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    Costes, Sylvain

    TitleBiophysicist Staff Sci/Engr
    SchoolLawrence Berkeley National Lab
    DepartmentBiological Systems & Eng
    Address1 Cyclotron Road
    Berkeley CA 94720
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. McDonald JS, McDonald RJ, Ekins JB, Tin AS, Costes S, Hudson TM, Schroeder DJ, Kallmes K, Kaufmann SH, Young PM, Lu A, Kadirvel R, Kallmes DF. Gadolinium-enhanced cardiac MR exams of human subjects are associated with significant increases in the DNA repair marker 53BP1, but not the damage marker ?H2AX. PLoS One. 2018; 13(1):e0190890. PMID: 29309426.
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      2. Colmenares SU, Swenson JM, Langley SA, Kennedy C, Costes S, Karpen GH. Drosophila Histone Demethylase KDM4A Has Enzymatic and Non-enzymatic Roles in Controlling Heterochromatin Integrity. Dev Cell. 2017 Jul 24; 42(2):156-169.e5. PMID: 28743002.
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      3. Paul-Gilloteaux P, Potiron V, Delpon G, Supiot S, Chiavassa S, Paris F, Costes S. Optimizing radiotherapy protocols using computer automata to model tumour cell death as a function of oxygen diffusion processes. Sci Rep. 2017 May 23; 7(1):2280. PMID: 28536438.
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      4. Heuskin AC, Osseiran AI, Tang J, Costes S. Simulating Space Radiation-Induced Breast Tumor Incidence Using Automata. Radiat Res. 2016 Jul; 186(1):27-38. PMID: 27333083.
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      5. Sridharan DM, Asaithamby A, Blattnig SR, Costes S, Doetsch PW, Dynan WS, Hahnfeldt P, Hlatky L, Kidane Y, Kronenberg A, Naidu MD, Peterson LE, Plante I, Ponomarev AL, Saha J, Snijders AM, Srinivasan K, Tang J, Werner E, Pluth JM. Evaluating biomarkers to model cancer risk post cosmic ray exposure. Life Sci Space Res (Amst). 2016 Jun; 9:19-47. PMID: 27345199.
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      6. Adams CJ, Yu JS, Mao JH, Jen KY, Costes S, Wade M, Shoemake J, Aina OH, Del Rosario R, Menchavez PT, Cardiff RD, Wahl GM, Balmain A. The Trp53 delta proline (Trp53?P) mouse exhibits increased genome instability and susceptibility to radiation-induced, but not spontaneous, tumor development. Mol Carcinog. 2016 Sep; 55(9):1387-96. PMID: 26310697; PMCID: PMC4891300 [Available on 09/01/17].
      7. Georgescu W, Osseiran A, Rojec M, Liu Y, Bombrun M, Tang J, Costes S. Characterizing the DNA Damage Response by Cell Tracking Algorithms and Cell Features Classification Using High-Content Time-Lapse Analysis. PLoS One. 2015; 10(6):e0129438. PMID: 26107175; PMCID: PMC4479605.
      8. Tang J, Huang Y, Nguyen DH, Costes S, Snijders AM, Mao JH. Genetic Background Modulates lncRNA-Coordinated Tissue Response to Low Dose Ionizing Radiation. Int J Genomics. 2015; 2015:461038. PMID: 25802832; PMCID: PMC4353441.
      9. Sridharan DM, Asaithamby A, Bailey SM, Costes S, Doetsch PW, Dynan WS, Kronenberg A, Rithidech KN, Saha J, Snijders AM, Werner E, Wiese C, Cucinotta FA, Pluth JM. Understanding cancer development processes after HZE-particle exposure: roles of ROS, DNA damage repair and inflammation. Radiat Res. 2015 Jan; 183(1):1-26. PMID: 25564719.
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      10. Illa-Bochaca I, Ouyang H, Tang J, Sebastiano C, Mao JH, Costes S, Demaria S, Barcellos-Hoff MH. Densely ionizing radiation acts via the microenvironment to promote aggressive Trp53-null mammary carcinomas. Cancer Res. 2014 Dec 01; 74(23):7137-48. PMID: 25304265.
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      11. Vadhavkar N, Pham C, Georgescu W, Deschamps T, Heuskin AC, Tang J, Costes S. Combinatorial DNA damage pairing model based on X-ray-induced foci predicts the dose and LET dependence of cell death in human breast cells. Radiat Res. 2014 Sep; 182(3):273-81. PMID: 25076115.
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      12. Tang J, Fernandez-Garcia I, Vijayakumar S, Martinez-Ruis H, Illa-Bochaca I, Nguyen DH, Mao JH, Costes S, Barcellos-Hoff MH. Irradiation of juvenile, but not adult, mammary gland increases stem cell self-renewal and estrogen receptor negative tumors. Stem Cells. 2014 Mar; 32(3):649-61. PMID: 24038768.
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      13. Chiolo I, Tang J, Georgescu W, Costes S. Nuclear dynamics of radiation-induced foci in euchromatin and heterochromatin. Mutat Res. 2013 Oct; 750(1-2):56-66. PMID: 23958412; PMCID: PMC3838906.
      14. Park CC, Georgescu W, Polyzos A, Pham C, Ahmed KM, Zhang H, Costes S. Rapid and automated multidimensional fluorescence microscopy profiling of 3D human breast cultures. Integr Biol (Camb). 2013 Apr; 5(4):681-91. PMID: 23407655; PMCID: PMC3641787.
      15. Nam JM, Ahmed KM, Costes S, Zhang H, Onodera Y, Olshen AB, Hatanaka KC, Kinoshita R, Ishikawa M, Sabe H, Shirato H, Park CC. ß1-Integrin via NF-?B signaling is essential for acquisition of invasiveness in a model of radiation treated in situ breast cancer. Breast Cancer Res. 2013; 15(4):R60. PMID: 23883667; PMCID: PMC3978561.
      16. Shaffer VA, Boerma M, Buonanno M, Costes S, Criswell T, Gonon G, Pandey BN, Pinto M, Rockwell S. Broadcasting in the airways: the fifth anniversary of the Radiation Research Podcast (1). Radiat Res. 2012 Jul; 178(1):99-100. PMID: 22686863.
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      17. Neumaier T, Swenson J, Pham C, Polyzos A, Lo AT, Yang P, Dyball J, Asaithamby A, Chen DJ, Bissell MJ, Thalhammer S, Costes S. Evidence for formation of DNA repair centers and dose-response nonlinearity in human cells. Proc Natl Acad Sci U S A. 2012 Jan 10; 109(2):443-8. PMID: 22184222; PMCID: PMC3258602.
      18. Maxwell CA, Benítez J, Gómez-Baldó L, Osorio A, Bonifaci N, Fernández-Ramires R, Costes S, Guinó E, Chen H, Evans GJ, Mohan P, Català I, Petit A, Aguilar H, Villanueva A, Aytes A, Serra-Musach J, Rennert G, Lejbkowicz F, Peterlongo P, Manoukian S, Peissel B, Ripamonti CB, Bonanni B, Viel A, Allavena A, Bernard L, Radice P, Friedman E, Kaufman B, Laitman Y, Dubrovsky M, Milgrom R, Jakubowska A, Cybulski C, Gorski B, Jaworska K, Durda K, Sukiennicki G, Lubinski J, Shugart YY, Domchek SM, Letrero R, Weber BL, Hogervorst FB, Rookus MA, Collee JM, Devilee P, Ligtenberg MJ, Luijt RB, Aalfs CM, Waisfisz Q, Wijnen J, Roozendaal CE, Easton DF, Peock S, Cook M, Oliver C, Frost D, Harrington P, Evans DG, Lalloo F, Eeles R, Izatt L, Chu C, Eccles D, Douglas F, Brewer C, Nevanlinna H, Heikkinen T, Couch FJ, Lindor NM, Wang X, Godwin AK, Caligo MA, Lombardi G, Loman N, Karlsson P, Ehrencrona H, Wachenfeldt Av, Barkardottir RB, Hamann U, Rashid MU, Lasa A, Caldés T, Andrés R, Schmitt M, Assmann V, Stevens K, Offit K, Curado J, Tilgner H, Guigó R, Aiza G, Brunet J, Castellsagué J, Martrat G, Urruticoechea A, Blanco I, Tihomirova L, Goldgar DE, Buys S, John EM, Miron A, Southey M, Daly MB, Schmutzler RK, Wappenschmidt B, Meindl A, Arnold N, Deissler H, Varon-Mateeva R, Sutter C, Niederacher D, Imyamitov E, Sinilnikova OM, Stoppa-Lyonne D, Mazoyer S, Verny-Pierre C, Castera L, de Pauw A, Bignon YJ, Uhrhammer N, Peyrat JP, Vennin P, Fert Ferrer S, Collonge-Rame MA, Mortemousque I, Spurdle AB, Beesley J, Chen X, Healey S, Barcellos-Hoff MH, Vidal M, Gruber SB, Lázaro C, Capellá G, McGuffog L, Nathanson KL, Antoniou AC, Chenevix-Trench G, Fleisch MC, Moreno V, Pujana MA. Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer. PLoS Biol. 2011 Nov; 9(11):e1001199. PMID: 22110403; PMCID: PMC3217025.
      19. Andarawewa KL, Costes S, Fernandez-Garcia I, Chou WS, Ravani SA, Park H, Barcellos-Hoff MH. Lack of radiation dose or quality dependence of epithelial-to-mesenchymal transition (EMT) mediated by transforming growth factor ß. Int J Radiat Oncol Biol Phys. 2011 Apr 01; 79(5):1523-31. PMID: 21310544.
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      20. Tang J, Enderling H, Becker-Weimann S, Pham C, Polyzos A, Chen CY, Costes S. Phenotypic transition maps of 3D breast acini obtained by imaging-guided agent-based modeling. Integr Biol (Camb). 2011 Apr; 3(4):408-21. PMID: 21373705; PMCID: PMC4009383.
      21. Chiolo I, Minoda A, Colmenares SU, Polyzos A, Costes S, Karpen GH. Double-strand breaks in heterochromatin move outside of a dynamic HP1a domain to complete recombinational repair. Cell. 2011 Mar 04; 144(5):732-44. PMID: 21353298; PMCID: PMC3417143.
      22. Groesser T, Chang H, Fontenay G, Chen J, Costes S, Helen Barcellos-Hoff M, Parvin B, Rydberg B. Persistence of ?-H2AX and 53BP1 foci in proliferating and non-proliferating human mammary epithelial cells after exposure to ?-rays or iron ions. Int J Radiat Biol. 2011 Jul; 87(7):696-710. PMID: 21271785.
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      23. Spencer VA, Costes S, Inman JL, Xu R, Chen J, Hendzel MJ, Bissell MJ. Depletion of nuclear actin is a key mediator of quiescence in epithelial cells. J Cell Sci. 2011 Jan 01; 124(Pt 1):123-32. PMID: 21172822; PMCID: PMC3001411.
      24. Rivera JF, Gurlo T, Daval M, Huang CJ, Matveyenko AV, Butler PC, Costes S. Human-IAPP disrupts the autophagy/lysosomal pathway in pancreatic ß-cells: protective role of p62-positive cytoplasmic inclusions. Cell Death Differ. 2011 Mar; 18(3):415-26. PMID: 20814419; PMCID: PMC3132000.
      25. Mukhopadhyay R, Costes S, Bazarov AV, Hines WC, Barcellos-Hoff MH, Yaswen P. Promotion of variant human mammary epithelial cell outgrowth by ionizing radiation: an agent-based model supported by in vitro studies. Breast Cancer Res. 2010; 12(1):R11. PMID: 20146798; PMCID: PMC2880432.
      26. Ghajar CM, Kachgal S, Kniazeva E, Mori H, Costes S, George SC, Putnam AJ. Mesenchymal cells stimulate capillary morphogenesis via distinct proteolytic mechanisms. Exp Cell Res. 2010 Mar 10; 316(5):813-25. PMID: 20067788; PMCID: PMC2845480.
      27. Costes S, Chiolo I, Pluth JM, Barcellos-Hoff MH, Jakob B. Spatiotemporal characterization of ionizing radiation induced DNA damage foci and their relation to chromatin organization. Mutat Res. 2010 Apr-Jun; 704(1-3):78-87. PMID: 20060491; PMCID: PMC3951968.
      28. Ponomarev AL, Costes S, Cucinotta FA. Stochastic properties of radiation-induced DSB: DSB distributions in large scale chromatin loops, the HPRT gene and within the visible volumes of DNA repair foci. Int J Radiat Biol. 2008 Nov; 84(11):916-29. PMID: 19016140.
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      29. Maxwell CA, Fleisch MC, Costes S, Erickson AC, Boissière A, Gupta R, Ravani SA, Parvin B, Barcellos-Hoff MH. Targeted and nontargeted effects of ionizing radiation that impact genomic instability. Cancer Res. 2008 Oct 15; 68(20):8304-11. PMID: 18922902.
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      30. Barkan D, Kleinman H, Simmons JL, Asmussen H, Kamaraju AK, Hoenorhoff MJ, Liu ZY, Costes S, Cho EH, Lockett S, Khanna C, Chambers AF, Green JE. Inhibition of metastatic outgrowth from single dormant tumor cells by targeting the cytoskeleton. Cancer Res. 2008 Aug 01; 68(15):6241-50. PMID: 18676848; PMCID: PMC2561279.
      31. Andarawewa KL, Erickson AC, Chou WS, Costes S, Gascard P, Mott JD, Bissell MJ, Barcellos-Hoff MH. Ionizing radiation predisposes nonmalignant human mammary epithelial cells to undergo transforming growth factor beta induced epithelial to mesenchymal transition. Cancer Res. 2007 Sep 15; 67(18):8662-70. PMID: 17875706.
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      32. Costes S, Ponomarev A, Chen JL, Nguyen D, Cucinotta FA, Barcellos-Hoff MH. Image-based modeling reveals dynamic redistribution of DNA damage into nuclear sub-domains. PLoS Comput Biol. 2007 Aug; 3(8):e155. PMID: 17676951; PMCID: PMC1937017.
      33. Fleisch MC, Maxwell CA, Kuper CK, Brown ET, Barcellos-Hoff MH, Costes S. Intensity-based signal separation algorithm for accurate quantification of clustered centrosomes in tissue sections. Microsc Res Tech. 2006 Dec; 69(12):964-72. PMID: 16941664.
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      34. Costes S, Boissière A, Ravani S, Romano R, Parvin B, Barcellos-Hoff MH. Imaging features that discriminate between foci induced by high- and low-LET radiation in human fibroblasts. Radiat Res. 2006 May; 165(5):505-15. PMID: 16669704.
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      35. Barcellos-Hoff MH, Costes S. A systems biology approach to multicellular and multi-generational radiation responses. Mutat Res. 2006 May 11; 597(1-2):32-8. PMID: 16417910.
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      36. Daelemans D, Costes S, Lockett S, Pavlakis GN. Kinetic and molecular analysis of nuclear export factor CRM1 association with its cargo in vivo. Mol Cell Biol. 2005 Jan; 25(2):728-39. PMID: 15632073; PMCID: PMC543413.
      37. Muriaux D, Costes S, Nagashima K, Mirro J, Cho E, Lockett S, Rein A. Role of murine leukemia virus nucleocapsid protein in virus assembly. J Virol. 2004 Nov; 78(22):12378-85. PMID: 15507624; PMCID: PMC525092.
      38. Daelemans D, Costes S, Cho EH, Erwin-Cohen RA, Lockett S, Pavlakis GN. In vivo HIV-1 Rev multimerization in the nucleolus and cytoplasm identified by fluorescence resonance energy transfer. J Biol Chem. 2004 Nov 26; 279(48):50167-75. PMID: 15294891.
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      39. Veitenhansl M, Stegner K, Hierl FX, Dieterle C, Feldmeier H, Gutt B, Landgraf R, Garrow AP, Vileikyte L, Findlow A, Waterman C, Boulton AJ, Shankhdhar K, Shankhdhar L, Shankhdhar U, Petrova NL, Foster AV, Edmonds ME, Ferraresi R, Caravaggi C, De Giglio R, Cavaiani P, Pogliaghi I, Sommariva E, Katz IA, Harlan A, Miranda-Palma B, Prieto-Sanchez L, Armstrong DG, Bowker JH, Mizel MS, Cernea S, Wohlgelernter J, Kidron M, Modi P, Raz I, Arbit E, Nosek L, Kapitza C, Beckett P, Gelfand R, Goldberg M, Heise T, Testa MA, Turner RR, Hayes JF, Scranton RE, Simonson DC, Yang YW, Hsu YJ, Naujok O, Francini F, Jörns A, Tiedge M, Lenzen S, Abdel-Wahab YH, Marenah L, Orr DF, Shaw C, Flatt PR, Chokkalingam K, Mansell PI, Clausen P, Ekbom P, Damm P, Feldt-Rasmussen U, Nielsen B, Mathiesen ER, Feldt-Rasmussen B, Dewan S, Da Silva N, Ternan PM, Leong KS, Wilding JP, Asatiani N, Kurashvili R, Dundua M, Shelestova E, Pagava K, Ramazashvili M, Hod M, Smirnov S, Petersen JL, Justesen TI, Ringholm Nielsen L, Müller C, Højlund K, Wensaas A, Kase ET, Aas V, Rustan AC, Thoresen GH, Levin K, Beck-Nielsen H, Gaster M, Im SS, Kang SY, Kim SY, Ahn YH, Lihn AS, Schmoll D, Werner T, Kienitz A, Meyer M, Barthel A, Ailett F, Sutherland C, Walther R, Grempler R, Sasson S, Reich R, Tenenbaum T, Alpert E, Anfossi G, Russo I, Traversa M, Massucco P, Mattiello L, Doronzo G, Trovati M, Lally S, Tan CY, Owens D, Tomkin GH, Porchay I, Péan F, Bellili N, Betoulle D, Balkau B, Tichet J, Marre M, Fumeron F, Chatellier G, Alhenc-Gelas F, Nichols GA, Brown JB, Hayes RP, Bowman L, Drexel H, Saely CH, Marte T, Benzer W, Langer P, Hoefle G, Moll W, Aczel S, Karagiannis E, Lübben G, Urquhart R, Edwards G, Bruce S, Howlett HS, Cugnardey N, Turner KC, Park JS, Fiedorek FT, Avogaro A, Gallo A, Pinton P, Rizzuto R, Murphy E, Ceolotto G, Caterson I, Guy-Grand B, Hill J, Barone M, Aiello A, Allochis G, Borzì V, Cannatà F, Caronna S, D'Avanzo A, Elli R, Formoso G, Paroli A, Scardapane R, Sorichetti P, Tatti P, Viviani G, Santeusanio F, Manzella D, Grella R, Abbatecola AM, Paolisso G, Søndergaard LG, Monster TB, Johnsen SP, Olsen ML, McLaughlin JK, Sørensen HT, Lervang HH, Rungby J, Lyssenko V, Fredriksson J, Almgren P, Anevski D, Orho-Melander M, Sjögren M, Tuomi T, Groop L, Jaziri R, Aubert R, Tuomilehto J, Hu G, Jousilahti P, Peltonen M, Lindstrom J, Laina A, Alevizaki M, Philippou G, Souvatzoglou A, Anastasiou E, Alba S, Metcalf BS, Voss LD, Jeffery AN, Wilkin TJ, Glüimer C, Colagiuri S, Vistisen D, Borch-Johnsen K, Haynes A, Bower C, Bulsara MK, Jones TW, Davis EA, Mortensen HB, Hougaard P, Holl R, Swift P, Pociot F, Knip M, Hansen L, Szadkowska A, Pietrzak I, Zmyslowska A, Wyka K, Bodalski J, Holl RW, Swift R, Hougaard R, Gerstl EM, Engelsberger I, Rabl W, Rosenbauer J, Gröbe H, Hofer SE, Krause U, Dabelea D, Morgan T, Pettitt DJ, Dolan L, Mayer-Davis EJ, Pihoker C, Hillier TA, Imperatore G, Ruggiero A, Hamman RE, Stylianou A, Tentolouris N, Perrea D, Tselepis AD, Lourida E, Kitsou E, Katsilambros N, Vedovato M, Dodesini AR, Lepore G, Tiengo A, Trevisan R, Penno G, Miccoli R, Pucci L, Lucchesi D, Bandinelli S, Fotino C, Triscornia S, Baldassari E, Del Prato S, Reboldi P, Santeusanio E, Fuller J, Langham RG, Gow RM, Zhang Y, Kelly DJ, Christensen PK, Parving HH, Gilbert RE, Chibalin AV, Zhong Z, Kotova O, Davidescu A, Ehrén I, Ekberg K, Wahren J, Wassef L, Buckley AJ, Rooney KB, Briody J, Thompson M, Ozanne SE, Thompson CH, Chamson-Reig A, Summers K, Arany EJ, Hill DJ, Solerte SB, Gazzaruso C, Locatelli E, Precerutti S, Schifino N, Ferrari E, Fioravanti M, Phenekos CV, Ginis A, Fragaki I, Chalkiadaki M, Tzioras C, Powell LA, McGuire GM, Jewhurst V, Trimble ER, Rasmussen BM, Vessby B, Uusitupa M, Berglund L, Pedersen E, Riccardi G, Rivellese AA, Tapsell L, Hermansen K, da Silva Xavier G, Rutter J, Rutter GA, Briaud IM, Lingohr MK, Dickson LM, McCuaig JR, Lawrence JC, Rhodes CJ, Wikstrom JD, Katzman SM, Shirihai OS, Yang J, Deng S, Wang X, Hessner MJ, Wu J, Wong RK, et al. 40th EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004. Diabetologia. 2004 Aug; 47(Suppl 1):A1-A464. PMID: 27770180.
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      40. Costes S, Daelemans D, Cho EH, Dobbin Z, Pavlakis G, Lockett S. Automatic and quantitative measurement of protein-protein colocalization in live cells. Biophys J. 2004 Jun; 86(6):3993-4003. PMID: 15189895; PMCID: PMC1304300.
      41. Catalfamo M, Karpova T, McNally J, Costes S, Lockett SJ, Bos E, Peters PJ, Henkart PA. Human CD8+ T cells store RANTES in a unique secretory compartment and release it rapidly after TcR stimulation. Immunity. 2004 Feb; 20(2):219-30. PMID: 14975243.
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      42. Yang HS, Jansen AP, Komar AA, Zheng X, Merrick WC, Costes S, Lockett SJ, Sonenberg N, Colburn NH. The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation. Mol Cell Biol. 2003 Jan; 23(1):26-37. PMID: 12482958; PMCID: PMC140682.
      43. Ortiz De Solórzano C, Costes S, Callahan DE, Parvin B, Barcellos-Hoff MH. Applications of quantitative digital image analysis to breast cancer research. Microsc Res Tech. 2002 Oct 15; 59(2):119-27. PMID: 12373722.
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      44. Costes S, Barcellos-Hoff MH. Radiation quality and tissue-specific microenvironments following exposure to 1 GeV/amu Fe. Adv Space Res. 2002; 30(4):865-70. PMID: 12530433.
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      45. Costes S, Sachs R, Hlatky L, Vannais D, Waldren C, Fouladi B. Large-mutation spectra induced at hemizygous loci by low-LET radiation: evidence for intrachromosomal proximity effects. Radiat Res. 2001 Nov; 156(5 Pt 1):545-57. PMID: 11604068.
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      46. Costes S, Streuli CH, Barcellos-Hoff MH. Quantitative image analysis of laminin immunoreactivity in skin basement membrane irradiated with 1 GeV/nucleon iron particles. Radiat Res. 2000 Oct; 154(4):389-97. PMID: 11023602.
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