McMurray, Cynthia

TitleBiochemist Senior Sci/Engr
InstitutionLawrence Berkeley National Lab
DepartmentMolecular Biophys & Integ Bio
Address1 Cyclotron Road
Berkeley CA 94720
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    Collapse Research 
    Collapse Research Activities and Funding
    SPOT-CHECK: capture of site-specific complexes in vivo
    NIH/NINDS R21NS105158Jun 1, 2018 - May 31, 2020
    Role: Principal Investigator
    DNA Expansion and Mismatch Repair
    NIH/NIGMS R01GM119161Aug 1, 2017 - Jul 31, 2021
    Role: Principal Investigator
    Metabolic markers for mitochondrial function
    NIH/NIEHS R01ES020766Sep 20, 2011 - Jun 30, 2016
    Role: Principal Investigator
    MT Function and Dysfunction in Single Neurons in Vivo
    NIH/NINDS RC1NS069177Sep 30, 2009 - Aug 31, 2012
    Role: Principal Investigator
    Age of Onset and Huntingtons Disease
    NIH/NINDS R01NS062384Sep 1, 2009 - Aug 31, 2012
    Role: Principal Investigator
    NIH/NIA R13AG032750Jun 15, 2008 - May 31, 2009
    Role: Principal Investigator
    Chemical Fingerprinting
    NIH/NINDS R01NS060115Jul 1, 2007 - May 31, 2019
    Role: Principal Investigator
    Asilomar Chromatin and Chromosomes Conference
    NIH/NCI R13CA119824Sep 15, 2005 - Aug 31, 2007
    Role: Principal Investigator
    Mismatch Repair and DNA expansion
    NIH/NIGMS R01GM066359Apr 1, 2004 - Mar 31, 2013
    Role: Principal Investigator
    Trafficking Defects in Huntingtons Disease
    NIH/NINDS R01NS040738Apr 1, 2001 - Jul 31, 2011
    Role: Principal Investigator
    NIH/NIMH R01MH056207Jul 1, 1998 - Jun 30, 2002
    Role: Principal Investigator
    NIH/NIDDK R01DK046394Jun 1, 1995 - May 31, 1999
    Role: Principal Investigator
    NIH/NINDS F32NS008204Oct 21, 1987
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Polyzos AA, Wood NI, Williams P, Wipf P, Morton AJ, McMurray C. XJB-5-131-mediated improvement in physiology and behaviour of the R6/2 mouse model of Huntington's disease is age- and sex- dependent. PLoS One. 2018; 13(4):e0194580. PMID: 29630611.
      View in: PubMed
    2. Polyzos AA, McMurray C. Close encounters: Moving along bumps, breaks, and bubbles on expanded trinucleotide tracts. DNA Repair (Amst). 2017 08; 56:144-155. PMID: 28690053.
      View in: PubMed
    3. Polyzos AA, McMurray C. The chicken or the egg: mitochondrial dysfunction as a cause or consequence of toxicity in Huntington's disease. Mech Ageing Dev. 2017 01; 161(Pt A):181-197. PMID: 27634555.
      View in: PubMed
    4. Lai Y, Budworth H, Beaver JM, Chan NL, Zhang Z, McMurray C, Liu Y. Crosstalk between MSH2-MSH3 and polß promotes trinucleotide repeat expansion during base excision repair. Nat Commun. 2016 Aug 22; 7:12465. PMID: 27546332; PMCID: PMC4996945.
    5. Polyzos A, Holt A, Brown C, Cosme C, Wipf P, Gomez-Marin A, Castro MR, Ayala-Peña S, McMurray C. Mitochondrial targeting of XJB-5-131 attenuates or improves pathophysiology in HdhQ150 animals with well-developed disease phenotypes. Hum Mol Genet. 2016 05 01; 25(9):1792-802. PMID: 26908614.
      View in: PubMed
    6. Budworth H, McMurray C. Problems and solutions for the analysis of somatic CAG repeat expansion and their relationship to Huntington's disease toxicity. Rare Dis. 2016; 4(1):e1131885. PMID: 27141411; PMCID: PMC4838321.
    7. Budworth H, Harris FR, Williams P, Lee DY, Holt A, Pahnke J, Szczesny B, Acevedo-Torres K, Ayala-Peña S, McMurray C. Suppression of Somatic Expansion Delays the Onset of Pathophysiology in a Mouse Model of Huntington's Disease. PLoS Genet. 2015 Aug; 11(8):e1005267. PMID: 26247199; PMCID: PMC4527696.
    8. McMurray C, Vijg J. Editorial overview: Molecular and genetic bases of disease: the double life of DNA. Curr Opin Genet Dev. 2014 Jun; 26:v-vii. PMID: 25282314; PMCID: PMC4445144.
    9. Lee DY, McMurray C. Trinucleotide expansion in disease: why is there a length threshold? Curr Opin Genet Dev. 2014 Jun; 26:131-40. PMID: 25282113; PMCID: PMC4252851.
    10. Trushina E, Canaria CA, Lee DY, McMurray C. Loss of caveolin-1 expression in knock-in mouse model of Huntington's disease suppresses pathophysiology in vivo. Hum Mol Genet. 2014 Jan 01; 23(1):129-44. PMID: 24021477; PMCID: PMC3857950.
    11. Lee DY, Xun Z, Platt V, Budworth H, Canaria CA, McMurray C. Distinct pools of non-glycolytic substrates differentiate brain regions and prime region-specific responses of mitochondria. PLoS One. 2013; 8(7):e68831. PMID: 23874783; PMCID: PMC3714274.
    12. Hura GL, Budworth H, Dyer KN, Rambo RP, Hammel M, McMurray C, Tainer JA. Comprehensive macromolecular conformations mapped by quantitative SAXS analyses. Nat Methods. 2013 Jun; 10(6):453-4. PMID: 23624664; PMCID: PMC3728378.
    13. Budworth H, McMurray C. Bidirectional transcription of trinucleotide repeats: roles for excision repair. DNA Repair (Amst). 2013 Aug; 12(8):672-84. PMID: 23669397; PMCID: PMC3720788.
    14. Budworth H, McMurray C. A brief history of triplet repeat diseases. Methods Mol Biol. 2013; 1010:3-17. PMID: 23754215; PMCID: PMC3913379.
    15. Platt V, Lee DY, Canaria CA, Frankel K, Bernstein S, McMurray C. Towards understanding region-specificity of triplet repeat diseases: coupled immunohistology and mass spectrometry imaging. Methods Mol Biol. 2013; 1010:213-30. PMID: 23754228.
      View in: PubMed
    16. Dalhus B, Nilsen L, Korvald H, Huffman J, Forstrøm RJ, McMurray C, Alseth I, Tainer JA, Bjørås M. Sculpting of DNA at abasic sites by DNA glycosylase homolog mag2. Structure. 2013 Jan 08; 21(1):154-166. PMID: 23245849; PMCID: PMC3545110.
    17. Xun Z, Rivera-Sánchez S, Ayala-Peña S, Lim J, Budworth H, Skoda EM, Robbins PD, Niedernhofer LJ, Wipf P, McMurray C. Targeting of XJB-5-131 to mitochondria suppresses oxidative DNA damage and motor decline in a mouse model of Huntington's disease. Cell Rep. 2012 Nov 29; 2(5):1137-42. PMID: 23122961; PMCID: PMC3513647.
    18. Lee DY, Platt V, Bowen B, Louie K, Canaria CA, McMurray C, Northen T. Resolving brain regions using nanostructure initiator mass spectrometry imaging of phospholipids. Integr Biol (Camb). 2012 Jun; 4(6):693-9. PMID: 22543711; PMCID: PMC3698601.
    19. Xun Z, Lee DY, Lim J, Canaria CA, Barnebey A, Yanonne SM, McMurray C. Retinoic acid-induced differentiation increases the rate of oxygen consumption and enhances the spare respiratory capacity of mitochondria in SH-SY5Y cells. Mech Ageing Dev. 2012 Apr; 133(4):176-85. PMID: 22336883; PMCID: PMC3357086.
    20. Majka J, Alford B, Ausio J, Finn RM, McMurray C. ATP hydrolysis by RAD50 protein switches MRE11 enzyme from endonuclease to exonuclease. J Biol Chem. 2012 Jan 20; 287(4):2328-41. PMID: 22102415; PMCID: PMC3268395.
    21. Lang WH, Coats JE, Majka J, Hura GL, Lin Y, Rasnik I, McMurray C. Conformational trapping of mismatch recognition complex MSH2/MSH3 on repair-resistant DNA loops. Proc Natl Acad Sci U S A. 2011 Oct 18; 108(42):E837-44. PMID: 21960445; PMCID: PMC3198364.
    22. Kovtun IV, Johnson KO, McMurray C. Cockayne syndrome B protein antagonizes OGG1 in modulating CAG repeat length in vivo. Aging (Albany NY). 2011 May; 3(5):509-14. PMID: 21566259; PMCID: PMC3156601.
    23. McMurray C. Mechanisms of trinucleotide repeat instability during human development. Nat Rev Genet. 2010 Nov; 11(11):786-99. PMID: 20953213; PMCID: PMC3175376.
    24. Liu Y, Prasad R, Beard WA, Hou EW, Horton JK, McMurray C, Wilson SH. Coordination between polymerase beta and FEN1 can modulate CAG repeat expansion. J Biol Chem. 2009 Oct 09; 284(41):28352-66. PMID: 19674974; PMCID: PMC2788885.
    25. Trushina E, Rana S, McMurray C, Hua DH. Tricyclic pyrone compounds prevent aggregation and reverse cellular phenotypes caused by expression of mutant huntingtin protein in striatal neurons. BMC Neurosci. 2009 Jul 08; 10:73. PMID: 19586540; PMCID: PMC2719645.
    26. Owen BA, H Lang W, McMurray C. The nucleotide binding dynamics of human MSH2-MSH3 are lesion dependent. Nat Struct Mol Biol. 2009 May; 16(5):550-7. PMID: 19377479; PMCID: PMC2982795.
    27. Rolseth V, Rundén-Pran E, Luna L, McMurray C, Bjørås M, Ottersen OP. Widespread distribution of DNA glycosylases removing oxidative DNA lesions in human and rodent brains. DNA Repair (Amst). 2008 Sep 01; 7(9):1578-88. PMID: 18603019; PMCID: PMC3842036.
    28. McMurray C. Hijacking of the mismatch repair system to cause CAG expansion and cell death in neurodegenerative disease. DNA Repair (Amst). 2008 Jul 01; 7(7):1121-34. PMID: 18472310; PMCID: PMC3215281.
    29. Koti JS, Morais MC, Rajagopal R, Owen BA, McMurray C, Anderson DL. DNA packaging motor assembly intermediate of bacteriophage phi29. J Mol Biol. 2008 Sep 19; 381(5):1114-32. PMID: 18674782; PMCID: PMC2614240.
    30. Delagoutte E, Goellner GM, Guo J, Baldacci G, McMurray C. Single-stranded DNA-binding protein in vitro eliminates the orientation-dependent impediment to polymerase passage on CAG/CTG repeats. J Biol Chem. 2008 May 09; 283(19):13341-56. PMID: 18263578; PMCID: PMC2442361.
    31. Kovtun IV, McMurray C. Features of trinucleotide repeat instability in vivo. Cell Res. 2008 Jan; 18(1):198-213. PMID: 18166978.
      View in: PubMed
    32. Kovtun IV, Liu Y, Bjoras M, Klungland A, Wilson SH, McMurray C. OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells. Nature. 2007 May 24; 447(7143):447-52. PMID: 17450122.
      View in: PubMed
    33. Trushina E, Singh RD, Dyer RB, Cao S, Shah VH, Parton RG, Pagano RE, McMurray C. Mutant huntingtin inhibits clathrin-independent endocytosis and causes accumulation of cholesterol in vitro and in vivo. Hum Mol Genet. 2006 Dec 15; 15(24):3578-91. PMID: 17142251.
      View in: PubMed
    34. Kovtun IV, McMurray C. Crosstalk of DNA glycosylases with pathways other than base excision repair. DNA Repair (Amst). 2007 Apr 01; 6(4):517-29. PMID: 17129768.
      View in: PubMed
    35. Trushina E, Du Charme J, Parisi J, McMurray C. Neurological abnormalities in caveolin-1 knock out mice. Behav Brain Res. 2006 Sep 15; 172(1):24-32. PMID: 16750274.
      View in: PubMed
    36. Owen BA, Yang Z, Lai M, Gajec M, Gajek M, Badger JD, Hayes JJ, Edelmann W, Kucherlapati R, Wilson TM, McMurray C. (CAG)(n)-hairpin DNA binds to Msh2-Msh3 and changes properties of mismatch recognition. Nat Struct Mol Biol. 2005 Aug; 12(8):663-70. PMID: 16025128.
      View in: PubMed
    37. Ortiz M, Sanoguet Z, Hu H, Chazin WJ, McMurray CT, McMurray C, Salisbury JL, Pastrana-Rios B. Dynamics of hydrogen-deuterium exchange in Chlamydomonas centrin. Biochemistry. 2005 Feb 22; 44(7):2409-18. PMID: 15709753.
      View in: PubMed
    38. Eide L, McMurray C. Culture of adult mouse neurons. Biotechniques. 2005 Jan; 38(1):99-104. PMID: 15679091.
      View in: PubMed
    39. Trushina E, Dyer RB, Badger JD, Ure D, Eide L, Tran DD, Vrieze BT, Legendre-Guillemin V, McPherson PS, Mandavilli BS, Van Houten B, Zeitlin S, McNiven M, Aebersold R, Hayden M, Parisi JE, Seeberg E, Dragatsis I, Doyle K, Bender A, Chacko C, McMurray C. Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro. Mol Cell Biol. 2004 Sep; 24(18):8195-209. PMID: 15340079; PMCID: PMC515048.
    40. Kantarci OH, Hebrink DD, Achenbach SJ, Atkinson EJ, de Andrade M, McMurray C, Weinshenker BG. CD95 polymorphisms are associated with susceptibility to MS in women. A population-based study of CD95 and CD95L in MS. J Neuroimmunol. 2004 Jan; 146(1-2):162-70. PMID: 14698859.
      View in: PubMed
    41. Kovtun IV, Spiro C, McMurray C. Triplet repeats and DNA repair: germ cell and somatic cell instability in transgenic mice. Methods Mol Biol. 2004; 277:309-19. PMID: 15201465.
      View in: PubMed
    42. Kovtun IV, Welch G, Guthrie HD, Hafner KL, McMurray C. CAG repeat lengths in X- and Y-bearing sperm indicate that gender bias during transmission of Huntington's disease gene is determined in the embryo. J Biol Chem. 2004 Mar 05; 279(10):9389-91. PMID: 14688268.
      View in: PubMed
    43. Trushina E, Heldebrant MP, Perez-Terzic CM, Bortolon R, Kovtun IV, Badger JD, Terzic A, Estévez A, Windebank AJ, Dyer RB, Yao J, McMurray C. Microtubule destabilization and nuclear entry are sequential steps leading to toxicity in Huntington's disease. Proc Natl Acad Sci U S A. 2003 Oct 14; 100(21):12171-6. PMID: 14527999; PMCID: PMC218731.
    44. Spiro C, McMurray C. Nuclease-deficient FEN-1 blocks Rad51/BRCA1-mediated repair and causes trinucleotide repeat instability. Mol Cell Biol. 2003 Sep; 23(17):6063-74. PMID: 12917330; PMCID: PMC180932.
    45. Morais MC, Kanamaru S, Badasso MO, Koti JS, Owen BA, McMurray C, Anderson DL, Rossmann MG. Bacteriophage phi29 scaffolding protein gp7 before and after prohead assembly. Nat Struct Biol. 2003 Jul; 10(7):572-6. PMID: 12778115.
      View in: PubMed
    46. McMurray C, Tainer JA. Cancer, cadmium and genome integrity. Nat Genet. 2003 Jul; 34(3):239-41. PMID: 12833042.
      View in: PubMed
    47. Kantarci OH, Schaefer-Klein JL, Hebrink DD, Achenbach SJ, Atkinson EJ, McMurray C, Weinshenker BG. A population-based study of IL4 polymorphisms in multiple sclerosis. J Neuroimmunol. 2003 Apr; 137(1-2):134-9. PMID: 12667657.
      View in: PubMed
    48. Johnson-Pais TL, Singer FR, Bone HG, McMurray C, Hansen MF, Leach RJ. Identification of a novel tandem duplication in exon 1 of the TNFRSF11A gene in two unrelated patients with familial expansile osteolysis. J Bone Miner Res. 2003 Feb; 18(2):376-80. PMID: 12568416.
      View in: PubMed
    49. Kantarci OH, Hebrink DD, Achenbach SJ, Atkinson EJ, Waliszewska A, Buckle G, McMurray C, de Andrade M, Hafler DA, Weinshenker BG. CTLA4 is associated with susceptibility to multiple sclerosis. J Neuroimmunol. 2003 Jan; 134(1-2):133-41. PMID: 12507781.
      View in: PubMed
    50. Sobell JL, Mikesell MJ, McMurray C. Genetics and etiopathophysiology of schizophrenia. Mayo Clin Proc. 2002 Oct; 77(10):1068-82. PMID: 12374251.
      View in: PubMed
    51. Hopfner KP, Craig L, Moncalian G, Zinkel RA, Usui T, Owen BA, Karcher A, Henderson B, Bodmer JL, McMurray C, Carney JP, Petrini JH, Tainer JA. The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair. Nature. 2002 Aug 01; 418(6897):562-6. PMID: 12152085.
      View in: PubMed
    52. Kantarci OH, Lesnick TG, Yang P, Meyer RL, Hebrink DD, McMurray C, Weinshenker BG. Myeloperoxidase -463 (G-->A) polymorphism associated with lower risk of lung cancer. Mayo Clin Proc. 2002 Jan; 77(1):17-22. PMID: 11794452.
      View in: PubMed

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