Bertozzi, Carolyn

TitleChemist Senior Faculty SE
InstitutionLawrence Berkeley National Lab
DepartmentMaterials Sciences
Address1 Cyclotron Road
Berkeley CA 94720
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    Collapse Research 
    Collapse Research Activities and Funding
    Making glycoproteomics via mass spectrometry more accessible to the greater scientific community
    NIH/NCI U01CA207702Sep 1, 2016 - Aug 31, 2019
    Role: Principal Investigator
    Stanford Chem-H Chemistry/Biology Interface Predoctoral Training Program
    NIH/NIGMS T32GM120007Jul 1, 2016 - Jun 30, 2021
    Role: Principal Investigator
    Revolutionizing the detection of O-GlcNAc
    NIH/NIDDK R21DK108781Jul 15, 2015 - Jun 30, 2017
    Role: Principal Investigator
    University of California Berkeley Chemistry-Biology Interface Training Program
    NIH/NIGMS T32GM066698Jul 1, 2004 - Jun 30, 2019
    Role: Co-Principal Investigator
    Chemical Glycoproteomics
    NIH/NCI R01CA200423Aug 1, 2002 - May 31, 2020
    Role: Principal Investigator
    Studies of Protein Glycosylation
    NIH/NIGMS R01GM066047Aug 1, 2002 - Apr 30, 2015
    Role: Principal Investigator
    Chemical Mycobateriology
    NIH/NIAID R01AI051622Apr 1, 2002 - Aug 31, 2021
    Role: Principal Investigator
    Chemical Mycobateriology
    NIH/NIAID R37AI051622Apr 1, 2002 - Aug 31, 2021
    Role: Principal Investigator
    Chemical Cell Surface Engineering
    NIH/NIGMS R01GM059907Aug 1, 1999 - Aug 31, 2017
    Role: Principal Investigator
    Metabolic Engineering with Bioorthogonal Chemical Reporters
    NIH/NIGMS R37GM058867Jan 1, 1999 - May 31, 2019
    Role: Principal Investigator
    NIH/NIGMS R01GM058867Jan 1, 1999 - Apr 30, 2009
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Yang AC, du Bois H, Olsson N, Gate D, Lehallier B, Berdnik D, Brewer KD, Bertozzi C, Elias JE, Wyss-Coray T. Multiple Click-Selective tRNA Synthetases Expand Mammalian Cell-Specific Proteomics. J Am Chem Soc. 2018 May 18. PMID: 29775058.
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    2. Keyser SGL, Utz A, Bertozzi C. Computation-guided rational design of a peptide motif that reacts with cyanobenzothiazoles via internal cysteine-lysine relay. J Org Chem. 2018 May 17. PMID: 29771122.
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    3. Rodriguez-Rivera FP, Zhou X, Theriot JA, Bertozzi C. Acute Modulation of Mycobacterial Cell Envelope Biogenesis by Front-Line Tuberculosis Drugs. Angew Chem Int Ed Engl. 2018 May 04; 57(19):5267-5272. PMID: 29392891.
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    4. Tomlin FM, Gordon CG, Han Y, Wu TS, Sletten EM, Bertozzi C. Site-specific incorporation of quadricyclane into a protein and photocleavage of the quadricyclane ligation adduct. Bioorg Med Chem. 2018 Apr 04. PMID: 29754834.
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    5. Kamariza M, Shieh P, Ealand CS, Peters JS, Chu B, Rodriguez-Rivera FP, Babu Sait MR, Treuren WV, Martinson N, Kalscheuer R, Kana BD, Bertozzi C. Rapid detection of Mycobacterium tuberculosis in sputum with a solvatochromic trehalose probe. Sci Transl Med. 2018 02 28; 10(430). PMID: 29491187.
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    6. Zhou MN, Delaveris CS, Kramer JR, Kenkel JA, Engleman EG, Bertozzi C. N-Carboxyanhydride Polymerization of Glycopolypeptides That Activate Antigen-Presenting Cells through Dectin-1 and Dectin-2. Angew Chem Int Ed Engl. 2018 Mar 12; 57(12):3137-3142. PMID: 29370452.
      View in: PubMed
    7. Aebersold R, Agar JN, Amster IJ, Baker MS, Bertozzi C, Boja ES, Costello CE, Cravatt BF, Fenselau C, Garcia BA, Ge Y, Gunawardena J, Hendrickson RC, Hergenrother PJ, Huber CG, Ivanov AR, Jensen ON, Jewett MC, Kelleher NL, Kiessling LL, Krogan NJ, Larsen MR, Loo JA, Ogorzalek Loo RR, Lundberg E, MacCoss MJ, Mallick P, Mootha VK, Mrksich M, Muir TW, Patrie SM, Pesavento JJ, Pitteri SJ, Rodriguez H, Saghatelian A, Sandoval W, Schlüter H, Sechi S, Slavoff SA, Smith LM, Snyder MP, Thomas PM, Uhlén M, Van Eyk JE, Vidal M, Walt DR, White FM, Williams ER, Wohlschlager T, Wysocki VH, Yates NA, Young NL, Zhang B. How many human proteoforms are there? Nat Chem Biol. 2018 Feb 14; 14(3):206-214. PMID: 29443976.
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    8. Tsai CT, Robinson PV, Cortez FJ, Elma MLB, Seftel D, Pourmandi N, Pandori MW, Bertozzi C. Antibody detection by agglutination-PCR (ADAP) enables early diagnosis of HIV infection by oral fluid analysis. Proc Natl Acad Sci U S A. 2018 Feb 06; 115(6):1250-1255. PMID: 29358368.
      View in: PubMed
    9. Woo CM, Lund PJ, Huang AC, Davis MM, Bertozzi C, Pitteri SJ. Mapping and Quantification of Over 2000 O-linked Glycopeptides in Activated Human T Cells with Isotope-Targeted Glycoproteomics (Isotag). Mol Cell Proteomics. 2018 Apr; 17(4):764-775. PMID: 29351928.
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    10. Freeman SA, Vega A, Riedl M, Collins RF, Ostrowski PP, Woods EC, Bertozzi C, Tammi MI, Lidke DS, Johnson P, Mayor S, Jaqaman K, Grinstein S. Transmembrane Pickets Connect Cyto- and Pericellular Skeletons Forming Barriers to Receptor Engagement. Cell. 2018 Jan 11; 172(1-2):305-317.e10. PMID: 29328918.
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    11. Woods EC, Kai F, Barnes JM, Pedram K, Pickup MW, Hollander MJ, Weaver VM, Bertozzi C. A bulky glycocalyx fosters metastasis formation by promoting G1 cell cycle progression. Elife. 2017 Dec 21; 6. PMID: 29266001.
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    12. Tsai CT, Mukai K, Robinson PV, Gray MA, Waschmann MB, Lyu SC, Tsai M, Chinthrajah RS, Nadeau KC, Bertozzi C, Galli SJ. Isotype-specific agglutination-PCR (ISAP): A sensitive and multiplex method for measuring allergen-specific IgE. J Allergy Clin Immunol. 2017 Dec 14. PMID: 29248495.
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    13. Bertozzi C. A Model for Accelerating Patient-to-Bench Research. ACS Cent Sci. 2017 Nov 22; 3(11):1129-1130. PMID: 29202011.
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    14. Kamariza M, Shieh P, Bertozzi C. Imaging Mycobacterial Trehalose Glycolipids. Methods Enzymol. 2018; 598:355-369. PMID: 29306442.
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    15. Tomlin FM, Gerling-Driessen UIM, Liu YC, Flynn RA, Vangala JR, Lentz CS, Clauder-Muenster S, Jakob P, Mueller WF, Ordoñez-Rueda D, Paulsen M, Matsui N, Foley D, Rafalko A, Suzuki T, Bogyo M, Steinmetz LM, Radhakrishnan SK, Bertozzi C. Inhibition of NGLY1 Inactivates the Transcription Factor Nrf1 and Potentiates Proteasome Inhibitor Cytotoxicity. ACS Cent Sci. 2017 Nov 22; 3(11):1143-1155. PMID: 29202016.
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    16. Bertozzi C. Atoms out of Blobs: CryoEM Takes the Nobel Prize in Chemistry. ACS Cent Sci. 2017 Oct 25; 3(10):1056. PMID: 29104918.
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    17. Spiciarich DR, Nolley R, Maund SL, Purcell SC, Herschel J, Iavarone AT, Peehl DM, Bertozzi C. Bioorthogonal Labeling of Human Prostate Cancer Tissue Slice Cultures for Glycoproteomics. Angew Chem Int Ed Engl. 2017 Jul 24; 56(31):8992-8997. PMID: 28649697.
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    18. Andres LM, Blong IW, Evans AC, Rumachik NG, Yamaguchi T, Pham ND, Thompson P, Kohler JJ, Bertozzi C. Chemical Modulation of Protein O-GlcNAcylation via OGT Inhibition Promotes Human Neural Cell Differentiation. ACS Chem Biol. 2017 Aug 18; 12(8):2030-2039. PMID: 28541657.
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    19. Hinderlich S, Tauber R, Bertozzi C, Hackenberger CPR. Werner Reutter: A Visionary Pioneer in Molecular Glycobiology. Chembiochem. 2017 07 04; 18(13):1141-1145. PMID: 28621497.
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    20. Bertozzi C. Miraculous Chemistry on the Han River. ACS Cent Sci. 2017 May 24; 3(5):360-361. PMID: 28573193.
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    21. Woo CM, Felix A, Byrd WE, Zuegel DK, Ishihara M, Azadi P, Iavarone AT, Pitteri SJ, Bertozzi C. Development of IsoTaG, a Chemical Glycoproteomics Technique for Profiling Intact N- and O-Glycopeptides from Whole Cell Proteomes. J Proteome Res. 2017 04 07; 16(4):1706-1718. PMID: 28244757.
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    22. Aldrich C, Bertozzi C, Georg GI, Kiessling L, Lindsley C, Liotta D, Merz KM, Schepartz A, Wang S. The Ecstasy and Agony of Assay Interference Compounds. ACS Infect Dis. 2017 Apr 14; 3(4):259-262. PMID: 28244723.
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    23. Aldrich C, Bertozzi C, Georg GI, Kiessling L, Lindsley C, Liotta D, Merz KM, Schepartz A, Wang S. The Ecstasy and Agony of Assay Interference Compounds. ACS Chem Biol. 2017 03 17; 12(3):575-578. PMID: 28244728.
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    24. Aldrich C, Bertozzi C, Georg GI, Kiessling L, Lindsley C, Liotta D, Merz KM, Schepartz A, Wang S. The Ecstasy and Agony of Assay Interference Compounds. Biochemistry. 2017 03 14; 56(10):1363-1366. PMID: 28244742.
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    25. Aldrich C, Bertozzi C, Georg GI, Kiessling L, Lindsley C, Liotta D, Merz KM, Schepartz A, Wang S. The Ecstasy and Agony of Assay Interference Compounds. J Chem Inf Model. 2017 03 27; 57(3):387-390. PMID: 28244743.
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    26. Aldrich C, Bertozzi C, Georg GI, Kiessling L, Lindsley C, Liotta D, Merz KM, Schepartz A, Wang S. The Ecstasy and Agony of Assay Interference Compounds. ACS Med Chem Lett. 2017 Apr 13; 8(4):379-382. PMID: 28435522.
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    27. Aldrich C, Bertozzi C, Georg GI, Kiessling L, Lindsley C, Liotta D, Merz KM, Schepartz A, Wang S. The Ecstasy and Agony of Assay Interference Compounds. J Med Chem. 2017 Mar 23; 60(6):2165-2168. PMID: 28244745.
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    28. Aldrich C, Bertozzi C, Georg GI, Kiessling L, Lindsley C, Liotta D, Merz KM, Schepartz A, Wang S. The Ecstasy and Agony of Assay Interference Compounds. ACS Chem Neurosci. 2017 03 15; 8(3):420-423. PMID: 28244737.
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    29. Aldrich C, Bertozzi C, Georg GI, Kiessling L, Lindsley C, Liotta D, Merz KM, Schepartz A, Wang S. The Ecstasy and Agony of Assay Interference Compounds. ACS Cent Sci. 2017 Mar 22; 3(3):143-147. PMID: 28386587.
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    30. Rodriguez-Rivera FP, Zhou X, Theriot JA, Bertozzi C. Visualization of mycobacterial membrane dynamics in live cells. J Am Chem Soc. 2017 03 08; 139(9):3488-3495. PMID: 28075574.
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    31. Schump MD, Fox DM, Bertozzi C, Riley LW. Subcellular Partitioning and Intramacrophage Selectivity of Antimicrobial Compounds against Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2017 Mar; 61(3). PMID: 28052847.
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    32. Jolly AL, Agarwal P, Metruccio MME, Spiciarich DR, Evans DJ, Bertozzi C, Fleiszig SMJ. Corneal surface glycosylation is modulated by IL-1R and Pseudomonas aeruginosa challenge but is insufficient for inhibiting bacterial binding. FASEB J. 2017 06; 31(6):2393-2404. PMID: 28223334.
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    33. Ganesan L, Shieh P, Bertozzi C, Levental I. Click-Chemistry Based High Throughput Screening Platform for Modulators of Ras Palmitoylation. Sci Rep. 2017 Jan 23; 7:41147. PMID: 28112226.
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    34. Bertozzi C, Paley MA. A Season of Giving to Science. ACS Cent Sci. 2016 Dec 28; 2(12):872-873. PMID: 28058273.
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    35. Bertozzi C. Ingredients for a Positive Safety Culture. ACS Cent Sci. 2016 Nov 23; 2(11):764-766. PMID: 27924302.
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    36. Palaniappan KK, Bertozzi C. Chemical Glycoproteomics. Chem Rev. 2016 Dec 14; 116(23):14277-14306. PMID: 27960262.
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    37. Bertozzi C. Design, Synthesis, Action! Molecular Machines Take the 2016 Nobel Prize in Chemistry. ACS Cent Sci. 2016 Oct 26; 2(10):674-675. PMID: 27800546.
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    38. Woo CM, Felix A, Zhang L, Elias JE, Bertozzi C. Isotope-targeted glycoproteomics (IsoTaG) analysis of sialylated N- and O-glycopeptides on an Orbitrap Fusion Tribrid using azido and alkynyl sugars. Anal Bioanal Chem. 2017 Jan; 409(2):579-588. PMID: 27695962.
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    39. Zhu X, Shieh P, Su M, Bertozzi C, Zhang W. A fluorogenic screening platform enables directed evolution of an alkyne biosynthetic tool. Chem Commun (Camb). 2016 Sep 28; 52(75):11239-42. PMID: 27561030; PMCID: PMC5023497 [Available on 09/28/17].
    40. Bertozzi C. Back to the Lecture. ACS Cent Sci. 2016 Aug 24; 2(8):483-5. PMID: 27610405; PMCID: PMC4999963.
    41. Xiao H, Woods EC, Vukojicic P, Bertozzi C. Precision glycocalyx editing as a strategy for cancer immunotherapy. Proc Natl Acad Sci U S A. 2016 09 13; 113(37):10304-9. PMID: 27551071; PMCID: PMC5027407 [Available on 03/13/17].
    42. Robinson PV, Tsai CT, de Groot AE, McKechnie JL, Bertozzi C. Glyco-seek: Ultrasensitive Detection of Protein-Specific Glycosylation by Proximity Ligation Polymerase Chain Reaction. J Am Chem Soc. 2016 08 31; 138(34):10722-5. PMID: 27454154.
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    43. Sogi KM, Holsclaw CM, Fragiadakis GK, Nomura DK, Leary JA, Bertozzi C. Biosynthesis and Regulation of Sulfomenaquinone, a Metabolite Associated with Virulence in Mycobacterium tuberculosis. ACS Infect Dis. 2016 Nov 11; 2(11):800-806. PMID: 27933784.
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    44. Bhat R, Belardi B, Mori H, Kuo P, Tam A, Hines WC, Le QT, Bertozzi C, Bissell MJ. Nuclear repartitioning of galectin-1 by an extracellular glycan switch regulates mammary morphogenesis. Proc Natl Acad Sci U S A. 2016 08 16; 113(33):E4820-7. PMID: 27496330; PMCID: PMC4995945 [Available on 02/16/17].
    45. Bertozzi C. Exercise Your Brain. ACS Cent Sci. 2016 Jul 27; 2(7):430-1. PMID: 27504487; PMCID: PMC4965850.
    46. Bertozzi C. Postdoc Labor Love. ACS Cent Sci. 2016 Jun 22; 2(6):359-60. PMID: 27413776; PMCID: PMC4919776.
    47. Sheta R, Roux-Dalvai F, Woo CM, Fournier F, Bourassa S, Bertozzi C, Droit A, Bachvarov D. Proteomic dataset for altered glycoprotein expression upon GALNT3 knockdown in ovarian cancer cells. Data Brief. 2016 Sep; 8:342-9. PMID: 27331112; PMCID: PMC4908283.
    48. Hudak JE, Belardi B, Appel MJ, Solania A, Robinson PV, Bertozzi C. Piperidine-based glycodendrons as protein N-glycan prosthetics. Bioorg Med Chem. 2016 10 15; 24(20):4791-4800. PMID: 27283789.
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    49. Bertozzi C. Achieving Gender Balance in the Chemistry Professoriate Is Not Rocket Science. ACS Cent Sci. 2016 Apr 27; 2(4):181-2. PMID: 27163045; PMCID: PMC4850509.
    50. Ngo JT, Adams SR, Deerinck TJ, Boassa D, Rodriguez-Rivera F, Palida SF, Bertozzi C, Ellisman MH, Tsien RY. Click-EM for imaging metabolically tagged nonprotein biomolecules. Nat Chem Biol. 2016 06; 12(6):459-65. PMID: 27110681; PMCID: PMC4871776 [Available on 10/25/16].
    51. Sheta R, Woo CM, Roux-Dalvai F, Fournier F, Bourassa S, Droit A, Bertozzi C, Bachvarov D. A metabolic labeling approach for glycoproteomic analysis reveals altered glycoprotein expression upon GALNT3 knockdown in ovarian cancer cells. J Proteomics. 2016 08 11; 145:91-102. PMID: 27095597.
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    52. Lantos AB, Carlevaro G, Araoz B, Ruiz Diaz P, Camara Mde L, Buscaglia CA, Bossi M, Yu H, Chen X, Bertozzi C, Mucci J, Campetella O. Sialic Acid Glycobiology Unveils Trypanosoma cruzi Trypomastigote Membrane Physiology. PLoS Pathog. 2016 Apr; 12(4):e1005559. PMID: 27058585; PMCID: PMC4825991.
    53. Bertozzi C. Happy Birthday ACS Central Science! ACS Cent Sci. 2016 Mar 23; 2(3):117-8. PMID: 27163035; PMCID: PMC4827488.
    54. Woo CM, Bertozzi C. Isotope Targeted Glycoproteomics (IsoTaG) to Characterize Intact, Metabolically Labeled Glycopeptides from Complex Proteomes. Curr Protoc Chem Biol. 2016 Mar 16; 8(1):59-82. PMID: 26995354; PMCID: PMC4809415 [Available on 03/16/17].
    55. Amit I, Baker D, Barker R, Berger B, Bertozzi C, Bhatia S, Biffi A, Demichelis F, Doudna J, Dowdy SF, Endy D, Helmstaedter M, Junca H, June C, Kamb S, Khvorova A, Kim DH, Kim JS, Krishnan Y, Lakadamyali M, Lappalainen T, Lewin S, Liao J, Loman N, Lundberg E, Lynd L, Martin C, Mellman I, Miyawaki A, Mummery C, Nelson K, Paz J, Peralta-Yahya P, Picotti P, Polyak K, Prather K, Qin J, Quake S, Regev A, Rogers JA, Shetty R, Sommer M, Stevens M, Stolovitzky G, Takahashi M, Tang F, Teichmann S, Torres-Padilla ME, Tripathi L, Vemula P, Verdine G, Vollmer F, Wang J, Ying JY, Zhang F, Zhang T. Voices of biotech. Nat Biotechnol. 2016 Mar; 34(3):270-5. PMID: 26963549.
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    56. Tsai CT, Robinson PV, Spencer CA, Bertozzi C. Ultrasensitive Antibody Detection by Agglutination-PCR (ADAP). ACS Cent Sci. 2016 Mar 23; 2(3):139-147. PMID: 27064772.
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    57. Agre P, Bertozzi C, Bissell M, Campbell KP, Cummings RD, Desai UR, Estes M, Flotte T, Fogleman G, Gage F, Ginsburg D, Gordon JI, Hart G, Hascall V, Kiessling L, Kornfeld S, Lowe J, Magnani J, Mahal LK, Medzhitov R, Roberts RJ, Sackstein R, Sarkar R, Schnaar R, Schwartz N, Varki A, Walt D, Weissman I. Training the next generation of biomedical investigators in glycosciences. J Clin Invest. 2016 Feb; 126(2):405-8. PMID: 26829621; PMCID: PMC4731185 [Available on 02/01/17].
    58. Bertozzi C, Chang CJ, Davis BG, Olvera de la Cruz M, Tirrell DA, Zhao D. Grand Challenges in Chemistry for 2016 and Beyond. ACS Cent Sci. 2016 Jan 27; 2(1):1-3. PMID: 27163017; PMCID: PMC4827666.
    59. Freeman SA, Goyette J, Furuya W, Woods EC, Bertozzi C, Bergmeier W, Hinz B, van der Merwe PA, Das R, Grinstein S. Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis. Cell. 2016 Jan 14; 164(1-2):128-140. PMID: 26771488; PMCID: PMC4715264 [Available on 01/14/17].
    60. Bertozzi C. Advice for "Hunting Season". ACS Cent Sci. 2015 Dec 23; 1(9):464-5. PMID: 27163007; PMCID: PMC4827657.
    61. Varki A, Cummings RD, Aebi M, Packer NH, Seeberger PH, Esko JD, Stanley P, Hart G, Darvill A, Kinoshita T, Prestegard JJ, Schnaar RL, Freeze HH, Marth JD, Bertozzi C, Etzler ME, Frank M, Vliegenthart JF, Lütteke T, Perez S, Bolton E, Rudd P, Paulson J, Kanehisa M, Toukach P, Aoki-Kinoshita KF, Dell A, Narimatsu H, York W, Taniguchi N, Kornfeld S. Symbol Nomenclature for Graphical Representations of Glycans. Glycobiology. 2015 Dec; 25(12):1323-4. PMID: 26543186; PMCID: PMC4643639 [Available on 12/01/16].
    62. Kim J, Bertozzi C. A Bioorthogonal Reaction of N-Oxide and Boron Reagents. Angew Chem Int Ed Engl. 2015 Dec 21; 54(52):15777-81. PMID: 26568479; PMCID: PMC4715665 [Available on 12/21/16].
    63. Woods EC, Yee NA, Shen J, Bertozzi C. Glycocalyx Engineering with a Recycling Glycopolymer that Increases Cell Survival In Vivo. Angew Chem Int Ed Engl. 2015 Dec 21; 54(52):15782-8. PMID: 26647316; PMCID: PMC4736730 [Available on 12/21/16].
    64. Bertozzi C. Chemistry Is Central to Repairing Genes and Global Health: Reflections on the 2015 Nobel Prizes in Chemistry and Physiology or Medicine. ACS Cent Sci. 2015 Oct 28; 1(7):343-4. PMID: 27162990; PMCID: PMC4827536.
    65. Kramer JR, Onoa B, Bustamante C, Bertozzi C. Chemically tunable mucin chimeras assembled on living cells. Proc Natl Acad Sci U S A. 2015 Oct 13; 112(41):12574-9. PMID: 26420872; PMCID: PMC4611660.
    66. Bertozzi C. It's about the Students. ACS Cent Sci. 2015 Sep 23; 1(6):279-80. PMID: 27162982; PMCID: PMC4827521.
    67. Bertozzi C, Paley MA. On Being a Closer. ACS Cent Sci. 2015 Aug 26; 1(5):217-8. PMID: 27162973; PMCID: PMC4827550.
    68. Robinson PV, de Almeida-Escobedo G, de Groot AE, McKechnie JL, Bertozzi C. Live-Cell Labeling of Specific Protein Glycoforms by Proximity-Enhanced Bioorthogonal Ligation. J Am Chem Soc. 2015 Aug 26; 137(33):10452-5. PMID: 26280358; PMCID: PMC4748840.
    69. Belardi B, Bertozzi C. Chemical Lectinology: Tools for Probing the Ligands and Dynamics of Mammalian Lectins In Vivo. Chem Biol. 2015 Aug 20; 22(8):983-93. PMID: 26256477; PMCID: PMC4567249.
    70. Agarwal P, Beahm BJ, Shieh P, Bertozzi C. Systemic Fluorescence Imaging of Zebrafish Glycans with Bioorthogonal Chemistry. Angew Chem Int Ed Engl. 2015 Sep 21; 54(39):11504-10. PMID: 26230529; PMCID: PMC4694582 [Available on 09/21/16].
    71. Bertozzi C. On the Move. ACS Cent Sci. 2015 Jul 22; 1(4):157-8. PMID: 27162965; PMCID: PMC4827477.
    72. Shieh P, Dien VT, Beahm BJ, Castellano JM, Wyss-Coray T, Bertozzi C. CalFluors: A Universal Motif for Fluorogenic Azide Probes across the Visible Spectrum. J Am Chem Soc. 2015 Jun 10; 137(22):7145-51. PMID: 25902190.
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    73. Bertozzi C. A Meeting Full of Firsts. ACS Cent Sci. 2015 May 27; 1(2):57. PMID: 27162947; PMCID: PMC4827500.
    74. Tapia H, Young L, Fox D, Bertozzi C, Koshland D. Increasing intracellular trehalose is sufficient to confer desiccation tolerance to Saccharomyces cerevisiae. Proc Natl Acad Sci U S A. 2015 May 12; 112(19):6122-7. PMID: 25918381; PMCID: PMC4434740.
    75. Woo CM, Iavarone AT, Spiciarich DR, Palaniappan KK, Bertozzi C. Isotope-targeted glycoproteomics (IsoTaG): a mass-independent platform for intact N- and O-glycopeptide discovery and analysis. Nat Methods. 2015 Jun; 12(6):561-7. PMID: 25894945; PMCID: PMC4599779.
    76. Siegrist MS, Aditham AK, Espaillat A, Cameron TA, Whiteside SA, Cava F, Portnoy DA, Bertozzi C. Host actin polymerization tunes the cell division cycle of an intracellular pathogen. Cell Rep. 2015 Apr 28; 11(4):499-507. PMID: 25892235; PMCID: PMC4417095.
    77. Bertozzi C. The Centrality of Chemistry. ACS Cent Sci. 2015 Mar 25; 1(1):1-2. PMID: 27162935; PMCID: PMC4827486.
    78. Kuhn J, Götting C, Beahm BJ, Bertozzi C, Faust I, Kuzaj P, Knabbe C, Hendig D. Xylosyltransferase II is the predominant isoenzyme which is responsible for the steady-state level of xylosyltransferase activity in human serum. Biochem Biophys Res Commun. 2015 Apr 10; 459(3):469-74. PMID: 25748573.
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    79. Agarwal P, Bertozzi C. Site-specific antibody-drug conjugates: the nexus of bioorthogonal chemistry, protein engineering, and drug development. Bioconjug Chem. 2015 Feb 18; 26(2):176-92. PMID: 25494884; PMCID: PMC4335810.
    80. Siegrist MS, Swarts BM, Fox DM, Lim SA, Bertozzi C. Illumination of growth, division and secretion by metabolic labeling of the bacterial cell surface. FEMS Microbiol Rev. 2015 Mar; 39(2):184-202. PMID: 25725012; PMCID: PMC4462956.
    81. Appel MJ, Bertozzi C. Formylglycine, a post-translationally generated residue with unique catalytic capabilities and biotechnology applications. ACS Chem Biol. 2015 Jan 16; 10(1):72-84. PMID: 25514000; PMCID: PMC4492166.
    82. Touchette MH, Holsclaw CM, Previti ML, Solomon VC, Leary JA, Bertozzi C, Seeliger JC. The rv1184c locus encodes Chp2, an acyltransferase in Mycobacterium tuberculosis polyacyltrehalose lipid biosynthesis. J Bacteriol. 2015 Jan 01; 197(1):201-10. PMID: 25331437; PMCID: PMC4288680.
    83. Shieh P, Bertozzi C. Design strategies for bioorthogonal smart probes. Org Biomol Chem. 2014 Dec 14; 12(46):9307-20. PMID: 25315039; PMCID: PMC4259128.
    84. Meniche X, Otten R, Siegrist MS, Baer CE, Murphy KC, Bertozzi C, Sassetti CM. Subpolar addition of new cell wall is directed by DivIVA in mycobacteria. Proc Natl Acad Sci U S A. 2014 Aug 05; 111(31):E3243-51. PMID: 25049412; PMCID: PMC4128124.
    85. Paszek MJ, DuFort CC, Rossier O, Bainer R, Mouw JK, Godula K, Hudak JE, Lakins JN, Wijekoon AC, Cassereau L, Rubashkin MG, Magbanua MJ, Thorn KS, Davidson MW, Rugo HS, Park JW, Hammer DA, Giannone G, Bertozzi C, Weaver VM. The cancer glycocalyx mechanically primes integrin-mediated growth and survival. Nature. 2014 Jul 17; 511(7509):319-25. PMID: 25030168; PMCID: PMC4487551.
    86. Smith EL, Bertozzi C, Beatty KE. An expanded set of fluorogenic sulfatase activity probes. Chembiochem. 2014 May 26; 15(8):1101-5. PMID: 24764280; PMCID: PMC4084507.
    87. Smith EL, Giddens JP, Iavarone AT, Godula K, Wang LX, Bertozzi C. Chemoenzymatic Fc glycosylation via engineered aldehyde tags. Bioconjug Chem. 2014 Apr 16; 25(4):788-95. PMID: 24702330; PMCID: PMC4004622.
    88. Shieh P, Siegrist MS, Cullen AJ, Bertozzi C. Imaging bacterial peptidoglycan with near-infrared fluorogenic azide probes. Proc Natl Acad Sci U S A. 2014 Apr 15; 111(15):5456-61. PMID: 24706769; PMCID: PMC3992625.
    89. Sletten EM, de Almeida G, Bertozzi C. A homologation approach to the synthesis of difluorinated cycloalkynes. Org Lett. 2014 Mar 21; 16(6):1634-7. PMID: 24588780; PMCID: PMC3993865.
    90. Beahm BJ, Dehnert KW, Derr NL, Kuhn J, Eberhart JK, Spillmann D, Amacher SL, Bertozzi C. A visualizable chain-terminating inhibitor of glycosaminoglycan biosynthesis in developing zebrafish. Angew Chem Int Ed Engl. 2014 Mar 24; 53(13):3347-52. PMID: 24554559; PMCID: PMC4029504.
    91. Siegrist MS, Bertozzi C. Mycobacterial lipid logic. Cell Host Microbe. 2014 Jan 15; 15(1):1-2. PMID: 24439891; PMCID: PMC4123792.
    92. Hatzios SK, Baer CE, Rustad TR, Siegrist MS, Pang JM, Ortega C, Alber T, Grundner C, Sherman DR, Bertozzi C. Osmosensory signaling in Mycobacterium tuberculosis mediated by a eukaryotic-like Ser/Thr protein kinase. Proc Natl Acad Sci U S A. 2013 Dec 24; 110(52):E5069-77. PMID: 24309377; PMCID: PMC3876250.
    93. Hudak JE, Canham SM, Bertozzi C. Glycocalyx engineering reveals a Siglec-based mechanism for NK cell immunoevasion. Nat Chem Biol. 2014 Jan; 10(1):69-75. PMID: 24292068; PMCID: PMC3893890.
    94. Hudak JE, Bertozzi C. Glycotherapy: new advances inspire a reemergence of glycans in medicine. Chem Biol. 2014 Jan 16; 21(1):16-37. PMID: 24269151; PMCID: PMC4111574.
    95. Belardi B, de la Zerda A, Spiciarich DR, Maund SL, Peehl DM, Bertozzi C. Imaging the glycosylation state of cell surface glycoproteins by two-photon fluorescence lifetime imaging microscopy. Angew Chem Int Ed Engl. 2013 Dec 23; 52(52):14045-9. PMID: 24259491; PMCID: PMC3920747.
    96. Bertozzi C, Wu P. In vivo chemistry. Curr Opin Chem Biol. 2013 Oct; 17(5):717-8. PMID: 24156981.
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    97. Palaniappan KK, Hangauer MJ, Smith TJ, Smart BP, Pitcher AA, Cheng EH, Bertozzi C, Boyce M. A chemical glycoproteomics platform reveals O-GlcNAcylation of mitochondrial voltage-dependent anion channel 2. Cell Rep. 2013 Oct 31; 5(2):546-52. PMID: 24120863; PMCID: PMC3869705.
    98. Mauris J, Mantelli F, Woodward AM, Cao Z, Bertozzi C, Panjwani N, Godula K, Argüeso P. Modulation of ocular surface glycocalyx barrier function by a galectin-3 N-terminal deletion mutant and membrane-anchored synthetic glycopolymers. PLoS One. 2013; 8(8):e72304. PMID: 23977277; PMCID: PMC3747151.
    99. Beatty KE, Williams M, Carlson BL, Swarts BM, Warren RM, van Helden PD, Bertozzi C. Sulfatase-activated fluorophores for rapid discrimination of mycobacterial species and strains. Proc Natl Acad Sci U S A. 2013 Aug 06; 110(32):12911-6. PMID: 23878250; PMCID: PMC3740907.
    100. Sogi KM, Gartner ZJ, Breidenbach MA, Appel MJ, Schelle MW, Bertozzi C. Mycobacterium tuberculosis Rv3406 is a type II alkyl sulfatase capable of sulfate scavenging. PLoS One. 2013; 8(6):e65080. PMID: 23762287; PMCID: PMC3675115.
    101. de Almeida G, Townsend LC, Bertozzi C. Synthesis and reactivity of dibenzoselenacycloheptynes. Org Lett. 2013 Jun 21; 15(12):3038-41. PMID: 23734979; PMCID: PMC3827634.
    102. Shin SH, Comolli LR, Tscheliessnig R, Wang C, Nam KT, Hexemer A, Siegerist CE, De Yoreo JJ, Bertozzi C. Self-assembly of "S-bilayers", a step toward expanding the dimensionality of S-layer assemblies. ACS Nano. 2013 Jun 25; 7(6):4946-53. PMID: 23705800.
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    103. Comolli LR, Siegerist CE, Shin SH, Bertozzi C, Regan W, Zettl A, De Yoreo J. Conformational transitions at an S-layer growing boundary resolved by cryo-TEM. Angew Chem Int Ed Engl. 2013 Apr 26; 52(18):4829-32. PMID: 23564404.
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    104. Van de Bittner GC, Bertozzi C, Chang CJ. Strategy for dual-analyte luciferin imaging: in vivo bioluminescence detection of hydrogen peroxide and caspase activity in a murine model of acute inflammation. J Am Chem Soc. 2013 Feb 06; 135(5):1783-95. PMID: 23347279; PMCID: PMC3583381.
    105. Siegrist MS, Whiteside S, Jewett JC, Aditham A, Cava F, Bertozzi C. (D)-Amino acid chemical reporters reveal peptidoglycan dynamics of an intracellular pathogen. ACS Chem Biol. 2013 Mar 15; 8(3):500-5. PMID: 23240806; PMCID: PMC3601600.
    106. Agarwal P, van der Weijden J, Sletten EM, Rabuka D, Bertozzi C. A Pictet-Spengler ligation for protein chemical modification. Proc Natl Acad Sci U S A. 2013 Jan 02; 110(1):46-51. PMID: 23237853; PMCID: PMC3538270.
    107. Shieh P, Hangauer MJ, Bertozzi C. Fluorogenic azidofluoresceins for biological imaging. J Am Chem Soc. 2012 Oct 24; 134(42):17428-31. PMID: 23025473; PMCID: PMC3596100.
    108. Swarts BM, Holsclaw CM, Jewett JC, Alber M, Fox DM, Siegrist MS, Leary JA, Kalscheuer R, Bertozzi C. Probing the mycobacterial trehalome with bioorthogonal chemistry. J Am Chem Soc. 2012 Oct 03; 134(39):16123-6. PMID: 22978752; PMCID: PMC3466019.
    109. Godula K, Bertozzi C. Density variant glycan microarray for evaluating cross-linking of mucin-like glycoconjugates by lectins. J Am Chem Soc. 2012 Sep 26; 134(38):15732-42. PMID: 22967056; PMCID: PMC3458438.
    110. Henkin AH, Cohen AS, Dubikovskaya EA, Park HM, Nikitin GF, Auzias MG, Kazantzis M, Bertozzi C, Stahl A. Real-time noninvasive imaging of fatty acid uptake in vivo. ACS Chem Biol. 2012 Nov 16; 7(11):1884-91. PMID: 22928772; PMCID: PMC3500440.
    111. Shin SH, Chung S, Sanii B, Comolli LR, Bertozzi C, De Yoreo JJ. Direct observation of kinetic traps associated with structural transformations leading to multiple pathways of S-layer assembly. Proc Natl Acad Sci U S A. 2012 Aug 07; 109(32):12968-73. PMID: 22822216; PMCID: PMC3420203.
    112. Chang PV, Bertozzi C. Imaging beyond the proteome. Chem Commun (Camb). 2012 Sep 14; 48(71):8864-79. PMID: 22801420; PMCID: PMC3660043.
    113. Belardi B, O'Donoghue GP, Smith AW, Groves JT, Bertozzi C. Investigating cell surface galectin-mediated cross-linking on glycoengineered cells. J Am Chem Soc. 2012 Jun 13; 134(23):9549-52. PMID: 22540968; PMCID: PMC3374418.
    114. Gordon CG, Mackey JL, Jewett JC, Sletten EM, Houk KN, Bertozzi C. Reactivity of biarylazacyclooctynones in copper-free click chemistry. J Am Chem Soc. 2012 Jun 06; 134(22):9199-208. PMID: 22553995; PMCID: PMC3368396.
    115. Onoe H, Hsiao SC, Douglas ES, Gartner ZJ, Bertozzi C, Francis MB, Mathies RA. Cellular microfabrication: observing intercellular interactions using lithographically-defined DNA capture sequences. Langmuir. 2012 May 29; 28(21):8120-6. PMID: 22512362.
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    116. Rabuka D, Rush JS, deHart GW, Wu P, Bertozzi C. Site-specific chemical protein conjugation using genetically encoded aldehyde tags. Nat Protoc. 2012 May 10; 7(6):1052-67. PMID: 22576105; PMCID: PMC3498491.
    117. Hudak JE, Barfield RM, de Hart GW, Grob P, Nogales E, Bertozzi C, Rabuka D. Synthesis of heterobifunctional protein fusions using copper-free click chemistry and the aldehyde tag. Angew Chem Int Ed Engl. 2012 Apr 23; 51(17):4161-5. PMID: 22407566; PMCID: PMC3379715.
    118. Yu SH, Boyce M, Wands AM, Bond MR, Bertozzi C, Kohler JJ. Metabolic labeling enables selective photocrosslinking of O-GlcNAc-modified proteins to their binding partners. Proc Natl Acad Sci U S A. 2012 Mar 27; 109(13):4834-9. PMID: 22411826; PMCID: PMC3323966.
    119. Griffin JE, Pandey AK, Gilmore SA, Mizrahi V, McKinney JD, Bertozzi C, Sassetti CM. Cholesterol catabolism by Mycobacterium tuberculosis requires transcriptional and metabolic adaptations. Chem Biol. 2012 Feb 24; 19(2):218-27. PMID: 22365605; PMCID: PMC3292763.
    120. Gilmore SA, Schelle MW, Holsclaw CM, Leigh CD, Jain M, Cox JS, Leary JA, Bertozzi C. Sulfolipid-1 biosynthesis restricts Mycobacterium tuberculosis growth in human macrophages. ACS Chem Biol. 2012 May 18; 7(5):863-70. PMID: 22360425; PMCID: PMC3355658.
    121. Yao JZ, Uttamapinant C, Poloukhtine A, Baskin JM, Codelli JA, Sletten EM, Bertozzi C, Popik VV, Ting AY. Fluorophore targeting to cellular proteins via enzyme-mediated azide ligation and strain-promoted cycloaddition. J Am Chem Soc. 2012 Feb 29; 134(8):3720-8. PMID: 22239252; PMCID: PMC3306817.
    122. de Almeida G, Sletten EM, Nakamura H, Palaniappan KK, Bertozzi C. Thiacycloalkynes for copper-free click chemistry. Angew Chem Int Ed Engl. 2012 Mar 05; 51(10):2443-7. PMID: 22282228; PMCID: PMC3384729.
    123. Dehnert KW, Baskin JM, Laughlin ST, Beahm BJ, Naidu NN, Amacher SL, Bertozzi C. Imaging the sialome during zebrafish development with copper-free click chemistry. Chembiochem. 2012 Feb 13; 13(3):353-7. PMID: 22262667; PMCID: PMC3385855.
    124. Breidenbach MA, Palaniappan KK, Pitcher AA, Bertozzi C. Mapping yeast N-glycosites with isotopically recoded glycans. Mol Cell Proteomics. 2012 Jun; 11(6):M111.015339. PMID: 22261724; PMCID: PMC3433913.
    125. Seeliger JC, Topp S, Sogi KM, Previti ML, Gallivan JP, Bertozzi C. A riboswitch-based inducible gene expression system for mycobacteria. PLoS One. 2012; 7(1):e29266. PMID: 22279533.
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    126. Seeliger JC, Holsclaw CM, Schelle MW, Botyanszki Z, Gilmore SA, Tully SE, Niederweis M, Cravatt BF, Leary JA, Bertozzi C. Elucidation and chemical modulation of sulfolipid-1 biosynthesis in Mycobacterium tuberculosis. J Biol Chem. 2012 Mar 09; 287(11):7990-8000. PMID: 22194604; PMCID: PMC3318749.
    127. An HJ, Gip P, Kim J, Wu S, Park KW, McVaugh CT, Schaffer DV, Bertozzi C, Lebrilla CB. Extensive determination of glycan heterogeneity reveals an unusual abundance of high mannose glycans in enriched plasma membranes of human embryonic stem cells. Mol Cell Proteomics. 2012 Apr; 11(4):M111.010660. PMID: 22147732; PMCID: PMC3322563.
    128. Jewett JC, Bertozzi C. Synthesis of a fluorogenic cyclooctyne activated by Cu-free click chemistry. Org Lett. 2011 Nov 18; 13(22):5937-9. PMID: 22029411; PMCID: PMC3219546.
    129. Sletten EM, Bertozzi C. A bioorthogonal quadricyclane ligation. J Am Chem Soc. 2011 Nov 09; 133(44):17570-3. PMID: 21962173; PMCID: PMC3206493.
    130. Bertozzi C. A decade of bioorthogonal chemistry. Acc Chem Res. 2011 Sep 20; 44(9):651-3. PMID: 21928847; PMCID: PMC4408923.
    131. Hudak JE, Yu HH, Bertozzi C. Protein glycoengineering enabled by the versatile synthesis of aminooxy glycans and the genetically encoded aldehyde tag. J Am Chem Soc. 2011 Oct 12; 133(40):16127-35. PMID: 21866965; PMCID: PMC3187659.
    132. Sletten EM, Bertozzi C. From mechanism to mouse: a tale of two bioorthogonal reactions. Acc Chem Res. 2011 Sep 20; 44(9):666-76. PMID: 21838330; PMCID: PMC3184615.
    133. Boyce M, Bertozzi C. Bringing chemistry to life. Nat Methods. 2011 Jul 28; 8(8):638-42. PMID: 21799498; PMCID: PMC3184769.
    134. Hatzios SK, Bertozzi C. The regulation of sulfur metabolism in Mycobacterium tuberculosis. PLoS Pathog. 2011 Jul; 7(7):e1002036. PMID: 21811406; PMCID: PMC3141025.
    135. Hatzios SK, Schelle MW, Newton GL, Sogi KM, Holsclaw CM, Fahey RC, Bertozzi C. The Mycobacterium tuberculosis CysQ phosphatase modulates the biosynthesis of sulfated glycolipids and bacterial growth. Bioorg Med Chem Lett. 2011 Sep 01; 21(17):4956-9. PMID: 21795043; PMCID: PMC3184767.
    136. Palaniappan KK, Pitcher AA, Smart BP, Spiciarich DR, Iavarone AT, Bertozzi C. Isotopic signature transfer and mass pattern prediction (IsoStamp): an enabling technique for chemically-directed proteomics. ACS Chem Biol. 2011 Aug 19; 6(8):829-36. PMID: 21604797; PMCID: PMC3220624.
    137. Hubbard SC, Boyce M, McVaugh CT, Peehl DM, Bertozzi C. Cell surface glycoproteomic analysis of prostate cancer-derived PC-3 cells. Bioorg Med Chem Lett. 2011 Sep 01; 21(17):4945-50. PMID: 21798741; PMCID: PMC3341932.
    138. Dehnert KW, Beahm BJ, Huynh TT, Baskin JM, Laughlin ST, Wang W, Wu P, Amacher SL, Bertozzi C. Metabolic labeling of fucosylated glycans in developing zebrafish. ACS Chem Biol. 2011 Jun 17; 6(6):547-52. PMID: 21425872; PMCID: PMC3117394.
    139. Boyce M, Carrico IS, Ganguli AS, Yu SH, Hangauer MJ, Hubbard SC, Kohler JJ, Bertozzi C. Metabolic cross-talk allows labeling of O-linked beta-N-acetylglucosamine-modified proteins via the N-acetylgalactosamine salvage pathway. Proc Natl Acad Sci U S A. 2011 Feb 22; 108(8):3141-6. PMID: 21300897; PMCID: PMC3044403.
    140. Shui W, Petzold CJ, Redding A, Liu J, Pitcher A, Sheu L, Hsieh TY, Keasling JD, Bertozzi C. Organelle membrane proteomics reveals differential influence of mycobacterial lipoglycans on macrophage phagosome maturation and autophagosome accumulation. J Proteome Res. 2011 Jan 07; 10(1):339-48. PMID: 21105745; PMCID: PMC3018347.
    141. Van de Bittner GC, Dubikovskaya EA, Bertozzi C, Chang CJ. In vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporter. Proc Natl Acad Sci U S A. 2010 Dec 14; 107(50):21316-21. PMID: 21115844; PMCID: PMC3003011.
    142. Binda O, Boyce M, Rush JS, Palaniappan KK, Bertozzi C, Gozani O. A chemical method for labeling lysine methyltransferase substrates. Chembiochem. 2011 Jan 24; 12(2):330-4. PMID: 21243721; PMCID: PMC3056122.
    143. Rush JS, Beatty KE, Bertozzi C. Bioluminescent probes of sulfatase activity. Chembiochem. 2010 Oct 18; 11(15):2096-9. PMID: 20872389; PMCID: PMC3069857.
    144. Beatty KE, Fisk JD, Smart BP, Lu YY, Szychowski J, Hangauer MJ, Baskin JM, Bertozzi C, Tirrell DA. Live-cell imaging of cellular proteins by a strain-promoted azide-alkyne cycloaddition. Chembiochem. 2010 Oct 18; 11(15):2092-5. PMID: 20836119; PMCID: PMC3069858.
    145. Topp S, Reynoso CM, Seeliger JC, Goldlust IS, Desai SK, Murat D, Shen A, Puri AW, Komeili A, Bertozzi C, Scott JR, Gallivan JP. Synthetic riboswitches that induce gene expression in diverse bacterial species. Appl Environ Microbiol. 2010 Dec; 76(23):7881-4. PMID: 20935124; PMCID: PMC2988590.
    146. Chung S, Shin SH, Bertozzi C, De Yoreo JJ. Self-catalyzed growth of S layers via an amorphous-to-crystalline transition limited by folding kinetics. Proc Natl Acad Sci U S A. 2010 Sep 21; 107(38):16536-41. PMID: 20823255; PMCID: PMC2944705.
    147. Sletten EM, Nakamura H, Jewett JC, Bertozzi C. Difluorobenzocyclooctyne: synthesis, reactivity, and stabilization by beta-cyclodextrin. J Am Chem Soc. 2010 Aug 25; 132(33):11799-805. PMID: 20666466; PMCID: PMC2923465.
    148. Godula K, Bertozzi C. Synthesis of glycopolymers for microarray applications via ligation of reducing sugars to a poly(acryloyl hydrazide) scaffold. J Am Chem Soc. 2010 Jul 28; 132(29):9963-5. PMID: 20608651; PMCID: PMC2907714.
    149. Chang PV, Dube DH, Sletten EM, Bertozzi C. A strategy for the selective imaging of glycans using caged metabolic precursors. J Am Chem Soc. 2010 Jul 21; 132(28):9516-8. PMID: 20568764; PMCID: PMC2907715.
    150. Jasti R, Bertozzi C. Progress and Challenges for the Bottom-Up Synthesis of Carbon Nanotubes with Discrete Chirality. Chem Phys Lett. 2010 Jul 09; 494(1-3):1-7. PMID: 21224898.
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    151. Bertozzi C. Straight talk with... Carolyn Bertozzi. Interview by Roxanne Palmer. Nat Med. 2010 Jul; 16(7):736. PMID: 20613742.
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    152. Cohen AS, Dubikovskaya EA, Rush JS, Bertozzi C. Real-time bioluminescence imaging of glycans on live cells. J Am Chem Soc. 2010 Jun 30; 132(25):8563-5. PMID: 20527879; PMCID: PMC2890245.
    153. Baskin JM, Dehnert KW, Laughlin ST, Amacher SL, Bertozzi C. Visualizing enveloping layer glycans during zebrafish early embryogenesis. Proc Natl Acad Sci U S A. 2010 Jun 08; 107(23):10360-5. PMID: 20489181; PMCID: PMC2890823.
    154. Jewett JC, Bertozzi C. Cu-free click cycloaddition reactions in chemical biology. Chem Soc Rev. 2010 Apr; 39(4):1272-9. PMID: 20349533; PMCID: PMC2865253.
    155. Muiá RP, Yu H, Prescher JA, Hellman U, Chen X, Bertozzi C, Campetella O. Identification of glycoproteins targeted by Trypanosoma cruzi trans-sialidase, a virulence factor that disturbs lymphocyte glycosylation. Glycobiology. 2010 Jul; 20(7):833-42. PMID: 20354005; PMCID: PMC2900898.
    156. Jewett JC, Sletten EM, Bertozzi C. Rapid Cu-free click chemistry with readily synthesized biarylazacyclooctynones. J Am Chem Soc. 2010 Mar 24; 132(11):3688-90. PMID: 20187640; PMCID: PMC2840677.
    157. Bertozzi C. Profile of Carolyn Bertozzi. Interview by Tinsley Davis. Proc Natl Acad Sci U S A. 2010 Feb 16; 107(7):2737-9. PMID: 20160128; PMCID: PMC2840349.
    158. Breidenbach MA, Gallagher JE, King DS, Smart BP, Wu P, Bertozzi C. Targeted metabolic labeling of yeast N-glycans with unnatural sugars. Proc Natl Acad Sci U S A. 2010 Mar 02; 107(9):3988-93. PMID: 20142501; PMCID: PMC2840165.
    159. Chang PV, Prescher JA, Sletten EM, Baskin JM, Miller IA, Agard NJ, Lo A, Bertozzi C. Copper-free click chemistry in living animals. Proc Natl Acad Sci U S A. 2010 Feb 02; 107(5):1821-6. PMID: 20080615; PMCID: PMC2836626.
    160. Yap MC, Kostiuk MA, Martin DD, Perinpanayagam MA, Hak PG, Siddam A, Majjigapu JR, Rajaiah G, Keller BO, Prescher JA, Wu P, Bertozzi C, Falck JR, Berthiaume LG. Rapid and selective detection of fatty acylated proteins using omega-alkynyl-fatty acids and click chemistry. J Lipid Res. 2010 Jun; 51(6):1566-80. PMID: 20028662; PMCID: PMC3035521.
    161. Laughlin ST, Bertozzi C. In vivo imaging of Caenorhabditis elegans glycans. ACS Chem Biol. 2009 Dec 18; 4(12):1068-72. PMID: 19954190; PMCID: PMC2807738.
    162. Varki A, Cummings RD, Esko JD, Freeze HH, Stanley P, Marth JD, Bertozzi C, Hart GW, Etzler ME. Symbol nomenclature for glycan representation. Proteomics. 2009 Dec; 9(24):5398-9. PMID: 19902428; PMCID: PMC2882983.
    163. Godula K, Umbel ML, Rabuka D, Botyanszki Z, Bertozzi C, Parthasarathy R. Control of the molecular orientation of membrane-anchored biomimetic glycopolymers. J Am Chem Soc. 2009 Jul 29; 131(29):10263-8. PMID: 19580278; PMCID: PMC2716393.
    164. Drake PM, Stock CM, Nathan JK, Gip P, Golden KP, Weinhold B, Gerardy-Schahn R, Bertozzi C. Polysialic acid governs T-cell development by regulating progenitor access to the thymus. Proc Natl Acad Sci U S A. 2009 Jul 21; 106(29):11995-2000. PMID: 19587240; PMCID: PMC2715481.
    165. Nessen MA, Kramer G, Back J, Baskin JM, Smeenk LE, de Koning LJ, van Maarseveen JH, de Jong L, Bertozzi C, Hiemstra H, de Koster CG. Selective enrichment of azide-containing peptides from complex mixtures. J Proteome Res. 2009 Jul; 8(7):3702-11. PMID: 19402736; PMCID: PMC2761887.
    166. Hsiao SC, Shum BJ, Onoe H, Douglas ES, Gartner ZJ, Mathies RA, Bertozzi C, Francis MB. Direct cell surface modification with DNA for the capture of primary cells and the investigation of myotube formation on defined patterns. Langmuir. 2009 Jun 16; 25(12):6985-91. PMID: 19505164; PMCID: PMC2812030.
    167. Agard NJ, Bertozzi C. Chemical approaches to perturb, profile, and perceive glycans. Acc Chem Res. 2009 Jun 16; 42(6):788-97. PMID: 19361192; PMCID: PMC2697281.
    168. Song J, Xu J, Filion T, Saiz E, Tomsia AP, Lian JB, Stein GS, Ayers DC, Bertozzi C. Elastomeric high-mineral content hydrogel-hydroxyapatite composites for orthopedic applications. J Biomed Mater Res A. 2009 Jun 15; 89(4):1098-107. PMID: 18546185; PMCID: PMC2745393.
    169. Perrine CL, Ganguli A, Wu P, Bertozzi C, Fritz TA, Raman J, Tabak LA, Gerken TA. Glycopeptide-preferring polypeptide GalNAc transferase 10 (ppGalNAc T10), involved in mucin-type O-glycosylation, has a unique GalNAc-O-Ser/Thr-binding site in its catalytic domain not found in ppGalNAc T1 or T2. J Biol Chem. 2009 Jul 24; 284(30):20387-97. PMID: 19460755; PMCID: PMC2740463.
    170. Harland CW, Botyanszki Z, Rabuka D, Bertozzi C, Parthasarathy R. Synthetic trehalose glycolipids confer desiccation resistance to supported lipid monolayers. Langmuir. 2009 May 05; 25(9):5193-8. PMID: 19323499; PMCID: PMC2699213.
    171. Douglas ES, Hsiao SC, Onoe H, Bertozzi C, Francis MB, Mathies RA. DNA-barcode directed capture and electrochemical metabolic analysis of single mammalian cells on a microelectrode array. Lab Chip. 2009 Jul 21; 9(14):2010-5. PMID: 19568668; PMCID: PMC2892333.
    172. Barb AW, Leavy TM, Robins LI, Guan Z, Six DA, Zhou P, Hangauer MJ, Bertozzi C, Raetz CR. Uridine-based inhibitors as new leads for antibiotics targeting Escherichia coli LpxC. Biochemistry. 2009 Apr 14; 48(14):3068-77. PMID: 19256534; PMCID: PMC2709817.
    173. Tang YJ, Shui W, Myers S, Feng X, Bertozzi C, Keasling JD. Central metabolism in Mycobacterium smegmatis during the transition from O2-rich to O2-poor conditions as studied by isotopomer-assisted metabolite analysis. Biotechnol Lett. 2009 Aug; 31(8):1233-40. PMID: 19357814; PMCID: PMC2709878.
    174. Hur GH, Meier JL, Baskin J, Codelli JA, Bertozzi C, Marahiel MA, Burkart MD. Crosslinking studies of protein-protein interactions in nonribosomal peptide biosynthesis. Chem Biol. 2009 Apr 24; 16(4):372-81. PMID: 19345117; PMCID: PMC2743379.
    175. Hatzios SK, Schelle MW, Holsclaw CM, Behrens CR, Botyanszki Z, Lin FL, Carlson BL, Kumar P, Leary JA, Bertozzi C. PapA3 is an acyltransferase required for polyacyltrehalose biosynthesis in Mycobacterium tuberculosis. J Biol Chem. 2009 May 08; 284(19):12745-51. PMID: 19276083; PMCID: PMC2676004.
    176. Gartner ZJ, Bertozzi C. Programmed assembly of 3-dimensional microtissues with defined cellular connectivity. Proc Natl Acad Sci U S A. 2009 Mar 24; 106(12):4606-10. PMID: 19273855; PMCID: PMC2660766.
    177. Wu P, Shui W, Carlson BL, Hu N, Rabuka D, Lee J, Bertozzi C. Site-specific chemical modification of recombinant proteins produced in mammalian cells by using the genetically encoded aldehyde tag. Proc Natl Acad Sci U S A. 2009 Mar 03; 106(9):3000-5. PMID: 19202059; PMCID: PMC2651276.
    178. Chen X, Wu P, Rousseas M, Okawa D, Gartner Z, Zettl A, Bertozzi C. Boron nitride nanotubes are noncytotoxic and can be functionalized for interaction with proteins and cells. J Am Chem Soc. 2009 Jan 28; 131(3):890-1. PMID: 19119844; PMCID: PMC2657038.
    179. Sletten EM, Bertozzi C. Bioorthogonal chemistry: fishing for selectivity in a sea of functionality. Angew Chem Int Ed Engl. 2009; 48(38):6974-98. PMID: 19714693; PMCID: PMC2864149.
    180. Shui W, Gilmore SA, Sheu L, Liu J, Keasling JD, Bertozzi C. Quantitative proteomic profiling of host-pathogen interactions: the macrophage response to Mycobacterium tuberculosis lipids. J Proteome Res. 2009 Jan; 8(1):282-9. PMID: 19053526; PMCID: PMC2655317.
    181. Godula K, Rabuka D, Nam KT, Bertozzi C. Synthesis and microcontact printing of dual end-functionalized mucin-like glycopolymers for microarray applications. Angew Chem Int Ed Engl. 2009; 48(27):4973-6. PMID: 19479916; PMCID: PMC2735190.
    182. Chang PV, Chen X, Smyrniotis C, Xenakis A, Hu T, Bertozzi C, Wu P. Metabolic labeling of sialic acids in living animals with alkynyl sugars. Angew Chem Int Ed Engl. 2009; 48(22):4030-3. PMID: 19388017; PMCID: PMC2868584.
    183. Jasti R, Bhattacharjee J, Neaton JB, Bertozzi C. Synthesis, characterization, and theory of [9]-, [12]-, and [18]cycloparaphenylene: carbon nanohoop structures. J Am Chem Soc. 2008 Dec 31; 130(52):17646-7. PMID: 19055403; PMCID: PMC2709987.
    184. Laughlin ST, Bertozzi C. Imaging the glycome. Proc Natl Acad Sci U S A. 2009 Jan 06; 106(1):12-7. PMID: 19104067; PMCID: PMC2629201.
    185. Toriello NM, Douglas ES, Thaitrong N, Hsiao SC, Francis MB, Bertozzi C, Mathies RA. Integrated microfluidic bioprocessor for single-cell gene expression analysis. Proc Natl Acad Sci U S A. 2008 Dec 23; 105(51):20173-8. PMID: 19075237; PMCID: PMC2629289.
    186. Drake PM, Nathan JK, Stock CM, Chang PV, Muench MO, Nakata D, Reader JR, Gip P, Golden KP, Weinhold B, Gerardy-Schahn R, Troy FA, Bertozzi C. Polysialic acid, a glycan with highly restricted expression, is found on human and murine leukocytes and modulates immune responses. J Immunol. 2008 Nov 15; 181(10):6850-8. PMID: 18981104; PMCID: PMC2718713.
    187. Shui W, Sheu L, Liu J, Smart B, Petzold CJ, Hsieh TY, Pitcher A, Keasling JD, Bertozzi C. Membrane proteomics of phagosomes suggests a connection to autophagy. Proc Natl Acad Sci U S A. 2008 Nov 04; 105(44):16952-7. PMID: 18971338; PMCID: PMC2579359.
    188. Holsclaw CM, Sogi KM, Gilmore SA, Schelle MW, Leavell MD, Bertozzi C, Leary JA. Structural characterization of a novel sulfated menaquinone produced by stf3 from Mycobacterium tuberculosis. ACS Chem Biol. 2008 Oct 17; 3(10):619-24. PMID: 18928249; PMCID: PMC2680727.
    189. Czlapinski JL, Schelle MW, Miller LW, Laughlin ST, Kohler JJ, Cornish VW, Bertozzi C. Conditional glycosylation in eukaryotic cells using a biocompatible chemical inducer of dimerization. J Am Chem Soc. 2008 Oct 08; 130(40):13186-7. PMID: 18788807; PMCID: PMC2709988.
    190. Rush JS, Bertozzi C. New aldehyde tag sequences identified by screening formylglycine generating enzymes in vitro and in vivo. J Am Chem Soc. 2008 Sep 17; 130(37):12240-1. PMID: 18722427; PMCID: PMC2721638.
    191. Codelli JA, Baskin JM, Agard NJ, Bertozzi C. Second-generation difluorinated cyclooctynes for copper-free click chemistry. J Am Chem Soc. 2008 Aug 27; 130(34):11486-93. PMID: 18680289; PMCID: PMC2646667.
    192. Paulick MG, Bertozzi C. The glycosylphosphatidylinositol anchor: a complex membrane-anchoring structure for proteins. Biochemistry. 2008 Jul 08; 47(27):6991-7000. PMID: 18557633; PMCID: PMC2663890.
    193. Sletten EM, Bertozzi C. A hydrophilic azacyclooctyne for Cu-free click chemistry. Org Lett. 2008 Jul 17; 10(14):3097-9. PMID: 18549231; PMCID: PMC2664610.
    194. Hatzios SK, Iavarone AT, Bertozzi C. Rv2131c from Mycobacterium tuberculosis is a CysQ 3'-phosphoadenosine-5'-phosphatase. Biochemistry. 2008 May 27; 47(21):5823-31. PMID: 18454554; PMCID: PMC2711008.
    195. Laughlin ST, Baskin JM, Amacher SL, Bertozzi C. In vivo imaging of membrane-associated glycans in developing zebrafish. Science. 2008 May 02; 320(5876):664-7. PMID: 18451302; PMCID: PMC2701225.
    196. Johnson JA, Baskin JM, Bertozzi C, Koberstein JT, Turro NJ. Copper-free click chemistry for the in situ crosslinking of photodegradable star polymers. Chem Commun (Camb). 2008 Jul 14; (26):3064-6. PMID: 18688349; PMCID: PMC2667816.
    197. Rabuka D, Forstner MB, Groves JT, Bertozzi C. Noncovalent cell surface engineering: incorporation of bioactive synthetic glycopolymers into cellular membranes. J Am Chem Soc. 2008 May 07; 130(18):5947-53. PMID: 18402449; PMCID: PMC2724873.
    198. Carlson BL, Ballister ER, Skordalakes E, King DS, Breidenbach MA, Gilmore SA, Berger JM, Bertozzi C. Function and structure of a prokaryotic formylglycine-generating enzyme. J Biol Chem. 2008 Jul 18; 283(29):20117-25. PMID: 18390551; PMCID: PMC2459300.
    199. Harland CW, Rabuka D, Bertozzi C, Parthasarathy R. The Mycobacterium tuberculosis virulence factor trehalose dimycolate imparts desiccation resistance to model mycobacterial membranes. Biophys J. 2008 Jun; 94(12):4718-24. PMID: 18326657; PMCID: PMC2397374.
    200. Tian E, Ten Hagen KG, Shum L, Hang HC, Imbert Y, Young WW, Bertozzi C, Tabak LA. An inhibitor of O-glycosylation induces apoptosis in NIH3T3 cells and developing mouse embryonic mandibular tissues. J Biol Chem. 2008 Feb 15; 283(7):4460. PMID: 18348354.
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    201. Leigh CD, Bertozzi C. Synthetic studies toward Mycobacterium tuberculosis sulfolipid-I. J Org Chem. 2008 Feb 01; 73(3):1008-17. PMID: 18173284.
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    202. Hsiao SC, Crow AK, Lam WA, Bertozzi C, Fletcher DA, Francis MB. DNA-coated AFM cantilevers for the investigation of cell adhesion and the patterning of live cells. Angew Chem Int Ed Engl. 2008; 47(44):8473-7. PMID: 18798192; PMCID: PMC2748828.
    203. Hangauer MJ, Bertozzi C. A FRET-based fluorogenic phosphine for live-cell imaging with the Staudinger ligation. Angew Chem Int Ed Engl. 2008; 47(13):2394-7. PMID: 18306205; PMCID: PMC2446402.
    204. Wu P, Chen X, Hu N, Tam UC, Blixt O, Zettl A, Bertozzi C. Biocompatible carbon nanotubes generated by functionalization with glycodendrimers. Angew Chem Int Ed Engl. 2008; 47(27):5022-5. PMID: 18509843; PMCID: PMC2847391.
    205. Paulick MG, Forstner MB, Groves JT, Bertozzi C. A chemical approach to unraveling the biological function of the glycosylphosphatidylinositol anchor. Proc Natl Acad Sci U S A. 2007 Dec 18; 104(51):20332-7. PMID: 18077333; PMCID: PMC2154431.
    206. Fernández-Suárez M, Baruah H, Martínez-Hernández L, Xie KT, Baskin JM, Bertozzi C, Ting AY. Redirecting lipoic acid ligase for cell surface protein labeling with small-molecule probes. Nat Biotechnol. 2007 Dec; 25(12):1483-7. PMID: 18059260; PMCID: PMC2654346.
    207. Kostiuk MA, Corvi MM, Keller BO, Plummer G, Prescher JA, Hangauer MJ, Bertozzi C, Rajaiah G, Falck JR, Berthiaume LG. Identification of palmitoylated mitochondrial proteins using a bio-orthogonal azido-palmitate analogue. FASEB J. 2008 Mar; 22(3):721-32. PMID: 17971398; PMCID: PMC2860959.
    208. Baskin JM, Prescher JA, Laughlin ST, Agard NJ, Chang PV, Miller IA, Lo A, Codelli JA, Bertozzi C. Copper-free click chemistry for dynamic in vivo imaging. Proc Natl Acad Sci U S A. 2007 Oct 23; 104(43):16793-7. PMID: 17942682; PMCID: PMC2040404.
    209. Martin DD, Vilas GL, Prescher JA, Rajaiah G, Falck JR, Bertozzi C, Berthiaume LG. Rapid detection, discovery, and identification of post-translationally myristoylated proteins during apoptosis using a bio-orthogonal azidomyristate analog. FASEB J. 2008 Mar; 22(3):797-806. PMID: 17932026; PMCID: PMC2865240.
    210. Parthasarathy R, Rabuka D, Bertozzi C, Groves JT. Molecular orientation of membrane-anchored mucin glycoprotein mimics. J Phys Chem B. 2007 Oct 25; 111(42):12133-5. PMID: 17915910.
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    211. Douglas ES, Chandra RA, Bertozzi C, Mathies RA, Francis MB. Self-assembled cellular microarrays patterned using DNA barcodes. Lab Chip. 2007 Nov; 7(11):1442-8. PMID: 17960269.
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    212. Paulick MG, Wise AR, Forstner MB, Groves JT, Bertozzi C. Synthetic analogues of glycosylphosphatidylinositol-anchored proteins and their behavior in supported lipid bilayers. J Am Chem Soc. 2007 Sep 19; 129(37):11543-50. PMID: 17715922.
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    213. Kumar P, Schelle MW, Jain M, Lin FL, Petzold CJ, Leavell MD, Leary JA, Cox JS, Bertozzi C. PapA1 and PapA2 are acyltransferases essential for the biosynthesis of the Mycobacterium tuberculosis virulence factor sulfolipid-1. Proc Natl Acad Sci U S A. 2007 Jul 03; 104(27):11221-6. PMID: 17592143; PMCID: PMC2040880.
    214. Chang PV, Prescher JA, Hangauer MJ, Bertozzi C. Imaging cell surface glycans with bioorthogonal chemical reporters. J Am Chem Soc. 2007 Jul 11; 129(27):8400-1. PMID: 17579403; PMCID: PMC2535820.
    215. Lin FL, van Halbeek H, Bertozzi C. Synthesis of mono- and dideoxygenated alpha,alpha-trehalose analogs. Carbohydr Res. 2007 Oct 15; 342(14):2014-30. PMID: 17559818; PMCID: PMC2072868.
    216. Leavy TM, Bertozzi C. A high-throughput assay for O-GlcNAc transferase detects primary sequence preferences in peptide substrates. Bioorg Med Chem Lett. 2007 Jul 15; 17(14):3851-4. PMID: 17531489; PMCID: PMC3225185.
    217. Chen X, Kis A, Zettl A, Bertozzi C. A cell nanoinjector based on carbon nanotubes. Proc Natl Acad Sci U S A. 2007 May 15; 104(20):8218-22. PMID: 17485677; PMCID: PMC1895932.
    218. Veiseh M, Veiseh O, Martin MC, Bertozzi C, Zhang M. Single-cell-based sensors and synchrotron FTIR spectroscopy: a hybrid system towards bacterial detection. Biosens Bioelectron. 2007 Sep 30; 23(2):253-60. PMID: 17560777; PMCID: PMC2065758.
    219. Carrico IS, Carlson BL, Bertozzi C. Introducing genetically encoded aldehydes into proteins. Nat Chem Biol. 2007 Jun; 3(6):321-2. PMID: 17450134.
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    220. Rabuka D, Parthasarathy R, Lee GS, Chen X, Groves JT, Bertozzi C. Hierarchical assembly of model cell surfaces: synthesis of mucin mimetic polymers and their display on supported bilayers. J Am Chem Soc. 2007 May 02; 129(17):5462-71. PMID: 17425309; PMCID: PMC2535821.
    221. Senaratne RH, Mougous JD, Reader JR, Williams SJ, Zhang T, Bertozzi C, Riley LW. Vaccine efficacy of an attenuated but persistent Mycobacterium tuberculosis cysH mutant. J Med Microbiol. 2007 Apr; 56(Pt 4):454-8. PMID: 17374883.
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    222. Jain M, Petzold CJ, Schelle MW, Leavell MD, Mougous JD, Bertozzi C, Leary JA, Cox JS. Lipidomics reveals control of Mycobacterium tuberculosis virulence lipids via metabolic coupling. Proc Natl Acad Sci U S A. 2007 Mar 20; 104(12):5133-8. PMID: 17360366; PMCID: PMC1829275.
    223. Laughlin ST, Bertozzi C. Metabolic labeling of glycans with azido sugars and subsequent glycan-profiling and visualization via Staudinger ligation. Nat Protoc. 2007; 2(11):2930-44. PMID: 18007630.
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    224. Agard NJ, Baskin JM, Prescher JA, Lo A, Bertozzi C. A comparative study of bioorthogonal reactions with azides. ACS Chem Biol. 2006 Nov 21; 1(10):644-8. PMID: 17175580.
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    225. Czlapinski JL, Bertozzi C. Synthetic glycobiology: Exploits in the Golgi compartment. Curr Opin Chem Biol. 2006 Dec; 10(6):645-51. PMID: 17056297.
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    226. Gao H, Leary J, Carroll KS, Bertozzi C, Chen H. Noncovalent complexes of APS reductase from M. tuberculosis: delineating a mechanistic model using ESI-FTICR MS. J Am Soc Mass Spectrom. 2007 Feb; 18(2):167-78. PMID: 17023175; PMCID: PMC2755055.
    227. Schelle MW, Bertozzi C. Sulfate metabolism in mycobacteria. Chembiochem. 2006 Oct; 7(10):1516-24. PMID: 16933356.
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    228. Rabuka D, Hubbard SC, Laughlin ST, Argade SP, Bertozzi C. A chemical reporter strategy to probe glycoprotein fucosylation. J Am Chem Soc. 2006 Sep 20; 128(37):12078-9. PMID: 16967952; PMCID: PMC3233198.
    229. Kehoe JW, Velappan N, Walbolt M, Rasmussen J, King D, Lou J, Knopp K, Pavlik P, Marks JD, Bertozzi C, Bradbury AR. Using phage display to select antibodies recognizing post-translational modifications independently of sequence context. Mol Cell Proteomics. 2006 Dec; 5(12):2350-63. PMID: 16971384.
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    230. Prescher JA, Bertozzi C. Chemical technologies for probing glycans. Cell. 2006 Sep 08; 126(5):851-4. PMID: 16959565.
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    231. Chartron J, Carroll KS, Shiau C, Gao H, Leary JA, Bertozzi C, Stout CD. Substrate recognition, protein dynamics, and iron-sulfur cluster in Pseudomonas aeruginosa adenosine 5'-phosphosulfate reductase. J Mol Biol. 2006 Nov 24; 364(2):152-69. PMID: 17010373; PMCID: PMC1769331.
    232. Stowell CL, Barvian KK, Young PC, Bigsby RM, Verdugo DE, Bertozzi C, Widlanski TS. A role for sulfation-desulfation in the uptake of bisphenol a into breast tumor cells. Chem Biol. 2006 Aug; 13(8):891-7. PMID: 16931338.
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    233. Link AJ, Vink MKS, Agard NJ, Prescher JA, Bertozzi C, Tirrell DA. Discovery of aminoacyl-tRNA synthetase activity through cell-surface display of noncanonical amino acids. Proc Natl Acad Sci U S A. 2006 Jul 05; 103(27):10180-10185. PMID: 16801548.
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    234. Chen X, Tam UC, Czlapinski JL, Lee GS, Rabuka D, Zettl A, Bertozzi C. Interfacing carbon nanotubes with living cells. J Am Chem Soc. 2006 May 17; 128(19):6292-3. PMID: 16683774.
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    235. Dube DH, Prescher JA, Quang CN, Bertozzi C. Probing mucin-type O-linked glycosylation in living animals. Proc Natl Acad Sci U S A. 2006 Mar 28; 103(13):4819-24. PMID: 16549800; PMCID: PMC1405625.
    236. Mougous JD, Senaratne RH, Petzold CJ, Jain M, Lee DH, Schelle MW, Leavell MD, Cox JS, Leary JA, Riley LW, Bertozzi C. A sulfated metabolite produced by stf3 negatively regulates the virulence of Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2006 Mar 14; 103(11):4258-63. PMID: 16537518; PMCID: PMC1449680.
    237. Senaratne RH, De Silva AD, Williams SJ, Mougous JD, Reader JR, Zhang T, Chan S, Sidders B, Lee DH, Chan J, Bertozzi C, Riley LW. 5'-Adenosinephosphosulphate reductase (CysH) protects Mycobacterium tuberculosis against free radicals during chronic infection phase in mice. Mol Microbiol. 2006 Mar; 59(6):1744-53. PMID: 16553880.
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    238. Chandra RA, Douglas ES, Mathies RA, Bertozzi C, Francis MB. Programmable cell adhesion encoded by DNA hybridization. Angew Chem Int Ed Engl. 2006 Jan 30; 45(6):896-901. PMID: 16370010.
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    239. Mougous JD, Lee DH, Hubbard SC, Schelle MW, Vocadlo DJ, Berger JM, Bertozzi C. Molecular basis for G protein control of the prokaryotic ATP sulfurylase. Mol Cell. 2006 Jan 06; 21(1):109-22. PMID: 16387658.
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    240. Rush J, Bertozzi C. An alpha-formylglycine building block for fmoc-based solid-phase peptide synthesis. Org Lett. 2006 Jan 05; 8(1):131-4. PMID: 16381585; PMCID: PMC2527029.
    241. Laughlin ST, Agard NJ, Baskin JM, Carrico IS, Chang PV, Ganguli AS, Hangauer MJ, Lo A, Prescher JA, Bertozzi C. Metabolic labeling of glycans with azido sugars for visualization and glycoproteomics. Methods Enzymol. 2006; 415:230-50. PMID: 17116478.
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    242. Perez-Vilar J, Mabolo R, McVaugh CT, Bertozzi C, Boucher RC. Mucin granule intraluminal organization in living mucous/goblet cells. Roles of protein post-translational modifications and secretion. J Biol Chem. 2006 Feb 24; 281(8):4844-55. PMID: 16377632.
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    243. Carroll KS, Gao H, Chen H, Leary JA, Bertozzi C. Investigation of the iron-sulfur cluster in Mycobacterium tuberculosis APS reductase: implications for substrate binding and catalysis. Biochemistry. 2005 Nov 08; 44(44):14647-57. PMID: 16262264.
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    244. Grogan MJ, Kaizuka Y, Conrad RM, Groves JT, Bertozzi C. Synthesis of lipidated green fluorescent protein and its incorporation in supported lipid bilayers. J Am Chem Soc. 2005 Oct 19; 127(41):14383-7. PMID: 16218633.
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    245. Hang HC, Bertozzi C. The chemistry and biology of mucin-type O-linked glycosylation. Bioorg Med Chem. 2005 Sep 01; 13(17):5021-34. PMID: 16005634.
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    246. Carroll KS, Gao H, Chen H, Stout CD, Leary JA, Bertozzi C. A conserved mechanism for sulfonucleotide reduction. PLoS Biol. 2005 Aug; 3(8):e250. PMID: 16008502; PMCID: PMC1175818.
    247. Prescher JA, Bertozzi C. Chemistry in living systems. Nat Chem Biol. 2005 Jun; 1(1):13-21. PMID: 16407987.
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    248. Pi N, Hoang MB, Gao H, Mougous JD, Bertozzi C, Leary JA. Kinetic measurements and mechanism determination of Stf0 sulfotransferase using mass spectrometry. Anal Biochem. 2005 Jun 01; 341(1):94-104. PMID: 15866533.
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    249. Dube DH, Bertozzi C. Glycans in cancer and inflammation--potential for therapeutics and diagnostics. Nat Rev Drug Discov. 2005 Jun; 4(6):477-88. PMID: 15931257.
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    250. Saad OM, Ebel H, Uchimura K, Rosen SD, Bertozzi C, Leary JA. Compositional profiling of heparin/heparan sulfate using mass spectrometry: assay for specificity of a novel extracellular human endosulfatase. Glycobiology. 2005 Aug; 15(8):818-26. PMID: 15843596.
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    251. Song J, Malathong V, Bertozzi C. Mineralization of synthetic polymer scaffolds: a bottom-up approach for the development of artificial bone. J Am Chem Soc. 2005 Mar 16; 127(10):3366-72. PMID: 15755154.
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    252. Lin FL, Hoyt HM, van Halbeek H, Bergman RG, Bertozzi C. Mechanistic investigation of the staudinger ligation. J Am Chem Soc. 2005 Mar 02; 127(8):2686-95. PMID: 15725026.
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    253. Pratt MR, Bertozzi C. Synthetic glycopeptides and glycoproteins as tools for biology. Chem Soc Rev. 2005 Jan; 34(1):58-68. PMID: 15643490.
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    254. Luchansky SJ, Bertozzi C. Azido sialic acids can modulate cell-surface interactions. Chembiochem. 2004 Dec 03; 5(12):1706-9. PMID: 15568180.
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    255. Agard NJ, Prescher JA, Bertozzi C. A strain-promoted [3 + 2] azide-alkyne cycloaddition for covalent modification of biomolecules in living systems. J Am Chem Soc. 2004 Nov 24; 126(46):15046-7. PMID: 15547999.
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    256. Chen X, Lee GS, Zettl A, Bertozzi C. Biomimetic engineering of carbon nanotubes by using cell surface mucin mimics. Angew Chem Int Ed Engl. 2004 Nov 19; 43(45):6111-6. PMID: 15549753.
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    257. de Graffenried CL, Laughlin ST, Kohler JJ, Bertozzi C. A small-molecule switch for Golgi sulfotransferases. Proc Natl Acad Sci U S A. 2004 Nov 30; 101(48):16715-20. PMID: 15548609; PMCID: PMC534710.
    258. Klapperich CM, Bertozzi C. Global gene expression of cells attached to a tissue engineering scaffold. Biomaterials. 2004 Nov; 25(25):5631-41. PMID: 15159079.
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    259. Vocadlo DJ, Bertozzi C. A strategy for functional proteomic analysis of glycosidase activity from cell lysates. Angew Chem Int Ed Engl. 2004 Oct 11; 43(40):5338-42. PMID: 15468183.
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    260. Kohler JJ, Czlapinski JL, Laughlin ST, Schelle MW, de Graffenried CL, Bertozzi C. Directing flux in glycan biosynthetic pathways with a small molecule switch. Chembiochem. 2004 Oct 04; 5(10):1455-8. PMID: 15457531.
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    261. Luchansky SJ, Argade S, Hayes BK, Bertozzi C. Metabolic functionalization of recombinant glycoproteins. Biochemistry. 2004 Sep 28; 43(38):12358-66. PMID: 15379575.
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    262. Tian E, Ten Hagen KG, Shum L, Hang HC, Imbert Y, Young WW, Bertozzi C, Tabak LA. An inhibitor of O-glycosylation induces apoptosis in NIH3T3 cells and developing mouse embryonic mandibular tissues. J Biol Chem. 2004 Nov 26; 279(48):50382-90. PMID: 15342645.
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    263. Prescher JA, Dube DH, Bertozzi C. Chemical remodelling of cell surfaces in living animals. Nature. 2004 Aug 19; 430(7002):873-7. PMID: 15318217.
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    264. de Graffenried CL, Bertozzi C. The roles of enzyme localisation and complex formation in glycan assembly within the Golgi apparatus. Curr Opin Cell Biol. 2004 Aug; 16(4):356-63. PMID: 15261667.
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    265. Mougous JD, Petzold CJ, Senaratne RH, Lee DH, Akey DL, Lin FL, Munchel SE, Pratt MR, Riley LW, Leary JA, Berger JM, Bertozzi C. Identification, function and structure of the mycobacterial sulfotransferase that initiates sulfolipid-1 biosynthesis. Nat Struct Mol Biol. 2004 Aug; 11(8):721-9. PMID: 15258569.
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    266. Song J, Cisar JS, Bertozzi C. Functional self-assembling bolaamphiphilic polydiacetylenes as colorimetric sensor scaffolds. J Am Chem Soc. 2004 Jul 14; 126(27):8459-65. PMID: 15238003.
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    267. Pratt MR, Bertozzi C. Syntheses of 6-sulfo sialyl Lewis X glycans corresponding to the L-selectin ligand "sulfoadhesin". Org Lett. 2004 Jul 08; 6(14):2345-8. PMID: 15228275.
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    268. Pratt MR, Hang HC, Ten Hagen KG, Rarick J, Gerken TA, Tabak LA, Bertozzi C. Deconvoluting the functions of polypeptide N-alpha-acetylgalactosaminyltransferase family members by glycopeptide substrate profiling. Chem Biol. 2004 Jul; 11(7):1009-16. PMID: 15271359.
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    269. de Graffenried CL, Bertozzi C. The stem region of the sulfotransferase GlcNAc6ST-1 is a determinant of substrate specificity. J Biol Chem. 2004 Sep 17; 279(38):40035-43. PMID: 15220337.
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    270. Woodruff PJ, Carlson BL, Siridechadilok B, Pratt MR, Senaratne RH, Mougous JD, Riley LW, Williams SJ, Bertozzi C. Trehalose is required for growth of Mycobacterium smegmatis. J Biol Chem. 2004 Jul 09; 279(28):28835-43. PMID: 15102847.
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    271. Macmillan D, Bertozzi C. Modular assembly of glycoproteins: towards the synthesis of GlyCAM-1 by using expressed protein ligation. Angew Chem Int Ed Engl. 2004 Mar 05; 43(11):1355-9. PMID: 15368405.
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    272. Luchansky SJ, Goon S, Bertozzi C. Expanding the diversity of unnatural cell-surface sialic acids. Chembiochem. 2004 Mar 05; 5(3):371-4. PMID: 14997530.
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    273. Hang HC, Yu C, Ten Hagen KG, Tian E, Winans KA, Tabak LA, Bertozzi C. Small molecule inhibitors of mucin-type O-linked glycosylation from a uridine-based library. Chem Biol. 2004 Mar; 11(3):337-45. PMID: 15123263.
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    275. Hang HC, Yu C, Kato DL, Bertozzi C. A metabolic labeling approach toward proteomic analysis of mucin-type O-linked glycosylation. Proc Natl Acad Sci U S A. 2003 Dec 09; 100(25):14846-51. PMID: 14657396; PMCID: PMC299823.
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    277. Dube DH, Bertozzi C. Metabolic oligosaccharide engineering as a tool for glycobiology. Curr Opin Chem Biol. 2003 Oct; 7(5):616-25. PMID: 14580567.
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    278. Wojczyk BS, Stwora-Wojczyk MM, Hagen FK, Striepen B, Hang HC, Bertozzi C, Roos DS, Spitalnik SL. cDNA cloning and expression of UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase T1 from Toxoplasma gondii. Mol Biochem Parasitol. 2003 Oct; 131(2):93-107. PMID: 14511808.
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    280. Vocadlo DJ, Hang HC, Kim EJ, Hanover JA, Bertozzi C. A chemical approach for identifying O-GlcNAc-modified proteins in cells. Proc Natl Acad Sci U S A. 2003 Aug 05; 100(16):9116-21. PMID: 12874386; PMCID: PMC171382.
    281. de Graffenried CL, Bertozzi C. Golgi localization of carbohydrate sulfotransferases is a determinant of L-selectin ligand biosynthesis. J Biol Chem. 2003 Oct 10; 278(41):40282-95. PMID: 12855678.
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    282. Pratt MR, Bertozzi C. Chemoselective ligation applied to the synthesis of a biantennary N-linked glycoform of CD52. J Am Chem Soc. 2003 May 21; 125(20):6149-59. PMID: 12785846.
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    283. Converse SE, Mougous JD, Leavell MD, Leary JA, Bertozzi C, Cox JS. MmpL8 is required for sulfolipid-1 biosynthesis and Mycobacterium tuberculosis virulence. Proc Natl Acad Sci U S A. 2003 May 13; 100(10):6121-6. PMID: 12724526; PMCID: PMC156336.
    284. Lemieux GA, De Graffenried CL, Bertozzi C. A fluorogenic dye activated by the staudinger ligation. J Am Chem Soc. 2003 Apr 23; 125(16):4708-9. PMID: 12696879.
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    285. Goon S, Schilling B, Tullius MV, Gibson BW, Bertozzi C. Metabolic incorporation of unnatural sialic acids into Haemophilus ducreyi lipooligosaccharides. Proc Natl Acad Sci U S A. 2003 Mar 18; 100(6):3089-94. PMID: 12615992; PMCID: PMC152251.
    286. Marcaurelle LA, Pratt MR, Bertozzi C. Synthesis of thioether-linked analogues of the 2,3-sialyl-TF and MECA-79 antigens: mucin-type glycopeptides associated with cancer and inflammation. Chembiochem. 2003 Mar 03; 4(2-3):224-8. PMID: 12616638.
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    287. Song J, Saiz E, Bertozzi C. A new approach to mineralization of biocompatible hydrogel scaffolds: an efficient process toward 3-dimensional bonelike composites. J Am Chem Soc. 2003 Feb 05; 125(5):1236-43. PMID: 12553825.
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    288. Armstrong JI, Verdugo DE, Bertozzi C. Synthesis of a bisubstrate analogue targeting estrogen sulfotransferase. J Org Chem. 2003 Jan 10; 68(1):170-3. PMID: 12515476.
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    289. Scherman MS, Winans KA, Stern RJ, Jones V, Bertozzi C, McNeil MR. Drug targeting Mycobacterium tuberculosis cell wall synthesis: development of a microtiter plate-based screen for UDP-galactopyranose mutase and identification of an inhibitor from a uridine-based library. Antimicrob Agents Chemother. 2003 Jan; 47(1):378-82. PMID: 12499218; PMCID: PMC148999.
    290. Luchansky SJ, Hang HC, Saxon E, Grunwell JR, Yu C, Dube DH, Bertozzi C. Constructing azide-labeled cell surfaces using polysaccharide biosynthetic pathways. Methods Enzymol. 2003; 362:249-72. PMID: 12968369.
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    291. Grunwell JR, Rath VL, Rasmussen J, Cabrilo Z, Bertozzi C. Characterization and mutagenesis of Gal/GlcNAc-6-O-sulfotransferases. Biochemistry. 2002 Dec 31; 41(52):15590-600. PMID: 12501187.
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    292. Luchansky SJ, Yarema KJ, Takahashi S, Bertozzi C. GlcNAc 2-epimerase can serve a catabolic role in sialic acid metabolism. J Biol Chem. 2003 Mar 07; 278(10):8035-42. PMID: 12499362.
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    293. Saxon E, Luchansky SJ, Hang HC, Yu C, Lee SC, Bertozzi C. Investigating cellular metabolism of synthetic azidosugars with the Staudinger ligation. J Am Chem Soc. 2002 Dec 18; 124(50):14893-902. PMID: 12475330.
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    294. Mougous JD, Leavell MD, Senaratne RH, Leigh CD, Williams SJ, Riley LW, Leary JA, Bertozzi C. Discovery of sulfated metabolites in mycobacteria with a genetic and mass spectrometric approach. Proc Natl Acad Sci U S A. 2002 Dec 24; 99(26):17037-42. PMID: 12482950; PMCID: PMC139265.
    295. Grunwell JR, Bertozzi C. Carbohydrate sulfotransferases of the GalNAc/Gal/GlcNAc6ST family. Biochemistry. 2002 Nov 05; 41(44):13117-26. PMID: 12403612.
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    296. Pi N, Armstrong JI, Bertozzi C, Leary JA. Kinetic analysis of NodST sulfotransferase using an electrospray ionization mass spectrometry assay. Biochemistry. 2002 Nov 05; 41(44):13283-8. PMID: 12403630.
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    297. Verdugo DE, Bertozzi C. A 96-well dot-blot assay for carbohydrate sulfotransferases. Anal Biochem. 2002 Aug 15; 307(2):330-6. PMID: 12202251.
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    298. Mougous JD, Green RE, Williams SJ, Brenner SE, Bertozzi C. Sulfotransferases and sulfatases in mycobacteria. Chem Biol. 2002 Jul; 9(7):767-76. PMID: 12144918.
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    299. Williams SJ, Senaratne RH, Mougous JD, Riley LW, Bertozzi C. 5'-adenosinephosphosulfate lies at a metabolic branch point in mycobacteria. J Biol Chem. 2002 Sep 06; 277(36):32606-15. PMID: 12072441.
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    300. Marcaurelle LA, Bertozzi C. Recent advances in the chemical synthesis of mucin-like glycoproteins. Glycobiology. 2002 Jun; 12(6):69R-77R. PMID: 12107076.
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    301. Conrad RM, Grogan MJ, Bertozzi C. Stereoselective synthesis of myo-inositol via ring-closing metathesis: a building block for glycosylphosphatidylinositol (GPI) anchor synthesis. Org Lett. 2002 Apr 18; 4(8):1359-61. PMID: 11950362.
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    302. Cook BN, Bertozzi C. Chemical approaches to the investigation of cellular systems. Bioorg Med Chem. 2002 Apr; 10(4):829-40. PMID: 11836089.
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    303. Kehoe JW, Maly DJ, Verdugo DE, Armstrong JI, Cook BN, Ouyang YB, Moore KL, Ellman JA, Bertozzi C. Tyrosylprotein sulfotransferase inhibitors generated by combinatorial target-guided ligand assembly. Bioorg Med Chem Lett. 2002 Feb 11; 12(3):329-32. PMID: 11814789.
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    304. Charter NW, Mahal LK, Koshland DE, Bertozzi C. Differential effects of unnatural sialic acids on the polysialylation of the neural cell adhesion molecule and neuronal behavior. J Biol Chem. 2002 Mar 15; 277(11):9255-61. PMID: 11786551.
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    305. Winans KA, Bertozzi C. An inhibitor of the human UDP-GlcNAc 4-epimerase identified from a uridine-based library: a strategy to inhibit O-linked glycosylation. Chem Biol. 2002 Jan; 9(1):113-29. PMID: 11841944.
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    306. Kiick KL, Saxon E, Tirrell DA, Bertozzi C. Incorporation of azides into recombinant proteins for chemoselective modification by the Staudinger ligation. Proc Natl Acad Sci U S A. 2002 Jan 08; 99(1):19-24. PMID: 11752401; PMCID: PMC117506.
    307. Grogan MJ, Pratt MR, Marcaurelle LA, Bertozzi C. Homogeneous glycopeptides and glycoproteins for biological investigation. Annu Rev Biochem. 2002; 71:593-634. PMID: 12045107.
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    308. Rodriguez EC, Marcaurelle LA, Bertozzi C. Aminooxy-, Hydrazide-, and Thiosemicarbazide-Functionalized Saccharides: Versatile Reagents for Glycoconjugate Synthesis. J Org Chem. 1998 Oct 16; 63(21):7134-7135. PMID: 11672350.
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    309. Roe BA, Boojamra CG, Griggs JL, Bertozzi C. Synthesis of beta-C-Glycosides of N-Acetylglucosamine via Keck Allylation Directed by Neighboring Phthalimide Groups. J Org Chem. 1996 Sep 06; 61(18):6442-6445. PMID: 11667491.
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    310. Kobertz WR, Bertozzi C, Bednarski MD. C-Glycosyl Aldehydes: Synthons for C-Linked Disaccharides. J Org Chem. 1996 Mar 08; 61(5):1894-1897. PMID: 11667074.
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