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    Petzold, Christopher

    TitleCompl Biologist Res Sci/Engr
    SchoolLawrence Berkeley National Lab
    DepartmentPhysical Biosciences
    Address1 Cyclotron Road
    Berkeley CA 94720
    Phone510/486-7237

       Overview 
       Overview
      Chris Petzold is a research scientist with Berkeley Lab’s Physical Biosciences Division. He obtained his Ph. D. in Chemistry from Purdue University with emphasis in gas-phase ion chemistry and mass spectrometric methods development. After graduating from Purdue, he performed his post-doctoral work at UC-Berkeley focusing on application of mass spectrometry to glycomics and lipidomics research. Chris joined Jay Keasling’s research group in 2005 as part of the team tasked to understand the impact of metabolic engineering on the host microbe via systems biology. His recent work focuses on developing analytic solutions to problems facing metabolic engineering. Recent work has focused on applying quantitative proteomics to further rational design and optimization of novel metabolic pathways for a wide variety applications.


       Bibliographic 
       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can sign in to make corrections and additions, or contact us for help.
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      1. Gupta S, Guttman M, Leverenz RL, Zhumadilova K, Pawlowski EG, Petzold CJ, Lee KK, Ralston CY, Kerfeld CA. Local and global structural drivers for the photoactivation of the orange carotenoid protein. Proc Natl Acad Sci U S A. 2015 Sep 18.
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      2. Petzold CJ, Chan LJ, Nhan M, Adams PD. Analytics for metabolic engineering. Front. Bioeng. Biotechnol. 2015; 135(3).
      3. Petzold CJ, Chan LJ, Nhan M, Adams PD. Analytics for Metabolic Engineering. Front Bioeng Biotechnol. 2015; 3:135.
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      4. Leverenz RL, Sutter M, Wilson A, Gupta S, Thurotte A, Bourcier de Carbon C, Petzold CJ, Ralston C, Perreau F, Kirilovsky D, Kerfeld CA. PHOTOSYNTHESIS. A 12 Å carotenoid translocation in a photoswitch associated with cyanobacterial photoprotection. Science. 2015 Jun 26; 348(6242):1463-6.
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      5. George KW, Thompson MG, Kang A, Baidoo E, Wang G, Chan LJ, Adams PD, Petzold CJ, Keasling JD, Soon Lee T. Metabolic engineering for the high-yield production of isoprenoid-based C5 alcohols in E. coli. Sci Rep. 2015; 5:11128.
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      6. Schwessinger B, Bahar O, Thomas N, Holton N, Nekrasov V, Ruan D, Canlas PE, Daudi A, Petzold CJ, Singan VR, Kuo R, Chovatia M, Daum C, Heazlewood JL, Zipfel C, Ronald PC. Correction: Transgenic expression of the dicotyledonous pattern recognition receptor EFR in rice leads to ligand-dependent activation of defense responses. PLoS Pathog. 2015 Apr; 11(4):e1004872.
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      7. González Fernández-Niño SM, Smith-Moritz AM, Chan LJ, Adams PD, Heazlewood JL, Petzold CJ. Standard flow liquid chromatography for shotgun proteomics in bioenergy research. Front Bioeng Biotechnol. 2015; 3:44.
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      8. Schwessinger B, Bahar O, Thomas N, Holton N, Nekrasov V, Ruan D, Canlas PE, Daudi A, Petzold CJ, Singan VR, Kuo R, Chovatia M, Daum C, Heazlewood JL, Zipfel C, Ronald PC. Transgenic Expression of the Dicotyledonous Pattern Recognition Receptor EFR in Rice Leads to Ligand-Dependent Activation of Defense Responses. PLoS Pathog. 2015 Mar; 11(3):e1004809.
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      9. Ebert B, Rautengarten C, Guo X, Xiong G, Stonebloom S, Smith-Moritz AM, Herter T, Chan LJ, Adams PD, Petzold CJ, Pauly M, Willats WG, Heazlewood JL, Scheller HV. Identification and Characterization of a Golgi-Localized UDP-Xylose Transporter Family from Arabidopsis. Plant Cell. 2015 Apr; 27(4):1218-27.
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      10. Poust S, Phelan RM, Deng K, Katz L, Petzold CJ, Keasling JD. Divergent Mechanistic Routes for the Formation of gem-Dimethyl Groups in the Biosynthesis of Complex Polyketides. Angew Chem Int Ed Engl. 2015 Feb 16; 54(8):2370-3.
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      11. Hurd TR, Sanchez CG, Teixeira FK, Petzold C, Dancel-Manning K, Wang JY, Lehmann R, Liang FX. Ultrastructural Analysis of Drosophila Ovaries by Electron Microscopy. Methods Mol Biol. 2015; 1328:151-62.
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      12. Alonso-Gutierrez J, Kim EM, Batth TS, Cho N, Hu Q, Chan LJ, Petzold CJ, Hillson NJ, Adams PD, Keasling JD, Garcia Martin H, Lee TS. Principal component analysis of proteomics (PCAP) as a tool to direct metabolic engineering. Metab Eng. 2015 Mar; 28:123-33.
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      13. Poust S, Yoon I, Adams PD, Katz L, Petzold CJ, Keasling JD. Understanding the Role of Histidine in the GHSxG Acyltransferase Active Site Motif: Evidence for Histidine Stabilization of the Malonyl-Enzyme Intermediate. PLoS One. 2014; 9(10):e109421.
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      14. Haushalter RW, Kim W, Chavkin TA, The L, Garber ME, Nhan M, Adams PD, Petzold CJ, Katz L, Keasling JD. Production of anteiso-branched fatty acids in Escherichia coli; next generation biofuels with improved cold-flow properties. Metab Eng. 2014 Sep 22; 26C:111-118.
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      15. Winger AM, Heazlewood JL, Chan LJ, Petzold CJ, Permaul K, Singh S. Secretome analysis of the thermophilic xylanase hyper-producer Thermomyces lanuginosus SSBP cultivated on corn cobs. J Ind Microbiol Biotechnol. 2014 Nov; 41(11):1687-96.
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      16. Hagen A, Poust S, de Rond T, Yuzawa S, Katz L, Adams PD, Petzold CJ, Keasling JD. In vitro analysis of carboxyacyl substrate tolerance in the loading and first extension modules of borrelidin polyketide synthase. Biochemistry. 2014 Sep 30; 53(38):5975-7.
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      17. Batth TS, Singh P, Ramakrishnan VR, Sousa MM, Chan LJ, Tran HM, Luning EG, Pan EH, Vuu KM, Keasling JD, Adams PD, Petzold CJ. A targeted proteomics toolkit for high-throughput absolute quantification of Escherichia coli proteins. Metab Eng. 2014 Sep 7; 26C:48-56.
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      18. Ghosh A, Nilmeier J, Weaver D, Adams PD, Keasling JD, Mukhopadhyay A, Petzold CJ, Martín HG. A Peptide-Based Method for 13C Metabolic Flux Analysis in Microbial Communities. PLoS Comput Biol. 2014 Sep; 10(9):e1003827.
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      19. Kirby J, Nishimoto M, Chow RW, Pasumarthi VN, Chan R, Chan LJ, Petzold CJ, Keasling JD. Use of Nonionic Surfactants for Improvement of Terpene Production in Saccharomyces cerevisiae. Appl Environ Microbiol. 2014 Nov 1; 80(21):6685-93.
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      20. Weaver LJ, Sousa MM, Wang G, Baidoo E, Petzold CJ, Keasling JD. A kinetic-based approach to understanding heterologous mevalonate pathway function in E. coli. Biotechnol Bioeng. 2015 Jan; 112(1):111-9.
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      21. Rennie EA, Ebert B, Miles GP, Cahoon RE, Christiansen KM, Stonebloom S, Khatab H, Twell D, Petzold CJ, Adams PD, Dupree P, Heazlewood JL, Cahoon EB, Scheller HV. Identification of a Sphingolipid a-Glucuronosyltransferase That Is Essential for Pollen Function in Arabidopsis. Plant Cell. 2014 Aug; 26(8):3314-25.
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      22. Frederix M, Hütter K, Leu J, Batth TS, Turner WJ, Rüegg TL, Blanch HW, Simmons BA, Adams PD, Keasling JD, Thelen MP, Dunlop MJ, Petzold CJ, Mukhopadhyay A. Development of a Native Escherichia coli Induction System for Ionic Liquid Tolerance. PLoS One. 2014; 9(7):e101115.
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      23. Gupta S, Celestre R, Petzold CJ, Chance MR, Ralston C. Development of a microsecond X-ray protein footprinting facility at the Advanced Light Source. J Synchrotron Radiat. 2014 Jul; 21(Pt 4):690-9.
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      24. George KW, Chen A, Jain A, Batth TS, Baidoo EE, Wang G, Adams PD, Petzold CJ, Keasling JD, Lee TS. Correlation analysis of targeted proteins and metabolites to assess and engineer microbial isopentenol production. Biotechnol Bioeng. 2014 Aug; 111(8):1648-58.
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      25. Chen X, Zuo S, Schwessinger B, Chern M, Canlas PE, Ruan D, Zhou X, Wang J, Daudi A, Petzold CJ, Heazlewood JL, Ronald PC. An XA21-Associated Kinase (OsSERK2) Regulates Immunity Mediated by the XA21 and XA3 Immune Receptors. Mol Plant. 2014 May; 7(5):874-92.
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      26. Parsons HT, Weinberg CS, Macdonald LJ, Adams PD, Petzold CJ, Strabala TJ, Wagner A, Heazlewood JL. Golgi Enrichment and Proteomic Analysis of Developing Pinus radiata Xylem by Free-Flow Electrophoresis. PLoS One. 2013; 8(12):e84669.
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      27. Ito J, Herter T, Baidoo EE, Lao J, Vega-Sánchez ME, Michelle Smith-Moritz A, Adams PD, Keasling JD, Usadel B, Petzold CJ, Heazlewood JL. Analysis of plant nucleotide sugars by hydrophilic interaction liquid chromatography and tandem mass spectrometry. Anal Biochem. 2014 Mar 1; 448:14-22.
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      28. Nowroozi FF, Baidoo EE, Ermakov S, Redding-Johanson AM, Batth TS, Petzold CJ, Keasling JD. Metabolic pathway optimization using ribosome binding site variants and combinatorial gene assembly. Appl Microbiol Biotechnol. 2014 Feb; 98(4):1567-81.
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      29. Petzold CJ, Schwarz RI. Cells determine cell density using a small protein bound to a unique tissue-specific phospholipid. PeerJ. 2013; 1:e192.
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      30. Dahl RH, Zhang F, Alonso-Gutierrez J, Baidoo E, Batth TS, Redding-Johanson AM, Petzold CJ, Mukhopadhyay A, Lee TS, Adams PD, Keasling JD. Engineering dynamic pathway regulation using stress-response promoters. Nat Biotechnol. 2013 Nov; 31(11):1039-46.
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      31. Alonso-Gutierrez J, Chan R, Batth TS, Adams PD, Keasling JD, Petzold CJ, Lee TS. Metabolic engineering of Escherichia coli for limonene and perillyl alcohol production. Metab Eng. 2013 Sep; 19:33-41.
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      32. Mann GW, Joshi HJ, Petzold CJ, Heazlewood JL. Proteome coverage of the model plant Arabidopsis thaliana: implications for shotgun proteomic studies. J Proteomics. 2013 Feb 21; 79:195-9.
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      33. Zhang F, Ouellet M, Batth TS, Adams PD, Petzold CJ, Mukhopadhyay A, Keasling JD. Enhancing fatty acid production by the expression of the regulatory transcription factor FadR. Metab Eng. 2012 Nov; 14(6):653-60.
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      34. McClendon SD, Batth T, Petzold CJ, Adams PD, Simmons BA, Singer SW. Thermoascus aurantiacus is a promising source of enzymes for biomass deconstruction under thermophilic conditions. Biotechnol Biofuels. 2012; 5(1):54.
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      35. McKee AE, Rutherford BJ, Chivian DC, Baidoo EK, Juminaga D, Kuo D, Benke PI, Dietrich JA, Ma SM, Arkin AP, Petzold CJ, Adams PD, Keasling JD, Chhabra SR. Manipulation of the carbon storage regulator system for metabolite remodeling and biofuel production in Escherichia coli. Microb Cell Fact. 2012; 11:79.
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      36. Park JI, Steen EJ, Burd H, Evans SS, Redding-Johnson AM, Batth T, Benke PI, D'haeseleer P, Sun N, Sale KL, Keasling JD, Lee TS, Petzold CJ, Mukhopadhyay A, Singer SW, Simmons BA, Gladden JM. A thermophilic ionic liquid-tolerant cellulase cocktail for the production of cellulosic biofuels. PLoS One. 2012; 7(5):e37010.
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      37. Singh P, Batth TS, Juminaga D, Dahl RH, Keasling JD, Adams PD, Petzold CJ. Application of targeted proteomics to metabolically engineered Escherichia coli. Proteomics. 2012 Apr; 12(8):1289-99.
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      38. Parsons HT, Christiansen K, Knierim B, Carroll A, Ito J, Batth TS, Smith-Moritz AM, Morrison S, McInerney P, Hadi MZ, Auer M, Mukhopadhyay A, Petzold CJ, Scheller HV, Loqué D, Heazlewood JL. Isolation and proteomic characterization of the Arabidopsis Golgi defines functional and novel components involved in plant cell wall biosynthesis. Plant Physiol. 2012 May; 159(1):12-26.
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      39. Groff D, Benke PI, Batth TS, Bokinsky G, Petzold CJ, Adams PD, Keasling JD. Supplementation of intracellular XylR leads to coutilization of hemicellulose sugars. Appl Environ Microbiol. 2012 Apr; 78(7):2221-9.
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      40. Batth TS, Keasling JD, Petzold CJ. Targeted proteomics for metabolic pathway optimization. Methods Mol Biol. 2012; 944:237-49.
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      41. Juminaga D, Baidoo EE, Redding-Johanson AM, Batth TS, Burd H, Mukhopadhyay A, Petzold CJ, Keasling JD. Modular engineering of L-tyrosine production in Escherichia coli. Appl Environ Microbiol. 2012 Jan; 78(1):89-98.
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      42. Ma SM, Garcia DE, Redding-Johanson AM, Friedland GD, Chan R, Batth TS, Haliburton JR, Chivian D, Keasling JD, Petzold CJ, Lee TS, Chhabra SR. Optimization of a heterologous mevalonate pathway through the use of variant HMG-CoA reductases. Metab Eng. 2011 Sep; 13(5):588-97.
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      43. Chhabra SR, Joachimiak MP, Petzold CJ, Zane GM, Price MN, Reveco SA, Fok V, Johanson AR, Batth TS, Singer M, Chandonia JM, Joyner D, Hazen TC, Arkin AP, Wall JD, Singh AK, Keasling JD. Towards a rigorous network of protein-protein interactions of the model sulfate reducer Desulfovibrio vulgaris Hildenborough. PLoS One. 2011; 6(6):e21470.
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      44. Rautengarten C, Ebert B, Herter T, Petzold CJ, Ishii T, Mukhopadhyay A, Usadel B, Scheller HV. The interconversion of UDP-arabinopyranose and UDP-arabinofuranose is indispensable for plant development in Arabidopsis. Plant Cell. 2011 Apr; 23(4):1373-90.
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      45. Ito J, Batth TS, Petzold CJ, Redding-Johanson AM, Mukhopadhyay A, Verboom R, Meyer EH, Millar AH, Heazlewood JL. Analysis of the Arabidopsis cytosolic proteome highlights subcellular partitioning of central plant metabolism. J Proteome Res. 2011 Apr 1; 10(4):1571-82.
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      46. Redding-Johanson AM, Batth TS, Chan R, Krupa R, Szmidt HL, Adams PD, Keasling JD, Lee TS, Mukhopadhyay A, Petzold CJ. Targeted proteomics for metabolic pathway optimization: application to terpene production. Metab Eng. 2011 Mar; 13(2):194-203.
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      47. Shui W, Petzold CJ, Redding A, Liu J, Pitcher A, Sheu L, Hsieh TY, Keasling JD, Bertozzi CR. Organelle membrane proteomics reveals differential influence of mycobacterial lipoglycans on macrophage phagosome maturation and autophagosome accumulation. J Proteome Res. 2011 Jan 7; 10(1):339-48.
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      48. Wollack JW, Silverman JM, Petzold CJ, Mougous JD, Distefano MD. A minimalist substrate for enzymatic peptide and protein conjugation. Chembiochem. 2009 Dec 14; 10(18):2934-43.
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      49. Dueber JE, Wu GC, Malmirchegini GR, Moon TS, Petzold CJ, Ullal AV, Prather KL, Keasling JD. Synthetic protein scaffolds provide modular control over metabolic flux. Nat Biotechnol. 2009 Aug; 27(8):753-9.
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      50. Steen EJ, Chan R, Prasad N, Myers S, Petzold CJ, Redding A, Ouellet M, Keasling JD. Metabolic engineering of Saccharomyces cerevisiae for the production of n-butanol. Microb Cell Fact. 2008; 7:36.
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      51. Shui W, Sheu L, Liu J, Smart B, Petzold CJ, Hsieh TY, Pitcher A, Keasling JD, Bertozzi CR. Membrane proteomics of phagosomes suggests a connection to autophagy. Proc Natl Acad Sci U S A. 2008 Nov 4; 105(44):16952-7.
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      52. Mahendra S, Petzold CJ, Baidoo EE, Keasling JD, Alvarez-Cohen L. Identification of the intermediates of in vivo oxidation of 1 ,4-dioxane by monooxygenase-containing bacteria. Environ Sci Technol. 2007 Nov 1; 41(21):7330-6.
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      53. Kumar P, Schelle MW, Jain M, Lin FL, Petzold CJ, Leavell MD, Leary JA, Cox JS, Bertozzi CR. PapA1 and PapA2 are acyltransferases essential for the biosynthesis of the Mycobacterium tuberculosis virulence factor sulfolipid-1. Proc Natl Acad Sci U S A. 2007 Jul 3; 104(27):11221-6.
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      54. Jain M, Petzold CJ, Schelle MW, Leavell MD, Mougous JD, Bertozzi CR, Leary JA, Cox JS. Lipidomics reveals control of Mycobacterium tuberculosis virulence lipids via metabolic coupling. Proc Natl Acad Sci U S A. 2007 Mar 20; 104(12):5133-8.
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      55. Shea RC, Petzold CJ, Liu JA, Kenttämaa HI. Experimental investigations of the internal energy of molecules evaporated via laser-induced acoustic desorption into a Fourier transform ion cyclotron resonance mass spectrometer. Anal Chem. 2007 Mar 1; 79(5):1825-32.
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      56. Shea RC, Petzold CJ, Campbell JL, Li S, Aaserud DJ, Kenttämaa HI. Characterization of laser-induced acoustic desorption coupled with a Fourier transform ion cyclotron resonance mass spectrometer. Anal Chem. 2006 Sep 1; 78(17):6133-9.
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      57. Mougous JD, Senaratne RH, Petzold CJ, Jain M, Lee DH, Schelle MW, Leavell MD, Cox JS, Leary JA, Riley LW, Bertozzi CR. A sulfated metabolite produced by stf3 negatively regulates the virulence of Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2006 Mar 14; 103(11):4258-63.
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      58. Liu JA, Petzold CJ, Ramirez-Arizmendi LE, Perez J, Kenttämaa H. Phenyl radicals react with dinucleoside phosphates by addition to purine bases and H-atom abstraction from a sugar moiety. J Am Chem Soc. 2005 Sep 21; 127(37):12758-9.
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      59. Petzold CJ, Stanton LH, Leary JA. Structural characterization of Lipoarabinomannans from Mycobacterium tuberculosis and Mycobacterium smegmatis by ESI mass spectrometry. J Am Soc Mass Spectrom. 2005 Jul; 16(7):1109-16.
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      60. Mougous JD, Petzold CJ, Senaratne RH, Lee DH, Akey DL, Lin FL, Munchel SE, Pratt MR, Riley LW, Leary JA, Berger JM, Bertozzi CR. Identification, function and structure of the mycobacterial sulfotransferase that initiates sulfolipid-1 biosynthesis. Nat Struct Mol Biol. 2004 Aug; 11(8):721-9.
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      61. Petzold CJ, Leavell MD, Leary JA. Screening and identification of acidic carbohydrates in bovine colostrum by using ion/molecule reactions and Fourier transform ion cyclotron resonance mass spectrometry: specificity toward phosphorylated complexes. Anal Chem. 2004 Jan 1; 76(1):203-10.
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      62. Gao H, Petzold CJ, Leavell MD, Leary JA. Investigation of ion/molecule reactions as a quantification method for phosphorylated positional isomers. an FT-ICR approach. J Am Soc Mass Spectrom. 2003 Aug; 14(8):916-24.
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      63. Amegayibor FS, Nash JJ, Lee AS, Thoen J, Petzold CJ, Kenttämaa HI. Chemical properties of a para-benzyne. J Am Chem Soc. 2002 Oct 16; 124(41):12066-7.
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      64. Petzold CJ, Ramírez-Arizmendi LE, Heidbrink JL, Pérez J, Kenttämaa HI. Gas-phase reactions of charged phenyl radicals with neutral biomolecules evaporated by laser-induced acoustic desorption. J Am Soc Mass Spectrom. 2002 Feb; 13(2):192-4.
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      65. Pérez J, Petzold CJ, Watkins MA, Vaughn WE, Kenttämaa HI. Laser desorption in transmission geometry inside a Fourier-transform ion cyclotron resonance mass spectrometer. J Am Soc Mass Spectrom. 1999 Nov; 10(11):1105-10.
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