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    Stjepanovic, Goran

    TitleBiophysicist Postdoc Fellow
    SchoolLawrence Berkeley National Lab
    DepartmentMolecular Biophys & Integ Bio
    Address1 Cyclotron Road
    Berkeley CA 94720
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      Collapse Biography 
      Collapse Education and Training
      Heidelberg University, GermanyPhD05/2012Biophysics and Biochemistry
      University of Zagreb, CroatiaMSc07/2005Molecular biology

      Collapse Overview 
      Collapse Overview
      Dr. Stjepanovic is Biophysicist Postdoc Fellow at Lawrence Berkeley National Lab, Molecular Biophysics and Integrated Bioimaging Division. Dr. Stjepanovic scientific career has revolved around structural biology and biochemistry of membrane transport processes, with an affinity for studies of peripheral membrane proteins, protein-lipid interactions, membrane trafficking and remodeling. He obtained his Ph.D. in biochemistry and biophysics from Heidelberg University with emphasis in structural membrane biology and mass spectrometric methods development. His research focused on the co-translational protein translocation across plasma membrane in bacteria and resulted in discovery of an essential membrane association mechanism of the signal recognition particle (SRP) machinery as well as a revised model for the SRP mediated protein translocation in prokaryotes. After graduating, he performed his post-doctoral work at NIH and University of California at Berkeley focusing on application of single particle electron microscopy and mass spectrometry to research of large, membrane associated, protein complexes in eukaryotes. He provided the first structural insights into the architecture and dynamics of the PI3-kinase complex which is essential to both the progression of endocytosis and autophagy. He is currently working towards in vitro reconstitution of autophagy machinery to gain insights in the autophagic membrane remodeling and identification of new targets or therapeutic compounds for treating cancer, infectious and other diseases associated with autophagy.

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      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Kasinath V, Faini M, Poepsel S, Reif D, Feng XA, Stjepanovic G, Aebersold R, Nogales E. Structures of human PRC2 with its cofactors AEBP2 and JARID2. Science. 2018 Jan 18. PMID: 29348366.
        View in: PubMed
      2. Gardner BM, Castanzo DT, Chowdhury S, Stjepanovic G, Stefely MS, Hurley JH, Lander GC, Martin A. The peroxisomal AAA-ATPase Pex1/Pex6 unfolds substrates by processive threading. Nat Commun. 2018 Jan 10; 9(1):135. PMID: 29321502.
        View in: PubMed
      3. Su MY, Morris KL, Kim DJ, Fu Y, Lawrence R, Stjepanovic G, Zoncu R, Hurley JH. Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex. Mol Cell. 2017 Dec 07; 68(5):835-846.e3. PMID: 29107538.
        View in: PubMed
      4. Stjepanovic G, Baskaran S, Lin MG, Hurley JH. Unveiling the role of VPS34 kinase domain dynamics in regulation of the autophagic PI3K complex. Mol Cell Oncol. 2017; 4(6):e1367873. PMID: 29209653.
        View in: PubMed
      5. Stjepanovic G, Baskaran S, Lin MG, Hurley JH. Vps34 Kinase Domain Dynamics Regulate the Autophagic PI 3-Kinase Complex. Mol Cell. 2017 Aug 03; 67(3):528-534.e3. PMID: 28757208.
        View in: PubMed
      6. Qi S, Li Z, Schulze-Gahmen U, Stjepanovic G, Zhou Q, Hurley JH. Structural basis for ELL2 and AFF4 activation of HIV-1 proviral transcription. Nat Commun. 2017 Jan 30; 8:14076. PMID: 28134250.
        View in: PubMed
      7. Schulze-Gahmen U, Echeverria I, Stjepanovic G, Bai Y, Lu H, Schneidman-Duhovny D, Doudna JA, Zhou Q, Sali A, Hurley JH. Insights into HIV-1 proviral transcription from integrative structure and dynamics of the Tat:AFF4:P-TEFb:TAR complex. Elife. 2016 Oct 12; 5. PMID: 27731797.
        View in: PubMed
      8. Qi S, Kim DJ, Stjepanovic G, Hurley JH. Structure of the Human Atg13-Atg101 HORMA Heterodimer: an Interaction Hub within the ULK1 Complex. Structure. 2015 10 06; 23(10):1848-57. PMID: 26299944; PMCID: PMC4598286 [Available on 10/06/16].
      9. Yang B, Stjepanovic G, Shen Q, Martin A, Hurley JH. Vps4 disassembles an ESCRT-III filament by global unfolding and processive translocation. Nat Struct Mol Biol. 2015 Jun; 22(6):492-8. PMID: 25938660; PMCID: PMC4456219.
      10. Davies CW, Stjepanovic G, Hurley JH. How the Atg1 complex assembles to initiate autophagy. Autophagy. 2015; 11(1):185-6. PMID: 25700739; PMCID: PMC4502730.
      11. Baskaran S, Carlson LA, Stjepanovic G, Young LN, Kim DJ, Grob P, Stanley RE, Nogales E, Hurley JH. Architecture and dynamics of the autophagic phosphatidylinositol 3-kinase complex. Elife. 2014 Dec 09; 3. PMID: 25490155; PMCID: PMC4281882.
      12. Stjepanovic G, Davies CW, Stanley RE, Ragusa MJ, Kim DJ, Hurley JH. Assembly and dynamics of the autophagy-initiating Atg1 complex. Proc Natl Acad Sci U S A. 2014 Sep 02; 111(35):12793-8. PMID: 25139988; PMCID: PMC4156731.
      13. Kressler D, Bange G, Ogawa Y, Stjepanovic G, Bradatsch B, Pratte D, Amlacher S, Strauß D, Yoneda Y, Katahira J, Sinning I, Hurt E. Synchronizing nuclear import of ribosomal proteins with ribosome assembly. Science. 2012 Nov 02; 338(6107):666-71. PMID: 23118189.
        View in: PubMed
      14. Stjepanovic G, Kapp K, Bange G, Graf C, Parlitz R, Wild K, Mayer MP, Sinning I. Lipids trigger a conformational switch that regulates signal recognition particle (SRP)-mediated protein targeting. J Biol Chem. 2011 Jul 01; 286(26):23489-97. PMID: 21543314; PMCID: PMC3123112.
      15. Erez E, Stjepanovic G, Zelazny AM, Brugger B, Sinning I, Bibi E. Genetic evidence for functional interaction of the Escherichia coli signal recognition particle receptor with acidic lipids in vivo. J Biol Chem. 2010 Dec 24; 285(52):40508-14. PMID: 20956528; PMCID: PMC3003349.
      16. Bozkurt G, Stjepanovic G, Vilardi F, Amlacher S, Wild K, Bange G, Favaloro V, Rippe K, Hurt E, Dobberstein B, Sinning I. Structural insights into tail-anchored protein binding and membrane insertion by Get3. Proc Natl Acad Sci U S A. 2009 Dec 15; 106(50):21131-6. PMID: 19948960; PMCID: PMC2795547.
      17. Ravaud S, Stjepanovic G, Wild K, Sinning I. The crystal structure of the periplasmic domain of the Escherichia coli membrane protein insertase YidC contains a substrate binding cleft. J Biol Chem. 2008 Apr 04; 283(14):9350-8. PMID: 18234665.
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      18. Bahari L, Parlitz R, Eitan A, Stjepanovic G, Bochkareva ES, Sinning I, Bibi E. Membrane targeting of ribosomes and their release require distinct and separable functions of FtsY. J Biol Chem. 2007 Nov 02; 282(44):32168-75. PMID: 17726013.
        View in: PubMed
      19. Parlitz R, Eitan A, Stjepanovic G, Bahari L, Bange G, Bibi E, Sinning I. Escherichia coli signal recognition particle receptor FtsY contains an essential and autonomous membrane-binding amphipathic helix. J Biol Chem. 2007 Nov 02; 282(44):32176-84. PMID: 17726012.
        View in: PubMed
      20. Krisko A, Stjepanovic G, Pifat G, Ruysschaert JM, Goormaghtigh E. Detection of apolipoprotein B100 early conformational changes during oxidation. Biochim Biophys Acta. 2007 Nov; 1768(11):2923-30. PMID: 17920034.
        View in: PubMed

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