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Wyrobek, Andrew

TitleGeneticist Senior Sci/Engr
InstitutionLawrence Berkeley National Lab
DepartmentBiological Systems & Eng
Address1 Cyclotron Road
Berkeley CA 94720
Phone510/486-7375
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Britten RA, Jewell JS, Duncan VD, Davis LK, Hadley MM, Wyrobek A. Spatial Memory Performance of Socially Mature Wistar Rats is Impaired after Exposure to Low (5 cGy) Doses of 1 GeV/n 48Ti Particles. Radiat Res. 2017 01; 187(1):60-65. PMID: 28085638.
      View in: PubMed
    2. Wyrobek A, Britten RA. Individual variations in dose response for spatial memory learning among outbred wistar rats exposed from 5 to 20 cGy of (56) Fe particles. Environ Mol Mutagen. 2016 06; 57(5):331-40. PMID: 27237589.
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    3. Britten RA, Jewell JS, Miller VD, Davis LK, Hadley MM, Wyrobek A. Impaired Spatial Memory Performance in Adult Wistar Rats Exposed to Low (5-20 cGy) Doses of 1 GeV/n (56)Fe Particles. Radiat Res. 2016 Mar; 185(3):332-7. PMID: 26943453.
      View in: PubMed
    4. Marchetti F, Bishop J, Gingerich J, Wyrobek A. Meiotic interstrand DNA damage escapes paternal repair and causes chromosomal aberrations in the zygote by maternal misrepair. Sci Rep. 2015 Jan 08; 5:7689. PMID: 25567288; PMCID: PMC4286742.
    5. Snijders AM, Langley S, Mao JH, Bhatnagar S, Bjornstad KA, Rosen CJ, Lo A, Huang Y, Blakely EA, Karpen GH, Bissell MJ, Wyrobek A. An interferon signature identified by RNA-sequencing of mammary tissues varies across the estrous cycle and is predictive of metastasis-free survival. Oncotarget. 2014 Jun 30; 5(12):4011-25. PMID: 24994117; PMCID: PMC4147302.
    6. Kim D, Marchetti F, Chen Z, Zaric S, Wilson RJ, Hall DA, Gaster RS, Lee JR, Wang J, Osterfeld SJ, Yu H, White RM, Blakely WF, Peterson LE, Bhatnagar S, Mannion B, Tseng S, Roth K, Coleman M, Snijders AM, Wyrobek A, Wang SX. Nanosensor dosimetry of mouse blood proteins after exposure to ionizing radiation. Sci Rep. 2013; 3:2234. PMID: 23868657; PMCID: PMC3715761.
    7. Budworth H, Snijders AM, Marchetti F, Mannion B, Bhatnagar S, Kwoh E, Tan Y, Wang SX, Blakely WF, Coleman M, Peterson L, Wyrobek A. DNA repair and cell cycle biomarkers of radiation exposure and inflammation stress in human blood. PLoS One. 2012; 7(11):e48619. PMID: 23144912; PMCID: PMC3492462.
    8. Snijders AM, Marchetti F, Bhatnagar S, Duru N, Han J, Hu Z, Mao JH, Gray JW, Wyrobek A. Genetic differences in transcript responses to low-dose ionizing radiation identify tissue functions associated with breast cancer susceptibility. PLoS One. 2012; 7(10):e45394. PMID: 23077491; PMCID: PMC3471924.
    9. Schmid TE, Grant PG, Marchetti F, Weldon RH, Eskenazi B, Wyrobek A. Elemental composition of human semen is associated with motility and genomic sperm defects among older men. Hum Reprod. 2013 Jan; 28(1):274-82. PMID: 23042799; PMCID: PMC3619967.
    10. Schmid TE, Eskenazi B, Marchetti F, Young S, Weldon RH, Baumgartner A, Anderson D, Wyrobek A. Micronutrients intake is associated with improved sperm DNA quality in older men. Fertil Steril. 2012 Nov; 98(5):1130-7.e1. PMID: 22935557.
      View in: PubMed
    11. Marchetti F, Eskenazi B, Weldon RH, Li G, Zhang L, Rappaport SM, Schmid TE, Xing C, Kurtovich E, Wyrobek A. Occupational exposure to benzene and chromosomal structural aberrations in the sperm of Chinese men. Environ Health Perspect. 2012 Feb; 120(2):229-34. PMID: 22086566; PMCID: PMC3279447.
    12. Lapuk A, Marr H, Jakkula L, Pedro H, Bhattacharya S, Purdom E, Hu Z, Simpson K, Pachter L, Durinck S, Wang N, Parvin B, Fontenay G, Speed T, Garbe J, Stampfer M, Bayandorian H, Dorton S, Clark TA, Schweitzer A, Wyrobek A, Feiler H, Spellman P, Conboy J, Gray JW. Exon-level microarray analyses identify alternative splicing programs in breast cancer. Mol Cancer Res. 2010 Jul; 8(7):961-74. PMID: 20605923; PMCID: PMC2911965.
    13. Xing C, Marchetti F, Li G, Weldon RH, Kurtovich E, Young S, Schmid TE, Zhang L, Rappaport S, Waidyanatha S, Wyrobek A, Eskenazi B. Benzene exposure near the U.S. permissible limit is associated with sperm aneuploidy. Environ Health Perspect. 2010 Jun; 118(6):833-9. PMID: 20418200; PMCID: PMC2898861.
    14. Kuo WL, Das D, Ziyad S, Bhattacharya S, Gibb WJ, Heiser LM, Sadanandam A, Fontenay GV, Hu Z, Wang NJ, Bayani N, Feiler HS, Neve RM, Wyrobek A, Spellman PT, Marton LJ, Gray JW. A systems analysis of the chemosensitivity of breast cancer cells to the polyamine analogue PG-11047. BMC Med. 2009 Dec 14; 7:77. PMID: 20003408; PMCID: PMC2803786.
    15. Garbe JC, Bhattacharya S, Merchant B, Bassett E, Swisshelm K, Feiler HS, Wyrobek A, Stampfer MR. Molecular distinctions between stasis and telomere attrition senescence barriers shown by long-term culture of normal human mammary epithelial cells. Cancer Res. 2009 Oct 01; 69(19):7557-68. PMID: 19773443; PMCID: PMC2782785.
    16. Mirzoeva OK, Das D, Heiser LM, Bhattacharya S, Siwak D, Gendelman R, Bayani N, Wang NJ, Neve RM, Guan Y, Hu Z, Knight Z, Feiler HS, Gascard P, Parvin B, Spellman PT, Shokat KM, Wyrobek A, Bissell MJ, McCormick F, Kuo WL, Mills GB, Gray JW, Korn WM. Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition. Cancer Res. 2009 Jan 15; 69(2):565-72. PMID: 19147570; PMCID: PMC2737189.
    17. Lowe XR, Bhattacharya S, Marchetti F, Wyrobek A. Early brain response to low-dose radiation exposure involves molecular networks and pathways associated with cognitive functions, advanced aging and Alzheimer's disease. Radiat Res. 2009 Jan; 171(1):53-65. PMID: 19138050.
      View in: PubMed
    18. Lowe XR, Marchetti F, Lu X, Wyrobek A. Molecular stress response in the CNS of mice after systemic exposure to interferon-alpha, ionizing radiation and ketamine. Neurotoxicology. 2009 Mar; 30(2):261-8. PMID: 19162068.
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    19. Marchetti F, Bishop J, Lowe X, Wyrobek A. Chromosomal mosaicism in mouse two-cell embryos after paternal exposure to acrylamide. Toxicol Sci. 2009 Jan; 107(1):194-205. PMID: 18930949; PMCID: PMC2735420.
    20. Straume T, Amundson SA, Blakely WF, Burns FJ, Chen A, Dainiak N, Franklin S, Leary JA, Loftus DJ, Morgan WF, Pellmar TC, Stolc V, Turteltaub KW, Vaughan AT, Vijayakumar S, Wyrobek A. NASA Radiation Biomarker Workshop, September 27-28, 2007. Radiat Res. 2008 Sep; 170(3):393-405. PMID: 18763867.
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    21. Marchetti F, Wyrobek A. DNA repair decline during mouse spermiogenesis results in the accumulation of heritable DNA damage. DNA Repair (Amst). 2008 Apr 02; 7(4):572-81. PMID: 18282746.
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    22. Marchetti F, Cabreros D, Wyrobek A. Laboratory methods for the detection of chromosomal structural aberrations in human and mouse sperm by fluorescence in situ hybridization. Methods Mol Biol. 2008; 410:241-71. PMID: 18642604.
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    23. Lowe XR, Lu X, Marchetti F, Wyrobek A. The expression of Troponin T1 gene is induced by ketamine in adult mouse brain. Brain Res. 2007 Oct 12; 1174:7-17. PMID: 17850769.
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    24. Sloter ED, Marchetti F, Eskenazi B, Weldon RH, Nath J, Cabreros D, Wyrobek A. Frequency of human sperm carrying structural aberrations of chromosome 1 increases with advancing age. Fertil Steril. 2007 May; 87(5):1077-86. PMID: 17433321.
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    25. Wyrobek A, Mulvihill JJ, Wassom JS, Malling HV, Shelby MD, Lewis SE, Witt KL, Preston RJ, Perreault SD, Allen JW, Demarini DM, Woychik RP, Bishop JB. Assessing human germ-cell mutagenesis in the Postgenome Era: a celebration of the legacy of William Lawson (Bill) Russell. Environ Mol Mutagen. 2007 Mar; 48(2):71-95. PMID: 17295306.
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    26. Marchetti F, Coleman MA, Jones IM, Wyrobek A. Candidate protein biodosimeters of human exposure to ionizing radiation. Int J Radiat Biol. 2006 Sep; 82(9):605-39. PMID: 17050475.
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    27. Tomascik-Cheeseman LM, Lowe XR, Eskenazi B, Kidd S, Nath J, Moore D, Wyrobek A. A father of four consecutive trisomic pregnancies with elevated frequencies of associated aneuploid sperm. Am J Med Genet A. 2006 Sep 01; 140A(17):1840-5. PMID: 16892324.
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    28. Marchetti F, Pearson FS, Bishop JB, Wyrobek A. Etoposide induces chromosomal abnormalities in mouse spermatocytes and stem cell spermatogonia. Hum Reprod. 2006 Apr; 21(4):888-95. PMID: 16311288.
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    29. Coleman MA, Yin E, Peterson LE, Nelson D, Sorensen K, Tucker JD, Wyrobek A. Low-dose irradiation alters the transcript profiles of human lymphoblastoid cells including genes associated with cytogenetic radioadaptive response. Radiat Res. 2005 Oct; 164(4 Pt 1):369-82. PMID: 16187739.
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    30. Silver EW, Eskenazi B, Evenson DP, Block G, Young S, Wyrobek A. Effect of antioxidant intake on sperm chromatin stability in healthy nonsmoking men. J Androl. 2005 Jul-Aug; 26(4):550-6. PMID: 15955895.
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    31. Marchetti F, Wyrobek A. Mechanisms and consequences of paternally-transmitted chromosomal abnormalities. Birth Defects Res C Embryo Today. 2005 Jun; 75(2):112-29. PMID: 16035041.
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    32. Wyrobek A, Schmid TE, Marchetti F. Cross-species sperm-FISH assays for chemical testing and assessing paternal risk for chromosomally abnormal pregnancies. Environ Mol Mutagen. 2005 Mar-Apr; 45(2-3):271-83. PMID: 15754381.
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    33. Wyrobek A, Schmid TE, Marchetti F. Relative susceptibilities of male germ cells to genetic defects induced by cancer chemotherapies. J Natl Cancer Inst Monogr. 2005; (34):31-5. PMID: 15784819.
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    34. Zudova D, Wyrobek A, Bishop J, Marchetti F. Impaired fertility in T-stock female mice after superovulation. Reproduction. 2004 Nov; 128(5):573-81. PMID: 15509703.
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    35. Motin VL, Georgescu AM, Fitch JP, Gu PP, Nelson DO, Mabery SL, Garnham JB, Sokhansanj BA, Ott LL, Coleman MA, Elliott JM, Kegelmeyer LM, Wyrobek A, Slezak TR, Brubaker RR, Garcia E. Temporal global changes in gene expression during temperature transition in Yersinia pestis. J Bacteriol. 2004 Sep; 186(18):6298-305. PMID: 15342600; PMCID: PMC515171.
    36. Tomascik-Cheeseman LM, Coleman MA, Marchetti F, Nelson DO, Kegelmeyer LM, Nath J, Wyrobek A. Differential basal expression of genes associated with stress response, damage control, and DNA repair among mouse tissues. Mutat Res. 2004 Jul 11; 561(1-2):1-14. PMID: 15238225.
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    37. Sloter E, Nath J, Eskenazi B, Wyrobek A. Effects of male age on the frequencies of germinal and heritable chromosomal abnormalities in humans and rodents. Fertil Steril. 2004 Apr; 81(4):925-43. PMID: 15066442.
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    38. Marchetti F, Bishop JB, Cosentino L, Moore D, Wyrobek A. Paternally transmitted chromosomal aberrations in mouse zygotes determine their embryonic fate. Biol Reprod. 2004 Mar; 70(3):616-24. PMID: 14585809.
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    39. Hill FS, Marchetti F, Liechty M, Bishop J, Hozier J, Wyrobek A. A new FISH assay to simultaneously detect structural and numerical chromosomal abnormalities in mouse sperm. Mol Reprod Dev. 2003 Oct; 66(2):172-80. PMID: 12950105.
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    40. Glaser RL, Broman KW, Schulman RL, Eskenazi B, Wyrobek A, Jabs EW. The paternal-age effect in Apert syndrome is due, in part, to the increased frequency of mutations in sperm. Am J Hum Genet. 2003 Oct; 73(4):939-47. PMID: 12900791; PMCID: PMC1180614.
    41. Barton TS, Wyrobek A, Hill FS, Robaire B, Hales BF. Numerical chromosomal abnormalities in rat epididymal spermatozoa following chronic cyclophosphamide exposure. Biol Reprod. 2003 Oct; 69(4):1150-7. PMID: 12773405.
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    42. Frias S, Van Hummelen P, Meistrich ML, Lowe XR, Hagemeister FB, Shelby MD, Bishop JB, Wyrobek A. NOVP chemotherapy for Hodgkin's disease transiently induces sperm aneuploidies associated with the major clinical aneuploidy syndromes involving chromosomes X, Y, 18, and 21. Cancer Res. 2003 Jan 01; 63(1):44-51. PMID: 12517776.
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    43. Perreault SD, Aitken RJ, Baker HW, Evenson DP, Huszar G, Irvine DS, Morris ID, Morris RA, Robbins WA, Sakkas D, Spano M, Wyrobek A. Integrating new tests of sperm genetic integrity into semen analysis: breakout group discussion. Adv Exp Med Biol. 2003; 518:253-68. PMID: 12817694.
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    44. Marchetti F, Wyrobek A. PAINT/DAPI analysis of mouse zygotes to detect paternally transmitted chromosomal aberrations. Adv Exp Med Biol. 2003; 518:131-45. PMID: 12817682.
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    45. Tiemann-Boege I, Navidi W, Grewal R, Cohn D, Eskenazi B, Wyrobek A, Arnheim N. The observed human sperm mutation frequency cannot explain the achondroplasia paternal age effect. Proc Natl Acad Sci U S A. 2002 Nov 12; 99(23):14952-7. PMID: 12397172; PMCID: PMC137526.
    46. Sorensen KJ, Attix CM, Christian AT, Wyrobek A, Tucker JD. Adaptive response induction and variation in human lymphoblastoid cell lines. Mutat Res. 2002 Aug 26; 519(1-2):15-24. PMID: 12160888.
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    47. Rubes J, Vozdova M, Robbins WA, Rezacova O, Perreault SD, Wyrobek A. Stable variants of sperm aneuploidy among healthy men show associations between germinal and somatic aneuploidy. Am J Hum Genet. 2002 Jun; 70(6):1507-19. PMID: 11992257; PMCID: PMC379139.
    48. Tomascik-Cheeseman L, Marchetti F, Lowe X, Shamanski FL, Nath J, Pedersen RA, Wyrobek A. CENP-B is not critical for meiotic chromosome segregation in male mice. Mutat Res. 2002 Jan 15; 513(1-2):197-203. PMID: 11719105.
      View in: PubMed

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