide. J Am Chem Soc. 2005 Nov 30; 127(47):16652-9. PMID: 16305254; PMCID: PMC1447675.
    119. Baksh MM, Dean C, Pautot S, DeMaria S, Isacoff E, Groves JT. Neuronal activation by GPI-linked neuroligin-1 displayed in synthetic lipid bilayer membranes. Langmuir. 2005 Nov 08; 21(23):10693-8. PMID: 16262338; PMCID: PMC1448170.
    120. Pautot S, Lee H, Isacoff E, Groves JT. Neuronal synapse interaction reconstituted between live cells and supported lipid bilayers. Nat Chem Biol. 2005 Oct; 1(5):283-9. PMID: 16408058; PMCID: PMC1448216.
    121. Gandhi CS, Isacoff E. Shedding light on membrane proteins. Trends Neurosci. 2005 Sep; 28(9):472-9. PMID: 16043238.
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    122. Guerrero G, Reiff DF, Rieff DF, Agarwal G, Ball RW, Borst A, Goodman CS, Isacoff E. Heterogeneity in synaptic transmission along a Drosophila larval motor axon. Nat Neurosci. 2005 Sep; 8(9):1188-96. PMID: 16116446; PMCID: PMC1402256.
    123. Reiff DF, Ihring A, Guerrero G, Isacoff E, Joesch M, Nakai J, Borst A. In vivo performance of genetically encoded indicators of neural activity in flies. J Neurosci. 2005 May 11; 25(19):4766-78. PMID: 15888652; PMCID: PMC1464576.
    124. Tombola F, Pathak MM, Isacoff E. Voltage-sensing arginines in a potassium channel permeate and occlude cation-selective pores. Neuron. 2005 Feb 03; 45(3):379-88. PMID: 15694325.
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    125. Cohen BE, Pralle A, Yao X, Swaminath G, Gandhi CS, Jan YN, Kobilka BK, Isacoff E, Jan LY. A fluorescent probe designed for studying protein conformational change. Proc Natl Acad Sci U S A. 2005 Jan 25; 102(4):965-70. PMID: 15657131; PMCID: PMC545863.
    126. Pathak M, Kurtz L, Tombola F, Isacoff E. The cooperative voltage sensor motion that gates a potassium channel. J Gen Physiol. 2005 Jan; 125(1):57-69. PMID: 15623895; PMCID: PMC1414780.
    127. Chang MC, Pralle A, Isacoff E, Chang CJ. A selective, cell-permeable optical probe for hydrogen peroxide in living cells. J Am Chem Soc. 2004 Dec 01; 126(47):15392-3. PMID: 15563161; PMCID: PMC1434465.
    128. Banghart M, Borges K, Isacoff E, Trauner D, Kramer RH. Light-activated ion channels for remote control of neuronal firing. Nat Neurosci. 2004 Dec; 7(12):1381-6. PMID: 15558062; PMCID: PMC1447674.
    129. Gandhi CS, Clark E, Loots E, Pralle A, Isacoff E. The orientation and molecular movement of a k(+) channel voltage-sensing domain. Neuron. 2003 Oct 30; 40(3):515-25. PMID: 14642276.
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    130. Gradl SN, Felix JP, Isacoff E, Garcia ML, Trauner D. Protein surface recognition by rational design: nanomolar ligands for potassium channels. J Am Chem Soc. 2003 Oct 22; 125(42):12668-9. PMID: 14558789; PMCID: PMC1458372.
    131. Dean C, Scholl FG, Choih J, DeMaria S, Berger J, Isacoff E, Scheiffele P. Neurexin mediates the assembly of presynaptic terminals. Nat Neurosci. 2003 Jul; 6(7):708-16. PMID: 12796785; PMCID: PMC1646425.
    132. Sonnleitner A, Isacoff E. Single ion channel imaging. Methods Enzymol. 2003; 361:304-19. PMID: 12624917.
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    133. Guerrero G, Siegel MS, Roska B, Loots E, Isacoff E. Tuning FlaSh: redesign of the dynamics, voltage range, and color of the genetically encoded optical sensor of membrane potential. Biophys J. 2002 Dec; 83(6):3607-18. PMID: 12496128; PMCID: PMC1302436.
    134. Gandhi CS, Isacoff E. Molecular models of voltage sensing. J Gen Physiol. 2002 Oct; 120(4):455-63. PMID: 12356848; PMCID: PMC2229531.
    135. Sonnleitner A, Mannuzzu LM, Terakawa S, Isacoff E. Structural rearrangements in single ion channels detected optically in living cells. Proc Natl Acad Sci U S A. 2002 Oct 01; 99(20):12759-64. PMID: 12228726; PMCID: PMC130533.
    136. Schönherr R, Mannuzzu LM, Isacoff E, Heinemann SH. Conformational switch between slow and fast gating modes: allosteric regulation of voltage sensor mobility in the EAG K+ channel. Neuron. 2002 Aug 29; 35(5):935-49. PMID: 12372287.
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    137. Guerrero G, Isacoff E. Genetically encoded optical sensors of neuronal activity and cellular function. Curr Opin Neurobiol. 2001 Oct; 11(5):601-7. PMID: 11595495.
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    138. Loots E, Isacoff E. Molecular coupling of S4 to a K(+) channel's slow inactivation gate. J Gen Physiol. 2000 Nov; 116(5):623-36. PMID: 11055991; PMCID: PMC2229480.
    139. Gandhi CS, Loots E, Isacoff E. Reconstructing voltage sensor-pore interaction from a fluorescence scan of a voltage-gated K+ channel. Neuron. 2000 Sep; 27(3):585-95. PMID: 11055440.
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    140. Mannuzzu LM, Isacoff E. Independence and cooperativity in rearrangements of a potassium channel voltage sensor revealed by single subunit fluorescence. J Gen Physiol. 2000 Mar; 115(3):257-68. PMID: 10694254; PMCID: PMC2217208.
    141. Siegel MS, Isacoff E. Green fluorescent protein-based sensors for detecting signal transduction and monitoring ion channel function. Methods Enzymol. 2000; 327:249-59. PMID: 11044988.
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    142. Glauner KS, Mannuzzu LM, Gandhi CS, Isacoff E. Spectroscopic mapping of voltage sensor movement in the Shaker potassium channel. Nature. 1999 Dec 16; 402(6763):813-7. PMID: 10617202.
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    143. Speca DJ, Lin DM, Sorensen PW, Isacoff E, Ngai J, Dittman AH. Functional identification of a goldfish odorant receptor. Neuron. 1999 Jul; 23(3):487-98. PMID: 10433261.
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    144. Zito K, Parnas D, Fetter RD, Isacoff E, Goodman CS. Watching a synapse grow: noninvasive confocal imaging of synaptic growth in Drosophila. Neuron. 1999 Apr; 22(4):719-29. PMID: 10230792.
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    145. Loots E, Isacoff E. Protein rearrangements underlying slow inactivation of the Shaker K+ channel. J Gen Physiol. 1998 Oct; 112(4):377-89. PMID: 9758858; PMCID: PMC2229423.
    146. Baker OS, Larsson HP, Mannuzzu LM, Isacoff E. Three transmembrane conformations and sequence-dependent displacement of the S4 domain in shaker K+ channel gating. Neuron. 1998 Jun; 20(6):1283-94. PMID: 9655514.
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    147. Harris RE, Larsson HP, Isacoff E. A permanent ion binding site located between two gates of the Shaker K+ channel. Biophys J. 1998 Apr; 74(4):1808-20. PMID: 9545043; PMCID: PMC1299525.
    148. Zito K, Fetter RD, Goodman CS, Isacoff E. Synaptic clustering of Fascilin II and Shaker: essential targeting sequences and role of Dlg. Neuron. 1997 Nov; 19(5):1007-16. PMID: 9390515.
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    149. Siegel MS, Isacoff E. A genetically encoded optical probe of membrane voltage. Neuron. 1997 Oct; 19(4):735-41. PMID: 9354320.
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    150. Harris RE, Isacoff E. Hydrophobic mutations alter the movement of Mg2+ in the pore of voltage-gated potassium channels. Biophys J. 1996 Jul; 71(1):209-19. PMID: 8804604; PMCID: PMC1233472.
    151. Larsson HP, Baker OS, Dhillon DS, Isacoff E. Transmembrane movement of the shaker K+ channel S4. Neuron. 1996 Feb; 16(2):387-97. PMID: 8789953.
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    152. Mannuzzu LM, Moronne MM, Isacoff E. Direct physical measure of conformational rearrangement underlying potassium channel gating. Science. 1996 Jan 12; 271(5246):213-6. PMID: 8539623.
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    153. Li M, Isacoff E, Jan YN, Jan LY. Assembly of potassium channels. Ann N Y Acad Sci. 1993 Dec 20; 707:51-9. PMID: 9137541.
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    154. Isacoff E, Jan YN, Jan LY. Molecular basis of K+ channel inactivation gating. EXS. 1993; 63:338-51. PMID: 8380732.
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    155. Baldwin TJ, Isacoff E, Li M, Lopez GA, Sheng M, Tsaur ML, Yan YN, Jan LY. Elucidation of biophysical and biological properties of voltage-gated potassium channels. Cold Spring Harb Symp Quant Biol. 1992; 57:491-9. PMID: 1339685.
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    156. Isacoff E, Jan YN, Jan LY. Putative receptor for the cytoplasmic inactivation gate in the Shaker K+ channel. Nature. 1991 Sep 05; 353(6339):86-90. PMID: 1881453.
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    157. Isacoff E, Jan YN, Jan LY. Evidence for the formation of heteromultimeric potassium channels in Xenopus oocytes. Nature. 1990 Jun 07; 345(6275):530-4. PMID: 2112229.
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    158. Isacoff E, Papazian D, Timpe L, Jan YN, Jan LY. Molecular studies of voltage-gated potassium channels. Cold Spring Harb Symp Quant Biol. 1990; 55:9-17. PMID: 2132867.
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    159. Birks RI, Isacoff E. Burst-patterned stimulation promotes nicotinic transmission in isolated perfused rat sympathetic ganglia. J Physiol. 1988 Aug; 402:515-32. PMID: 2907049; PMCID: PMC1191905.
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