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    Melia, Thomas

    TitlePhysicist Postdoc Fellow
    SchoolLawrence Berkeley National Lab
    Address1 Cyclotron Road
    Berkeley CA 94720
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Yu S, Melia T. The coordination of membrane fission and fusion at the end of autophagosome maturation. Curr Opin Cell Biol. 2017 Aug; 47:92-98. PMID: 28463755.
        View in: PubMed
      2. Nguyen N, Shteyn V, Melia T. Sensing Membrane Curvature in Macroautophagy. J Mol Biol. 2017 Feb 17; 429(4):457-472. PMID: 28088480.
        View in: PubMed
      3. Holland P, Knævelsrud H, Søreng K, Mathai BJ, Lystad AH, Pankiv S, Bjørndal GT, Schultz SW, Lobert VH, Chan RB, Zhou B, Liestøl K, Carlsson SR, Melia T, Di Paolo G, Simonsen A. HS1BP3 negatively regulates autophagy by modulation of phosphatidic acid levels. Nat Commun. 2016 Dec 22; 7:13889. PMID: 28004827.
        View in: PubMed
      4. Horenkamp FA, Kauffman KJ, Kohler LJ, Sherwood RK, Krueger KP, Shteyn V, Roy CR, Melia T, Reinisch KM. The Legionella Anti-autophagy Effector RavZ Targets the Autophagosome via PI3P- and Curvature-Sensing Motifs. Dev Cell. 2015 Sep 14; 34(5):569-76. PMID: 26343456; PMCID: PMC4594837.
      5. Dancourt J, Melia T. Lipidation of the autophagy proteins LC3 and GABARAP is a membrane-curvature dependent process. Autophagy. 2014 Aug; 10(8):1470-1. PMID: 24991828; PMCID: PMC4203524.
      6. Nath S, Dancourt J, Shteyn V, Puente G, Fong WM, Nag S, Bewersdorf J, Yamamoto A, Antonny B, Melia T. Lipidation of the LC3/GABARAP family of autophagy proteins relies on a membrane-curvature-sensing domain in Atg3. Nat Cell Biol. 2014 May; 16(5):415-24. PMID: 24747438; PMCID: PMC4111135.
      7. Choy A, Dancourt J, Mugo B, O'Connor TJ, Isberg RR, Melia T, Roy CR. The Legionella effector RavZ inhibits host autophagy through irreversible Atg8 deconjugation. Science. 2012 Nov 23; 338(6110):1072-6. PMID: 23112293; PMCID: PMC3682818.
      8. Johnson CW, Melia T, Yamamoto A. Modulating macroautophagy: a neuronal perspective. Future Med Chem. 2012 Sep; 4(13):1715-31. PMID: 22924509; PMCID: PMC3566761.
      9. Shi L, Shen QT, Kiel A, Wang J, Wang HW, Melia T, Rothman JE, Pincet F. SNARE proteins: one to fuse and three to keep the nascent fusion pore open. Science. 2012 Mar 16; 335(6074):1355-9. PMID: 22422984; PMCID: PMC3736847.
      10. Jotwani A, Richerson DN, Motta I, Julca-Zevallos O, Melia T. Approaches to the study of Atg8-mediated membrane dynamics in vitro. Methods Cell Biol. 2012; 108:93-116. PMID: 22325599.
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      11. Xu Y, Melia T, Toomre DK. Using light to see and control membrane traffic. Curr Opin Chem Biol. 2011 Dec; 15(6):822-30. PMID: 22079055.
        View in: PubMed
      12. Klionsky DJ, Baehrecke EH, Brumell JH, Chu CT, Codogno P, Cuervo AM, Debnath J, Deretic V, Elazar Z, Eskelinen EL, Finkbeiner S, Fueyo-Margareto J, Gewirtz D, Jäättelä M, Kroemer G, Levine B, Melia T, Mizushima N, Rubinsztein DC, Simonsen A, Thorburn A, Thumm M, Tooze SA. A comprehensive glossary of autophagy-related molecules and processes (2nd edition). Autophagy. 2011 Nov; 7(11):1273-94. PMID: 21997368; PMCID: PMC3359482.
      13. Shi L, Kümmel D, Coleman J, Melia T, Giraudo CG. Dual roles of Munc18-1 rely on distinct binding modes of the central cavity with Stx1A and SNARE complex. Mol Biol Cell. 2011 Nov; 22(21):4150-60. PMID: 21900493; PMCID: PMC3204075.
      14. Nair U, Jotwani A, Geng J, Gammoh N, Richerson D, Yen WL, Griffith J, Nag S, Wang K, Moss T, Baba M, McNew JA, Jiang X, Reggiori F, Melia T, Klionsky DJ. SNARE proteins are required for macroautophagy. Cell. 2011 Jul 22; 146(2):290-302. PMID: 21784249; PMCID: PMC3143362.
      15. Ji H, Coleman J, Yang R, Melia T, Rothman JE, Tareste D. Protein determinants of SNARE-mediated lipid mixing. Biophys J. 2010 Jul 21; 99(2):553-60. PMID: 20643074; PMCID: PMC2905075.
      16. Filimonenko M, Isakson P, Finley KD, Anderson M, Jeong H, Melia T, Bartlett BJ, Myers KM, Birkeland HC, Lamark T, Krainc D, Brech A, Stenmark H, Simonsen A, Yamamoto A. The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy. Mol Cell. 2010 Apr 23; 38(2):265-79. PMID: 20417604; PMCID: PMC2867245.
      17. Jeong H, Then F, Melia T, Mazzulli JR, Cui L, Savas JN, Voisine C, Paganetti P, Tanese N, Hart AC, Yamamoto A, Krainc D. Acetylation targets mutant huntingtin to autophagosomes for degradation. Cell. 2009 Apr 03; 137(1):60-72. PMID: 19345187; PMCID: PMC2940108.
      18. Giraudo CG, Garcia-Diaz A, Eng WS, Chen Y, Hendrickson WA, Melia T, Rothman JE. Alternative zippering as an on-off switch for SNARE-mediated fusion. Science. 2009 Jan 23; 323(5913):512-6. PMID: 19164750; PMCID: PMC3736854.
      19. Giraudo CG, Garcia-Diaz A, Eng WS, Yamamoto A, Melia T, Rothman JE. Distinct domains of complexins bind SNARE complexes and clamp fusion in vitro. J Biol Chem. 2008 Jul 25; 283(30):21211-9. PMID: 18499660; PMCID: PMC2475712.
      20. Tareste D, Shen J, Melia T, Rothman JE. SNAREpin/Munc18 promotes adhesion and fusion of large vesicles to giant membranes. Proc Natl Acad Sci U S A. 2008 Feb 19; 105(7):2380-5. PMID: 18268324; PMCID: PMC2268145.
      21. Li F, Pincet F, Perez E, Eng WS, Melia T, Rothman JE, Tareste D. Energetics and dynamics of SNAREpin folding across lipid bilayers. Nat Struct Mol Biol. 2007 Oct; 14(10):890-6. PMID: 17906638.
        View in: PubMed
      22. Melia T. Putting the clamps on membrane fusion: how complexin sets the stage for calcium-mediated exocytosis. FEBS Lett. 2007 May 22; 581(11):2131-9. PMID: 17350005.
        View in: PubMed
      23. Shen J, Tareste DC, Paumet F, Rothman JE, Melia T. Selective activation of cognate SNAREpins by Sec1/Munc18 proteins. Cell. 2007 Jan 12; 128(1):183-95. PMID: 17218264.
        View in: PubMed
      24. Melia T, You D, Tareste DC, Rothman JE. Lipidic antagonists to SNARE-mediated fusion. J Biol Chem. 2006 Oct 06; 281(40):29597-605. PMID: 16887809.
        View in: PubMed
      25. Giraudo CG, Eng WS, Melia T, Rothman JE. A clamping mechanism involved in SNARE-dependent exocytosis. Science. 2006 Aug 04; 313(5787):676-80. PMID: 16794037.
        View in: PubMed
      26. Giraudo CG, Hu C, You D, Slovic AM, Mosharov EV, Sulzer D, Melia T, Rothman JE. SNAREs can promote complete fusion and hemifusion as alternative outcomes. J Cell Biol. 2005 Jul 18; 170(2):249-60. PMID: 16027221; PMCID: PMC2171417.
      27. Zhang Z, Melia T, He F, Yuan C, McGough A, Schmid MF, Wensel TG. How a G protein binds a membrane. J Biol Chem. 2004 Aug 06; 279(32):33937-45. PMID: 15173184.
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      28. Fix M, Melia T, Jaiswal JK, Rappoport JZ, You D, Söllner TH, Rothman JE, Simon SM. Imaging single membrane fusion events mediated by SNARE proteins. Proc Natl Acad Sci U S A. 2004 May 11; 101(19):7311-6. PMID: 15123811; PMCID: PMC409915.
      29. Hu C, Ahmed M, Melia T, Söllner TH, Mayer T, Rothman JE. Fusion of cells by flipped SNAREs. Science. 2003 Jun 13; 300(5626):1745-9. PMID: 12805548.
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      30. Scott BL, Van Komen JS, Liu S, Weber T, Melia T, McNew JA. Liposome fusion assay to monitor intracellular membrane fusion machines. Methods Enzymol. 2003; 372:274-300. PMID: 14610819.
        View in: PubMed
      31. Melia T, Weber T, McNew JA, Fisher LE, Johnston RJ, Parlati F, Mahal LK, Sollner TH, Rothman JE. Regulation of membrane fusion by the membrane-proximal coil of the t-SNARE during zippering of SNAREpins. J Cell Biol. 2002 Sep 02; 158(5):929-40. PMID: 12213837; PMCID: PMC2173141.
      32. He W, Melia T, Cowan CW, Wensel TG. Dependence of RGS9-1 membrane attachment on its C-terminal tail. J Biol Chem. 2001 Dec 28; 276(52):48961-6. PMID: 11677233.
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      33. McNew JA, Weber T, Parlati F, Johnston RJ, Melia T, Söllner TH, Rothman JE. Close is not enough: SNARE-dependent membrane fusion requires an active mechanism that transduces force to membrane anchors. J Cell Biol. 2000 Jul 10; 150(1):105-17. PMID: 10893260; PMCID: PMC2185554.
      34. Melia T, Malinski JA, He F, Wensel TG. Enhancement of phototransduction protein interactions by lipid surfaces. J Biol Chem. 2000 Feb 04; 275(5):3535-42. PMID: 10652348.
        View in: PubMed
      35. Melia T, Sowa ME, Schutze L, Wensel TG. Formation of helical protein assemblies of IgG and transducin on varied lipid tubules. J Struct Biol. 1999 Dec 01; 128(1):119-30. PMID: 10600566.
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      36. Melia T, Cowan CW, Angleson JK, Wensel TG. A comparison of the efficiency of G protein activation by ligand-free and light-activated forms of rhodopsin. Biophys J. 1997 Dec; 73(6):3182-91. PMID: 9414230; PMCID: PMC1181221.

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