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    Melia, Thomas

    TitlePhysicist Postdoc Fellow
    SchoolLawrence Berkeley National Lab
    DepartmentPhysics
    Address1 Cyclotron Road
    Berkeley CA 94720
    Phone510/495-8173
    vCardDownload vCard

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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Yu S, Melia T. The coordination of membrane fission and fusion at the end of autophagosome maturation. Curr Opin Cell Biol. 2017 Aug; 47:92-98. PMID: 28463755.
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      2. Holland P, Knævelsrud H, Søreng K, Mathai BJ, Lystad AH, Pankiv S, Bjørndal GT, Schultz SW, Lobert VH, Chan RB, Zhou B, Liestøl K, Carlsson SR, Melia T, Di Paolo G, Simonsen A. HS1BP3 negatively regulates autophagy by modulation of phosphatidic acid levels. Nat Commun. 2016 Dec 22; 7:13889. PMID: 28004827.
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      3. Horenkamp FA, Kauffman KJ, Kohler LJ, Sherwood RK, Krueger KP, Shteyn V, Roy CR, Melia T, Reinisch KM. The Legionella Anti-autophagy Effector RavZ Targets the Autophagosome via PI3P- and Curvature-Sensing Motifs. Dev Cell. 2015 Sep 14; 34(5):569-76. PMID: 26343456.
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      4. Dancourt J, Melia T. Lipidation of the autophagy proteins LC3 and GABARAP is a membrane-curvature dependent process. Autophagy. 2014 Aug; 10(8):1470-1. PMID: 24991828.
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      5. Nath S, Dancourt J, Shteyn V, Puente G, Fong WM, Nag S, Bewersdorf J, Yamamoto A, Antonny B, Melia T. Lipidation of the LC3/GABARAP family of autophagy proteins relies on a membrane-curvature-sensing domain in Atg3. Nat Cell Biol. 2014 May; 16(5):415-24. PMID: 24747438.
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      6. Choy A, Dancourt J, Mugo B, O'Connor TJ, Isberg RR, Melia T, Roy CR. The Legionella effector RavZ inhibits host autophagy through irreversible Atg8 deconjugation. Science. 2012 Nov 23; 338(6110):1072-6. PMID: 23112293.
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      7. Johnson CW, Melia T, Yamamoto A. Modulating macroautophagy: a neuronal perspective. Future Med Chem. 2012 Sep; 4(13):1715-31. PMID: 22924509.
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      8. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NY, Ashida H, Askanas V, Askew DS, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai XY, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Bamber BA, Bampton ET, Bánhegyi G, Bartholomew CR, Bassham DC, Bast RC, Batoko H, Bay BH, Beau I, Béchet DM, Begley TJ, Behl C, Behrends C, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Bernassola F, Besteiro S, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Blum JS, Boise LH, Bonaldo P, Boone DL, Bornhauser BC, Bortoluci KR, Bossis I, Bost F, Bourquin JP, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady NR, Brancolini C, Brech A, Brenman JE, Brennand A, Bresnick EH, Brest P, Bridges D, Bristol ML, Brookes PS, Brown EJ, Brumell JH, Brunetti-Pierri N, Brunk UT, Bulman DE, Bultman SJ, Bultynck G, Burbulla LF, Bursch W, Butchar JP, Buzgariu W, Bydlowski SP, Cadwell K, Cahová M, Cai D, Cai J, Cai Q, Calabretta B, Calvo-Garrido J, Camougrand N, Campanella M, Campos-Salinas J, Candi E, Cao L, Caplan AB, Carding SR, Cardoso SM, Carew JS, Carlin CR, Carmignac V, Carneiro LA, Carra S, Caruso RA, Casari G, Casas C, Castino R, Cebollero E, Cecconi F, Celli J, Chaachouay H, Chae HJ, Chai CY, Chan DC, Chan EY, Chang RC, Che CM, Chen CC, Chen GC, Chen GQ, Chen M, Chen Q, Chen SS, Chen W, Chen X, Chen X, Chen X, Chen YG, Chen Y, Chen Y, Chen YJ, Chen Z, Cheng A, Cheng CH, Cheng Y, Cheong H, Cheong JH, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang HL, Chiarelli R, Chiba T, Chin LS, Chiou SH, Chisari FV, Cho CH, Cho DH, Choi AM, Choi D, Choi KS, Choi ME, Chouaib S, Choubey D, Choubey V, Chu CT, Chuang TH, Chueh SH, Chun T, Chwae YJ, Chye ML, Ciarcia R, Ciriolo MR, Clague MJ, Clark RS, Clarke PG, Clarke R, Codogno P, Coller HA, Colombo MI, Comincini S, Condello M, Condorelli F, Cookson MR, Coombs GH, Coppens I, Corbalan R, Cossart P, Costelli P, Costes S, Coto-Montes A, Couve E, Coxon FP, Cregg JM, Crespo JL, Cronjé MJ, Cuervo AM, Cullen JJ, Czaja MJ, D'Amelio M, Darfeuille-Michaud A, Davids LM, Davies FE, De Felici M, de Groot JF, de Haan CA, De Martino L, De Milito A, De Tata V, Debnath J, Degterev A, Dehay B, Delbridge LM, Demarchi F, Deng YZ, Dengjel J, Dent P, Denton D, Deretic V, Desai SD, Devenish RJ, Di Gioacchino M, Di Paolo G, Di Pietro C, Díaz-Araya G, Díaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dikic I, Dinesh-Kumar SP, Ding WX, Distelhorst CW, Diwan A, Djavaheri-Mergny M, Dokudovskaya S, Dong Z, Dorsey FC, Dosenko V, Dowling JJ, Doxsey S, Dreux M, Drew ME, Duan Q, Duchosal MA, Duff K, Dugail I, Durbeej M, Duszenko M, Edelstein CL, Edinger AL, Egea G, Eichinger L, Eissa NT, Ekmekcioglu S, El-Deiry WS, Elazar Z, Elgendy M, Ellerby LM, Eng KE, Engelbrecht AM, Engelender S, Erenpreisa J, Escalante R, Esclatine A, Eskelinen EL, Espert L, Espina V, Fan H, Fan J, Fan QW, Fan Z, Fang S, Fang Y, Fanto M, Fanzani A, Farkas T, Farré JC, Faure M, Fechheimer M, Feng CG, Feng J, Feng Q, Feng Y, Fésüs L, Feuer R, Figueiredo-Pereira ME, Fimia GM, Fingar DC, Finkbeiner S, Finkel T, Finley KD, Fiorito F, Fisher EA, Fisher PB, Flajolet M, Florez-McClure ML, Florio S, Fon EA, Fornai F, Fortunato F, Fotedar R, Fowler DH, Fox HS, Franco R, Frankel LB, Fransen M, Fuentes JM, Fueyo J, Fujii J, Fujisaki K, Fujita E, Fukuda M, Furukawa RH, Gaestel M, Gailly P, Gajewska M, Galliot B, Galy V, Ganesh S, Ganetzky B, Ganley IG, Gao FB, Gao GF, Gao J, Garcia L, Garcia-Manero G, Garcia-Marcos M, Garmyn M, Gartel AL, Gatti E, Gautel M, Gawriluk TR, Gegg ME, Geng J, Germain M, Gestwicki JE, Gewirtz DA, Ghavami S, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr; 8(4):445-544. PMID: 22966490.
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      9. Shi L, Shen QT, Kiel A, Wang J, Wang HW, Melia T, Rothman JE, Pincet F. SNARE proteins: one to fuse and three to keep the nascent fusion pore open. Science. 2012 Mar 16; 335(6074):1355-9. PMID: 22422984.
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      10. Jotwani A, Richerson DN, Motta I, Julca-Zevallos O, Melia T. Approaches to the study of Atg8-mediated membrane dynamics in vitro. Methods Cell Biol. 2012; 108:93-116. PMID: 22325599.
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      11. Xu Y, Melia T, Toomre DK. Using light to see and control membrane traffic. Curr Opin Chem Biol. 2011 Dec; 15(6):822-30. PMID: 22079055.
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      12. Klionsky DJ, Baehrecke EH, Brumell JH, Chu CT, Codogno P, Cuervo AM, Debnath J, Deretic V, Elazar Z, Eskelinen EL, Finkbeiner S, Fueyo-Margareto J, Gewirtz D, Jäättelä M, Kroemer G, Levine B, Melia T, Mizushima N, Rubinsztein DC, Simonsen A, Thorburn A, Thumm M, Tooze SA. A comprehensive glossary of autophagy-related molecules and processes (2nd edition). Autophagy. 2011 Nov; 7(11):1273-94. PMID: 21997368.
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      13. Shi L, Kümmel D, Coleman J, Melia T, Giraudo CG. Dual roles of Munc18-1 rely on distinct binding modes of the central cavity with Stx1A and SNARE complex. Mol Biol Cell. 2011 Nov; 22(21):4150-60. PMID: 21900493.
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      14. Nair U, Jotwani A, Geng J, Gammoh N, Richerson D, Yen WL, Griffith J, Nag S, Wang K, Moss T, Baba M, McNew JA, Jiang X, Reggiori F, Melia T, Klionsky DJ. SNARE proteins are required for macroautophagy. Cell. 2011 Jul 22; 146(2):290-302. PMID: 21784249.
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      15. Ji H, Coleman J, Yang R, Melia T, Rothman JE, Tareste D. Protein determinants of SNARE-mediated lipid mixing. Biophys J. 2010 Jul 21; 99(2):553-60. PMID: 20643074.
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      16. Filimonenko M, Isakson P, Finley KD, Anderson M, Jeong H, Melia T, Bartlett BJ, Myers KM, Birkeland HC, Lamark T, Krainc D, Brech A, Stenmark H, Simonsen A, Yamamoto A. The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy. Mol Cell. 2010 Apr 23; 38(2):265-79. PMID: 20417604.
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      17. Jeong H, Then F, Melia T, Mazzulli JR, Cui L, Savas JN, Voisine C, Paganetti P, Tanese N, Hart AC, Yamamoto A, Krainc D. Acetylation targets mutant huntingtin to autophagosomes for degradation. Cell. 2009 Apr 3; 137(1):60-72. PMID: 19345187.
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      18. Giraudo CG, Garcia-Diaz A, Eng WS, Chen Y, Hendrickson WA, Melia T, Rothman JE. Alternative zippering as an on-off switch for SNARE-mediated fusion. Science. 2009 Jan 23; 323(5913):512-6. PMID: 19164750.
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      19. Giraudo CG, Garcia-Diaz A, Eng WS, Yamamoto A, Melia T, Rothman JE. Distinct domains of complexins bind SNARE complexes and clamp fusion in vitro. J Biol Chem. 2008 Jul 25; 283(30):21211-9. PMID: 18499660.
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      20. Tareste D, Shen J, Melia T, Rothman JE. SNAREpin/Munc18 promotes adhesion and fusion of large vesicles to giant membranes. Proc Natl Acad Sci U S A. 2008 Feb 19; 105(7):2380-5. PMID: 18268324.
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      21. Li F, Pincet F, Perez E, Eng WS, Melia T, Rothman JE, Tareste D. Energetics and dynamics of SNAREpin folding across lipid bilayers. Nat Struct Mol Biol. 2007 Oct; 14(10):890-6. PMID: 17906638.
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      22. Melia T. Putting the clamps on membrane fusion: how complexin sets the stage for calcium-mediated exocytosis. FEBS Lett. 2007 May 22; 581(11):2131-9. PMID: 17350005.
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      23. Shen J, Tareste DC, Paumet F, Rothman JE, Melia T. Selective activation of cognate SNAREpins by Sec1/Munc18 proteins. Cell. 2007 Jan 12; 128(1):183-95. PMID: 17218264.
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      24. Melia T, You D, Tareste DC, Rothman JE. Lipidic antagonists to SNARE-mediated fusion. J Biol Chem. 2006 Oct 6; 281(40):29597-605. PMID: 16887809.
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      25. Giraudo CG, Eng WS, Melia T, Rothman JE. A clamping mechanism involved in SNARE-dependent exocytosis. Science. 2006 Aug 4; 313(5787):676-80. PMID: 16794037.
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      26. Giraudo CG, Hu C, You D, Slovic AM, Mosharov EV, Sulzer D, Melia T, Rothman JE. SNAREs can promote complete fusion and hemifusion as alternative outcomes. J Cell Biol. 2005 Jul 18; 170(2):249-60. PMID: 16027221.
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      27. Zhang Z, Melia T, He F, Yuan C, McGough A, Schmid MF, Wensel TG. How a G protein binds a membrane. J Biol Chem. 2004 Aug 6; 279(32):33937-45. PMID: 15173184.
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      28. Fix M, Melia T, Jaiswal JK, Rappoport JZ, You D, Söllner TH, Rothman JE, Simon SM. Imaging single membrane fusion events mediated by SNARE proteins. Proc Natl Acad Sci U S A. 2004 May 11; 101(19):7311-6. PMID: 15123811.
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      29. Hu C, Ahmed M, Melia T, Söllner TH, Mayer T, Rothman JE. Fusion of cells by flipped SNAREs. Science. 2003 Jun 13; 300(5626):1745-9. PMID: 12805548.
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      30. Scott BL, Van Komen JS, Liu S, Weber T, Melia T, McNew JA. Liposome fusion assay to monitor intracellular membrane fusion machines. Methods Enzymol. 2003; 372:274-300. PMID: 14610819.
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      31. Melia T, Weber T, McNew JA, Fisher LE, Johnston RJ, Parlati F, Mahal LK, Sollner TH, Rothman JE. Regulation of membrane fusion by the membrane-proximal coil of the t-SNARE during zippering of SNAREpins. J Cell Biol. 2002 Sep 2; 158(5):929-40. PMID: 12213837.
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      32. He W, Melia T, Cowan CW, Wensel TG. Dependence of RGS9-1 membrane attachment on its C-terminal tail. J Biol Chem. 2001 Dec 28; 276(52):48961-6. PMID: 11677233.
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      33. McNew JA, Weber T, Parlati F, Johnston RJ, Melia T, Söllner TH, Rothman JE. Close is not enough: SNARE-dependent membrane fusion requires an active mechanism that transduces force to membrane anchors. J Cell Biol. 2000 Jul 10; 150(1):105-17. PMID: 10893260.
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      34. Melia T, Malinski JA, He F, Wensel TG. Enhancement of phototransduction protein interactions by lipid surfaces. J Biol Chem. 2000 Feb 4; 275(5):3535-42. PMID: 10652348.
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      35. Melia T, Sowa ME, Schutze L, Wensel TG. Formation of helical protein assemblies of IgG and transducin on varied lipid tubules. J Struct Biol. 1999 Dec 1; 128(1):119-30. PMID: 10600566.
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      36. Melia T, Cowan CW, Angleson JK, Wensel TG. A comparison of the efficiency of G protein activation by ligand-free and light-activated forms of rhodopsin. Biophys J. 1997 Dec; 73(6):3182-91. PMID: 9414230.
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